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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
EV71 replication
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "EV71 replication" in MCE Product Catalog:
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4 Cited Publications
Synonyms: BTA798 diphosphate
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Vapendavir diphosphate (BTA798 diphosphate) is a potent enteroviral capsid binder (CB). Vapendavir diphosphate (BTA798 diphosphate) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains .
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Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains .
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Infection Flavonoids Monophenols Flavones Phenols Plants Disease Research Fields Medicago truncatula Gaertn. Labiatae Extract
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DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies .
Cat. No.: HY-W016407
CAS No.: 25379-88-8
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Methyl 3,4-dihydroxyphenylacetate is a potent enterovirus 71 (EV71) infection inhibitor. Methyl 3,4-dihydroxyphenylacetate inhibits EV71 replication in rhabdomyosarcoma (RD) cells .
Cat. No.: HY-106254S
CAS No.: 2738376-73-1
Synonyms: BTA798-d5
Cat. No.: HY-162022
CAS No.: 314062-80-1
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BTA-188, a pyridazinyl oxime ether, is an orally active, potent inhibitor of rhinoviruses (HRV) and enterovirus (EV) 71 in vitro. BTA-188 inhibits HRV-2 replication with an IC50 of 0.8 nM and an IC90 of 11 nM. BTA-188 inhibits enterovirus with an IC50 of 82 and an IC90 of 109 nM. BTA-188 is a potential chemotherapeutic agent for infections caused by the viruses in the Picornaviridae .
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AN-12-H5, an antienterovirus compound, targets the replication processes of PV and enterovirus 71 (EV71) .
Cat. No.: HY-128660
CAS No.: 2187352-99-2
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RYL-634 is a potent broad-spectrum antiviral agent. RYL-634 exerts its antiviral effect by inhibiting the activity of human dihydroorotate dehydrogenase (HsDHODH) and blocking the supply of pyrimidines required for viral replication. RYL-634 shows significant inhibition against many viruses, with the EC50 values against DENV, ZIKV, EV71, HCV and HIV are 7 nM, 20 nM, 4 nM, 5 nM and 13 nM respectively. RYL-634 can be used for the study of various virus infection-related diseases .
Cat. No.: HY-157082
CAS No.: 2925912-67-8
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ZHSI-1 is an EV71 (Enterovirus 71) inhibitor that inhibits EV71/CVA16 replication and virus-induced pyroptosis associated with viral pathogenesis. ZHSI-1 effectively prevents EV71 infection in neonatal and young mice in animal models. ZHSI-1 can be used to study viral infections such as hand, foot and mouth disease (HFMD) .
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N-Bromoacetamide is an ion channel modulator that modifies proteins by cleaving peptide bonds. N-Bromoacetamide prolongs sodium channel opening time, increases Na + influx, and eliminates fast inactivation of voltage-gated Na + channels. N-Bromoacetamide irreversibly eliminates the calcium-dependent component of calcium-activated potassium channel opening and reduces channel open probability. N-Bromoacetamide slows the inactivation of inactivating K + currents. N-Bromoacetamide also exhibits anti-enterovirus 71 (EV71) activity, inhibiting EV71 replication, reducing viral yield, and alleviating EV71-induced cytopathic effects. N-Bromoacetamide can be used in research on enterovirus infection .
Cat. No.: HY-106254AR
CAS No.: 1198151-75-5
Synonyms: BTA798 diphosphate (Standard)
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Vapendavir diphosphate (Standard) is the analytical standard of Vapendavir diphosphate (HY-106254A). This product is intended for research and analytical applications. Vapendavir diphosphate (BTA798 diphosphate) is a potent enteroviral capsid binder (CB). Vapendavir diphosphate (BTA798 diphosphate) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains .
Cat. No.: HY-185183
CAS No.: 717098-99-2
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DTriP-22 is a highly potent and low-toxicity inhibitor of enterovirus 71 3D polymerase (EV71 3D polymerase). DTriP-22 exhibits broad-spectrum anti-RNA virus activity (particularly against picornaviruses) beyond EV71, but shows no activity against DNA viruses. DTriP-22 acts at the early stage of viral replication and exerts its function by specifically inhibiting viral RNA synthesis. DTriP-22 can be used in anti-enterovirus research .
Cat. No.: HY-187716
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PROTAC 3CPro degrader-1 is a picornavirus 3C protease (3CPro) PROTAC degrader with an DC50 value of 0.16 μM. PROTAC 3CPro degrader-1 directly inhibits the catalytic function of 3CPro, induces degradation via the ubiquitin-proteasome pathway, and binds to CRBN to form a ternary complex. PROTAC 3CPro degrader-1 inhibits viral replication, degrades drug-resistant EV71 3CPro mutants, and exhibits broad-spectrum activity against multiple picornavirus 3CPro variants. PROTAC 3CPro degrader-1 can be used in studies related to picornavirus infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
