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Isoforms Recommended: CA Ⅱ CA
Results for "

CA

" in MedChemExpress (MCE) Product Catalog:

1348

Inhibitors & Agonists

5

Screening Libraries

38

Fluorescent Dye

42

Biochemical Assay Reagents

120

Peptides

10

Inhibitory Antibodies

161

Natural
Products

95

Recombinant Proteins

91

Isotope-Labeled Compounds

76

Antibodies

6

Click Chemistry

39

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103350
    CA-074
    25+ Cited Publications

    		 Cathepsin Neurological Disease Cancer
    CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
    CA-074
  • HY-103319
    Calmidazolium chloride
    4 Publications Verification

    R 24571

    		 Autophagy Calmodulin Neurological Disease Cancer
    Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively . Also in anti-cancer research . Calmidazolium binds to calmodulin with a Kd of 3 nM.
    Calmidazolium chloride
  • HY-134923
    CA77.1
    5+ Cited Publications

    		 Autophagy Neurological Disease
    CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in?lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's?disease research .
    CA77.1
  • HY-17449
    Fosbretabulin disodium

    CA 4DP; CA 4P; Combretastatin A4 disodium phosphate

    		 Microtubule/Tubulin Apoptosis Cancer
    Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 proagent that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis .
    Fosbretabulin disodium
  • HY-100350
    CA-074 methyl ester
    35+ Cited Publications

    CA-074Me

    		 Cathepsin Neurological Disease Cancer
    CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.
    CA-074 methyl ester
  • HY-101093
    CA-170
    2 Publications Verification

    		 PD-1/PD-L1 Inflammation/Immunology Cancer
    CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes .
    CA-170
  • HY-128370
    Calcium trinatrium diethylenetriaminepentaacetic acid hydrate

    CA-DTPA trisodium salt hydrate

    		 CMV Infection
    Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Diethylenetriaminepentaacetic acid calcium trisodium salt hydrate is a nontoxic inhibitor of CMV replication .
    Calcium trinatrium diethylenetriaminepentaacetic acid hydrate
  • HY-112698
    CA-5f
    4 Publications Verification

    		 p62 Atg8/LC3 Autophagy Apoptosis Cancer
    CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity .
    CA-5f
  • HY-135317
    Emavusertib
    5+ Cited Publications

    CA-4948

    		 IRAK Apoptosis FLT3 NF-κB MyD88 Inflammation/Immunology Cancer
    Emavusertib is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib exhibits antitumor activity in mouse model
    Emavusertib
  • HY-136460
    Calcium ionophore I

    ETH 1001

    		 Calcium Channel Others
    Calcium ionophore I (ETH 1001) is a selective Ca 2+ ionophore for biological membranes. Calcium ionophore I can be used in Ca2+-selective microelectrodes that can be used for quantitative intracellular measurements of resting Ca2+-activities and of slowly changing Ca2+-levels .
    Calcium ionophore I
  • HY-D1631
    Calcium Green-5N AM

    		Fluorescent Dye Calcium Channel Neurological Disease
    Calcium Green-5N AM is a Ca 2+-sensitive fluorescent probe (Kd = 14 μM). Calcium Green-5N AM shows enhanced fluorescence intensity upon binding to Ca 2+, and it can monitor free Ca 2+ in neurons .
    Calcium Green-5N AM
  • HY-110243
    CAIX Inhibitor S4
    1 Publications Verification

    		 Carbonic Anhydrase Cancer
    CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth .
    CAIX Inhibitor S4
  • HY-P11292
    Caloxin 1b3

    		Calcium Channel Cardiovascular Disease
    Caloxin 1b3, a peptide, is a selective plasma membrane Ca 2+ pump 1 (PMCA1) inhibitor. Caloxin 1b3 significantly inhibits PMCA1 Ca 2+–Mg 2+-ATPase in the rabbit duodenal mucosa than the PMCA4 in the human erythrocyte ghosts. Caloxin 1b3 also increases cytosolic Ca 2+ concentration in endothelial cells. Caloxin 1b3 can be used for cardiovascular disorders research .
    Caloxin 1b3
  • HY-41076
    Ca2+ channel agonist 1
    1 Publications Verification

    		 Calcium Channel CDK Neurological Disease
    Ca 2+ channel agonist 1 is an agonist of N-type Ca 2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.
    Ca2+ channel agonist 1
  • HY-P1075
    CALP3
    2 Publications Verification

    		 Calcium Channel Neurological Disease Cancer
    CALP3, a Ca 2+-like peptide, is a potent Ca 2+ channel blocker that activates EF hand motifs of Ca 2+-binding proteins. CALP3 can functionally mimic increased [Ca 2+]i by modulating the activity of Calmodulin (CaM), Ca 2+ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .
    CALP3
  • HY-W749867
    Ca(II)-EDTA disodium dihydrate

    CAlcium disodium EDTA dihydrate

    		 Bacterial Infection Others
    CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis . CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning .
    Ca(II)-EDTA disodium dihydrate
  • HY-124594
    CA inhibitor 1
    1 Publications Verification

    GS-6207 analog

    		 HIV Infection
    CA inhibitor 1 (GS-6207 analog) is a potent HIV capsid inhibitor for HIV inhibition . CA inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    CA inhibitor 1
  • HY-B2217D
    Calcium hydroxide, ACS, 95%

    		Bacterial Biochemical Assay Reagents Inflammation/Immunology
    Calcium hydroxide, ACS, 95% has high bactericidal activity and high pH. Calcium hydroxide, ACS, 95% has ability to induce hard tissue formation. Calcium hydroxide, ACS, 95% can dissociate into calcium (Ca) and hydroxyl ions (OH). Calcium hydroxide, ACS, 95% has the potential for intra-canal medicament research .
    Calcium hydroxide, ACS, 95%
  • HY-100298
    Caldaret

    MCC-135

    		 Na+/Ca2+ Exchanger Cardiovascular Disease
    Caldaret is an intracellular Ca 2+ handling modulator that acts through reverse mode Na +/Ca 2+ exchanger inhibition.
    Caldaret
  • HY-P10655
    Caloxin 1C2

    		Proton Pump Calcium Channel Cardiovascular Disease
    Caloxin 1C2 is a specific PMCA (plasma-membrane Ca 2+-ATPases) inhibitor. Caloxin 1C2 is selective for PMCA4 over PMCA1, 2 and 3. The Ki values of Caloxin 1C2 are 2.3 μM for PMCA4 and 21 μM for PMCA1. Caloxin 1C2 dose not cause any significant effects on total Ca 2+ transfer. Caloxin 1C2 affects coronary contractility .
    Caloxin 1C2
  • HY-D1631A
    Calcium green-5N hexapotassium

    		Fluorescent Dye Neurological Disease
    Calcium green-5N hexapotassium is a cell-impermeant Ca 2+-sensitive fluorescent probe. Calcium green-5N hexapotassium shows enhancement in fluorescence intensity on binding Ca 2+, and can monitor free Ca 2+ in neurons .
    Calcium green-5N hexapotassium
  • HY-16147
    Combretastatin A1 phosphate

    Oxi4503; CA1P; Combretastatin A1 diphosphate

    		 Microtubule/Tubulin Cancer
    Combretastatin A1 phosphate (Oxi4503) is a potent vascular disruptive agent. Combretastatin A1 phosphate exerts anti-angiogenic effects on tumors. Combretastatin A1 phosphate has the potential for the research of pancreatic neuroendocrine tumors .
    Combretastatin A1 phosphate
  • HY-P1076A
    CALP2 TFA

    		Calmodulin Inflammation/Immunology
    CALP2 TFA is a calmodulin (CaM) antagonist (Kd of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca 2+-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca 2+ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages .
    CALP2 TFA
  • HY-137459
    Vocacapsaicin

    CA-008

    		 TRP Channel Neurological Disease
    Vocacapsaicin (CA-008), a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin can provide meaningful and long-lasting pain relief .
    Vocacapsaicin
  • HY-RS01776
    CA9 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CA9 Human Pre-designed siRNA Set A contains three designed siRNAs for CA9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CA9 Human Pre-designed siRNA Set A
    CA9 Human Pre-designed siRNA Set A
  • HY-P5422
    Caloxin 3A1

    		Calcium Channel Others
    Caloxin 3A1 is a biological active peptide. (This peptide belongs to caloxins, the extracellular plasma membrane (PM) Ca2+ pump inhibitors. Caloxin 3A1 inhibits plasma membrane calcium pumps (PMCAs) but not the sarcoplasmic reticulum Ca2+-pump. This peptide does not inhibit formation of the acylphosphate intermediate from ATP.)
    Caloxin 3A1
  • HY-146819
    CAIX/CAXII-IN-1

    		Carbonic Anhydrase Cancer
    Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC50 values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity.
    CAIX/CAXII-IN-1
  • HY-CE01249
    CA-CoA

    CA-Coenzyme A

    		 Biochemical Assay Reagents Metabolic Disease
    CA-CoA (CA-Coenzyme A) is a coenzyme A derivative.
    CA-CoA
  • HY-179271
    CA/HDAC-IN-1

    		Carbonic Anhydrase HDAC Cancer
    CA/HDAC-IN-1 (Compound 11) is a CA and HDAC inhibitor with Ki values of 7.4 nM, 31.0 nM, and 7.3 nM for hCA II, hCA IX, and hCA XII, respectively, and IC50 values of 0.21 μM and 3.60 μM for HDAC3 and HDAC8, respectively. CA/HDAC-IN-1 has anti-cancer activity against colon cancer, breast cancer, and melanoma .
    CA/HDAC-IN-1
  • HY-179530
    CA-II/TNAP-IN-1

    		Carbonic Anhydrase Phosphatase Cancer
    CA-II/TNAP-IN-1 (compound 15) is a potent dual inhibitor against b-TNAP and b-CAII with IC50s of 0.69 and 1.25 μM, respectively. CA-II/TNAP-IN-1 exhibits anti-cancer effects. CA-II/TNAP-IN-1 can be used for cancer research .
    CA-II/TNAP-IN-1
  • HY-P1479
    Calmodulin-Dependent Protein Kinase II (290-309)

    		Autophagy CaMK Neurological Disease
    Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II .
    Calmodulin-Dependent Protein Kinase II (290-309)
  • HY-115745
    Calmodulin antagonist-1

    		Calmodulin Cardiovascular Disease
    Calmodulin antagonist-1 (A-5) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca 2+-phosphodiesterase (PDE) (IC50=66 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca 2+-PDE (IC50=560 μM) in a competitive fashion with respect to cyclic GMP .
    Calmodulin antagonist-1
  • HY-E70197
    Calpain-1 (pig)

    μ-CAlpain

    		 Cathepsin Others
    Calpain-1 (pig) (μ-Calpain) is an intracellular Ca 2+-regulated cysteine protease. Calpain-1 (pig) exhibits neuroprotective effect .
    Calpain-1 (pig)
  • HY-178475
    CA IX/GPX4-IN-1

    		Carbonic Anhydrase Glutathione Peroxidase Ferroptosis Cancer
    CA IX/GPX4-IN-1 (Compound 22abcb) is a dual targeted inhibitor of CA IX and GPX4 activity. CA IX/GPX4-IN-1 can effectively kill SUM159PT cells (IC50 = 416 nM) by inducing iron death under hypoxic conditions. CA IX/GPX4-IN-1 has an IC50 of 663 nM to CA IX in SUM159PT-CAIX-FL cells. CA IX/GPX4-IN-1 can significantly inhibit tumor growth and can be reversed by ferroptosis inhibitors. CA IX/GPX4-IN-1 can be used for research on breast cancer and other cancers .
    CA IX/GPX4-IN-1
  • HY-156013
    CA inhibitor 2

    		Carbonic Anhydrase Endocrinology Cancer
    CA inhibitor 2 (Compound 4H) is a carbonic anhydrase inhibitor (IC50: 0.033 μM) .
    CA inhibitor 2
  • HY-168604
    CA Ⅱ-IN-1

    		Carbonic Anhydrase Cardiovascular Disease
    CA Ⅱ-IN-1 (compound 2i) is a CA Ⅱ isozyme inhibitor, with IC50 of 0.44 µM. CA Ⅱ-IN-1 can be used for metabolic studies .
    CA Ⅱ-IN-1
  • HY-169209
    CA-M11

    		ATM/ATR Cancer
    CA-M11 (compund CA-M11) can enter the liver area of bile salt transport and release Mirin .
    CA-M11
  • HY-159122
    CA IX-IN-2

    		Carbonic Anhydrase Reactive Oxygen Species (ROS) Apoptosis Cancer
    CA IX-IN-2 (Compound 9o) is an inhibitor for carbonic anhydrase (CA), that inhibits CA IX, CA XII and CA II with an IC50 of 5.6, 7.4 and 430 nM, respectively. CA IX-IN-2 inhibits the proliferation of cancer cell HCT-116, SW480, MDA-MB 231 and MCF-7, with IC50s of 14.63-29.33 μM. CA IX-IN-2 intercalates DNA, arrests cell cycle at G1/S phase, and induces apoptosis in MDA-MB-231. CA IX-IN-2 affects the mitochondrial membrane potential (MMP), increases the intracellular ROS levels, causes mitochondrial damage, and inhibits the cell migration of MDA-MB-231. CA IX-IN-2 exhibits antitumor efficacy in mouse models .
    CA IX-IN-2
  • HY-111207
    CA224

    		CDK Apoptosis Cancer
    CA224 (Compound 1) is a selective and orally active Cdk4–cyclin D1 inhibitor with an IC50 of 6.2 µM. CA224 induces cell apoptosis and shows antitumor activity .
    CA224
  • HY-137459A
    Vocacapsaicin hydrochloride

    CA-008 hydrochloride

    		 TRP Channel Neurological Disease
    Vocacapsaicin (CA-008) hydrochloride, a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin hydrochloride can provide meaningful and long-lasting pain relief .
    Vocacapsaicin hydrochloride
  • HY-168767
    CA IX-IN-3

    		Carbonic Anhydrase Others
    CA IX-IN-3 (Compound 27) is a selective and potent carbonic anhydrase IX (CA IX) inhibitor with an IC50 of 0.48 nM .
    CA IX-IN-3
  • HY-149011
    CA IX-IN-1

    		Carbonic Anhydrase Cancer
    CA IX-IN-1 (compound 12g) is an effective and selective inhibitor of hCA IX with IC50 value of 7 nM. CA IX-IN-1 exhibits antitumor activity .
    CA IX-IN-1
  • HY-175219
    CA-II/Dkk1-IN-1

    		Carbonic Anhydrase Cancer
    CA-II/Dkk1-IN-1 (Compound 5d) is a dual-functional inhibitor of CA-II and Dkk1 with a IC50 of 6.90  nM for CA-II. CA-II/Dkk1-IN-1 has significantly antioxidant activity and superior DNA binding capacity. CA-II/Dkk1-IN-1 can be used for cancers research, such as esophageal, renal, and lung cancer .
    CA-II/Dkk1-IN-1
  • HY-163380
    CA/MAO-B-IN-1

    		Carbonic Anhydrase Neurological Disease
    CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC50s of 8.8 and 7.0 nM, respectively. CA/MAO-B-IN-1 reveals a human oral absorption of 71.9% through in silico prediction .
    CA/MAO-B-IN-1
  • HY-158328A
    CA IX/VEGFR-2-IN-2

    		Carbonic Anhydrase VEGFR Reactive Oxygen Species (ROS) MDM-2/p53 Bcl-2 Family Cytochrome P450 Caspase Cancer
    CA IX/VEGFR-2-IN-2 (compound 5e) is a dual-targeted inhibitor. CA IX/VEGFR-2-IN-2 shows strong inhibitory effects on both CA IX (Ki=3.1 μM) and VEGFR-2 (IC50=32.1 nM). CA IX/VEGFR-2-IN-2 can be used for the study of pancreatic (PANC1), breast cancer (MCF7) and prostate cancer (PC3) .
    CA IX/VEGFR-2-IN-2
  • HY-172950
    CAXII-IN-2

    		Carbonic Anhydrase Cancer
    CAXII-IN-2 (compound 3j) is a potent CAXII inhibitor. CAXII-IN-2 inhibits CA IX and CAXII with Ki of 27.4 and 4.0 nM, respectively .
    CAXII-IN-2
  • HY-135317F
    Emavusertib phosphate

    CA-4948 phosphate

    		 IRAK FLT3 NF-κB MyD88 Apoptosis Inflammation/Immunology Cancer
    Emavusertib phosphate (CA-4948 phosphate) is the phosphate salt form of Emavusertib (HY-135317). Emavusertib phosphate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib phosphate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib phosphate exhibits antitumor activity in mouse model .
    Emavusertib phosphate
  • HY-135317E
    Emavusertib maleate

    CA-4948 maleate

    		 IRAK FLT3 NF-κB MyD88 Apoptosis Inflammation/Immunology Cancer
    Emavusertib maleate (CA-4948 maleate) is the maleate salt form of Emavusertib (HY-135317). Emavusertib maleate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib maleate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib maleate exhibits antitumor activity in mouse model .
    Emavusertib maleate
  • HY-135317C
    Emavusertib tosylate

    CA-4948 tosylate

    		 IRAK FLT3 NF-κB MyD88 Apoptosis Inflammation/Immunology Cancer
    Emavusertib tosylate (CA-4948 tosylate) is the tosylate salt form of Emavusertib (HY-135317). Emavusertib tosylate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib tosylate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib tosylate exhibits antitumor activity in mouse model .
    Emavusertib tosylate
  • HY-135317B
    Emavusertib hydrochloride

    CA-4948 hydrochloride

    		 IRAK FLT3 Apoptosis NF-κB MyD88 Inflammation/Immunology Cancer
    Emavusertib hydrochloride (CA-4948 tosylate) is the hydrochloride salt form of Emavusertib (HY-135317). Emavusertib hydrochloride is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib hydrochloride inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib hydrochloride exhibits antitumor activity in mouse model .
    Emavusertib hydrochloride

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