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Caspase substrate

" in MedChemExpress (MCE) Product Catalog:

63

Inhibitors & Agonists

15

Fluorescent Dye

55

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1

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3

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111832
    1,2,3,6-Tetragalloylglucose

    TeGG

    		 UGT Infection Metabolic Disease
    1,2,3,6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase UGT1A1, targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 μM and 4.31 μM, respectively, and binds to UGT1A1 with Ki of 3.55 μM. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease .
    1,2,3,6-Tetragalloylglucose
  • HY-B1302
    Quinidine hydrochloride monohydrate
    20+ Cited Publications

    		 P-glycoprotein PARP Caspase Apoptosis Potassium Channel Cardiovascular Disease Neurological Disease
    Quinidine hydrochloride monohydrate is an orally active antiarrhythmic agent. Quinidine hydrochloride monohydrate reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine hydrochloride monohydrate exerts sustained block and open-channel block effects on IK(f). Quinidine hydrochloride monohydrate alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine hydrochloride monohydrate can be used in studies related to uterine sarcoma and seizures .
    Quinidine hydrochloride monohydrate
  • HY-P1003
    Ac-DEVD-AMC
    4 Publications Verification

    		 Fluorescent Dye Others
    Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .
    Ac-DEVD-AMC
  • HY-N4183
    Licoflavone C
    1 Publications Verification

    		 Apoptosis Caspase Estrogen Receptor/ERR Cardiovascular Disease Infection
    Licoflavone C is a broad-spectrum antiviral inhibitor with estrogen-like properties. Licoflavone C binds to viral endonuclease (CEN) and inhibits the replication of various bunyaviruses including severe fever with thrombocytopenia syndrome virus (SFTSV) and lymphocytic choriomeningitis virus in a non-substrate competitive manner. The IC50 values of Licoflavone C against SFTSV CEN and SFTSV CEN are 35.5 μM and 135.8 μM, respectively, and its Kd value against SFTSV CEN is 9.53 μM. After viral entry into cells, Licoflavone C reduces viral loads in mouse tissues in a dose-dependent manner, and exhibits extremely low cytotoxicity and genotoxicity. Licoflavone C induces apoptosis by increasing caspase 3/7 activity, blocks the cell cycle, and alleviates chemotherapy-induced chromosomal damage. Licoflavone C is applicable to the research on severe fever with thrombocytopenia syndrome and related viral infection mechanisms .
    Licoflavone C
  • HY-P1093
    Ac-LEHD-AFC
    3 Publications Verification

    		 Caspase Others
    Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .
    Ac-LEHD-AFC
  • HY-P1986
    Z-DEVD-AFC

    		Caspase Cancer
    Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
    Z-DEVD-AFC
  • HY-101310
    SYM 2081

    		iGluR EAAT Bcl-2 Family Caspase Cardiovascular Disease Neurological Disease Inflammation/Immunology
    SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of EAAT1 (Km of 54 μM). SYM 2081 inhibits EAAT2-mediated glutamate transport (Kb is 3.4 μM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression). SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain .
    SYM 2081
  • HY-P4547
    Ac-Trp-Glu-His-Asp-AMC

    AC-WEHD-AMC

    		 Caspase Others
    Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .
    Ac-Trp-Glu-His-Asp-AMC
  • HY-P2377
    Ac-YVAD-AFC
    4 Publications Verification

    		 Fluorescent Dye Others
    Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .
    Ac-YVAD-AFC
  • HY-172158
    ALKBH5-IN-5
    1 Publications Verification

    		 Anaplastic lymphoma kinase (ALK) Caspase Cancer
    ALKBH5-IN-5 is a highly selective ALKBH5 (IC50 = 0.62 μM, Kd = 804 nM). ALKBH5-IN-5 disrupts ALKBH5 binding to m 6A-RNA and 6mA-DNA substrates. ALKBH5-IN-5 promotes differentiation, induces apoptosis, cause G2-M phase arrest and exerts strong antiproliferative effects in cancer cells. ALKBH5-IN-5 reduces TACC3 and MYC protein levels and increases cleaved caspase-3 levels. ALKBH5-IN-5 exerts antitumor activity in tumor xenograft mice models. ALKBH5-IN-5 can be used for the research of acute myeloid leukemia .
    ALKBH5-IN-5
  • HY-P1169
    Ac-IETD-AFC
    1 Publications Verification

    		 Caspase Others
    Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .
    Ac-IETD-AFC
  • HY-D1652
    Ac-LEHD-AMC

    		Caspase Others
    Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity .
    Ac-LEHD-AMC
  • HY-P2065
    Ac-VEID-AMC

    		Fluorescent Dye Others
    Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
    Ac-VEID-AMC
  • HY-P2091
    Ac-YVAD-pNA

    		Caspase Inflammation/Immunology
    Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .
    Ac-YVAD-pNA
  • HY-P2617A
    Ac-WEHD-AFC TFA

    		Caspase Inflammation/Immunology Cancer
    Ac-WEHD-AFC TFA is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC TFA can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .
    Ac-WEHD-AFC TFA
  • HY-P5983
    Ac-VEID-AFC
    1 Publications Verification

    		 Caspase Cancer
    Ac-VEID-AFC is a caspase-6 fluorogenic substrate, and can be used in the caspase 6 activity assay .
    Ac-VEID-AFC
  • HY-P3115
    Ac-LEVD-AFC

    		Fluorescent Dye Biochemical Assay Reagents Others
    Ac-LEVD-AFC is capspase-4 fluorogenic substrate peptide that can be used for caspase-4 activity studies .
    Ac-LEVD-AFC
  • HY-P2016
    Ac-Nle-Pro-Nle-Asp-AMC

    		Proteasome Others
    Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .
    Ac-Nle-Pro-Nle-Asp-AMC
  • HY-P10145
    Ac-LEVD-pNA

    		Biochemical Assay Reagents Caspase Others
    Ac-LEVD-pNA is a chromogenic substrate for caspase-4 and can be used to detect caspase-4 activity .
    Ac-LEVD-pNA
  • HY-P2617
    Ac-WEHD-AFC

    		Caspase Inflammation/Immunology Cancer
    Ac-WEHD-AFC is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .
    Ac-WEHD-AFC
  • HY-P2208
    Z-IETD-AFC

    		Fluorescent Dye Cancer
    Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .
    Z-IETD-AFC
  • HY-P2616A
    Mca-YVADAP-Lys(Dnp)-OH TFA

    		Cholinesterase (ChE) Caspase Others
    Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .
    Mca-YVADAP-Lys(Dnp)-OH TFA
  • HY-120833
    Ac-Ile-Glu-Thr-Asp-pNA

    		Caspase Others
    Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .
    Ac-Ile-Glu-Thr-Asp-pNA
  • HY-P3363
    Z-DEVD-AMC

    		Caspase Cancer
    Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .
    Z-DEVD-AMC
  • HY-P10236
    Ac-WEHD-pNA

    		Caspase Others
    Ac-WEHD-pNA is a colorimetric substrate for caspase 1, 4, 5 and 14, which is utilized to measure the caspase activity .
    Ac-WEHD-pNA
  • HY-P2616
    Mca-YVADAP-Lys(Dnp)-OH

    		Caspase Angiotensin-converting Enzyme (ACE) Others
    Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .
    Mca-YVADAP-Lys(Dnp)-OH
  • HY-P2615
    Ac-VDVAD-AFC

    		Fluorescent Dye Cancer
    Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .
    Ac-VDVAD-AFC
  • HY-P4403
    Z-DEVD-R110

    (Z-Asp-Glu-Val-Asp)₂-Rhodamine 110

    		 Fluorescent Dye Apoptosis Caspase Others
    Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)2-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .
    Z-DEVD-R110
  • HY-P10322
    Z-IETD-R110

    		Fluorescent Dye Cancer
    Z-IETD-R110 is a fluorescent substrate of caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8 is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells .
    Z-IETD-R110
  • HY-P2620
    Ac-LETD-AFC

    		Fluorescent Dye Metabolic Disease Cancer
    Ac-LETD-AFC is a caspase-8 fluorogenic substrate. Ac-LETD-AFC can measure caspase-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism .
    Ac-LETD-AFC
  • HY-P3110
    Ac-DNLD-AMC

    		Fluorescent Dye Others
    Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .
    Ac-DNLD-AMC
  • HY-P10450
    (Asp)2-Rhodamine 110

    D2R; (D)2-Rhodamine 110

    		 Caspase Others
    (Asp)2-Rhodamine 110 (D2R) is a fluorescent caspase substrate .
    (Asp)2-Rhodamine 110
  • HY-P10083
    Ac-VQVD-pNA

    		Fluorescent Dye Others
    Ac-VQVD-pNA is a chromogenic substrate of caspase 3 .
    Ac-VQVD-pNA
  • HY-P2615A
    Ac-VDVAD-AFC TFA
    2 Publications Verification

    		 Fluorescent Dye Cancer
    Ac-VDVAD-AFC TFA is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC TFA can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .
    Ac-VDVAD-AFC TFA
  • HY-P4392
    Z-VAD-AMC

    		Caspase Others
    Z-VAD-AMC is a substrate of caspase-9 .
    Z-VAD-AMC
  • HY-P4401
    Z-VEID-AFC

    		Caspase Others
    Z-VEID-AFC is a fluorescent substrate for caspase-6 .
    Z-VEID-AFC
  • HY-P10084
    Ac-VAD-pNA

    		Caspase Others
    Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .
    Ac-VAD-pNA
  • HY-W713878
    Ac-VDVAD-pNA

    		Caspase Others
    Ac-VDVAD-pNA is a caspase-2 substrate. Ac-VDVAD-pNA can be used to test the activity of caspase-2 .
    Ac-VDVAD-pNA
  • HY-P10452
    Ac-LEVDGWK(Dnp)-NH2

    		Caspase Others
    Ac-LEVDGWK(Dnp)-NH2 is a substrate for Caspase-3, and can be used to detect Caspase-3 activity .
    Ac-LEVDGWK(Dnp)-NH2
  • HY-P3475
    Mca-VDQMDGW-K(Dnp)-NH2

    		Fluorescent Dye Others
    Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .
    Mca-VDQMDGW-K(Dnp)-NH2
  • HY-P2614
    Mca-DEVDAP-K(Dnp)-OH

    		Caspase Others
    Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3 .
    Mca-DEVDAP-K(Dnp)-OH
  • HY-P10276
    Ac-VAD-AFC

    		Caspase Cancer
    Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases .
    Ac-VAD-AFC
  • HY-W338079
    Ac-Asp-Glu-Val-Asp-pNA

    		Caspase Others
    Ac-Asp-Glu-Val-Asp-pNA is a peptidic substrate of caspase-3/7 .
    Ac-Asp-Glu-Val-Asp-pNA
  • HY-P5974
    Z-YVAD-pNA

    Z-Tyr-Val-Ala-Asp-pNA

    		 Caspase Others
    Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a caspase-1 substrate .
    Z-YVAD-pNA
  • HY-P3362
    Ac-IETD-AMC

    		Fluorescent Dye Others
    Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .
    Ac-IETD-AMC
  • HY-P3476
    Mca-VDQVDGW-Lys(Dnp)-NH2

    		Fluorescent Dye Caspase Cancer
    Mca-VDQVDGW-Lys(Dnp)-NH2 is a fluorogenic substrate of caspase-7. Mca-VDQVDGW-K(Dnp)-NH2 can be used to quantify caspase-7 activity.
    Mca-VDQVDGW-Lys(Dnp)-NH2
  • HY-P10454
    (Z-IETD)2-Rh 110

    (Z-Ile-Glu-Thr-Asp)2-R110

    		 Caspase Others
    (Z-IETD)2-Rh 110 is a fluorescent substrate of caspase-8 (λex= 488 nm, λem= 523 nm), which can be used to detect the activity of caspase-8 and the process of apoptosis .
    (Z-IETD)2-Rh 110
  • HY-P1169A
    Ac-IETD-AFC TFA

    		Caspase Others
    Ac-IETD-AFC TFA is a synthetic fluorogenic substrate that can be used to specifically detect caspase-8 activity. INDO 1 pentasodium is imbued with the fluorophore AFC (7-amino-4-trifluoromethylcoumarin). When caspase-8 recognizes and cleaves the amide bond following the IETD sequence in this substrate, AFC is released and emits fluorescence (Ex = ~400 nm; Em = ~505 nm) .
    Ac-IETD-AFC TFA
  • HY-P10240
    Ac-WVAD-AMC

    		Fluorescent Dye Others
    Ac-WVAD-AMC is a fluorogenic substrate for caspase 1 .
    Ac-WVAD-AMC
  • HY-P10001
    Z-IETD-pNA

    Z-Ile-Glu-Thr-Asp-pNA

    		 Caspase Cancer
    Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. Z-IETD-pNA is hydrlyzed by caspase 8 to generate pNA .
    Z-IETD-pNA

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