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Results for "

J2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Arp2/3 Complex (1) Biochemical Assay Reagents (1) Calcium Channel (2) Cytochrome P450 (3) Drug Derivative (3) Drug Metabolite (1) Endogenous Metabolite (7) ERK (2) Fluorescent Dye (1) Fungal (1) Histone Demethylase (4) HIV (1) HSP (1) iGluR (1) Insecticide (1) Isotope-Labeled Compounds (2) JAK (1) NF-κB (2) Parasite (5) PPAR (5) Prostaglandin Receptor (2) Reactive Oxygen Species (ROS) (2) Reference Standards (3) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Endocrinology (1) Infection (6) Inflammation/Immunology (7) Metabolic Disease (3) Neurological Disease (6)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Inhibitors & Agonists

Fluorescent Dyes

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108568

15-Deoxy-Δ-12,14-prostaglandin J2 2 Publications Verification 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2	PPAR Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC₅₀ of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC₅₀ of 7 μM ^[2].

HY-124653

HSP27 inhibitor J2 Maximum Cited Publications 6 Publications Verification J2	HSP	Cancer
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition ^[2].

HY-113366

Prostaglandin J2 PGJ2	Prostaglandin Receptor Endogenous Metabolite	Neurological Disease
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with K_is of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC₅₀ value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) ^[2] .

HY-N0319

Salvianolic acid C Maximum Cited Publications 6 Publications Verification	Cytochrome P450	Cancer
Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with K_is of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

HY-N0515

Ophiopogonin D 1 Publications Verification	PPAR NF-κB Calcium Channel Reactive Oxygen Species (ROS) ERK	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases ^[2] .

HY-15648A

GSK-J2 4 Publications Verification	Histone Demethylase	Cancer
GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

HY-175443

AMPA-IN-3	iGluR	Neurological Disease
AMPA-IN-3 is an AMPA receptor inhibitor. AMPA-IN-3 inhibits TARP J2-dependent AMPA receptor activity with a pIC₅₀ value of 10.7. A AMPA-IN-3 can be used for the research of neurological disease .

HY-N6744

Chaetoglobosin A	Apoptosis Endogenous Metabolite Fungal Parasite Arp2/3 Complex	Infection Cancer
Chaetoglobosin A is a secondary metabolite and nematicide. Chaetoglobosin A is produced by Penicillium aquamarinium. Chaetoglobosin A targets Filamentous actin in cells, thereby inducing cell cycle arrest, and inhibiting membrane ruffle formation and cell migration. Chaetoglobosin A preferentially induces Apoptosis in chronic lymphocytic leukemia cells. Chaetoglobosin A induces dose- and time-dependent death in J2 larvae of the southern root-knot nematode (Meloidogyne incognita). Chaetoglobosin A can be used in studies related to root-knot nematode disease and chronic lymphocytic leukemia ^[2].

HY-113505

Delta-12-Prostaglandin J2 Δ12-PGJ2	Endogenous Metabolite Apoptosis	Cancer
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation ^[2].

HY-117026

LKY-047 1 Publications Verification	Cytochrome P450	Metabolic Disease Inflammation/Immunology
LKY-047, a Decursin derivative, is a potent and selective reversible competitive cytochrome P45022J2 (CYP2J2) inhibitor with an IC₅₀ of 1.7 μM. LKY-047 is inactive against other human P450s, such as CYPs 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A .

HY-125737

15-Deoxy-Δ12,14-prostaglandin J2 glutathione 15-Deoxy-Δ12,14-PGJ2 Glutathione	Prostaglandin Receptor	Others
15-deoxy-Δ12,14-Prostaglandin J2 glutathione (15-deoxy-Δ12,14-PGJ2 glutathione) is a non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione. The biological properties of this compound have not been characterized.

HY-N0515R

Ophiopogonin D (Standard)	Reference Standards PPAR NF-κB Calcium Channel ERK Reactive Oxygen Species (ROS)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases ^[2] .

HY-108568S

15-Deoxy-Δ-12,14-prostaglandin J2-d4 15d-PGJ2-d₄; 15-Deoxy-Δ12,14-PGJ2-d₄	Isotope-Labeled Compounds PPAR Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
15-Deoxy-Δ-12,14-prostaglandin J2-d₄ is the deuterium labeled 15-Deoxy-Δ-12,14-prostaglandin J2. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC₅₀ of 2 μM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC₅₀ of 7 μM ^[2].

HY-176243

15-Deoxy-Δ12,14-Prostaglandin J2-2-glyceryl ester	Drug Derivative Endogenous Metabolite PPAR	Neurological Disease Inflammation/Immunology Cancer
15-Deoxy-Δ12,14-Prostaglandin J2-2-glyceryl ester is a derivate of 15-Deoxy-Δ-12,14-prostaglandin J2 (HY-108568). 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC₅₀ of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC₅₀ of 7 μM ^[2] .

HY-113366S

Prostaglandin J2-d4	Isotope-Labeled Compounds	Others
Prostaglandin J2-d₄ is the deuterium labeled Prostaglandin J2 .

HY-15648H

GSK-J5 hydrochloride	Histone Demethylase Parasite	Cancer
GSK-J5 hydrochloride is a cell-permeable?ester derivative of?GSK J2 (HY-15648A), inactive. GSK-J5 hydrochloride is also an?isomer of GSK-J4 (HY-15648B) and often used as a negative group .

HY-15648I

GSK-J2 sodium	Histone Demethylase	Cancer
GSK-J2 sodium is the sodium form of GSK-J2 (HY-15648A). GSK-J2 is an isomer of GSK-J1, and does not have any specific activity. GSK-J1 (HY-15648) is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A .

HY-123897

Chamaejasmenin C	Parasite	Infection
Chamaejasmenin C, a biflavanone, shows nematicidal activity against second-stage juveniles (J2s) of B. xylophilus and B. mucronatus ^[2].

HY-122508

Hydroxyebastine	Drug Metabolite	Neurological Disease
Hydroxyebastine is an Ebastine (HY-B0674) (a histamine H₁-receptor antagonist) metabolite. Hydroxyebastine is metabolized to Carebastine (HY-121356) by CYP2J2 and CYP3A4 .

HY-148060

JAK-IN-21 1 Publications Verification	JAK	Cancer
JAK-IN-21 (Example 4) is a selective and potent JAK inhibitor with IC₅₀s of 1.73, 2.04, 109 and 62.9 nM against JAK1, JAK2, J2V617F and TYK2, respectively .

HY-N15483

13,14-Dihydro-15-keto prostaglandin J2 13,14-Dihydro-15-keto-PGJ2	Biochemical Assay Reagents	Endocrinology
13,14-Dihydro-15-keto prostaglandin J2 (13,14-Dihydro-15-keto-PGJ2) is the dehydration product of 13,14-dihydro-15-keto PGD2 (HY-118830) .

HY-172633

15-Deoxy-Δ12,14-prostaglandin J2 serinol amide 15-Deoxy-Δ12,14-PGJ2 serinol amide	Drug Derivative	Others
15-Deoxy-Δ12,14-prostaglandin J2 serinol amide (15-Deoxy-Δ12,14-PGJ2 serinol amide) is a derivative of 15-deoxy-Δ12,14-PGJ2-2-glyceryl ester .

HY-121325

Fervenulin 1 Publications Verification	Parasite	Infection
Fervenulin has nematicidal activity and inhibits egg hatch and J2 mortality of M. incognita with MICs of 30 μg/mL and 120 μg/mL, respectively .

HY-N9246

4'-Methoxyflavanone	Others	Others
4'-Methoxyflavanone is a flavonoid compound. 4'-Methoxyflavanone is isolated from the natural Isaria fumosorosea KCH J2. 4'-Methoxyflavanone regulates metabolic disorders, prevents cardiovascular disease and protects neurons .

HY-N15498

Gibepyrone D	Insecticide	Infection
Gibepyrone D is an α-pyrone compound found in Gibberella fujikuroi and the endophytic fungus Fusarium oxysporum 162. Gibepyrone D exhibits significant lethal activity against nematodes with an LC₅₀ value of 134 μg/mL (72 h) against the J2 larvae of Meloidogyne incognita. Gibepyrone D is promising for research of nematicides ^[2].

HY-D3313

15-Deoxy-Δ12,14-Prostaglandin J2-biotin 15-Deoxy-Δ12,14-PGJ2-biotin	Fluorescent Dye Drug Derivative	Others
15-Deoxy-Δ12,14-Prostaglandin J2-biotin is a biotin-labled 15-Deoxy-Δ12,14-Prostaglandin J2 (HY-108568). 15-Deoxy-Δ12,14-Prostaglandin J2-biotin is a biotin can be used as a fluorescent probe.

HY-W727209

Fluazaindolizine	Parasite	Infection
Fluazaindolizine is a fluorinated nematicide. Fluazaindolizine induces mortality in second-stage juveniles (J2) of Meloidogyne incognita and Tylenchulus semipenetrans in vitro. Fluazaindolizine impacts plant-parasitic nematode parasitism. Fluazaindolizine can be used for the research of plant-parasitic nematode infestation .

HY-RS03465

CYP2J2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CYP2J2 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP2J2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CYP2J2 Human Pre-designed siRNA Set A CYP2J2 Human Pre-designed siRNA Set A

HY-RS15351

UBE2J2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UBE2J2 Human Pre-designed siRNA Set A contains three designed siRNAs for UBE2J2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UBE2J2 Human Pre-designed siRNA Set A UBE2J2 Human Pre-designed siRNA Set A

HY-N0319R

Salvianolic acid C (Standard)	Reference Standards Cytochrome P450	Cancer
Salvianolic acid C (Standard) is the analytical standard of Salvianolic acid C. This product is intended for research and analytical applications. Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

HY-113038AR

α-Hydroxyglutaric acid disodium (Standard) 2-Hydroxyglutarate disodium (Standard); 2-Hydroxyglutaric acid disodium (Standard); 2-Hydroxypentanedioic acid disodium (Standard)	Reference Standards Histone Demethylase Endogenous Metabolite	Cancer
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years ^[2].

HY-146352

HIV-1 inhibitor-28	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC₅₀ of 58 nM for WT HIV-1 strain and an IC₅₀ of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC₅₀ = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS .

HY-RS26031

Ube2j2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ube2j2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ube2j2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ube2j2 Rat Pre-designed siRNA Set A Ube2j2 Rat Pre-designed siRNA Set A

HY-RS19535

Ube2j2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ube2j2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ube2j2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ube2j2 Mouse Pre-designed siRNA Set A Ube2j2 Mouse Pre-designed siRNA Set A

15-Deoxy-Δ12,14-Prostaglandin J2-biotin 15-Deoxy-Δ12,14-PGJ2-biotin	Fluorescent Dyes
15-Deoxy-Δ12,14-Prostaglandin J2-biotin is a biotin-labled 15-Deoxy-Δ12,14-Prostaglandin J2 (HY-108568). 15-Deoxy-Δ12,14-Prostaglandin J2-biotin is a biotin can be used as a fluorescent probe.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-108568

15-Deoxy-Δ-12,14-prostaglandin J2 2 Publications Verification 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2	Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	PPAR Endogenous Metabolite
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC₅₀ of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC₅₀ of 7 μM ^[2].

HY-113366

Prostaglandin J2 PGJ2	Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with K_is of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC₅₀ value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) ^[2] .

HY-N0319

Salvianolic acid C Maximum Cited Publications 6 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Cytochrome P450
Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with K_is of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

HY-N0515

Ophiopogonin D 1 Publications Verification	Ophiopogon japonicus (L. f.) Ker-Gawl. Cardiovascular Disease Liliaceae Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	PPAR NF-κB Calcium Channel Reactive Oxygen Species (ROS) ERK
Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases ^[2] .

HY-N6744

Chaetoglobosin A	Infection Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Marine natural products Endogenous metabolite Marine microorganism Disease Research Fields Indole Alkaloids Source Classification	Apoptosis Endogenous Metabolite Fungal Parasite Arp2/3 Complex
Chaetoglobosin A is a secondary metabolite and nematicide. Chaetoglobosin A is produced by Penicillium aquamarinium. Chaetoglobosin A targets Filamentous actin in cells, thereby inducing cell cycle arrest, and inhibiting membrane ruffle formation and cell migration. Chaetoglobosin A preferentially induces Apoptosis in chronic lymphocytic leukemia cells. Chaetoglobosin A induces dose- and time-dependent death in J2 larvae of the southern root-knot nematode (Meloidogyne incognita). Chaetoglobosin A can be used in studies related to root-knot nematode disease and chronic lymphocytic leukemia ^[2].

HY-113505

Delta-12-Prostaglandin J2 Δ12-PGJ2	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Apoptosis
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation ^[2].

HY-N0515R

Ophiopogonin D (Standard)	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Plants Steroids Source Classification	Reference Standards PPAR NF-κB Calcium Channel ERK Reactive Oxygen Species (ROS)
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases ^[2] .

HY-123897

Chamaejasmenin C	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Parasite
Chamaejasmenin C, a biflavanone, shows nematicidal activity against second-stage juveniles (J2s) of B. xylophilus and B. mucronatus ^[2].

HY-N15483

13,14-Dihydro-15-keto prostaglandin J2 13,14-Dihydro-15-keto-PGJ2	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Biochemical Assay Reagents
13,14-Dihydro-15-keto prostaglandin J2 (13,14-Dihydro-15-keto-PGJ2) is the dehydration product of 13,14-dihydro-15-keto PGD2 (HY-118830) .

HY-N9246

4'-Methoxyflavanone	Flavonoids Microorganisms Flavonones Source Classification	Others
4'-Methoxyflavanone is a flavonoid compound. 4'-Methoxyflavanone is isolated from the natural Isaria fumosorosea KCH J2. 4'-Methoxyflavanone regulates metabolic disorders, prevents cardiovascular disease and protects neurons .

HY-N15498

Gibepyrone D	Microorganisms Ketones, Aldehydes, Acids Source Classification	Insecticide
Gibepyrone D is an α-pyrone compound found in Gibberella fujikuroi and the endophytic fungus Fusarium oxysporum 162. Gibepyrone D exhibits significant lethal activity against nematodes with an LC₅₀ value of 134 μg/mL (72 h) against the J2 larvae of Meloidogyne incognita. Gibepyrone D is promising for research of nematicides ^[2].

HY-N0319R

Salvianolic acid C (Standard)	Structural Classification Ketones, Aldehydes, Acids Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Source Classification	Reference Standards Cytochrome P450
Salvianolic acid C (Standard) is the analytical standard of Salvianolic acid C. This product is intended for research and analytical applications. Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

HY-113038AR

α-Hydroxyglutaric acid disodium (Standard) 2-Hydroxyglutarate disodium (Standard); 2-Hydroxyglutaric acid disodium (Standard); 2-Hydroxypentanedioic acid disodium (Standard)	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Histone Demethylase Endogenous Metabolite
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years ^[2].

Species:	Human (3)
Tag:	His (2) GST (1)
Source:	E. coli Cell-free (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71404

	UBE2J2 Protein, Human (GST) Ubiquitin-Conjugating Enzyme E2 J2; Non-Canonical Ubiquitin-Conjugating Enzyme 2; NCUBE-2; UBE2J2; NCUBE2	Human	E. coli
	The UBE2J2 protein plays a crucial role in cellular processes by catalyzing the covalent attachment of ubiquitin to other proteins. Its function is involved in the selective degradation of misfolded membrane proteins extending into the endoplasmic reticulum (ERAD), as suggested by the similarity of related processes. UBE2J2 Protein, Human (GST) is the recombinant human-derived UBE2J2 protein, expressed by E. coli , with N-GST labeled tag.

HY-P705911

	CYP2J2 Protein, Human (His) Albendazole monooxygenase hydroxylating; Albendazole monooxygenase sulfoxide-forming; Arachidonic acid epoxygenase; CYPIIJ2; Hydroperoxy icosatetraenoate isomerase; CYP2J2	Human	E. coli

HY-P702220

	ATP5J2 Protein, Human (Cell-Free, His) ATP synthase subunit f, mitochondrial; ATP synthase membrane subunit f	Human	E. coli Cell-free
	ATP5J2 protein is a component of mitochondrial membrane ATP synthase (complex V), which uses the proton gradient established by the respiratory chain electron transport complex to help ADP synthesize ATP. ATP5J2 is located in the F(0) domain as a small subunit and cooperates with subunit a in the membrane. ATP5J2 Protein, Human (Cell-Free, His) is the recombinant human-derived ATP5J2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

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HY-108568S

15-Deoxy-Δ-12,14-prostaglandin J2-d4

15-Deoxy-Δ-12,14-prostaglandin J2-d₄ is the deuterium labeled 15-Deoxy-Δ-12,14-prostaglandin J2. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC₅₀ of 2 μM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC₅₀ of 7 μM ^[2].

HY-113366S

Prostaglandin J2-d4
Prostaglandin J2-d₄ is the deuterium labeled Prostaglandin J2 .

Host:	Mouse (8) Rabbit (2)
Reactivity:	Human (9) Rat (3) Mouse (1)
Application:	IHC-P (6) ICC/IF (6) IP (1) WB (5) FC (9) ELISA (4)
Isotype:	IgG (2) IgG1 (6) IgG2a (2)
Conjugation:	Non-conjugated (9)
Clonality:	Monoclonal (5) Recombinant (1)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83003

	DNAJA1 Antibody (YA2748) DNAJA1; DNAJ2; HDJ2; HSJ2; HSPF4; DnaJ homolog subfamily A member 1; DnaJ protein homolog 2; HSDJ; Heat shock 40 kDa protein 4; Heat shock protein J2; HSJ-2; Human DnaJ protein 2; hDj-2	WB, FC, IP	Human, Mouse, Rat
	DNAJA1 Antibody (YA2748) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DNAJA1.

HY-P88250

	CYP2J2 (Cytochrome p450 2J2) Antibody (YA7934) CPJ2	WB, ICC/IF, FC	Human
	CYP2J2 (Cytochrome p450 2J2) Antibody (YA7934) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CYP2J2 (Cytochrome p450 2J2).

HY-P88250A

	CYP2J2 (Cytochrome p450 2J2) Antibody (YA7934)(PBS only) CPJ2	WB, ICC/IF, FC	Human
	CYP2J2 (Cytochrome p450 2J2) Antibody (YA7934) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CYP2J2 (Cytochrome p450 2J2).

HY-P88768

	POLR2J2 Antibody (YA8452) HRPB11B; RPB11b1	IHC-P, ICC/IF, FC	Human
	POLR2J2 Antibody (YA8452) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to POLR2J2.

HY-P83911

	TRBC1 Antibody (YA3608) TCRB; TCRBC1; BV05S1J2.2	IHC-P, FC, ELISA	Human
	TRBC1 Antibody (YA3608) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRBC1.

HY-P83912

	TRBC1 Antibody (YA3609) TCRB; TCRBC1; BV05S1J2.2	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat
	TRBC1 Antibody (YA3609) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRBC1.

HY-P88768A

	POLR2J2 Antibody (YA8452)(PBS only) HRPB11B; RPB11b1	IHC-P, ICC/IF, FC	Human
	POLR2J2 Antibody (YA8452) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to POLR2J2.

HY-P83911A

	TRBC1 Antibody (YA3608)(PBS only) TCRB; TCRBC1; BV05S1J2.2	IHC-P, FC, ELISA	Human
	TRBC1 Antibody (YA3608) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRBC1.

HY-P83912A

	TRBC1 Antibody (YA3609)(PBS only) TCRB; TCRBC1; BV05S1J2.2	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat
	TRBC1 Antibody (YA3609) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRBC1.