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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
436 Results for "
SRC
" in MedChemExpress (MCE) Product Catalog:
Products (436)
436 Results for "SRC" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P1199
CAS No.: 149299-77-4
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P701321
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SRC; Tyrosine Kinase Pp60c-SRC; Prev. SRC1; P60-SRC; C-SRC; Protooncogene SRC, Rous Sarcoma; ASV; Tyrosine-Protein Kinase SRC-1; V-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog; Pp60c-SRC; Proto-Oncogene Tyrosine-Protein Kinase SRC; THC6; SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase; Proto-Oncogene C-SRC
Species:
Human
Source:
E. coli
1
1 Cited Publications
1
Target:
Research Areas:
Tanaproget is an orally effective, selective nonsteroidal progesterone receptor (PR) agonist targeting human PR with an IC50 of 1.7 nM. Tanaproget promotes the interaction between PR receptors and coactivators (such as SRC-1), thereby inhibiting the secretion of matrix metalloproteinases (MMP-3/MMP-7) and reducing endometrial tissue invasion and angiogenesis. Tanaproget can be used for contraception and endometriosis inhibition research .
1
1 Cited Publications
Synonyms: BMS-354825-d8
1
1 Cited Publications
TG 100801 is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
1
1
1 Cited Publications
PD173955 is an orally active inhibitor of Src (IC50= 22 nM), Yes, Abl, ATP and MAP kinases. PD173955 can effectively prevent the mitotic process and has anticancer activity .
1
1
1 Cited Publications
Cat. No.: HY-P73486
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: YES1; YES Proto-Oncogene 1; SRC Family Tyrosine Kinase; HsT441; C-Yes; Yes; V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1; Tyrosine-Protein Kinase Yes; Proto-Oncogene C-Yes; YES1 Proto-Oncogene; SRC Family Tyrosine Kinase; Proto-Oncogene Tyrosine-Pro
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-18302
CAS No.: 1003311-62-3
Target:
Research Areas:
c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties .
1
1 Cited Publications
SD-1008 is a potent JAK inhibitor. SD-1008 inhibits tyrosyl phosphorylation of STAT3, JAK2 and Src. SD-1008 also reduces STAT3-dependent luciferase activity. SD-1008 enhances apoptosis induced by Paclitaxel in ovarian cancer cells via directly blocking the JAK-STAT3 signaling pathway .
1
1 Cited Publications
STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers .
1
1
1 Cited Publications
YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization .
1
1 Cited Publications
Cat. No.: HY-P73269
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LCK; P56(LSTRA) Protein-Tyrosine Kinase; LCK Proto-Oncogene, SRC Family Tyrosine Kinase; Tyrosine-Protein Kinase; Lymphocyte Cell-Specific Protein-Tyrosine Kinase; Proto-Oncogene Lck; T Cell-Specific Protein-Tyrosine Kinase; Protein YT16; Leukocyte C-Term
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-N0909
CAS No.: 80418-25-3
Synonyms: 20(S)-Notoginsenoside R2; Ginsenoside Ng-R2
1
1 Cited Publications
Cat. No.: HY-N0819
CAS No.: 89412-79-3
Synonyms: RR82
Target:
Research Areas:
Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM) and can target DNA and RNA G4s in cells. Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells .
Synonyms: TPX-0022; CSF1R-IN-2
Target:
Research Areas:
Elzovantinib (TPX-0022) is an oral-active inhibitor of SRC, MET and c-FMS, with IC50 values of 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
