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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
175 Results for "
PTP1B
" in MedChemExpress (MCE) Product Catalog:
Products (175)
175 Results for "PTP1B" in MCE Product Catalog:
Cat. No.: HY-P1799A
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Cat. No.: HY-111469R
CAS No.: 888213-72-7
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CPT-157633 (Standard) is the analytical standard of CPT-157633 (HY-111469). This product is intended for research and analytical applications. CPT-157633, a difluoro-phosphonomethyl phenylalanine derivative, and is a PTP1B inhibitor. CPT-157633 prevents binge drinKing-induced glucose intolerance [1].
Cat. No.: HY-163899
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Cat. No.: HY-N12915
CAS No.: 2130080-86-1
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Cat. No.: HY-135564B
CAS No.: 154639-24-4
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(Rac)-RK-682, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively [1].
Cat. No.: HY-164425
CAS No.: 2597832-98-7
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ENT-03 is a centrally acting mammalian aminosterol. ENT-03 upregulates cFos activation, inhibits PTP1b and induces phosphorylation of STAT3. ENT-03 normalizes blood glucose, induces weight loss. ENT-03 can be used in the research of type 2 diabetes and obesity [1].
Cat. No.: HY-N18421
CAS No.: 13192-07-9
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Cat. No.: HY-122416
CAS No.: 68236-11-3
Synonyms: Lonchocarpol A; Senegalensin
Cat. No.: HY-160550
CAS No.: 3018836-86-4
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DPM-1003 is a modulator of protein tyrosine phosphatase 1B (PTP1B) and C-X-C chemokine receptor 4 (CXCR4). DPM-1003 binds to the non-catalytic disordered C-terminal fragment of PTP1B. DPM-1003 inhibits the PI3Kγ-mediated AKT/mTOR signaling pathway downstream of CXCR4. DPM-1003 improves the survival rate of mice in a transfusion-related acute lung injury model, and exerts a lung injury protective effect in preclinical mouse models of acute lung injury and sepsis. DPM-1003 can be used in research related to acute lung injury, acute respiratory distress syndrome, transfusion-related acute lung injury and sepsis [1].
Cat. No.: HY-160514
CAS No.: 2097148-94-0
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LXQ46 is an orally active inhibitor for protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 0.190 μM. LXQ46 enhances insulin and leptin signaling pathways in insulin-resistant C2C12. LXQ46 ameliorates type 2 diabetes and increases insulin tolerance in mouse models [1].
Cat. No.: HY-N12177
CAS No.: 1647101-05-0
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Cat. No.: HY-N12761
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Cat. No.: HY-N3734
CAS No.: 27468-20-8
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Cat. No.: HY-120159
CAS No.: 1710337-31-7
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GS-493 is a selective protein tyrosine phosphatase SHP2 (PTPN11) inhibitor with an IC50 of 71 nM. GS-493 is 29- and 45-fold more active toward SHP2 than related SHP1 and PTP1B. GS-493 blocks cellular motility and growth of cancer cells. Antitumor activity [1].
Cat. No.: HY-182463
CAS No.: 173792-68-2
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Moreollic acid is a PTP1B inhibitor, with an IC50 of 4.44 μM and a Ki of 1.75 μM against human targets. Moreollic acid blocks cell cycle progression from the G1 to S phase and inhibits tumor cell proliferation. Moreollic acid can be used in research related to type 2 diabetes, obesity, colon cancer and other cancers [1] .
Cat. No.: HY-N17601
CAS No.: 50277-02-6
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Cat. No.: HY-N7165
CAS No.: 69297-40-1
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Synonyms: BMOV
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Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer [1] .
Cat. No.: HY-157673
CAS No.: 61599-23-3
Synonyms: 16:1 PE
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1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) is a phosphatidylethanolamine that can enhance PP2A and PTP1B activities in malignant pleural mesothelioma cells. 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine induces apoptosis of NCI-H28 malignant pleural mesothelioma cells [1].
Cat. No.: HY-181683
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Antidiabetic agent 8 is an orally active multi-target inhibitor, with IC50 values of 9.79, 6.36 and 19.08 μM against α-glucosidase, α-amylase and PTP1B, respectively. Antidiabetic agent 8 reduces postprandial blood glucose elevation. Antidiabetic agent 8 can be used in the research of type 2 diabetes [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
