2. Apoptosis
  3. Apoptosis
  4. Nimustine

Nimustine is a nitrosourea alkylating agent. Nimustine induces cell apoptosis, and activates DNA damage response and MAPK signaling. Nimustine shows anti-cancer effects, it can be used for the research of cancer.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Nimustine hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Nimustine Chemical Structure

Nimustine Chemical Structure

CAS No. : 42471-28-3

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Nimustine Related Antibodies

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Description

Nimustine is a nitrosourea alkylating agent. Nimustine induces cell apoptosis, and activates DNA damage response and MAPK signaling. Nimustine shows anti-cancer effects, it can be used for the research of cancer[1][2].

In Vitro

Nimustine (50 μM; 72-120 h) causes cell death by inducing cell apoptosis[1].
Nimustine (50 μM; 24-96 h) activates the DNA damage response pathway[1].
Nimustine (50 μM; 24-120 h) activates MAPK signaling in glioma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nimustine Related Antibodies

Apoptosis Analysis[1]

Cell Line: LN-229 cell line
Concentration: 50 μM
Incubation Time: 72-120 hours
Result: Time-dependently induced apoptosis.

Western Blot Analysis[1]

Cell Line: LN-229 and glioma cell lines
Concentration: 50 μM
Incubation Time: 24-120 hours
Result: Induced cleavage of caspase-8 and -9 and the effector caspase-3. Increased phosphorylation of ERK kinase and H2AX. Decreased phosphorylation of JNK
In Vivo

Nimustine (15 four times a week and 30 mg/kg twice with an interval of 2 weeks; i.v.) effectively inhibits tumor growth and the higher dose is more effective[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C3H/HeN mice with solid FM3A tumors[2]
Dosage: 15 and 30 mg/kg
Administration: Intravenous injection; 15 (4 times a week) and 30 mg/kg (twice with an interval of 2 weeks)
Result: The intermittent large-dose injections resulted in better inhibition of tumor growth than did the fractionated small-dose injections.
Clinical Trial
Molecular Weight

272.69

Formula

C9H13ClN6O2
CAS No.
SMILES

O=C(NCC1=CN=C(C)N=C1N)N(CCCl)N=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nimustine Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nimustine42471-28-3Apoptosisnitrosourea alkylatingapoptosisDNA damageMAPKanti-cancerLN-229gliomamiceFM3AInhibitorinhibitorinhibit

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