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Results for "

E1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E1/E2/E3 Enzyme (11) 15-PGDH (1) 5-HT Receptor (3) Adrenergic Receptor (1) Akt (3) Aldehyde Dehydrogenase (ALDH) (1) Amino Acid Derivatives (1) AMPK (2) Amyloid-β (1) Androgen Receptor (1) Antibiotic (1) Antibody-Drug Conjugates (ADCs) (2) AP-1 (1) Apoptosis (20) Arenavirus (1) Atg7 (2) Atg8/LC3 (1) ATM/ATR (1) Autophagy (9) Bacterial (4) Bcr-Abl (1) BCRP (1) Biochemical Assay Reagents (7) c-Myc (1) Calcium Channel (1) Carbonic Anhydrase (2) Caspase (2) Cathepsin (3) CD19 (1) CD3 (4) CDK (14) Cholinesterase (ChE) (1) Claudin (1) COX (1) Cytochrome P450 (29) Deubiquitinase (1) DNA Stain (1) DNA/RNA Synthesis (5) Drug Derivative (6) Drug Intermediate (2) Drug Isomer (2) Drug Metabolite (2) Drug-Linker Conjugates for ADC (2) EGFR (1) Endogenous Metabolite (37) Environmental Pollutants (1) Epigenetic Reader Domain (3) Estrogen Receptor/ERR (7) Eukaryotic Initiation Factor (eIF) (1) FABP (1) Fatty Acid Synthase (FASN) (1) Ferroptosis (1) Fungal (3) GABA Receptor (2) Glucokinase (1) GSK-3 (1) HCV (2) HDAC (1) Heme Oxygenase (HO) (2) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) Histone Methyltransferase (3) HIV (1) HPV (3) HSP (1) HSV (1) IFNAR (1) iGluR (2) Influenza Virus (1) Insecticide (2) Interleukin Related (1) Isotope-Labeled Compounds (30) JNK (3) Keap1-Nrf2 (2) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (2) mGluR (1) Microtubule/Tubulin (1) MMP (1) MOFs (13) Molecular Glues (1) mTOR (2) Na+/K+ ATPase (1) Necroptosis (2) NEDD8-activating Enzyme (3) NF-κB (4) NKCC (1) NO Synthase (1) Notch (1) Orphan Nuclear Receptor (2) Oxytocin Receptor (2) P2Y Receptor (1) p38 MAPK (4) Parasite (3) PD-1/PD-L1 (1) PDHK (3) PDK-1 (1) Phosphatase (2) Phosphodiesterase (PDE) (1) Pregnane X Receptor (PXR) (1) Prostaglandin Receptor (24) PROTACs (4) PTEN (1) Radionuclide-Drug Conjugates (RDCs) (1) Raf (1) RAR/RXR (2) Reactive Oxygen Species (ROS) (3) Reference Standards (21) SARS-CoV (8) Sigma Receptor (5) Sirtuin (1) Small Interfering RNA (siRNA) (17) STAT (2) Steroid Sulfatase (1) TGF-β Receptor (1) TNF Receptor (2) Topoisomerase (2) Transmembrane Glycoprotein (2) VD/VDR (1) VEGFR (1) Virus Protease (2) Wnt (2) β-glucuronidase (1) γ-secretase (1)
By Research Areas:	Cancer (83) Cardiovascular Disease (24) Endocrinology (23) Infection (23) Inflammation/Immunology (38) Metabolic Disease (34) Neurological Disease (26)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Phospholipids (1) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (11) siRNAs (17)

284

Inhibitors & Agonists

Screening Libraries

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Isotope-Labeled Compounds

Antibodies

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Targets Recommended: E1/E2/E3 Enzyme

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0131

Prostaglandin E1 Maximum Cited Publications 21 Publications Verification Alprostadil; PGE1	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and *EP1*, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases ^[1] .

HY-B0234

Estrone 5+ Cited Publications E1; Oestrone	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-114041

Resolvin E1 2 Publications Verification RvE1	Endogenous Metabolite	Inflammation/Immunology
Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production ^[1] .

HY-137894A

Tagtociclib hydrate 4 Publications Verification PF-07104091 hydrate	CDK GSK-3	Cancer
PF-07104091 hydrate is a potent and selective CDK2/cyclin E₁ and GSK3β inhibitor, with K_is of 1.16 and 537.81 nM, respectively. PF-07104091 hydrate has anti-tumor activity for cyclin E₁-amplified cancers. (patent WO2020157652A2).

HY-13296

PYR-41 20+ Cited Publications	E1/E2/E3 Enzyme Apoptosis	Cancer
PYR-41 is a selective and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC₅₀ of < 10 μM, with little activity at E2 and E3.

HY-17573

Carbetocin 2 Publications Verification	Oxytocin Receptor	Neurological Disease Endocrinology
Carbetocin, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a K_i of 7.1 nM. Carbetocin has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (K_i=1.17 μM). Carbetocin has the potential for postpartum hemorrhage research. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS ^[1] .

HY-B0234R

Estrone (Standard) 5+ Cited Publications E1(Standard); Oestrone (Standard)	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone (Standard) is the analytical standard of Estrone. This product is intended for research and analytical applications. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-110273

N106 1 Publications Verification	Calcium Channel E1/E2/E3 Enzyme	Cardiovascular Disease
N106 is a first-in-class sarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research ^[1].

HY-114304

COH000 2 Publications Verification	E1/E2/E3 Enzyme	Cancer
COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC₅₀ of 0.2 μM for SUMOylation in vitro ^[1].

HY-118189

Misoprostol acid 1 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology
Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers ^[1]. Misoprostol is an oral agent used to induce labor .

HY-B0234S2

Estrone-d4 E1-d₄; Oestrone-d₄	Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone-d₄ is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-17573A

Carbetocin acetate 2 Publications Verification	Oxytocin Receptor	Neurological Disease Endocrinology
Carbetocin acetate, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a K_i of 7.1 nM. Carbetocin acetate has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (K_i=1.17 μM). Carbetocin acetate has the potential for postpartum hemorrhage research. Carbetocin acetate can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS ^[1] .

HY-147652

G-quadruplex DNA fluorescence probe 1	DNA Stain	Others
G-quadruplex DNA fluorescence probe 1 (Compound E1) is a selective G-quadruplex DNA targeting fluorescent probe. G-quadruplex DNA fluorescence probe 1 can pass through membrane and enter living cells with low cytotoxicity ^[1].

HY-N11709

Theasaponin E1	Apoptosis VEGFR ATM/ATR PTEN Akt mTOR HIF/HIF Prolyl-Hydroxylase NF-κB Notch Cholinesterase (ChE) Amyloid-β γ-secretase Ferroptosis Fungal	Infection Neurological Disease Metabolic Disease Cancer
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and *4E-BP1* proteins, downregulates the expression of *HIF-1α* and NF-κB, and reduces the protein expression of Notch ligands Dll4 and *Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase* and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections ^[1] .

HY-N6853

Mogroside I E1	DNA/RNA Synthesis AMPK	Metabolic Disease Cancer
Mogroside I E1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities ^[1].

HY-103436

NSC624206	E1/E2/E3 Enzyme	Cancer
NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC₅₀ of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC₅₀=13 μM) but has no effect on ubiquitin adenylation ^[1].

HY-N3389

Licoisoflavone A 2 Publications Verification	SARS-CoV Sirtuin CDK Apoptosis	Infection Metabolic Disease Cancer
Licoisoflavone A is an orally active isoflavone. Licoisoflavone A inhibits proliferation, induces apoptosis, and causes G1/S phase arrest in colorectal cancer (CRC) cells. Licoisoflavone A inhibits the CDK2-Cyclin E1 axis. Licoisoflavone A inhibits lipid peroxidation with an IC₅₀ of 7.2 μM. Licoisoflavone A shows a dose-dependent inhibition effect on SARS-CoV-2 infection. Licoisoflavone A exhibits significant anti-tumor efficacy in mice bearing CT26 cell subcutaneous xenografts. Licoisoflavone A can be used for the study of colorectal cancer and SARS-CoV-2 infection ^[1] .

HY-108531

ER 50891	RAR/RXR	Metabolic Disease
ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis ^[1].

HY-116096

15-epi-PGE1 15(R)-Prostaglandin E1; 15-Epiprostaglandin E1	15-PGDH	Others
15-epi-PGE1 (15R-Prostaglandin E1; 15-Epiprostaglandin E1) is a stereoisomer of PGE1 (HY-B0131) but with less biological activity . 15-epi-PGE1 is a non-competitive inhibitor for human placental 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) with an IC₅₀ of 170 μM ^[1].

HY-114041S

Resolvin E1-d4 RvE1-d4	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
Resolvin E1-d₄ (RvE1-d₄) is deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production ^[1] .

HY-P2319A

OVA-E1 peptide TFA	p38 MAPK JNK	Inflammation/Immunology
OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes ^[1].

HY-161251

SPOP-IN-2	E1/E2/E3 Enzyme	Cancer
SPOP-IN-2 (compound E1) is a Speckle-type POZ protein (SPOP) inhibitor with IC₅₀ of 0.58 μM, which disrupt the SPOP-subtrate interaction and selectively inhibits proliferation of ccRCC ^[1].

HY-170897

CDK2-IN-40	CDK	Cancer
CDK2-IN-40 is a CDK2 (Cyclin dependent kinase 2) inhibitor, extracted from patent WO 2024/254245 A1 (Example 1). CDK2-IN-40 inhibits CDK2/Cyclin E1 with an IC₅₀ of ≤ 10 nM ^[1].

HY-137584

1a,1b-Dihomo prostaglandin E1 1a,1b-Dihomo PGE1	Prostaglandin Receptor	Cardiovascular Disease
1a,1b-Dihomo prostaglandin E1 (1a,1b-Dihomo PGE1) is an E1-type prostaglandin. 1a,1b-Dihomo prostaglandin E1 can be used for research on platelet aggregation ^[1].

HY-120665

Prostaglandin B1 PGB1	Prostaglandin Receptor	Endocrinology
Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1 (HY-B0131). Prostaglandin E1 is a prostanoid receptor ligand ^[1] .

HY-113053

Prostaglandin A1	Endogenous Metabolite Apoptosis	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Prostaglandin A1 is a dehydration derivate of Prostaglandin E1. Prostaglandin A1 exhibits inhibitory activities against tumor growth, inflammation, virus replication, platelet aggregation and excitotoxin-induced neurons apoptosis ^[1].

HY-109045A

Teslexivir hydrochloride BTA074 hydrochloride; AP 611074 hydrochloride	E1/E2/E3 Enzyme HPV	Infection
Teslexivir (BTA074) hydrochloride is a potent antiviral agent. Teslexivir hydrochloride is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an association that is a necessary step in the DNA replication and thus viral production for Human Papilloma Virus (HPV) 6 and 11. Teslexivir hydrochloride can be used for condyloma research ^[1].

HY-B0234S1

Estrone-d2 E1-d₂; Oestrone-d₂	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone-d₂ is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-B0234S

Estrone-13C3 E1-¹³C₃; Oestrone-¹³C₃	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone- ¹³C₃ is the ¹³C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-B0131R

Prostaglandin E1 (Standard) Alprostadil(Standard); PGE1 (Standard)	Reference Standards Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases ^[1] .

HY-114041S1

Resolvin E1-d4-1 RvE1-d₄-1	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
Resolvin E1-d₄-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production ^[1] .

HY-116463

E1R	Sigma Receptor	Neurological Disease
E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity ^[1].

HY-116015

Dihomo-γ-Linolenic acid methyl ester	Endogenous Metabolite	Inflammation/Immunology
Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic Acid (DGLA) (HY-A0143). Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is metabolized mainly through the cyclooxygenase (COX) pathway to the anti-inflammatory eicosanoid prostaglandin (PG) E1. Dihomo-γ-Linolenic acid has anti-inflammatory and antiproliferation effects ^[1] .

HY-N11038

Drynachromoside A	Others	Others
Drynachromoside A is a chromone glycoside. Drynachromoside A has biochemical effects on the osteoblastic (MC3T3-E1 cells) proliferation activities ^[1].

HY-137117

15-keto-PGE1 15-keto Prostaglandin E1	Drug Metabolite	Others
15-keto-PGE1 is an inactive Prostaglandin E1 (PGE1) metabolite. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation ^[1].

HY-23337S

1-Methyl-3-((tetrahydrofuran-3-yl)methyl)urea-d3	Isotope-Labeled Compounds	Others
1-Methyl-3-((tetrahydrofuran-3-yl)methyl)urea-d₃ is the deuterium labeled γ-Tocotrienol. γ-Tocotrienol is an active form of vitamin E[1].

HY-114942

Prostaglandin E1 ethyl ester Prostaglandin E1 Et ester; PGE1-EE	Prostaglandin Receptor	Cardiovascular Disease
Prostaglandin E1 ethyl ester (Prostaglandin E1 Et ester) is the esterified form of Prostaglandin E1 (PGE1; HY-B0131). Prostaglandin E1 (Alprostadil) is a prostaglandin receptor ligand that induces vasodilation and inhibits platelet aggregation ^[1].

HY-138206

Prostaglandin E1 isopropyl ester PGE1 isopropyl ester	Prostaglandin Receptor	Cardiovascular Disease
Prostaglandin E1 isopropyl ester is an isopropyl ester form of prostaglandin E1 (HY-B0131). Prostaglandin E1 isopropyl ester exhibits a faster penetration flux than prostaglandin E1 ^[1].

HY-168397

tetranor-Prostaglandin E1	Prostaglandin Receptor	Endocrinology
tetranor-Prostaglandin E1 is metabolite of Prostaglandin E1 (HY-B0131) and Prostaglandin E2 (HY-101952) that is formed by β-oxidation ^[1].

HY-177936

NAE-IN-3	NEDD8-activating Enzyme	Cancer
NAE-IN-3 (compound 1) is a potent, selective and non-covalent competitive NEDD8-activating enzyme (NAE) inhibitor (IC₅₀ = 0.8 μM). NAE-IN-3 inhibits NAE by blocking the ATP-binding domain. NAE-IN-3 exhibits selectivity over analogous E1 enzymes UAE and SAE. NAE-IN-3 can be used for cancer research ^[1].

HY-108531A

ER 50891 quarterhydrate	RAR/RXR	Cancer
ER 50891 quarterhydrate is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis ^[1].

HY-137567

Prostaglandin E1 ethanolamide	Prostaglandin Receptor	Cancer
Prostaglandin E1 ethanolamide is an analog of prostaglandin E1 (PGE1) and may effectively inhibit GLI2-induced expression of target genes, including Gli1 and Ptch1, and tumor growth ^[1].

HY-157976

Dinorprostaglandin E1 dinor-PGE1	Endogenous Metabolite Prostaglandin Receptor	Others
Dinorprostaglandin E1 (dinor-PGE1) is the hepatocyte metabolite of prostaglandin E1 and prostaglandin E. Prostaglandin E1 and prostaglandin E inhibit glucagon, epinephrine, isoproterenol (beta-adrenergic agonist), or epinephrine-stimulated glycogenolysis when co-treated with Isoproterenol (HY-B0468) ^[1].

HY-137133

Prostaglandin E1 alcohol	Prostaglandin Receptor	Inflammation/Immunology Cancer
Prostaglandin E1 alcohol (compound 89) is a prostaglandin analog ^[1].

HY-130226

11-epi-PGE1 11β-Prostaglandin E1	Endogenous Metabolite Prostaglandin Receptor	Cardiovascular Disease Endocrinology Cancer
11-epi-PGE1 (11β-Prostaglandin E1) is a less potent isomer of Prostaglandin E1 (HY-B0131). Prostaglandin E1 is a prostanoid receptor ligand ^[1].

HY-N12191

Cangorinine E-1	HSV	Others
Cangorinine E-1 (compound 11) is a dihydroagarofuran derivative of the sesquiterpenoid family. Cangorinine E-1 exhibits weak inhibitory effects on herpes simplex virus type II (HSV) ^[1].

HY-N12648

Anemarsaponin E1	Others	Inflammation/Immunology
Anemarsaponin E1 can be isolated from Guizhi-Shaoyao-Zhimu decoction (GSZD), and can be used for research of rheumatoid arthritis (RA), gout, osteoarthritis, etc ^[1].

HY-P2319

OVA-E1 peptide	p38 MAPK JNK	Inflammation/Immunology
OVA-E1 peptide, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes ^[1].

HY-128043

11-Deoxy prostaglandin E1 AY-23578; Doproston B; 11-Deoxy-PGE1	Prostaglandin Receptor	Inflammation/Immunology
11-Deoxy prostaglandin E1 (AY-23578; Doproston B) is an analog of prostaglandin E1 (PGE1) with bronchodilator activity. 11-Deoxy prostaglandin E1 inhibits histamine-induced bronchoconstriction and causes relaxation of tracheal strips in isolated guinea pigs ^[1].

HY-19167

Ecraprost AS 013; Lipo-pro-prostaglandin E1	Prostaglandin Receptor	Inflammation/Immunology
Ecraprost is a prodrug of prostaglandin E1. Ecraprost inhibits platelet adhesion, macrophage infiltration and proliferating cell nuclear antigen positive cell expression on the injured arterial walls ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0131

Prostaglandin E1 Maximum Cited Publications 21 Publications Verification Alprostadil; PGE1	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and *EP1*, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases ^[1] .

HY-B0234

Estrone 5+ Cited Publications E1; Oestrone	Monophenols Microorganisms Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Estrogen Receptor/ERR Endogenous Metabolite
Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-N6972

Cepharanthine 10+ Cited Publications	Infection Alkaloids Stephania cepharantha Hayata Classification of Application Fields Plants Isoquinoline Alkaloids Menispermaceae Inflammation/Immunology Disease Research Fields Stephania japonica (Thunb.) Miers	Autophagy SARS-CoV Cytochrome P450 Apoptosis Parasite
Cepharanthine is a natural product that can be isolated from the plant Stephania cephalantha Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC₅₀) and 90% inhibitory concentration (IC₉₀) values of 1.90 and 4.46 μM ^[1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model . Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects .

HY-114041

Resolvin E1 2 Publications Verification RvE1	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production ^[1] .

HY-N0123

Aloin-A 5+ Cited Publications Barbaloin-A	Quinones Structural Classification Liliaceae Classification of Application Fields Anthraquinones Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Disease Research Fields Source Classification Cancer	Wnt
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) ^[1] .

HY-B0234R

Estrone (Standard) 5+ Cited Publications E1(Standard); Oestrone (Standard)	Structural Classification Monophenols Microorganisms Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite
Estrone (Standard) is the analytical standard of Estrone. This product is intended for research and analytical applications. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-122808

(-)-Camphoric acid	Classification of Application Fields Ketones, Aldehydes, Acids Cinnamomum glanduliferum (Wall.) Nees Metabolic Disease Plants Lauraceae Disease Research Fields Source Classification	mGluR NF-κB AP-1
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid induces glutamate receptor expression. Camphoric acid also significantly induces the activation of NF-κB and *AP-1*. Camphoric acid significantly stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells. Camphoric acid has weak regulatory function towards glutamate receptors. Camphoric acid can induce mRNA expression of glutamate signaling molecules and activate transcription factors, thereby stimulating osteoblast differentiation ^[1] .

HY-Y0110

2-Naphthol 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-N4110

Friedelin 1 Publications Verification	Structural Classification Terpenoids Celastraceae Plants Pentacyclic Triterpenoids Maytenus ilicifolia Mart. ex Reissek	Cytochrome P450 NF-κB Interleukin Related
Friedelin is derived from the leaves of Maytenus ilicifolia (Mart). Friedelin is an orally active non-competitive inhibitor of CYP3A4, with IC₅₀ and K_i values of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of *CYP2E1, with IC₅₀* and K_i values of 22.54 μM and 18.02 μM, respectively. Friedelin can be used in research related to inflammation, neurological diseases, and metabolic disorders ^[1] .

HY-113026

Delta-Tocopherol	Classification of Application Fields Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Apoptosis
Delta-Tocopherol is an isomer of Vitamin E .

HY-W042193

2-Piperidone δ-Valerolactam	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Piperidone is an endogenous metabolite. 2-Piperidone is the biomarker for the activity of CYP2E1 ^[1].

HY-N1407

Polygalaxanthone III	Structural Classification Xanthones Classification of Application Fields Polygalaceae Phenols Polyphenols Plants Polygala tenuifolia Willd. Inflammation/Immunology Disease Research Fields Source Classification	Cytochrome P450 STAT
Polygalaxanthone III is a representative xanthone component of Polygala tenuifolia. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by *CYP2E1, with an IC₅₀* of 50.56 μM. Polygalaxanthone III repairs skin damage induced by M. furfur via activating STAT3 phosphorylation and exerts anti-inflammatory effects. Polygalaxanthone III can be used for research on M. furfur-related skin damage ^[1].

HY-136933

Gitoxin	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Scrophulariaceae Plants Disease Research Fields Steroids Source Classification	Na+/K+ ATPase
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na ⁺/K ⁺-ATPase inhibitor, with an IC₅₀ of 1.18e-6 M against the porcine high-affinity subtype and an IC₅₀ of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure ^[1] .

HY-N5132

(-)-Fenchone	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Other Diseases Umbelliferae Plants Vernonia Schreb. Disease Research Fields Source Classification	Cytochrome P450
(-)-Fenchone is a bicyclic monoterpene and serves as a substrate for human liver microsomal cytochrome P450 enzymes CYP2A6 and CYP2B6. (-)-Fenchone is not metabolized by human CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4 enzymes. (-)-Fenchone undergoes hydroxylation to produce 6-exo-hydroxyfenchone, 6-endo-hydroxyfenchone, and 10-hydroxyfenchone. During the metabolism of (-)-Fenchone, CYP2A6 may play a more important role than CYP2B6 ^[1].

HY-N11709

Theasaponin E1	Triterpenes Structural Classification Terpenoids Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Apoptosis VEGFR ATM/ATR PTEN Akt mTOR HIF/HIF Prolyl-Hydroxylase NF-κB Notch Cholinesterase (ChE) Amyloid-β γ-secretase Ferroptosis Fungal
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and *4E-BP1* proteins, downregulates the expression of *HIF-1α* and NF-κB, and reduces the protein expression of Notch ligands Dll4 and *Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase* and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections ^[1] .

HY-N6853

Mogroside I E1	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Sweeteners Source Classification Food Research	DNA/RNA Synthesis AMPK
Mogroside I E1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities ^[1].

HY-155157

PF-07247685	Cardiovascular Disease Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC₅₀=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice ^[1].

HY-N3389

Licoisoflavone A 2 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Source Classification	SARS-CoV Sirtuin CDK Apoptosis
Licoisoflavone A is an orally active isoflavone. Licoisoflavone A inhibits proliferation, induces apoptosis, and causes G1/S phase arrest in colorectal cancer (CRC) cells. Licoisoflavone A inhibits the CDK2-Cyclin E1 axis. Licoisoflavone A inhibits lipid peroxidation with an IC₅₀ of 7.2 μM. Licoisoflavone A shows a dose-dependent inhibition effect on SARS-CoV-2 infection. Licoisoflavone A exhibits significant anti-tumor efficacy in mice bearing CT26 cell subcutaneous xenografts. Licoisoflavone A can be used for the study of colorectal cancer and SARS-CoV-2 infection ^[1] .

HY-120665

Prostaglandin B1 PGB1	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Prostaglandin Receptor
Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1 (HY-B0131). Prostaglandin E1 is a prostanoid receptor ligand ^[1] .

HY-113053

Prostaglandin A1	Animals Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite Apoptosis
Prostaglandin A1 is a dehydration derivate of Prostaglandin E1. Prostaglandin A1 exhibits inhibitory activities against tumor growth, inflammation, virus replication, platelet aggregation and excitotoxin-induced neurons apoptosis ^[1].

HY-B0131R

Prostaglandin E1 (Standard) Alprostadil(Standard); PGE1 (Standard)	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Reference Standards Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases ^[1] .

HY-116015

Dihomo-γ-Linolenic acid methyl ester	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic Acid (DGLA) (HY-A0143). Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is metabolized mainly through the cyclooxygenase (COX) pathway to the anti-inflammatory eicosanoid prostaglandin (PG) E1. Dihomo-γ-Linolenic acid has anti-inflammatory and antiproliferation effects ^[1] .

HY-N11038

Drynachromoside A	Drynaria roosii Nakaike Flavonoids Polypodiaceae Plants Other Flavonoids Source Classification	Others
Drynachromoside A is a chromone glycoside. Drynachromoside A has biochemical effects on the osteoblastic (MC3T3-E1 cells) proliferation activities ^[1].

HY-N8382

Chalepensin	Structural Classification Natural Products Haloxylon ammodendron (C. A. Mey.) Bunge Amaranthaceae Plants Source Classification	Cytochrome P450 Parasite Insecticide
Chalepensin is a nematicide and CYP inhibitor. Chalepensin inhibits CYP2A6, *CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4* to varying degrees, with IC₅₀ values of 82.3 μM, 2.86 μM, 3.01 μM, 0.21 μM, 6.58 μM, 1.67 μM, 61.1 μM, and 61.7 μM, respectively. Chalepensin potently and selectively kills third-stage infective larvae of Strongyloides venezuelensis ^[1] .

HY-N1902R

4-Hydroxyphenylacetic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Phenols Plants Compositae Endogenous metabolite Erythrina latissima E. Mey. Source Classification	Reference Standards Keap1-Nrf2 Endogenous Metabolite
4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 ^[1]. IC₅₀ & Target:Nrf2 ^[1] In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1 ^[1].

HY-N12191

Cangorinine E-1	Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Celastraceae Plants Tripterygium wilfordii Hook. f. Source Classification	HSV
Cangorinine E-1 (compound 11) is a dihydroagarofuran derivative of the sesquiterpenoid family. Cangorinine E-1 exhibits weak inhibitory effects on herpes simplex virus type II (HSV) ^[1].

HY-N12648

Anemarsaponin E1	Structural Classification Liliaceae Anemarrhena asphodeloides Bunge Plants Steroids Source Classification	Others
Anemarsaponin E1 can be isolated from Guizhi-Shaoyao-Zhimu decoction (GSZD), and can be used for research of rheumatoid arthritis (RA), gout, osteoarthritis, etc ^[1].

HY-N14064

Luminacin E1	Natural Products Microorganisms Source Classification	Adrenergic Receptor
Luminacin E1 has a strong inhibitory effect on capillary formation (IC₅₀ is less than 0.1 μg/mL) ^[1].

HY-N0123R

Aloin-A (Standard) Barbaloin-A (Standard)	Quinones Structural Classification Liliaceae Anthraquinones Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Source Classification	Reference Standards Wnt
Aloin (Standard) is the analytical standard of Aloin. This product is intended for research and analytical applications. Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) ^[1] .

HY-N17760

(25RS)-Schidigera-saponin E1	Structural Classification Natural Products Yucca schidigera Roezl ex Ortgies Plants Asparagaceae Juss. Source Classification	Fungal
(25RS)-Schidigera-saponin E1 is a steroidal saponin with anti-yeast activity, which can be isolated from the stems of Yucca schidigera (Mojave yucca). (25RS)-Schidigera-saponin E1 exerts weak anti-yeast activity by affecting the integrity of microbial cell membranes, with a MIC≥100 μg/mL against some food spoilage yeasts. (25RS)-Schidigera-saponin E1 can be used in the field of food preservation to extend the shelf life of foods containing cooked rice, beans, fermented condiments, etc.

HY-155156

PF-07238025	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
PF-07238025 is a BCKDC kinase (BDK) inhibitor (EC₅₀=19 nM). PF-07238025 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07238025 improved cardiometabolic endpoints and improves glucose tolerance in mice ^[1].

HY-W007888R

2-Hydroxy-4-methylbenzaldehyde (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases ^[1] .

HY-W042193R

2-Piperidone (Standard) δ-Valerolactam (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2-Piperidone is an endogenous metabolite. 2-Piperidone is the biomarker for the activity of CYP2E1 ^[1].

HY-N2586

Tenuifoliside C	Monophenols Classification of Application Fields Simple Phenylpropanols Polygalaceae Phenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Polygala tenuifolia Willd. Source Classification	Others
Tenuifoliside C, isolated from polygala tenuifolia willd, significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 ^[1].

HY-113026R

Delta-Tocopherol (Standard)	Structural Classification Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Apoptosis
Delta-Tocopherol (Standard) is the analytical standard of Delta-Tocopherol. This product is intended for research and analytical applications. Delta-Tocopherol is an isomer of Vitamin E .

HY-N17235

4-MeCat-2-sulfate	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Drug Metabolite
4-MeCat-2-sulfate is a phenolic metabolite. 4-MeCat-2-sulfate can be detected in plasma after ingestion of fruit pure´e .

HY-N14645

Ipolamiide	Structural Classification Iridoids Acanthaceae Satureja hortensisL. Terpenoids Plants Source Classification	Phosphatase
Ipolamiide is an antiosteoporotic agent that can be isolated from Barleria lupulina. Ipolamiide exhibits a potent antiosteoporotic effect. Ipolamiide dose-dependently enhances alkaline phosphatase (ALP) activity in MC3T3-E1 cells. Ipolamiide can be used for osteoporosis research ^[1].

HY-N14021

Petasites japonicus extract	Natural Products Plants Compositae Piptadenia Benth. Source Classification	DNA/RNA Synthesis
Petasites japonicus extract is the extract from Petasites japonicus with antioxidant, anti-inflammatory, anti-obesity, neuroprotective and anti-cancer effects. Petasites japonicus extract promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells ^[1].

HY-N6972R

Cepharanthine (Standard)	Structural Classification Alkaloids Stephania cepharantha Hayata Plants Isoquinoline Alkaloids Menispermaceae Stephania japonica (Thunb.) Miers	Autophagy Reference Standards SARS-CoV Cytochrome P450 Apoptosis Parasite
Cepharanthine (Standard) is the analytical standard of Cepharanthine. This product is intended for research and analytical applications. Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC₅₀) and 90% inhibitory concentration (IC90) values of 1.90 and 4.46?μM ^[1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model . Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects .

HY-124371

Amentoflavone hexaacetate	Flavonoids Viburnaceae Plants Biflavones Viburnum lantana L. Source Classification	Phosphodiesterase (PDE)
Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor with antiplatelet aggregation activity. Amentoflavone hexaacetate can inhibit the aggregation of eluted human platelets induced by ADP or collagen. Amentoflavone hexaacetate can also inhibit the cAMP phosphodiesterase activity in human platelets. Amentoflavone hexaacetate can significantly increase the cAMP level of platelets in the presence of prostaglandin E1. Amentoflavone hexaacetate has anti-angiogenic and anti-metastatic effects ^[1].

HY-N0997

(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one	Classification of Application Fields Phenols Curcuma kwangsiensis S. K. Lee & C. F. Liang Plants Inflammation/Immunology Disease Research Fields Cancer Source Classification Zingiberaceae	NO Synthase
(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one (compound7) is a nature product isolated from rhizomes of Curcuma kwangsiensis. (6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one has inhibitory effect on NO production induced by LPS in macrophages with an IC₅₀ value of 8.93 μM ^[1].

HY-N1641

1-O-Deacetylkhayanolide E Deacetylkhayanolide E	Natural Products Classification of Application Fields Khaya anthotheca (Welw.) C.DC. Other Diseases Plants Disease Research Fields Meliaceae Source Classification	Others
1-O-Deacetylkhayanolide E is a khayanolide, which can be isolated from the stem bark of African mahogany Khaya senegalensis ^[1].

HY-125568

Pyridoxatin	Alkaloids Microorganisms Classification of Application Fields Other Diseases Pyridine Alkaloids Disease Research Fields Source Classification	MMP
Pyridoxatin is a free radical scavenger of microbial origin. Pyridoxatin is isolated from a fungus culture identified as Acremonium sp. BX86. Pyridoxatin inhibits lipid peroxidation induced by free radicals in rat liver microsomes free from vitamin E .

HY-Y0110R

2-Naphthol (Standard)	Structural Classification Monophenols Microorganisms Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2-Naphthol (Standard) is the analytical standard of 2-Naphthol. This product is intended for research and analytical applications. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-N4110R

Friedelin (Standard)	Structural Classification Natural Products Celastraceae Plants Maytenus ilicifolia Mart. ex Reissek	Reference Standards Cytochrome P450
Friedelin (Standard) is the analytical standard of Friedelin. This product is intended for research and analytical applications. Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC₅₀ and Kivalues of 10.79 ?μM and 6.16? μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC₅₀ and Ki values of 22.54? μM and 18.02 μM, respectively ^[1].

HY-N1407R

Polygalaxanthone III (Standard)	Structural Classification Xanthones Polygalaceae Phenols Polyphenols Plants Polygala tenuifolia Willd. Source Classification	Reference Standards Cytochrome P450 STAT
Polygalaxanthone III (Standard) is the analytical standard of Polygalaxanthone III (HY-N1407). This product is intended for research and analytical applications. Polygalaxanthone III is a representative xanthone component of Polygala tenuifolia. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by *CYP2E1, with an IC₅₀* of 50.56 μM. Polygalaxanthone III repairs skin damage induced by M. furfur via activating STAT3 phosphorylation and exerts anti-inflammatory effects. Polygalaxanthone III can be used for research on M. furfur-related skin damage ^[1].

HY-N17139

6'-O-Glucopyranosylalbiflorin	Structural Classification Flavonoids Paeonia lactiflora Pall. Flavones Plants Paeoniaceae Source Classification	Others
6'-O-Glucopyranosylalbiflorin is a monoterpene glycoside compound containing two β-D-glucose units, which has bone formation-promoting effects. 0.01-10 μM 6'-O-Glucopyranosylalbiflorin shows significant activity against osteoblast MC3T3-E1 cells, promoting alkaline phosphatase activity and calcium deposition to stimulate osteoblast differentiation. 6'-O-Glucopyranosylalbiflorin can be used in research of osteoporosis. 6'-O-Glucopyranosylalbiflorin can be naturally extracted from the dried roots of Paeonia lactiflora Pall. (peony) from Vinh Phuc province, Vietnam ^[1].

HY-N13018

M145724 (3Z,6E)-1-N-Methylalbonoursin	Natural Products Microorganisms Source Classification	Endogenous Metabolite
M145724 ((3Z,6E)-1-N-Methylalbonoursin) is a metabolite, which can be isolated from Streptomyces albus ^[1].

HY-N0964

*(E)-1-(4-Hydroxyphenyl)dec-1-en-3-one*	Phenols Plants Alpinia galanga (L.) Willd. Source Classification Zingiberaceae	Others
(E)-1-(4-Hydroxyphenyl)dec-1-en-3-one is a Phenols product that can be isolated from the roots of Alpinia galanga ^[1].

HY-N13414

*(3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol*	Phenols Polyphenols Plants Curcuma longa Source Classification Zingiberaceae	Others
(3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol is a natural product ^[1].

Cat. No.	Product Name	Chemical Structure

HY-B0234S2

Estrone-d4
Estrone-d₄ is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-N7148S

α-Vitamin E-d6
α-Vitamin E-d₆ is the deuterium labeled α-Vitamin E .

HY-114041S

Resolvin E1-d4

Resolvin E1-d₄ (RvE1-d₄) is deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production ^[1] .

HY-Y0110S1

2-Naphthol-d7
2-Naphthol-d₇ is the deuterium labeled 2-Naphthol ^[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-B0234S1

Estrone-d2
Estrone-d₂ is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-B0234S

Estrone-13C3
Estrone- ¹³C₃ is the ¹³C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-144427S

Vitamin E-13C2,d6
Vitamin E- ¹³C₂,d₆ is a ¹³C-labeled and deuterium labeled Vitamin E .

HY-13631ES3

Deruxtecan-d2
Deruxtecan-d₂ is the deuterium labeled Deruxtecan (HY-13631E) . Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

HY-114041S1

Resolvin E1-d4-1

Resolvin E1-d₄-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production ^[1] .

HY-23337S

1-Methyl-3-((tetrahydrofuran-3-yl)methyl)urea-d3
1-Methyl-3-((tetrahydrofuran-3-yl)methyl)urea-d₃ is the deuterium labeled γ-Tocotrienol. γ-Tocotrienol is an active form of vitamin E[1].

HY-B1462S

Chlorzoxazone-d3
Chlorzoxazone-d₃ is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans.

HY-13631ES2

Deruxtecan-d4-1
Deruxtecan-d₄-1 is the deuterium labeled Adenosine Deruxtecan (HY-13631E) . Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

HY-150612S

(R)-STU104-d6

(R)-STU104-d₆ is a deuterium labeled (R)-STU104 (HY-150612). (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC₅₀s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis ^[1].

HY-B0131S

Prostaglandin E1-d4

Prostaglandin E1-d₄ is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases ^[1] .

HY-B0131S2

Prostaglandin E1-d9
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-139968S

13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4
13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d₄ is the deuterium labeled 13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1 ^[1].

HY-113113S

13,14-Dihydro PGE1-d4
13,14-Dihydro PGE1-d₄ (13,14-Dihydroprostaglandin E1-d₄) is deuterium labeled 13,14-Dihydro PGE1. 13,14-Dihydro PGE₁ is a metabolite of PGE₁ (Prostaglandin E1) which inhibits the ADP-induced platelet aggregation (ID₅₀ = 10.8 ng/mL platelet rich plasma) ^[1] .

HY-B0234S4

Estrone-d2-1
Estrone-d₂-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-B0234S3

Estrone-13C2
Estrone- ¹³C₂ is the ¹³C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells ^[1] .

HY-118189S

Misoprostol acid-d5

Misoprostol acid-d₅ is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers ^[1]. Misoprostol is an oral agent used to induce labor .

HY-19717S

DCVC-13C3,15N
DCVC- ¹³C₃, ¹⁵N is ¹⁵N and ¹³C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures ^[1] .

HY-W094748S1

Dibenzo-p-dioxin-13C12
Dibenzo-p-dioxin- ¹³C₁₂ is ¹³C labeled Dibenzo[b,e][1,4]dioxin ^[1].

HY-W715121S

2,3,7,8-Tetrabromo dibenzo-p-dioxin-13C12
2,3,7,8-Tetrabromo dibenzo-p-dioxin- ¹³C₁₂ is ¹³C labeled 2,3,7,8-Tetrabromodibenzo[b,E][1,4]dioxine ^[1].

HY-W654160

E,E-Dienestrol-d6
E,E-Dienestrol-d₆ is the deuterium labeled 4,4′-[(1E,2E)-1,2-Diethylidene-1,2-ethanediyl]bis[phenol] (HY-W587857).

HY-W517076S

1,2,3,6,7,8-Hexachloro dibenzo-p-dioxin-13C12
1,2,3,6,7,8-Hexachloro dibenzo-p-dioxin- ¹³C₁₂ is ¹³C labeled 1,2,3,6,7,8-Hexachlorodibenzo[b,e][1,4]dioxine ^[1].

HY-W715180S

2,3-Dibromo-7,8-dichloro dibenzo-p-dioxin-13C12
2,3-Dibromo-7,8-dichloro dibenzo-p-dioxin- ¹³C₁₂ is ¹³C labeled 2,3-Dibromo-7,8-dichlorodibenzo[b,E][1,4]dioxine ^[1].

HY-Y0110S

2-Naphthol-d8
2-Naphthol-d₈ is the deuterium labeled 2-Naphthol ^[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-W717038

Di-(tert-butyl-dimethylsilyl) curcumin-d6
Di-(tert-butyl-dimethylsilyl) curcumin-d₆ is the deuterium labeled (1E,4Z,6E)-1,7-Bis(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one (HY-W703940).

HY-W710827

N,N'-Methylenebisacrylamide-d6

N,N'-Methylenebisacrylamide-d₆ is the deuterium labeled N,N'-Methylenebisacrylamide (HY-D0848). N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel ^[1] .

HY-W094748S

*Dibenzo[b,e][1,4]dioxin-d8*
Dibenzo[b,e][1,4]dioxin-d₈ is the deuterium labeled Dibenzo[b,e][1,4]dioxin ^[1].

HY-76206S

*(E)-1,4-Dibromobut-2-ene-d6*
(E)-1,4-Dibromobut-2-ene-d₆ is the deuterium labeled (E)-1,4-Dibromobut-2-ene ^[1].

HY-W777873S

(9Z,12Z,15E)-1-Palmitoyl-2-linolenoyl-3-chloropropanediol-d5
(9Z,12Z,15E)-1-Palmitoyl-2-linolenoyl-3-chloropropanediol-d5 is a deuterated 3-monochloropropanediol (3-MCPD) glycidyl ester.

HY-W552229S

2,8-Dichloro dibenzo-p-dioxin-13C12
2,8-Dichloro dibenzo-p-dioxin- ¹³C₁₂ is ¹³C labeled 2,8-Dichlorodibenzo[b,e][1,4]dioxine ^[1].

HY-W724345

Fomepizole-d2

Fomepizole-d₂ (4-Methylpyrazole-d₂) is the deuterium labeled Fomepizole (HY-B0876). Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning ^[1] .

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