Search Result

Results for "

MD-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (1) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (1) COX (2) Environmental Pollutants (1) ERK (2) Histone Acetyltransferase (2) Interleukin Related (4) IRAK (2) MMP (2) MyD88 (2) NF-κB (6) NOD-like Receptor (NLR) (1) PARP (1) Reactive Oxygen Species (ROS) (3) Reference Standards (5) Small Interfering RNA (siRNA) (3) TNF Receptor (3) Toll-like Receptor (TLR) (24)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (21) Metabolic Disease (2) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0795

Procyanidin B1 Maximum Cited Publications 7 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to *TLR4/MD-2* complex, and has anti-inflammatory activity.

HY-W251428

Phosphatidylglycerols (egg) sodium salt Egg PG	Biochemical Assay Reagents	Others
Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein *CD14/MD-2* complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit *COX-2* expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) ^[2] .

HY-N2345

Procyanidin B3 1 Publications Verification	Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor	Inflammation/Immunology Cancer
Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the *TLR4/MD-2* complex. Procyanidin B3 can be used in research on prostate cancer and arthritis ^[2] .

HY-N0774

Isofraxidin 4 Publications Verification	ERK COX MMP Toll-like Receptor (TLR)	Inflammation/Immunology
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of *ERK1/2* in hepatoma cells . Isofraxidin attenuates the expression of iNOS and *COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2*) complex formation ^[2].

HY-103483

MD2-IN-1 Maximum Cited Publications 7 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).

HY-128598

MD2-TLR4-IN-1 1 Publications Verification	Toll-like Receptor (TLR) NF-κB	Inflammation/Immunology Cancer
MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. MD2-TLR4-IN-1 inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced expression of TNF-α and IL-6 in macrophages with IC₅₀ values of 0.89 μM and 0.53 μM, respectively. MD2-TLR4-IN-1 can be used for the study of acute lung injury (ALI) .

HY-108708

GeA-69	PARP	Cancer
GeA-69 is a selective, allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2 (MD2), with a K_d value of 2.1 μM. GeA-69 involves in DNA damage repair mechanisms and prevents recruitment of PARP14 MD2 to sites of laser-induced DNA damage ^[2].

HY-W082785A

L6H21 1 Publications Verification	TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Inflammation/Immunology
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low K_D value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC₅₀ values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research ^[2] .

HY-126154

L48H37 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment .

HY-D1056H

Lipopolysaccharides, from S. marcescens 1 Publications Verification LPS, from Serratia marcescens	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides, from S. marcescens (Serratia marcescens) are lipopolysaccharide endotoxins and TLR-4 activators derived from Serratia marcescens, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. marcescens exhibit a typical three-part structure: O-antigen (O-antigen), core oligosaccharide (core oligosaccharide), and lipid A (Lipid A). Lipopolysaccharides, from S. marcescens induce NF-κB activation in mouse cells via Toll-like receptor (TLR4)/MD-2. The lipopolysaccharides of S. marcescens can induce apoptosis in host immune cells, thereby suppressing the host's innate immunity ^[2]. It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

HY-W014223

2,4′-Dihydroxybenzophenone Ultraviolet absorber UV-0	Environmental Pollutants Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) MyD88 IRAK	Inflammation/Immunology
2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of *MD2* and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber ^[2].

HY-U00435

Neoseptin 3 4 Publications Verification	Toll-like Receptor (TLR)	Cancer
Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC₅₀ of 18.5 μM.

HY-N9347

Stepharine 3 Publications Verification	Toll-like Receptor (TLR)	Cardiovascular Disease Inflammation/Immunology
Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects .

HY-113898

Ganoderic acid K	Angiotensin-converting Enzyme (ACE) Toll-like Receptor (TLR) Interleukin Related	Cardiovascular Disease Neurological Disease
Ganoderic acid K is a triterpenoid compound. Ganoderic acid K can be isolated from Ganoderma lucidum. Ganoderic acid K inhibits ACE activity with an IC₅₀ of 2.6×10 ^-5 M. Ganoderic acid K exhibits direct, high-affinity binding to recombinant *MD2* protein, with a K_d value of 0.47 μM. It potently inhibits LPS-induced release of TNF-α and IL-6. It reduces cerebral infarction volume and ameliorates neurological dysfunction in mice with ischemic stroke in the tMCAO model. Ganoderic acid K can be used in studies related to hypertension and ischemic stroke ^[2].

HY-N0774R

Isofraxidin (Standard)	ERK Reference Standards COX MMP Toll-like Receptor (TLR)	Inflammation/Immunology
Isofraxidin (Standard) is the analytical standard of Isofraxidin. This product is intended for research and analytical applications. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation ^[2].

HY-161026

JM-9	Toll-like Receptor (TLR)	Inflammation/Immunology
JM-9 is a inhibitor of *MD2. JM-9 suppresses high glucose and palmitic acid -induced inflammation in MPMs. JM-9 improves diabetic kidney disease by inhibiting MD2-mediated* inflammation .

HY-117573

1Z105	Toll-like Receptor (TLR)	Inflammation/Immunology
1Z105 is an oral active *TLR4/MD2* ligand. 1Z105 enhances dendritic cell maturation and antigen presentation and prevents rthritis ^[2].

HY-N0795R

Procyanidin B1 (Standard)	Reference Standards Toll-like Receptor (TLR)	Inflammation/Immunology
Procyanidin B1 (Standard) is the analytical standard of Procyanidin B1. This product is intended for research and analytical applications. Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to TLR4/MD-2 complex, and has anti-inflammatory activity.

HY-179036

APG-7	Toll-like Receptor (TLR)	Metabolic Disease Inflammation/Immunology Cancer
APG-7 binds to the *TLR4/MD-2* interface, thereby inhibiting NO production (IC₅₀ of 24.2 μg/mL). APG-7 is an Apigenin (HY-N1201) derivative. APG-7 has low toxicity to the 3T3 fibroblast cell line. APG-7 can be used for the study of oxidative stress and inflammation .

HY-149248

NF-κB-IN-8	NF-κB	Inflammation/Immunology
NF-κB-IN-8 competitively antagonizes LPS binding to MD-2. NF-κB-IN-8 reduces the expression of inflammatory factors by binding to MD-2. NF-κB-IN-8 also inhibits ALP activity. NF-κB-IN-8 can be used for the research of inflammation such as acute lung injury (ALI) .

HY-103483R

MD2-IN-1 (Standard)	Reference Standards Toll-like Receptor (TLR)	Inflammation/Immunology
MD2-IN-1 (Standard) is the analytical standard of MD2-IN-1 (HY-103483). This product is intended for research and analytical applications. MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a K_d of 189 μM for the recombinant human MD2 (rhMD2).

HY-P5117

TAT-CIRP	Toll-like Receptor (TLR)	Neurological Disease
TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice .

HY-W014223R

2,4′-Dihydroxybenzophenone (Standard) Ultraviolet absorber UV-0 (Standard)	Reference Standards Toll-like Receptor (TLR) Reactive Oxygen Species (ROS) MyD88 IRAK NF-κB	Inflammation/Immunology
2,4′-Dihydroxybenzophenone (Standard) is the analytical standard of 2,4′-Dihydroxybenzophenone. This product is intended for research and analytical applications. 2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber ^[2].

HY-RS26109

Ly96 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ly96 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ly96 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ly96 Rat Pre-designed siRNA Set A Ly96 Rat Pre-designed siRNA Set A

HY-RS07908

LY96 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY96 Human Pre-designed siRNA Set A contains three designed siRNAs for LY96 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY96 Human Pre-designed siRNA Set A LY96 Human Pre-designed siRNA Set A

HY-N2345R

Procyanidin B3 (Standard)	Reference Standards Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor	Inflammation/Immunology Cancer
Procyanidin B3 (Standard) is the analytical standard of Procyanidin B3. This product is intended for research and analytical applications. Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis ^[2] .

HY-P11580

Pap12-6-10	Toll-like Receptor (TLR) Bacterial	Infection
Pap12-6-10 is an MD-2 ligand that binds to the hydrophobic pocket of MD-2 to inhibit the dimerization of the *TLR4/MD-2* complex and downstream inflammatory signal transduction. Pap12-6-10 also binds to LPS to permeabilize bacterial cell membranes and induce oxidative stress, leading to bacterial death. Pap12-6-10 regulates LPS-induced inflammatory responses through the TLR4 signaling pathway and exhibits antibacterial activity against multidrug-resistant Gram-negative bacteria. Pap12-6-10 shows low tendency to induce drug resistance and low preclinical cytotoxicity, and it prevents organ damage in a mouse model of sepsis. Pap12-6-10 can be used for research related to Gram-negative sepsis and carbapenem-resistant Acinetobacter baumannii infections .

HY-N19801

N-Palmitoyl-D-glucosamine	Toll-like Receptor (TLR) NF-κB Interleukin Related TNF Receptor	Neurological Disease Inflammation/Immunology
N-Palmitoyl-D-glucosamine is an orally active TLR4 antagonist. N-Palmitoyl-D-glucosamine stably binds *MD-2* with, preventing LPS-induced NF-κB signaling, decreases pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), increases anti-inflammatory IL-10 and IL-1rα, and normalizes miR-20a-5p, miR-106a-5p, and miR-27a-3p levels. N-Palmitoyl-D-glucosamine decreases allodynia and prevents myelino-axonal degeneration of peripheral nerves. N-Palmitoyl-D-glucosamine can be used for the researches of keratitis and peripheral neuropathy .

HY-RS19614

Ly96 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ly96 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ly96 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ly96 Mouse Pre-designed siRNA Set A Ly96 Mouse Pre-designed siRNA Set A

HY-182034

GAP214	Toll-like Receptor (TLR) Interleukin Related TNF Receptor	Inflammation/Immunology
GAP214 is a monosaccharide lipid A analogue and *TLR4/MD-2* complex modulator.GAP214 binds to the *TLR4/MD-2* complex via hydrophobic interactions, salt bridges, and hydrogen bonds, induces dimerization of the complex to initiate intracellular signaling cascades.GAP214 functions as an immunostimulant and vaccine adjuvant, enhances antigen-specific IgG antibody production in a mouse model .

Cat. No.	Product Name	Type

HY-W251428

Phosphatidylglycerols (egg) sodium salt Egg PG	Biochemical Assay Reagents
Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein *CD14/MD-2* complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit *COX-2* expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) ^[2] .

Phosphatidylglycerols (egg) sodium salt

Egg PG

Biochemical Assay Reagents

Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein CD14/MD-2 complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) ^[2] .

HY-D1056H

Lipopolysaccharides, from S. marcescens 1 Publications Verification LPS, from Serratia marcescens	Biochemical Assay Reagents
Lipopolysaccharides, from S. marcescens (Serratia marcescens) are lipopolysaccharide endotoxins and TLR-4 activators derived from Serratia marcescens, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. marcescens exhibit a typical three-part structure: O-antigen (O-antigen), core oligosaccharide (core oligosaccharide), and lipid A (Lipid A). Lipopolysaccharides, from S. marcescens induce NF-κB activation in mouse cells via Toll-like receptor (TLR4)/MD-2. The lipopolysaccharides of S. marcescens can induce apoptosis in host immune cells, thereby suppressing the host's innate immunity ^[2]. It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

Lipopolysaccharides, from S. marcescens

1 Publications Verification

LPS, from Serratia marcescens

Biochemical Assay Reagents

Lipopolysaccharides, from S. marcescens (Serratia marcescens) are lipopolysaccharide endotoxins and TLR-4 activators derived from Serratia marcescens, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. marcescens exhibit a typical three-part structure: O-antigen (O-antigen), core oligosaccharide (core oligosaccharide), and lipid A (Lipid A). Lipopolysaccharides, from S. marcescens induce NF-κB activation in mouse cells via Toll-like receptor (TLR4)/MD-2. The lipopolysaccharides of S. marcescens can induce apoptosis in host immune cells, thereby suppressing the host's innate immunity ^[2].
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

Cat. No.	Product Name	Target	Research Area

HY-P5117

TAT-CIRP	Toll-like Receptor (TLR)	Neurological Disease
TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice .

HY-P11580

Pap12-6-10	Toll-like Receptor (TLR) Bacterial	Infection
Pap12-6-10 is an MD-2 ligand that binds to the hydrophobic pocket of MD-2 to inhibit the dimerization of the *TLR4/MD-2* complex and downstream inflammatory signal transduction. Pap12-6-10 also binds to LPS to permeabilize bacterial cell membranes and induce oxidative stress, leading to bacterial death. Pap12-6-10 regulates LPS-induced inflammatory responses through the TLR4 signaling pathway and exhibits antibacterial activity against multidrug-resistant Gram-negative bacteria. Pap12-6-10 shows low tendency to induce drug resistance and low preclinical cytotoxicity, and it prevents organ damage in a mouse model of sepsis. Pap12-6-10 can be used for research related to Gram-negative sepsis and carbapenem-resistant Acinetobacter baumannii infections .

Procyanidin B1 Maximum Cited Publications 7 Publications Verification	Flavonoids other families Functional Molecules Classification of Application Fields Research of Health Products Phenols Polyphenols Plants Biflavones Inflammation/Immunology Disease Research Fields Source Classification	Toll-like Receptor (TLR)
Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to *TLR4/MD-2* complex, and has anti-inflammatory activity.

Procyanidin B3 1 Publications Verification	Flavonoids other families Functional Molecules Classification of Application Fields Research of Health Products Phenols Polyphenols Plants Biflavones Disease Research Fields Source Classification Cancer	Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor
Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the *TLR4/MD-2* complex. Procyanidin B3 can be used in research on prostate cancer and arthritis ^[2] .

Isofraxidin 4 Publications Verification	Monophenols Classification of Application Fields Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	ERK COX MMP Toll-like Receptor (TLR)
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of *ERK1/2* in hepatoma cells . Isofraxidin attenuates the expression of iNOS and *COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2*) complex formation ^[2].

Stepharine 3 Publications Verification	Cardiovascular Disease Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Toll-like Receptor (TLR)
Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects .

Isofraxidin (Standard)	Structural Classification Monophenols Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae Source Classification	ERK Reference Standards COX MMP Toll-like Receptor (TLR)
Isofraxidin (Standard) is the analytical standard of Isofraxidin. This product is intended for research and analytical applications. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation ^[2].

Procyanidin B1 (Standard)	Structural Classification Flavonoids other families Phenols Polyphenols Plants Biflavones Source Classification	Reference Standards Toll-like Receptor (TLR)
Procyanidin B1 (Standard) is the analytical standard of Procyanidin B1. This product is intended for research and analytical applications. Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to TLR4/MD-2 complex, and has anti-inflammatory activity.

Procyanidin B3 (Standard)	Structural Classification Flavonoids other families Phenols Polyphenols Plants Biflavones Source Classification	Reference Standards Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor
Procyanidin B3 (Standard) is the analytical standard of Procyanidin B3. This product is intended for research and analytical applications. Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis ^[2] .

N-Palmitoyl-D-glucosamine	Structural Classification Natural Products Microorganisms Source Classification	Toll-like Receptor (TLR) NF-κB Interleukin Related TNF Receptor
N-Palmitoyl-D-glucosamine is an orally active TLR4 antagonist. N-Palmitoyl-D-glucosamine stably binds *MD-2* with, preventing LPS-induced NF-κB signaling, decreases pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), increases anti-inflammatory IL-10 and IL-1rα, and normalizes miR-20a-5p, miR-106a-5p, and miR-27a-3p levels. N-Palmitoyl-D-glucosamine decreases allodynia and prevents myelino-axonal degeneration of peripheral nerves. N-Palmitoyl-D-glucosamine can be used for the researches of keratitis and peripheral neuropathy .

Species:	Human (3) Mouse (1)
Tag:	SUMO (1) His (3) Fc (1)
Source:	HEK293 (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P79098

	MD-2/LY96 Protein, Human (His) Lymphocyte antigen 96; LY96; Ly-96; ESOP-1; Protein MD-2; ESOP1; MD2; Myeloid Differentiation Protein 2/Lymphocyte Antigen 96	Human	E. coli
	Myeloid differentiation factor-2 (MD2) (LY96 gene) is a small glycoprotein expressed by macrophages and dendritic cells. MD2 functions as a co-receptor for toll-like receptor (TLR) 4 and is required for its activation. Recognition of LPS by TLR4 requires MD-2 since most of the lipid chains of LPS interact with a hydrophobic pocket in MD-2. MD2 confers invasiveness by activating MAPK and NF-kB signaling pathways and inducing epithelial-mesenchymal transition. MD-2/LY96 Protein, Human (His) is the recombinant human-derived MD-2/LY96 protein, expressed by E. coli , with C-10*His labeled tag.

HY-P701067

	MD-2/LY96 Protein, Human (142a.a, His) 1 Publications Verification Lymphocyte antigen 96; LY96; Ly-96; ESOP1; ESOP-1; MD-2;	Human	E. coli
	MD2 protein binds bacterial lipopolysaccharide (LPS) and collaborates with TLR4 in the innate immune response to LPS. It also interacts with TLR2 in the response to cell wall components from bacteria. MD2 enhances TLR4-dependent NF-kappa-B activation and forms a heterogeneous homomer, participating in a multi-protein complex with CD14 and TLR4. Ligand binding induces complex oligomerization, crucial for the cellular response to LPS. MD-2/LY96 Protein, Human (142a.a, His) is the recombinant human-derived MD2 protein, expressed by E. coli , with C-His labeled tag.

HY-P77081

	MD-2/LY96 Protein, Mouse (HEK293, Fc) Lymphocyte antigen 96; Ly-96; ESOP-1	Mouse	HEK293
	MD-2/LY96 Protein, acting as a monomer, robustly and specifically binds to interleukin-13 (IL13), distinguishing it from interleukin-4 (IL4) with which it does not interact.This selective binding highlights MD-2/LY96's pivotal role in mediating cellular responses to IL13, underscoring its significance in IL13-related biological activities.MD-2/LY96 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived MD-2/LY96 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71540

	MAD2L1 Protein, Human (His-SUMO) 1 Publications Verification HsMAD2; MAD 2; MAD2 like 1; MAD2 mitotic arrest deficient like 1; MAD2-like protein 1; Mad2l1; MD2L1_HUMAN; Mitotic arrest deficient 2-like protein 1; Mitotic spindle assembly checkpoint protein MAD2A; REV7	Human	E. coli
	MAD2L1 is a critical spindle assembly checkpoint component that delays anaphase until correct chromosome alignment. During prophase, it forms a heterotetrameric complex with MAD1L1 at unattached kinetochores, recruiting O-MAD2 and aiding transformation. MAD2L1 Protein, Human (His-SUMO) is the recombinant human-derived MAD2L1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (1) IP (1) WB (2) FC (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87187

	MD2 Antibody (YA6875) ESOP 1 antibody; LY 96 antibody; MD 2 antibody	WB	Human, Mouse, Rat
	MD2 Antibody (YA6875) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MD2.

HY-P810361

	MAD2L2 Antibody (YA9683) Homolog of REV7 S cerevisiae, hREV7, MAD2 (mitotic arrest deficient yeast, homolog) like 2, MAD2 homolog, MAD2 like 2, MAD2 mitotic arrest deficient like 2, MAD2-like protein 2, MAD2B, Mad2l2, MD2L2_HUMAN	WB, IHC-P, FC, IP	Human, Mouse, Rat
	MAD2L2 Antibody (YA9683) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to MAD2L2.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

MD-2

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Antibodies

Oligonucleotides

Natural
Products