49 Results for "

Eicosapentaenoic Acid

" in MedChemExpress (MCE) Product Catalog:
Products (49)

49 Results for "Eicosapentaenoic Acid" in MCE Product Catalog:

33
33 Publications Verification
Cat. No.: HY-B0660
CAS No.: 10417-94-4
Synonyms: EPA; Timnodonic Acid
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .
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33
33 Publications Verification
Cat. No.: HY-W011269
CAS No.: 73167-03-0
Synonyms: EPA sodium; Timnodonic Acid sodium
Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation .
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2
2 Cited Publications
Cat. No.: HY-114041
CAS No.: 552830-51-0
Purity:  95.30%
Synonyms: RvE1
Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .
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Cat. No.: HY-B0747
CAS No.: 86227-47-6
Synonyms: EPA ethyl ester; Ethyl eicosapentaenoate; AMR101
Eicosapentaenoic acid ethyl ester (EPA ethyl ester) is an orally active ω-3 fatty acid agent. Eicosapentaenoic acid ethyl ester could improve the activity of liver β-oxidase in vitro, reduce the level of liver total triglyceride, increase the content of liver triglyceride and phospholipid ω-3 fatty acid, and increase the total ω-3 fatty acid level in rats .
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Cat. No.: HY-W011311
CAS No.: 2734-47-6
Eicosapentaenoic acid methyl ester is a degradation product of monogalactosyldiacylglycerol (Compound 1). Compound 1 can be isolated from the marine diatom Phaeodactylum tricornutum. Compound 1 induces Apoptosis .
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Cat. No.: HY-B0660S
CAS No.: 1197205-73-4
Synonyms: EPA-d5; Timnodonic Acid-d5
Eicosapentaenoic Acid-d5 is the deuterium labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA; Timnodonic acid) is an omega-3 fatty acid.
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Cat. No.: HY-113120
CAS No.: 20290-75-9
Purity:  ≥98.0%
Synonyms: 6Z,9Z,12Z,15Z-Octadecatetraenoic Acid
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit 5-lipoxygenase and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease .
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Cat. No.: HY-B0660R
CAS No.: 10417-94-4
Synonyms: EPA (Standard); Timnodonic Acid (Standard)
Eicosapentaenoic Acid (Standard) is the analytical standard of Eicosapentaenoic Acid. This product is intended for research and analytical applications. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .
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Cat. No.: HY-130675A
CAS No.: 86282-92-0
Purity:  ≥99.0%
Synonyms: 15(S)-hydroxy-Eicosapentaenoic Acid; 15(S)-hydroxy EPA
Target:  

Lipoxygenase

Research Areas:  

Inflammation/Immunology

15(S)-HEPE is a monohydroxy fatty acid. 15(S)-HEPE is biosynthesized from eicosapentaenoic acid by 15-lipoxygenase (15-LO). Serum levels of 15(S)-HEPE are elevated in patients with asthma.
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Cat. No.: HY-101495
CAS No.: 141110-17-0
Purity:  ≥99.0%
Synonyms: 18-Hydroxy-5(Z),8(Z),11(Z),14(Z),16(E)-Eicosapentaenoic Acid
Target:  

Drug Derivative

Research Areas:  

Metabolic Disease

18-HEPE (18-Hydroxy-5(Z),8(Z),11(Z),14(Z),16(E)-eicosapentaenoic acid) is an ester product.
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Cat. No.: HY-133159
CAS No.: 865532-70-3
Purity:  ≥95.0%
Synonyms: (-)-Resolvin E2
Resolvin E2 ((-)-Resolvin E2) is an endogenous lipid mediator produced from eicosapentaenoic acid (EPA) under the catalysis of 5-lipoxygenase (5-LOX), and its production increases in hypoxic environments. Resolvin E2 antagonizes BLT1, partially activates ChemR23, and promotes ubiquitin-proteasome-mediated degradation of COX-2. Resolvin E2 reduces the production of prostaglandin E2, blocks polymorphonuclear leukocyte infiltration, and promotes the resolution of airway inflammation. Resolvin E2 ameliorates lipopolysaccharide (LPS) (HY-D1056)-induced depressive-like behaviors . Resolvin E2 can be used in research related to depression, murine peritonitis, neonatal asthma, and other conditions .
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Cat. No.: HY-113481
CAS No.: 802-31-3
Prostaglandin E3 is an eicosanoid derived from eicosapentaenoic acid. Prostaglandin E3 inhibits polarization towards M1 but promotes polarization of M2a macrophages. Prostaglandin E3 shows anti-inflammatory and anti-tumor activity .
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Cat. No.: HY-113040A
CAS No.: 725246-18-4
Purity:  ≥93.0%
Synonyms: 17(R),18(S)-EETeTr
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease

(17R,18S)-Epoxyeicosatetraenoic acid (17 (R),18 (S)-EETeTr) is a physiologically active fatty acid metabolite and also a vasodilator targeting BKα. (17R,18S)-Epoxyeicosatetraenoic acid activates the outward potassium current mediated by BK channels, and this effect is independent of the BKβ1 subunit, intracellular/extracellular calcium levels, and sarcoplasmic reticulum calcium release regulated by RyR3. (17R,18S)-Epoxyeicosatetraenoic acid is produced by the epoxidation of eicosapentaenoic acid mediated by CYP1A1 variants. (17R,18S)-Epoxyeicosatetraenoic acid is applicable to research related to arrhythmia .
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Cat. No.: HY-130138C
CAS No.: 845673-97-4
Purity:  96.74%
Target:  

Calcium Channel

Research Areas:  

Inflammation/Immunology

5,6-DiHETE is an anti-inflammatory lipid mediator derived from eicosapentaenoic acid (EPA). 5,6-DiHETE has the ability to suppress vascular hyperpermeability during inflammation and is used in the research of inflammatory diseases .
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Cat. No.: HY-114041S
Synonyms: RvE1-d4
Resolvin E1-d4 (RvE1-d4) is deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .
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Cat. No.: HY-158812
CAS No.: 2133456-02-5
Target:  

Drug Derivative

Research Areas:  

Metabolic Disease

Eicosapentaenoyl-L-carnitine chloride is a long-chain acylcarnitine composed of Eicosapentaenoic Acid (HY-B0660) and L-Carnitine (HY-B0399). The levels of Eicosapentaenoyl-L-carnitine chloride are increased in the eyes of mice fed a diet high in n-3/n-6 polyunsaturated fatty acids (PUFAs) in a mouse model of myopia induced by out-of-focus lenses .
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Cat. No.: HY-113445
CAS No.: 71953-80-5
Purity:  ≥95.0%
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease Cancer

Thromboxane B3 is an eicosanoid and the stable hydrolysis product of thromboxane A3, which is synthesized from eicosapentaenoic acid by cyclooxygenase (COX) and thromboxane synthase. Thromboxane B3 participates in inflammatory cell regulation, tumorigenesis and cell proliferation processes. Elevated levels of Thromboxane B3 correlate with high-risk regions of esophageal cancer. Thromboxane B3 can be used in studies related to bladder cancer, renal cell carcinoma and esophageal squamous cell carcinoma .
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Cat. No.: HY-N7833
CAS No.: 24257-10-1
Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.
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Cat. No.: HY-130319A
CAS No.: 286390-03-2
Target:  

PPAR

9-HEPE, a oxidation product of Eicosapentaenoic acid, is a racemic mixture of 9(R)-HEPE and 9(S)-HEPE. 9-HEPE induces fatty acid oxidation, adipogenesis, and glucose uptake via activation of PPARs in vivo .
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Cat. No.: HY-114041S1
CAS No.: 2714040-94-3
Synonyms: RvE1-d4-1
Resolvin E1-d4-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .
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