Search Result

Results for "

GLI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Gli (14) Akt (3) Apoptosis (6) Autophagy (2) Bacterial (1) Caspase (2) CDK (1) DYRK (1) EGFR (1) Endogenous Metabolite (2) Epigenetic Reader Domain (1) ERK (1) GSK-3 (1) HDAC (1) Hedgehog (19) HSP (1) JNK (1) MOFs (1) PI3K (1) PI4K (1) PKA (1) Prostaglandin Receptor (1) RAR/RXR (1) Reference Standards (1) Small Interfering RNA (siRNA) (16) Smo (8)
By Research Areas:	Cancer (28) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (4) Mouse Pre-designed siRNA Sets (5) Human Pre-designed siRNA Sets (7) siRNAs (16)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Antibodies

Oligonucleotides

Targets Recommended: Gli

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13901

GANT 61 Maximum Cited Publications 67 Publications Verification NSC 136476	Gli Autophagy	Cancer
GANT 61 is an inhibitor of *Gli1* and *Gli2* targeting the Hedgehog/GLI pathway.

HY-P4860

Adropin (34-76) (human, mouse, rat) 1 Publications Verification	Akt Gli JNK PKA	Metabolic Disease
Adropin (34-76) is a secretory domain of Adropin. Adropin (34-76) can inhibit cAMP level and glucose production in hepatocytes, and has a hypoglycemic effect. Adropin (34-76) plays an antifibrotic role by inhibiting the *GLI1* signaling pathway .

HY-12316

20(S)-Hydroxycholesterol 3 Publications Verification 20α-Hydroxycholesterol	Smo Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Cancer
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC₅₀ of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .

HY-N2112

Glaucocalyxin A 2 Publications Verification	PI3K Akt Apoptosis	Cancer
Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect .

HY-B0877

Halcinonide 1 Publications Verification SQ-18566	Smo Caspase RAR/RXR CDK	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Halcinonide (SQ-18566) is an orally active Smoothened (Smo) agonist. Halcinonide activates the Hedgehog signaling pathway by binding to Smo and promoting its internalization and expression, thereby activating *Gli* transcription factors. Halcinonide not only stimulates cell proliferation, increases the expression of cyclin D2/CDK6 and inhibits the degradation of caspase-3, but also suppresses Bcl-2/Bax-mediated apoptosis, oxidative stress and inflammatory responses. Halcinonide activates RxRγ to upregulate the expression of myelin genes, thereby reducing cerebral infarction and improving behavioral deficits. Halcinonide has been used in studies related to multiple sclerosis and ischemic stroke .

HY-13282

GANT 58 5+ Cited Publications NSC 75503	MOFs Gli	Cancer
GANT 58 (NSC 75503) is a potent *GLI* antagonist that inhibits GLI1-induced transcription with IC₅₀ of 5 μM .

HY-122590

Glabrescione B	Gli	Cancer
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator *Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA* interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells .

HY-18366A

RU-SKI 43 hydrochloride 2 Publications Verification	Hedgehog	Cancer
RU-SKI 43 hydrochloride is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 hydrochloride reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 hydrochloride has anti-cancer activity .

HY-107551

Hh Pathway-IN-1	Hedgehog Gli	Cancer
Hh Pathway-IN-1, a Hedgehog (Hh) pathway inhibitor, is a potent *Gli* antagonist. Hh Pathway-IN-1 inhibits Hh pathway functional with an IC₅₀ value of 1.1 µM in C3H10T1/2 cells. Hh Pathway-IN-1 does not inhibit Wnt signaling. Hh Pathway-IN-1 shows anti-proliferative activity. Hh Pathway-IN-1 decreases the GLI1 mRNA expression. Hh Pathway-IN-1 inhibits colony formation in a dose-dependent manner .

HY-P10875

HL2-m5	Hedgehog	Cancer
HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with K_d of 170 nM for Shh. HL2-m5 inhibits activation of Hedgehog signaling pathway and transcription of *Gli*-controlled gene with an IC₅₀ of 230 nM .

HY-RS05475

GLI2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GLI2 Human Pre-designed siRNA Set A contains three designed siRNAs for GLI2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLI2 Human Pre-designed siRNA Set A GLI2 Human Pre-designed siRNA Set A

HY-RS05472

GLI1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GLI1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLI1 Human Pre-designed siRNA Set A GLI1 Human Pre-designed siRNA Set A

HY-18366

RU-SKI 43	Hedgehog	Cancer
RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC₅₀ of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity .

HY-110240

IHR-1	Smo	Others
IHR-1 is a cell membrane impermeable Smo antagonist .

HY-143400

HSP70-IN-3	HSP Hedgehog	Cancer
HSP70-IN-3 is a potent HSP70 inhibitor (IC₅₀s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1 .

HY-RS05474

Gli1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gli1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gli1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gli1 Rat Pre-designed siRNA Set A Gli1 Rat Pre-designed siRNA Set A

HY-W111144

T-1330	Hedgehog	Cancer
T-1330 (Compound 45) is a Hh pathway inhibitor and reduces Gli1 expression .

HY-117407

ALLO-2	Smo	Cancer
ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC₅₀ of 6 nM .

HY-107408

SANT 2	Hedgehog Gli	Metabolic Disease Cancer
SANT 2 is a potent Hh-signaling pathway antagonist. SANT 2 interferes with the expression of *Gli1*. SANT 2 causes developmental delay in medaka embryos. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers .

HY-117485

CBR-096-4	Hedgehog	Inflammation/Immunology
CBR-096-4 is a derivative of Itraconazole (HY-17514). CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and αSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis .

HY-161459

GLI1-IN-1	Apoptosis Hedgehog Gli	Cancer
GLI1-IN-1 (CBC-1) is a GLI-1 inhibitor with excellent water solubility and anticancer activity. GLI1-IN-1 can induce apoptosis and suppress the growth of colorectal cancer by inhibiting the Hedgehog(HH) (IC₅₀=1.3 μM) pathway .

HY-172449

GLI1-IN-3	Hedgehog	Cancer
GLI1-IN-3 (Compound 11a), a triterpenoid analogue, can inhibit Hedgehog signaling in GLI1 overexpression cancer cells. GLI1-IN-3 inhibits the proliferation in NSCLC and prostate cancer cell lines exhibiting hyper-activated Hh signaling. GLI1-IN-3 can also decrease the expression of endogenous GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells .

HY-RS05476

GLI3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GLI3 Human Pre-designed siRNA Set A contains three designed siRNAs for GLI3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLI3 Human Pre-designed siRNA Set A GLI3 Human Pre-designed siRNA Set A

HY-RS05477

GLI4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GLI4 Human Pre-designed siRNA Set A contains three designed siRNAs for GLI4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLI4 Human Pre-designed siRNA Set A GLI4 Human Pre-designed siRNA Set A

HY-RS27255

Gli2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gli2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gli2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gli2 Rat Pre-designed siRNA Set A Gli2 Rat Pre-designed siRNA Set A

HY-RS21349

Gli3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gli3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gli3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gli3 Mouse Pre-designed siRNA Set A Gli3 Mouse Pre-designed siRNA Set A

HY-RS05473

Gli1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gli1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gli1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gli1 Mouse Pre-designed siRNA Set A Gli1 Mouse Pre-designed siRNA Set A

HY-119607

DYRKi	DYRK	Cancer
DYRKi is an inhibitor of DYRK1 and DYRK1B with IC₅₀ values of 3.7 µM and 90 nM, respectively, which is used as a potent antagonist of Hh/Gli signaling. DYRKi impairs SMO-dependent and SMO-independent oncogenic GLI activity in human medulloblastoma cells. DYRKi is promising for research of HH/GLI-associated cancers .

HY-13901R

GANT 61 (Standard) NSC 136476 (Standard)	Gli Autophagy Reference Standards	Cancer
GANT 61 (Standard) is the analytical standard of GANT 61. This product is intended for research and analytical applications. GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.

HY-137567

Prostaglandin E1 ethanolamide	Prostaglandin Receptor	Cancer
Prostaglandin E1 ethanolamide is an analog of prostaglandin E1 (PGE1) and may effectively inhibit GLI2-induced expression of target genes, including Gli1 and Ptch1, and tumor growth .

HY-RS05481

GLIS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GLIS2 Human Pre-designed siRNA Set A contains three designed siRNAs for GLIS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLIS2 Human Pre-designed siRNA Set A GLIS2 Human Pre-designed siRNA Set A

HY-RS05482

GLIS3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GLIS3 Human Pre-designed siRNA Set A contains three designed siRNAs for GLIS3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLIS3 Human Pre-designed siRNA Set A GLIS3 Human Pre-designed siRNA Set A

HY-RS05480

GLIS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GLIS1 Human Pre-designed siRNA Set A contains three designed siRNAs for GLIS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLIS1 Human Pre-designed siRNA Set A GLIS1 Human Pre-designed siRNA Set A

HY-RS21582

Glis2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Glis2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Glis2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Glis2 Mouse Pre-designed siRNA Set A Glis2 Mouse Pre-designed siRNA Set A

HY-N8270

Physalin H	Hedgehog Endogenous Metabolite	Cancer
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively .

HY-122017

Methoxy-SANT-2 TC-132	Hedgehog	Cancer
Methoxy-SANT-2 (TC-132) is a potent hedgehog antagonist with an IC₅₀ value of 79.8 nM. Methoxy-SANT-2 inhibits the Gli1 reporter gene expression. Methoxy-SANT-2 has the potential for the research of cancer .

HY-176056

Hedgehog IN-9	Hedgehog Gli Epigenetic Reader Domain	Cancer
Hedgehog IN-9 (Compound 1) is a Hedgehog inhibitor. Hedgehog IN-9 prevents *GLI1* expression and enhances cellular BRD2 protein levels. Hedgehog IN-9 inhibits growth of medulloblastoma spheroid cells and can be used for synthesis of photoaffinity labeling probe .

HY-12487

NL-103	HDAC Hedgehog Gli	Cancer
NL-103 is an inhibitor of histone deacetylases (HDACs) and Hedgehog, with the IC₅₀ values of 21.3 nM, 57 nM, 74 nM, and 680 nM for HDAC1, HDAC2, HDAC3, and HDAC6, respectively. NL-103 can downregulate the expression of *Gli2*. NL-103 can be used in anti-cancer research .

HY-159893

SMO-IN-5	Smo Hedgehog Apoptosis	Cancer
SMO-IN-5 ((Compound 25(B31)) is a potent and competitive inhibitor of smoothened (SMO) that can inhibit Hedgehog (Hh) signaling. SMO-IN-5 interacts with Smo through hydrogen bonds, hydrophobic interactions, and electrostatic forces. SMO-IN-5 inhibits PC cell proliferation, migration, and induces apoptosis by suppressing Gli1 expression. SMO-IN-5 exhibits antitumor activity in pancreatic cancer. .

HY-147670

TPB15	Hedgehog Smo Gli Apoptosis	Cancer
TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity .

HY-162273

Antibacterial agent 189	Bacterial Smo Gli	Infection Cancer
Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins .

HY-RS27868

Gli3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gli3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gli3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gli3 Rat Pre-designed siRNA Set A Gli3 Rat Pre-designed siRNA Set A

HY-RS20743

Gli2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gli2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gli2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gli2 Mouse Pre-designed siRNA Set A Gli2 Mouse Pre-designed siRNA Set A

HY-RS29495

Glis3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Metabolic Disease Inflammation/Immunology
Glis3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Glis3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control. Components Glis3 siRNA-1: 5 nmol (HPLC) Glis3 siRNA-2: 5 nmol (HPLC) Glis3 siRNA-3: 5 nmol (HPLC) siRNA Negative Control: 5 nmol (HPLC) FAM-labeled siRNA Negative Control: 5 nmol (HPLC) GAPDH siRNA Positive Control: 5 nmol (HPLC)

Glis3 Mouse Pre-designed siRNA Set A Glis3 Mouse Pre-designed siRNA Set A

HY-RS28100

Glis2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Glis2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Glis2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Glis2 Rat Pre-designed siRNA Set A Glis2 Rat Pre-designed siRNA Set A

HY-183335

SMO-IN-6	Smo Hedgehog Gli Apoptosis Caspase	Cancer
Anticancer agent 321 is a Smoothened (SMO) inhibitor with a human IC₅₀ of 0.12 μM, enhanced aqueous solubility, good plasma and metabolic stability, moderate therapeutic index, preliminary safety profile, and moderate oral bioavailability in rats.Anticancer agent 321 binds to SMO’s 7-transmembrane helical channel, forming hydrogen bonds with Asp384 and hydrophobic/π-π interactions with His470, Phe391, Tyr394, stabilizing SMO’s inactive conformation to inhibit Hedgehog/GLI signaling.Anticancer agent 321 inhibits proliferation, suppresses colony formation, induces apoptosis, and downregulates Hedgehog/GLI pathway target genes GLI1, GLI2, Ptch1, HHip in cancer cells.Anticancer agent 321 inhibits tumor growth, downregulates Ki67 and SOX2, and upregulates cleaved-caspase 3 in tumor tissues.Anticancer agent 321 can be used for the research of cutaneous squamous cell carcinoma .

HY-182641

SAG analog (cis-isomer) SAG-Cl (cis-isomer)	Gli	Cardiovascular Disease
SAG analog (cis-isomer) (SAG-Cl (cis-isomer)) (Compound 10b) is a *Gli1* activator with an EC₅₀ of 7.6 nM. SAG analog (cis-isomer) is non-toxic .

HY-N9684

Degalactotigonin	EGFR GSK-3 Hedgehog Akt ERK Apoptosis	Cancer
Degalactotigonin is a saponin-selective inhibitor targeting the EGFR, GSK3β and *Hedgehog/Gli1* pathways and can be isolated from Solanum nigrum (Solanum nigrum). Degalactotigonin inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, and at the same time inhibits the Hedgehog/Gli1 pathway through GSK3β inactivation, thereby inducing cancer cell apoptosis, arresting the cell cycle, and inhibiting migration and invasion. Degalactotigonin can be used in targeted research on malignant tumors such as pancreatic cancer and osteosarcoma .

HY-182721

Pipinib	PI4K Hedgehog	Cancer
Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb (PI4KB) inhibitor with an IC₅₀ of 2.2 μM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma .

Cat. No.	Product Name

HY-L038

Differentiation Inducing Compound Library

2,405 compounds

Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method.

MCE Differentiation Inducing Compound Library contains a unique collection of 2,405 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

HY-L020

Wnt/Hedgehog/Notch Compound Library

601 compounds

The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.

MCE designs a unique collection of 601 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

Cat. No.	Product Name	Target	Research Area

HY-P4860

Adropin (34-76) (human, mouse, rat) 1 Publications Verification	Akt Gli JNK PKA	Metabolic Disease
Adropin (34-76) is a secretory domain of Adropin. Adropin (34-76) can inhibit cAMP level and glucose production in hepatocytes, and has a hypoglycemic effect. Adropin (34-76) plays an antifibrotic role by inhibiting the *GLI1* signaling pathway .

HY-P10875

HL2-m5	Hedgehog	Cancer
HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with K_d of 170 nM for Shh. HL2-m5 inhibits activation of Hedgehog signaling pathway and transcription of *Gli*-controlled gene with an IC₅₀ of 230 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12316

20(S)-Hydroxycholesterol 3 Publications Verification 20α-Hydroxycholesterol	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Smo Endogenous Metabolite
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC₅₀ of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .

HY-N2112

Glaucocalyxin A 2 Publications Verification	Classification of Application Fields Terpenoids Labiatae Diterpenoids Plants Glycyrrhiza lepidota Pursh Disease Research Fields Source Classification Cancer	PI3K Akt Apoptosis
Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect .

HY-N8270

Physalin H	Cardiacglycosides Solanum nigrum Linn. Plants Solanaceae Steroids Source Classification	Hedgehog Endogenous Metabolite
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively .

HY-N9684

Degalactotigonin	Plantaginaceae Digitalis purpurea L. Structural Classification Natural Products Plants Source Classification	EGFR GSK-3 Hedgehog Akt ERK Apoptosis
Degalactotigonin is a saponin-selective inhibitor targeting the EGFR, GSK3β and *Hedgehog/Gli1* pathways and can be isolated from Solanum nigrum (Solanum nigrum). Degalactotigonin inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, and at the same time inhibits the Hedgehog/Gli1 pathway through GSK3β inactivation, thereby inducing cancer cell apoptosis, arresting the cell cycle, and inhibiting migration and invasion. Degalactotigonin can be used in targeted research on malignant tumors such as pancreatic cancer and osteosarcoma .

Host:	Mouse (4) Rabbit (5)
Reactivity:	Human (8) Rat (3) Mouse (3)
Application:	IHC-P (6) ICC/IF (5) IHC-F (1) WB (5) FC (3) ELISA (3)
Isotype:	IgG, Kappa (1) IgG (4) IgG1 (2) IgG2a (2)
Conjugation:	Non-conjugated (9)
Clonality:	Polyclonal (1) Monoclonal (6) Recombinant (4)
Modification:	Unmodified (7)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84001

	Gli1 Antibody (YA3698) GLI	IHC-P, ICC/IF, FC, ELISA	Human
	Gli1 Antibody (YA3698) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Gli1.

HY-P84001A

	Gli1 Antibody (YA3698)(PBS only) GLI	IHC-P, ICC/IF, FC, ELISA	Human
	Gli1 Antibody (YA3698) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Gli1.

HY-P83731

	Gli1 Antibody GLI 1; GLI1; GLI-1; GLI; GLI Kruppel family member 1; GLIoma associated oncogene; GLIoma associated oncogene homolog 1 (zinc finger protein); Oncogene GLI; Zfp 5; Zfp5; Zinc finger protein GLI 1; Zinc finger protein GLI1; GLI1_HUMAN.	WB, IHC-P, IHC-F, ICC/IF, FC	Human, Mouse, Rat
	Gli1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Gli1.

HY-P82211

	GLI3 Antibody (YA1956) GLI3; Transcriptional activator GLI3; GLI3 form of 190 kDa; GLI3-190; GLI3 full length protein; GLI3FL	WB, ICC/IF	Human
	GLI3 Antibody (YA1956) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GLI3.

HY-P86893

	Gli2 Antibody (YA6586) CJS antibody; GLI 2 antibody; GLI family zinc finger 2 antibody; GLI Kruppel family member GLI2 antibody; GLI2 antibody; GLI2_HUMAN antibody; GLIoma associated oncogene family zinc finger antibody; HPE9 antibody; Oncogene GLI2 antibody; PHS2 antibody; CJS antibody; GLI 2 antibody; GLI family zinc finger 2 antibody; GLI Kruppel family member GLI2 antibody; GLI2 antibody; GLI2_HUMAN antibody; GLIoma associated oncogene family zinc finger antibody; HPE9 antibody; Oncogene GLI2 antibody; PHS2 antibody; Tax helper protein 1 antibody; Tax helper protein 2 antibody; Tax helper protein antibody; Tax responsive element 2 holding protein antibody; Tax responsive element 25 bp sequence binding protein antibody; THP antibody; THP1 antibody; THP2 antibody; Zinc finger protein GLI2 antibody;	WB	Human, Mouse, Rat
	Gli2 Antibody (YA6586) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Gli2.

HY-P80142

	Gli1 Antibody (YA414)	WB, IHC-P	Mouse, Rat
	Gli1 Antibody (YA414) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Gli1.

HY-P87870

	GLI-1 Antibody (YA7555)	WB, ICC/IF, ELISA	Human
	GLI-1 Antibody (YA7555) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to GLI-1.

HY-P88958

	GLI4 Antibody (YA8642) HKR4; ZNF928	IHC-P	Human
	GLI4 Antibody (YA8642) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GLI4.

HY-P88958A

	GLI4 Antibody (YA8642)(PBS only) HKR4; ZNF928	IHC-P	Human
	GLI4 Antibody (YA8642) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GLI4.

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