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By Research Areas:	Cancer (91) Cardiovascular Disease (69) Endocrinology (43) Infection (98) Inflammation/Immunology (97) Metabolic Disease (133) Neurological Disease (88)
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446

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Recombinant Proteins

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Oligonucleotides

Sulfasalazine 75+ Cited Publications NSC 667219	NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer ^[1] .

Ganciclovir 25+ Cited Publications BW 759; 2'-Nor-2'-deoxyguanosine	CMV HSV Antibiotic Nucleoside Antimetabolite/Analog	Infection Cancer
Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC₅₀ of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain ^[1] .

Losartan potassium 50+ Cited Publications DuP-753 potassium	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀ of 20 nM.

Telmisartan 15+ Cited Publications BIBR 277	Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology Cancer
Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

Propylthiouracil 3 Publications Verification 6-n-Propylthiouracil; 6-Propyl-2-thiouracil; PTU	Environmental Pollutants Thyroid Hormone Receptor	Endocrinology
Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and **type-1 deiodinase (DIO1)** inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research ^[1].

Barbadin 15+ Cited Publications	Apoptosis Arrestin	Others
Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC₅₀ values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis ^[1] .

Crinecerfont SSR-125543	CFTR	Metabolic Disease
Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency ^[1] . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Insulin degludec	Insulin Receptor	Endocrinology
Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC₅₀ value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes ^[1] .

Tiagabine NO050328; NO328; TGB	GABA Receptor	Neurological Disease
Tiagabine (NO050328; NO328; TGB) is an orally active, highly selective, and reversible *GAT-1* inhibitor and anticonvulsant that crosses the blood-brain barrier. By blocking the reuptake of GABA in neurons and glial cells, tiagabine increases extracellular GABA levels to enhance inhibitory signal transduction, thereby exerting multiple activities such as anticonvulsant, neuroprotective, and antioxidant effects. Tiagabine exhibits linear pharmacokinetic properties. Although it is metabolized by CYP3A and has a high protein binding rate, it carries a low risk of cognitive impairment. Tiagabine is widely used in research on related diseases including epilepsy (including refractory partial seizures), alcohol withdrawal symptoms, and Huntington's disease ^[1] .

LRK-4189	mTOR	Cancer
LRK-4189 is an orally active PIP4K2C (a regulator of mTOR complex) degrader and type 1 immune activator. LRK-4189 induces the degradation of the lipid kinase PIP4K2C. LRK-4189 triggers the interferon signaling pathway in microsatellite-stable (MSS) colorectal cancer cells, activates immunogenic tumor killing, and induces endogenous cell death. LRK-4189 sensitizes microsatellite-stable colorectal cancer tumors to NK cell killing and dendritic cell phagocytosis. LRK-4189 can be used for the research of microsatellite-stable colorectal cancer ^[1] .

Crinecerfont hydrochloride SSR-125543 hydrochloride	CFTR	Metabolic Disease
Crinecerfont (SSR-125543) hydrochloride is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont hydrochloride blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont hydrochloride improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont hydrochloride can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency ^[1] . Crinecerfont hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Perillartine 2 Publications Verification DL-Perillartine	Endogenous Metabolite	Others
Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.

WS3	Keap1-Nrf2	Inflammation/Immunology
WS3 is a novel proliferative molecule that promotes pancreatic β cell proliferation in rodent and human primary islets. WS3 can be used for the research of type 1 diabetes ^[1].

ZD 7155hydrochloride 1 Publications Verification	Angiotensin Receptor	Cardiovascular Disease Endocrinology
ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

JMV 2959 3 Publications Verification	GHSR	Neurological Disease Endocrinology
JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32 nM.

Olvanil NE-19550; N-Vanillyloleamide	TRP Channel	Neurological Disease
Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC₅₀ of 0.7 nM ^[1].

BVT-14225 1 Publications Verification	11β-HSD	Metabolic Disease
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC₅₀ of 52 nM.

Volagidemab REMD-477; AMG-477	GCGR	Metabolic Disease
Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D) ^[1] .

AZD 4017	11β-HSD	Metabolic Disease
AZD 4017 is a potent, selective 11β-Hydroxysteroid Dehydrogenase Type 1 *(11β-HSD1)* inhibitor, with an IC₅₀ of 7 nM.

Lenvervimab GC1102	HBV	Infection
Lenvervimab (GC1102) is a IgG1-type recombinant human hepatitis B Immunoglobulin. Lenvervimab can be used for research of hepatitis B virus infection ^[1] .

GSK2245035 2 Publications Verification	Toll-like Receptor (TLR) IFNAR TNF Receptor	Inflammation/Immunology
GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC₅₀s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma ^[1].

Nifeviroc	CCR HIV	Infection Inflammation/Immunology
Nifeviroc is an orally active CCR5 antagonist. Nifeviroc is used for the study of HIV type-1 infection ^[1].

TMC310911 1 Publications Verification ASC-09	HIV Protease	Infection
TMC310911 is a potent and orally active *HIV type-1* (HIV-1) protease inhibitor with EC₅₀** values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant *HIV-1* isolates. TMC310911 has strong antiviral activity ^[1] .

IW927	TNF Receptor	Neurological Disease Inflammation/Immunology Cancer
IW927 is a photochemically enhanced *TNF-α-TNFR1* interaction inhibitor that blocks the binding of TNF-α to *TNFRc1* with an IC₅₀ value of 50 nM. IW927 binds reversibly to the *TNFRc1* with weak affinity (K_d = 40-100 μM), covalently modifies the receptor via a photochemical reaction, and does not bind the related cytokine receptors TNFRc2 or CD40. IW927 disrupts TNFα-induced IκB phosphorylation with an IC₅₀ value of 600 nM. IW927 can be used to develop light-independent inhibitors ^[1].

Otelixizumab ChAglyCD3; TRX 4	CD3	Metabolic Disease
Otelixizumab (ChAglyCD3) is an anti-human CD3 monoclonal antibody and can be used for the research of type 1 diabetes ^[1].

Tromantadine hydrochloride 1 Publications Verification	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication ^[1].

ABT-239 2 Publications Verification	Histamine Receptor TRP Channel	Neurological Disease Endocrinology
ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist.

Linoleoyl ethanolamide Linoleic acid monoethanolamide	Cannabinoid Receptor	Neurological Disease
Linoleoyl ethanolamide (Linoleic acid monoethanolamide) is classified as a fatty acid ethanolamide. Linoleoyl ethanolamide only weakly binds G-protein-coupled cannabinoid receptors of type-1（CB1）and CB2 receptors, and inhibits the binding of ^[3H]CP-55,940 with K_is of 10 and 25 μM, respectively. Linoleoyl ethanolamide is 4-fold less potent than anandamide at causing catalepsy in mice and it does not prolong sleep time ^[1] .

Yatein	HSV Apoptosis	Infection Cancer
Yatein is a lignan isolated from A. chilensis, with antiproliferative activity ^[1]. Yatein suppresses *herpes simplex virus type 1* (HSV-1 )** replication by interruption the immediate-early gene expression .

Ganciclovir sodium 25+ Cited Publications BW 759 sodium; 2'-Nor-2'-deoxyguanosine sodium	CMV HSV Antibiotic Nucleoside Antimetabolite/Analog	Infection Cancer
Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC₅₀ of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain ^[1] .

Ganciclovir-d5 BW 759-d₅; 2'-Nor-2'-deoxyguanosine-d₅	Isotope-Labeled Compounds CMV HSV Antibiotic Nucleoside Antimetabolite/Analog	Infection
Ganciclovir-d₅ is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC₅₀ of 5.2 μM for feline herpesvirus type-1 (FHV-1) ^[1] .

Ganciclovir (Standard) BW 759 (Standard); 2'-Nor-2'-deoxyguanosine (Standard)	Reference Standards CMV HSV Antibiotic Nucleoside Antimetabolite/Analog	Infection Cancer
Ganciclovir (Standard) is the analytical standard of Ganciclovir. This product is intended for research and analytical applications. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain ^[1] .

5-Nitrobarbituric acid	HSV	Infection Inflammation/Immunology
5-Nitrobarbituric acid is a herpes simplex virus type-1 (HSV-1) inhibitor (IC₅₀=1.7 μM) ^[1].

Emicerfont GW876008	CRFR	Neurological Disease Endocrinology
Emicerfont is a corticotropin-releasing factor type 1 (CRF₁) receptor antagonist with an IC₅₀ of 66 nM.

A-784168	TRP Channel	Neurological Disease
A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1). Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration ^[1].

Azilsartan-d5 TAK-536-d₅	Angiotensin Receptor	Others
Azilsartan-d₅ is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.

ARN11391	Chloride Channel	Neurological Disease
ARN 11391 is a selective enhancer of inositol triphosphate receptor type 1 (ITPR1). ARN 11391 can be used in the study of spinocerebellar ataxia ^[1].

JMV 2959 hydrochloride 3 Publications Verification	GHSR	Neurological Disease Endocrinology
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32±3 nM in LLC-PK₁ cells.

Irbesartan-d6	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology
Irbesartan-d₆ is the deuterium labeled Irbesartan. Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

ASP6432	LPL Receptor	Infection
ASP6432 is a potent and selective **type 1 lysophosphatidic acid receptor (LPA1) antagonist with IC₅₀**s of 11 nM and 30 nM for human LPA1 and rat LPA1, respectively ^[1].

Formycin A NSC 102811	HIV Nucleoside Antimetabolite/Analog Antibiotic	Infection Cancer
Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC₅₀ of 10 μM. Formycin A shows antitumor and antiviral activities ^[1] .

GLPG2737	CFTR	Others
GLPG2737 is a potent CFTR type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis ^[1].

(-)-Mecambridine	Enterovirus	Infection
(-)-Mecambridine (Compound 2) is a retroprotoberberine alkaloid found in Papaver pseudocanescens M. Pop. (-)-Mecambridine has weak inhibitory activity against poliovirus type 1 ^[1].

(3-Hydroxyphenyl)boronic acid 3-Hydroxybenzeneboronic acid	Drug Intermediate	Endocrinology
(3-Hydroxyphenyl)boronic acid (3-Hydroxybenzeneboronic acid) is a drug intermediate that can be used for the synthesis of 17β-hydroxysteroid dehydrogenase type 1 inhibitors ^[1].

BL-9020 EDP-10; JHL-1311	Interleukin Related	Endocrinology
BL-9020 is a human monoclonal antibody (mAb) targeting *NKp46/NCR1. BL-9020 can be used in type 1* diabetes mellitus research.

DS37571084	PTHR	Metabolic Disease Endocrinology
DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC₅₀ value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism ^[1].

Cat. No.	Product Name

HY-L165

Dopamine Receptor Compound Library

263 compounds

Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life.

MCE designs a unique collection of 263 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

Cat. No.	Product Name	Type

HY-D1301

BODIPY 581/591 C11

130+ Cited Publications

Fluorescent Dye

BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .

HY-DY1022

BODIPY 581/591 C11 (solution)

Fluorescent Dye

BODIPY 581/591 C11 (solution) is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype) , or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .
Solvent and concentration: DMSO: 2 mM

HY-D3174

PiF

Fluorescent Dye

PiF is a fluorescent probe with high specificity for pancreatic β-cells (Ex/Em = 535 nm/565 nm), and its fluorescence signal increases significantly with elevated insulin concentrations in in vitro experiments. PiF enables visualization of rat and human islets transplanted via the portal vein in mouse livers with low liver background signals. The fluorine atom of PiF can be replaced by radioactive ¹⁸F to prepare a PET tracer. PiF can be used for research on type 1 diabetes ^[1].

Cat. No.	Product Name	Type

HY-W111692

Sodium polyphosphate, crystal,+200 mesh, 96%

Biochemical Assay Reagents

Sodium polyphosphate, crystal,+200 mesh, 96% is an inorganic polyphosphate that also serves as a stabilizer, dispersant, chelating agent, and coacervate-forming agent. Sodium polyphosphate provides electrostatic stabilization for mineral and material suspensions, but its dispersing efficacy decreases under acidic pH, high temperature, high calcium concentration, or a combination of these conditions. Sodium polyphosphate can chelate alkaline earth metals, reduce solution pH, and alter the rate of pH decline at a divalent cation/phosphorus molar ratio of 0.18. Sodium polyphosphate forms coacervates with smaller divalent cations and precipitates with larger divalent cations, where the functional requirements of cations depend on polyphosphate concentration, average degree of polymerization, and cation type .

HY-D1056F

Biotin-Lipopolysaccharide, from E.coli O111:B4

Biotin-LPS, from Escherichia coli (O111:B4)

Biochemical Assay Reagents

Biotin-Lipopolysaccharide, from E.coli O111:B4 (Biotin-LPS, from Escherichia coli (O111:B4)) is a biotin-conjugated Lipopolysaccharide (LPS) (HY-D1056A1) that can be coupled with streptavidin protein. Biotin-Lipopolysaccharide, from E.coli O111:B4 can be used to identify Lipopolysaccharide ligands. Lipopolysaccharides, from E. coli O111:B4 (LPS, from Escherichia coli (O111:B4)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O111:B4) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O111:B4 possess the typical three-part structure: O-antigen, R3-type core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O111:B4 activate TLR-4 in immune cells and can cause significant gastric diseases. Lipopolysaccharides, from E. coli O111:B4 can also induce M1-type polarization in mouse macrophages ^[1] .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

HY-W002734

(3-Hydroxyphenyl)boronic acid 3-Hydroxybenzeneboronic acid	Biochemical Assay Reagents
(3-Hydroxyphenyl)boronic acid (3-Hydroxybenzeneboronic acid) is a drug intermediate that can be used for the synthesis of 17β-hydroxysteroid dehydrogenase type 1 inhibitors ^[1].

HY-NP0219

Collagen petide (Fish)	Biochemical Assay Reagents
Collagen petide (Fish) is a fish-derived peptide. Collagen petide (Fish) promotes the multidirectional differentiation of various stem cell types .

HY-158525

A3G3S3 glycan A3G3S3 N-linked oligosaccharide	Biochemical Assay Reagents
A3G3S3 glycan (A3G3S3 N-linked oligosaccharide) is an N-glycosylated plasma protein that plays an important role in indicating different stages of type 1 diabetes ^[1].

Cat. No.	Product Name	Target	Research Area

HY-13948

Angiotensin II human Maximum Cited Publications 222 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Angiotensin Receptor Apoptosis	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway ^[1] .

HY-13948A

Angiotensin II human acetate Maximum Cited Publications 222 Publications Verification Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate	Angiotensin Receptor Apoptosis	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway ^[1] .

HY-108743

Insulin degludec	Insulin Receptor	Endocrinology
Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC₅₀ value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes ^[1] .

HY-N2466

Melanotan I 1 Publications Verification MT-I; [Nle4,D-Phe7]-α-MSH	Melanocortin Receptor	Neurological Disease Cancer
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction ^[1] .

HY-P3507

Dalazatide ShK-186	Potassium Channel	Metabolic Disease Inflammation/Immunology
Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease ^[1] .

HY-P1856

Proinsulin C-peptide (human) 1 Publications Verification	Insulin Receptor PDGFR MAPKAPK2 (MK2)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Proinsulin C-peptide (human) is a peptide consisting of 31 amino acids that links the A and B chains of proinsulin to ensure its correct folding. Proinsulin C-peptide (human) inhibits the high glucose-induced increase in PDGF-β receptor protein expression and the phosphorylation of p42/p44 MAP kinase. Proinsulin C-peptide (human) increases the deformability of erythrocytes derived from type 1 diabetes, inhibits insulin-induced neointimal thickening, and suppresses the proliferation of rat aortic smooth muscle cells cultured under high-glucose conditions ^[1] .

HY-109555

Insulin glulisine HMR 1964	Insulin Receptor	Metabolic Disease Inflammation/Immunology
Insulin glulisine (HMR 1964) is a rapid-acting insulin analog whose pharmacokinetic and pharmacodynamic properties mimic physiological insulin secretion in humans, with a rapid onset of action. Insulin glulisine controls hyperglycemia. Insulin glulisine is applicable to research related to type 1 diabetes and type 2 diabetes ^[1].

HY-P1745

InsB (9-23) Insulin B chain (9-23)	MHC Insulin Receptor IFNAR	Inflammation/Immunology
InsB (9-23) (Insulin B chain (9-23)) is an HLA-DQ8-restricted insulin B-chain peptide composed of amino acid residues 9-23. InsB (9-23) serves as a major MHC II class-restricted antigen. InsB (9-23) supports the recognition and activation of T cells, stimulates the secretion of IFN-γ and cytokines, and induces cross-reactive immune responses. InsB (9-23)-specific CD4 T cells can initiate diabetes . InsB (9-23) can be used in research related to type 1 diabetes and autoimmune diabetes ^[1] .

HY-P2141

TRV-120027 3 Publications Verification TRV027	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027, a *β-arrestin-1*-biased agonist of the angiotensin II receptor type 1 (AT1R), engages β-arrestins while blocking G-protein signaling ^[1]. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R-β-arrestin-1-TRPC3-PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment .

HY-P3137

TRV056	Angiotensin Receptor	Cardiovascular Disease
TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists ^[1].

HY-13948B

Angiotensin II human TFA Maximum Cited Publications 222 Publications Verification Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA	Angiotensin Receptor Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway ^[1] .

HY-P1201

Cyclosomatostatin 1 Publications Verification	Somatostatin Receptor	Cancer
Cyclosomatostatin is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells ^[1].

HY-P3507A

Dalazatide TFA ShK-186 TFA	Potassium Channel	Metabolic Disease Inflammation/Immunology
Dalazatide (ShK-186) TFA is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide TFA can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease ^[1] .

HY-109552

Pramlintide acetate hydrate	Peptides	Metabolic Disease
Pramlintide acetate hydrate is the acetate hydrate of Pramlintide (HY-P0058). Pramlintide acetate hydrate can be used for the stufy of type 1 and type 2 diabetes ^[1].

HY-P1840

Galanin Receptor Ligand M35	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (K_d=0.1 nM). Galanin Receptor Ligand M35 exerts a K_i values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively ^[1] .

HY-P1985

Notch 1	Notch	Cardiovascular Disease Cancer
Notch 1 (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation ^[1] .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II ^[1]. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P3136

TRV055 TRV120055	Angiotensin Receptor ERK	Cardiovascular Disease
TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates *TGF-β1* and *p-ERK1/2*. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses ^[1]

HY-P4127A

M65 TFA	PACAP Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
M65 TFA is a deleted peptide of maxadilan (61 a.a.) with deletion of the residues between positions 24 and 42 and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches ^[1] .

HY-P1105

GaTx2	Chloride Channel	Neurological Disease
GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent K_D of ∼20 pM. GaTx2 is a peptide toxin inhibitor from Leiurus quinquestriatus hebraeus venom. GaTx2 is useful in determining the role and the membrane localization of ClC-2 in specific cell types .

HY-P10868

Pegtarazimod RLS-0071	Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Pegtarazimod (RLS-0071) is a dual-target anti-inflammatory peptide that exerts its effects by simultaneously regulating the complement system and neutrophil-associated inflammatory pathways. Pegtarazimod reduces ROS production both in vitro and in vivo, and decreases the level of neutrophil elastase, a marker of neutrophil extracellular traps (NETs), in vivo, thereby alleviating inflammatory responses. Pegtarazimod significantly improves the survival rate of mice in multiple in vivo models of acute graft-versus-host disease (aGVHD). Pegtarazimod inhibits the activation of the C1 complex, reduces the herpes zoster-like spread of herpes simplex virus type 1 skin infection, and improves the survival rate of infected mice . Pegtarazimod can be used in research related to acute graft-versus-host disease, acute pulmonary diseases, and skin herpes simplex virus type 1 infection ^[1] .

HY-P4685

(Sar1,Ile4,8)-Angiotensin II	Angiotensin Receptor	Metabolic Disease
(Sar1,Ile4,8)-Angiotensin II is a functionally selective angiotensin II type 1 receptor (AT1R) agonist. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β ^[1].

HY-P3136A

TRV055 hydrochloride TRV120055 hydrochloride	Angiotensin Receptor	Cardiovascular Disease
TRV055 (TRV120055) hydrochloride is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV055 hydrochloride induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. RV055 hydrochloride activates AT1 receptor/Gαq-mediated signaling pathways, upregulates *TGF-β1* and *p-ERK1/2*. RV055 hydrochloride induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. RV055 hydrochloride can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses ^[1]

HY-P2200

Siamycin I BMY-29304	HIV Antibiotic	Infection Inflammation/Immunology
Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED₅₀s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research ^[1] .

HY-P4127

M65	Peptides	Neurological Disease
M65 is a deleted peptide of maxadilan (61 a.a.) with deletion of the residues between positions 24 and 42 and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches ^[1] .

HY-P5114A

Maurocalcine TFA	Calcium Channel	Others
Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine TFA induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine TFA exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine TFA can be applied to in vivo cell tracking or other cell imaging techniques ^[1] .

HY-N2466A

Melanotan I acetate 1 Publications Verification MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate	Melanocortin Receptor	Cancer
Melanotan I acetate is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I acetate can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I acetate can be used for sunlight-induced skin cancers research ^[1] .

HY-P5372A

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA	Protease Activated Receptor (PAR)	Cancer
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type' .

HY-P5396A

GAD65 (524-543) acetate	Amino Acid Decarboxylase	Others
GAD65 (524-543) acetate is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) acetate is one of the first fragments of the islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) acetate is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) acetate increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells ^[1].

HY-P2141A

TRV-120027 TFA 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027 TFA, a *β-arrestin-1*-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ?-arrestins while blocking G-protein signaling ^[1]. TRV120027?TFA induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the?acute decompensated heart failure (ADHF) treatment .

HY-13948BS

Angiotensin II human-13C6,15N TFA Angiotensin II-13C6,15N TFA; Ang II-13C6,15N TFA; DRVY(I-13C6,15N)HPF TFA	Isotope-Labeled Compounds	Cancer
Angiotensin II human- ¹³C₆, ¹⁵N TFA (Ang II- ¹³C₆, ¹⁵N TFA) is ¹³C- and ¹⁵N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions ^[1] .

HY-P1985A

Notch 1 TFA	Notch	Cardiovascular Disease Cancer
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

HY-P35433

Tifuvirtide T-1249	HIV	Inflammation/Immunology
Tifuvirtide (T-1249) is a peptide human immunodeficiency virus type-1 (HIV-1) fusion inhibitor. Tifuvirtide is a synthetically designed hybrid retroviral envelope polypeptide. Tifuvirtide has antiretroviral activity. Tifuvirtide can be used for the research of HIV infection ^[1].

HY-P10512

BDC2.5 mimotope	Peptides	Others
BDC2.5 mimotope is a potent antigen-mimicking peptide that can activate CD4+ T cell populations that have the same antigen recognition properties as BDC2.5 cells. BDC2.5 mimotope can be used to study the prevention or treatment of type 1 diabetes by targeting specific T cell populations ^[1].

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney ^[1] .

HY-P5488

BDC2.5 Mimotope 1040-63	Peptides	Others
BDC2.5 Mimotope 1040-63 is a biological active peptide. (The TCR transgenic model (BDC2.5) mimitope was used in type 1 diabetes (T1D) study. T1D is an autoimmune disease in which T cells mediate damage to pancreatic islet b cells. T1D is caused by autoreactive T cell destruction of insulin-producing cells. BDC2.5 mimotope was utilized to support the study on antigen presentation of antigenic peptides to islet autoantigen-specific T cells.)

HY-P10597

*Angiotensin II type 1* receptor (181-187)**	Angiotensin Receptor	Others
Angiotensin II type 1 receptor (181-187) is a 9-amino acid sequence of the second extracellular loop of angiotensin II (Ang II) in the renin-angiotensin system. Angiotensin II type 1 receptor (181-187) serves as the localization epitope of angiotensin II receptor autoantibodies (AT1RaAb) and is used to detect and quantify AT1RaAb levels in serum ^[1].

HY-P1753

VIR-165	HIV	Infection
VIR-165 is a modified form of virus inhibitory peptide (VIRIP) that binds the fusion peptide of the gp41 subunit and prevents its insertion into the target membrane. VIRIP inhibits a wide variety of human immunodeficiency virus type 1 (HIV-1) strains ^[1].

HY-P5372

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2	Protease Activated Receptor (PAR)	Cancer
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type' .

HY-106171

NBI-6024	Insulin Receptor	Metabolic Disease
NBI-6024, an altered peptide ligand (APL), is an epitope recognized by inflammatory interferon-gamma-producing T helper lymphocytes in type 1 diabetic patients ^[1] .

HY-P10612

Tetanus toxin peptide	Bacterial	Metabolic Disease
Tetanus toxin peptide is a specific peptide isolated from the toxin produced by Clostridium tetani. Tetanus toxin peptide can be used as an immunogen to induce diabetes in mice. Tetanus toxin peptide can be used in the study of type 1 diabetes ^[1].

HY-P4773

HSV-1 Protease substrate	HSV	Infection
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (k_cat/K_m) at pH 7.5 for cleavage is 5.2 M ^-1 s ^-1 ^[1].

HY-P4025

ELDKWA	HIV	Others
ELDKWA is the highly conserved amino acids on the ecto-domain of gp41. ELDKWA acts as the epitope of a neutralizing monoclonal antibody 2F5 (mAb 2F5) directed against human immunodeficiency virus type 1 ^[1] .

HY-P1201A

Cyclosomatostatin TFA	Somatostatin Receptor	Cancer
Cyclosomatostatin TFA is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin TFA can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells ^[1].

HY-P10949

pep-10L peptide	Glycoprotein VI	Cardiovascular Disease
Pep-10L peptide is a glycoprotein VI (GPVI) antagonist with K_i values of 180, 225, and 179 μM for CPR, GPO-1, and Type 1 collagen, respectively. Pep-10L peptide has anti-thrombotic effects ^[1].

HY-P1840A

Galanin Receptor Ligand M35 TFA	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (K_d=0.1 nM). Galanin Receptor Ligand M35 TFA exerts a K_i values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively ^[1] .

HY-P3959

(Tyr0)-Urocortin, rat	CRFR	Endocrinology
(Tyr0)-Urocortin, rat is a high-affinity agonist of corticotropin-releasing factor receptor type 1 (CRF-R1) and type 2 (CRF-R2). (Tyr0)-Urocortin, rat shows inhibitory binding constants (Ki) of 1-2 nM ^[1].

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation ^[1] .

HY-P5114

Maurocalcine	Calcium Channel	Others
Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ ³H]ryanodine binding on RyR1 with an EC₅₀ value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques ^[1] .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99222

Teplizumab MGA-031; PRV-031	CD3	Metabolic Disease
Teplizumab (MGA-031) is a Fc receptor non-binding anti-human CD3 monoclonal antibody. Teplizumab reduces the loss of beta-cell function. Teplizumab can be used in the research of type 1 diabetes ^[1] .

HY-P99294

Ganitumab 1 Publications Verification AMG 479; Human Anti-IGF1R Recombinant Antibody	IGF-1R	Cancer
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the *human type 1* insulin-like growth factor receptor** (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (K_D=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer ^[1].

HY-P99383

Volagidemab REMD-477; AMG-477	GCGR	Metabolic Disease
Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D) ^[1] .

HY-P99693

Lenvervimab GC1102	HBV	Infection
Lenvervimab (GC1102) is a IgG1-type recombinant human hepatitis B Immunoglobulin. Lenvervimab can be used for research of hepatitis B virus infection ^[1] .

HY-P99538

Ublituximab LFB-R603; TG-1101; TGTX-1101	CD20	Cancer
Ublituximab (LFB-R603; TG-1101; TGTX-1101) is a next-generation, type 1 chimeric monoclonal antibody targeting a unique epitope on the CD20 antigen. Ublituximab has anticancer effects ^[1].

HY-P99395

Talacotuzumab 1 Publications Verification JNJ 56022473; CSL 362	Interleukin Related	Cancer
Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has K_Ds of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models ^[1] .

HY-P99211

Otelixizumab ChAglyCD3; TRX 4	CD3	Metabolic Disease
Otelixizumab (ChAglyCD3) is an anti-human CD3 monoclonal antibody and can be used for the research of type 1 diabetes ^[1].

HY-P99959

Unasnemab MT-3921; rH116A3	TGF-β Receptor	Neurological Disease
Unasnemab (MT-3921) is a humanised IgG1 monoclonal antibody that binds to repulsive guidance molecule A (RGMa). Unasnemab improves locomotor function and promotes neuroregeneration. Unasnemab exerts ameliorative effects on hippocampal neurogenesis impairment and cognitive decline in db/db mice, Streptozotocin (STZ) (HY-13753)-induced type 1 diabetic and bilateral common carotid artery stenosis (BCAS)-induced mice. Unasnemab can be used for the research of spinal cord injury, diabetes-induced neurological impairments ^[1] .

HY-P990001

Anti-Mouse IL-10 Antibody (JES5-2A5) 1 Publications Verification	Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse IL-10 Antibody (JES5-2A5) is an anti-mouse IL-10 IgG1 monoclonal antibody. Anti-Mouse IL-10 Antibody (JES5-2A5) restores the anti-tumor activity of IL-6 by blocking the IL-10/SOCS3 axis. Anti-Mouse IL-10 Antibody (JES5-2A5) can reverse microcirculation and cognitive deficits. Anti-Mouse IL-10 Antibody (JES5-2A5) can be used for researches on cancer and metabolic disease such as osteosarcoma and type 1 diabetes mellitus (T1DM) ^[1] .

HY-P990087

Zovostotug OR-2805	Inhibitory Antibodies	Inflammation/Immunology Cancer
Zovostotug is a human CD163 (scavenger receptor cysteine-rich (SRCR) type 1 M130) mAb ^[1].

HY-P990335

Anti-ANGPTL4 Antibody	ANGPTL	Inflammation/Immunology
Anti-ANGPTL4 Antibody is a CHO expressed human antibody targeting ANGPTL4. Anti-ANGPTL4 Antibody has a huIgG1-type heavy chain and a huλ-type light chain with a predicted molecular weight (MW) of 150 kDa. An isotype control for Anti-ANGPTL4 Antibody can be found in Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99403

Refanezumab GSK249320	Inhibitory Antibodies	Neurological Disease
Refanezumab (GSK249320) is a brain-penetrant IgG1-type humanized monoclonal antibody directed against myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab has the potential for the enhancement of recovery of function poststroke ^[1] .

HY-P990022

Prafnosbart DS-6016A	TGF-β Receptor	Metabolic Disease
Prafnosbart (DS-6016A) is an IgG1-kappa, anti-ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1) humanized monoclonal antibody. Prafnosbart can be used for bone metabolism disorders research ^[1].

HY-P991326

BL-9020 EDP-10; JHL-1311	Interleukin Related	Endocrinology
BL-9020 is a human monoclonal antibody (mAb) targeting *NKp46/NCR1. BL-9020 can be used in type 1* diabetes mellitus research.

HY-P991552

AFM15	CD3	Metabolic Disease Inflammation/Immunology
AFM15 is a humanized monoclonal antibody inhibitor targeting CD3E. AFM15 can be used to study metabolic and immune system diseases, such as type 1 diabetes and inflammatory bowel disease (IBD) ^[1].

HY-P991181

VTX-1218	Transmembrane Glycoprotein	Cancer
VTX-1218 is a VSIG4 inhibitor with human K_d 7.4 nM. VTX-1218 blocks VSIG4 activity, relieves VSIG4-mediated macrophage suppression, repolarizes tumor-associated macrophages and induces T cell activation. VTX-1218 upregulates cytokines and chemokines linked to immune cell recruitment. VTX-1218 can be used for the research of multiple cancer types .

HY-P99800

Pritoxaximab	Inhibitory Antibodies	Infection
Pritoxaximab is an IgG1κ antibody targeting shiga toxin type 1 ^[1].

HY-P99898

Setoxaximab	Bacterial	Others
Setoxaximab is an IgG1-κ humanized chimeric antibody targeting shiga toxin type 1 ^[1].

HY-P990336

Anti-ANGPTL8 Antibody	ANGPTL	Inflammation/Immunology
Anti-ANGPTL8 Antibody is a CHO expressed human antibody targeting ANGPTL8. Anti-ANGPTL8 Antibody has a huIgG1-type heavy chain and a huκ-type light chain with a predicted molecular weight (MW) of 150 kDa. An isotype control for Anti-ANGPTL8 Antibody can be found in Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990381

Anti-CSF2/GM-CSF Antibody	c-Fms	Inflammation/Immunology
The Anti-CSF2/GM-CSF Antibody is a CHO-expressed human antibody that targets CSF2/GM-CSF. The Anti-CSF2/GM-CSF Antibody has a huIgG1-type heavy chain and a huλ-type light chain, with a predicted molecular weight (MW) of 145.02 kDa. The isotype control for the Anti-CSF2/GM-CSF Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P992086

Anti-Mouse VEGF Antibody (G6-31)	VEGFR	Cancer
Anti-Mouse VEGF Antibody (G6-31) is a anti-mouse VEGF antibody. Anti-Mouse VEGF Antibody (G6-31) blocks VEGF-A-mediated angiogenesis and shows antitumor activity. Anti-Mouse VEGF Antibody (G6-31) can be used for the research of cancer, such as multiple endocrine neoplasia type 1 ^[1].

HY-P992159

Anti-ZnT8 Antibody (mAb43)	SLC39 (Zinc Transporter)	Metabolic Disease Inflammation/Immunology
Anti-ZnT8 Antibody (mAb43) is a monoclonal antibody targeting the zinc transporter ZnT8, with islet-specific biodistribution characteristics. Anti-ZnT8 Antibody (mAb43) binds to extracellular ZnT8 on the surface of pancreatic β-cells and masks its insulin-co-localizing sites to block autoimmune recognition. Anti-ZnT8 Antibody (mAb43) also promotes an increase in the proportion of regulatory T cells and inhibits B cell antigen presentation, thereby effectively blocking the T cell-mediated cascade of β-cell destruction. Anti-ZnT8 Antibody (mAb43) eliminates insulitis, preserves β-cell mass and induces seroconversion of autoantibodies, without directly altering the insulin secretion function or content of β-cells. Anti-ZnT8 Antibody (mAb43) can be used for research related to type 1 diabetes ^[1].

Species:	Virus (3) Human (52) Rat (3) Mouse (12) Cynomolgus (3) E.coli (1) Canine (3)
Tag:	SUMO (2) His (50) Strep (1) Tag Free (6) Avi (3) GST (13) Fc (21) Flag (3)
Source:	HEK293 (39) E. coli Cell-free (2) sf9 insect cells (7) P. pastoris (2) Sf9 insect cells (9) E. coli (18)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703944

	OX1R Protein, Human (HEK293, Flag) HCRTR1; Orexin/Hypocretin receptor Type 1; Hypocretin receptor Type 1; Orexin receptor Type 1; Ox-1-R; Ox1-R; Ox1R	Human	HEK293
	OX1R, a moderately selective excitatory receptor, binds orexin-A and orexin-B neuropeptides. Upon orexin-A binding, OX1R activates cellular events, elevating cytoplasmic Ca(2+) levels. This interaction positions OX1R as a mediator in orexin neuropeptide signaling, influencing intracellular calcium dynamics in response to orexin-A. OX1R Protein, Human (HEK293, Flag) is the recombinant human-derived OX1R protein, expressed by HEK293 , with N-Flag labeled tag.

HY-P70066

	*CDO1/Cysteine dioxygenase type 1* Protein, Human (His)** 1 Publications Verification rHuCysteine dioxygenase Type 1/CDO1, His; Cysteine Dioxygenase Type 1; Cysteine Dioxygenase Type I; CDO; CDO-I; CDO1	Human	E. coli
	Cysteine dioxygenase (CDO1) plays a crucial role in cellular metabolism by catalyzing the oxidation of cysteine to cysteine sulfenic acid, a key step involving the addition of molecular dioxygen . This enzymatic process underlies cysteine catabolism and helps regulate sulfur amino acid metabolism. CDO1/Cysteine dioxygenase type 1 Protein, Human (His) is the recombinant human-derived CDO1/Cysteine dioxygenase type 1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P77857

	TGF alpha/TGFA Protein, Mouse (HEK293, Fc) 1 Publications Verification ETGF; TGF-alpha; TGF Type 1; TGFA	Mouse	HEK293
	TGF α/TGFA is a mitogenic peptide that binds to the EGF receptor (EGFR) and acts synergistically with TGF β to achieve anchorage-independent cell proliferation in soft agar.It interacts with SDCBP and the SNTA1 PDZ domain, which is critical for cell surface localization.TGF alpha/TGFA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TGF alpha/TGFA protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P700149AF

	Animal-Free TGF alpha/TGFA Protein, Human (His) ETGF; TGF-alpha; TGF Type 1; TGFA	Human	E. coli
	TGF α/TGFA protein is a mitogenic polypeptide that binds to EGFR and acts synergistically with TGF β to promote anchorage-dependent cell proliferation. Its interaction with MAGI3, SDCBP, and the SNTA1 PDZ domain, especially with SDCBP, is critical for efficient cell surface targeting. Animal-Free TGF alpha/TGFA Protein, Human (His) is the recombinant human-derived animal-FreeTGF alpha/TGFA protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P7705

	Calcineurin B Protein, Human (His) rHuCNB, His; Calcineurin Subunit B Type 1; PPP3R1; CNB	Human	E. coli
	Calcineurin B Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Calcineurin Subunit B Type 1 is an anti-tumor factor.

HY-P73685

	PTP1B Protein, Human (His) 1 Publications Verification PTP-1B; PTPN1; Tyrosine-protein phosphatase non-receptor Type 1	Human	E. coli
	PTP1B is an important tyrosine protein phosphatase that regulates the endoplasmic reticulum unfolded protein response by dephosphorylating EIF2AK3/PERK and inhibiting its kinase activity. It affects the signaling cascade induced by CKII and p60c-src, and may regulate the EFNA5-EPHA3 pathway, affecting cell reorganization. PTP1B Protein, Human (His) is the recombinant human-derived PTP1B protein, expressed by E. coli , with N-His labeled tag.

HY-P70557

	RSPO3/R-spondin-3 Protein, Human (HEK293, Fc-His) R-spondin-3; RSPO3; Protein with TSP Type-1 repeat; Roof plate-specific spondin-3; Thrombospondin Type-1 domain-containing protein 2; PWTSR; THSD2; CRISTIN1	Human	HEK293
	RSPO3 is a potent activator of the canonical Wnt pathway and can bind to LGR4-6 receptors to initiate a complex with phosphorylated LRP6 and Frizzled receptors. This interaction activates the canonical Wnt pathway and upregulates target genes. RSPO3/R-spondin-3 Protein, Human (HEK293, Fc-His) is the recombinant human-derived RSPO3/R-spondin-3 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag.

HY-P705422

	NAT1 Protein, Human (His) Arylamide acetylase 1; Monomorphic arylamine N-acetyltransferase; MNAT; N-acetyltransferase Type 1; NAT-1	Human	E. coli

HY-P77231

	THSD1 Protein, Mouse (HEK293, His) Thrombospondin Type-1 Domain-Containing Protein 1; THSD1; TMTSP	Mouse	HEK293
	THSD1 protein actively regulates the assembly of nascent focal adhesions and affects the attachment of endothelial cells to the extracellular matrix. As a key player, THSD1 forms a complex with PTK2/FAK1, TLN1 and VCL and contributes to focal adhesion dynamics. THSD1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived THSD1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P702232

	CCR1 Protein, Mouse (Cell-Free, His) C-C chemokine receptor Type 1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R	Mouse	E. coli Cell-free
	CCR1 Protein, a C-C chemokine receptor, binds MIP-1-alpha, RANTES, and, to a lesser extent, MIP-1-beta or MCP-1, initiating signal transduction and elevating intracellular calcium levels. This receptor is crucial in modulating stem cell proliferation, regulating processes vital for tissue homeostasis and immune responses. CCR1's interaction with CREB3 suggests its involvement in complex signaling networks governing cellular functions. CCR1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived CCR1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CCR1 Protein, Mouse (Cell-Free, His) is 355 a.a., with molecular weight of 43.7 kDa.

HY-P705662

	CAMKI alpha/CAMK1 Protein, Human (Active) rHuCAMK1, His; Calcium/Calmodulin-Dependent Protein Kinase Type 1; CaM Kinase I; CaMKI-Alpha; CAMK1	Human	E. coli
	CAMKI alpha/CAMK1 Protein, Human, a recombinant human CAMK1 produced in HEK293 cells. CAMK1 is involved in multiple cell functions, including calmodulin binding, ATP binding, signal transduction, development and cell differentiation.

HY-P72454

	TGFBR1/ALK-5 Protein, Mouse (HEK293, Fc) 1 Publications Verification TGF-beta receptor Type-1; ALK-5; SKR4; TbetaR-I; AAT5	Mouse	HEK293
	TGFBR1 is a transmembrane kinase that cooperates with TGFBR2 to form the TGF-β receptor complex.This complex is activated by cytokines and regulates a variety of processes, including cell cycle arrest, mesenchymal cell control, wound healing, and carcinogenesis.TGFBR1/ALK-5 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TGFBR1/ALK-5 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72453

	TGFBR1/ALK-5 Protein, Human (HEK293, Fc) TGF-beta receptor Type-1; ALK-5; SKR4; TbetaR-I; AAT5	Human	HEK293
	TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (HEK293, Fc) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P705411

	SRD5A1 Protein, Human (Cell-Free, His) SR Type 1; Steroid 5-alpha-reductase 1; S5AR 1	Human	E. coli Cell-free

HY-P74523

	TGFBR1/ALK-5 Protein, Human (HEK293, His-Fc) TGF-beta receptor Type-1; ALK-5; SKR4; TbetaR-I; AAT5	Human	HEK293
	TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (HEK293, His-Fc) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P704918

	TGFBR1/ALK-5 Protein, Human (HEK293, Llama Fc) TGF-beta receptor Type-1; ALK-5; SKR4; TbetaR-I; AAT5	Human	HEK293

HY-P7714

	CAMKI alpha/CAMK1 Protein, Human (Active, HEK293, His) rHuCAMK1, His; Calcium/Calmodulin-Dependent Protein Kinase Type 1; CaM Kinase I; CaMKI-Alpha; CAMK1	Human	HEK293
	CAMKI alpha/CAMK1 Protein, Human (HEK293, His), a recombinant human CAMK1 produced in HEK293 cells, has a His tag at the N-terminus. CAMK1 is involved in multiple cell functions, including calmodulin binding, ATP binding, signal transduction, development and cell differentiation.

HY-P71360

	THSD1 Protein, Human (HEK293, His) Thrombospondin Type-1 Domain-Containing Protein 1; Transmembrane Molecule with Thrombospondin Module; THSD1; TMTSP	Human	HEK293
	THSD1 Protein positively regulates nascent focal adhesion assembly, influencing endothelial cell attachment to the extracellular matrix. It forms a complex with PTK2/FAK1, TLN1, and VCL, interacting specifically with TLN1. THSD1 Protein, Human (HEK293, His) is the recombinant human-derived THSD1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72812

	Activin RIA Protein, Human (HEK293, His-Fc) Activin receptor Type-1; ACTR-I; ALK-2; SKR1; TSR-I; ACVR1; ACVRLK2	Human	HEK293
	Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Activin RIA Protein, Human (HEK293, His-Fc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag . It consists of 124 amino acids (M1-V124).

HY-P74522

	TGFBR1/ALK-5 Protein, Human (Active, sf9, His-GST) TGF-beta receptor Type-1; ALK-5; SKR4; TbetaR-I; AAT5	Human	Sf9 insect cells
	TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (sf9, His-GST) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P75538

	ACVR1 Protein, Rat (HEK293, hFc) Activin receptor Type-1; ACTR-I; SKR1; TSR-I; TSK-7L; Acvrlk2; Tgfb1	Rat	HEK293
	Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. ACVR1 Protein, Rat (HEK293, hFc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 103 amino acids (M21-E123).

HY-P76715

	ACVR1 Protein, Canine (HEK293, His) Activin receptor Type-1; ACTR-I; SKR1; TSR-I; TSK-7L; Acvrlk2; Tgfb1	Canine	HEK293
	Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. ACVR1 Protein, Canine (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag.

HY-P77289

	ACVR1 Protein, Cynomolgus (HEK293, Fc) Activin receptor Type-1; ACTR-I; SKR1; TSR-I; TSK-7L; Acvrlk2; Tgfb1	Cynomolgus	HEK293
	Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. ACVR1 Protein, Cynomolgus (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 101 amino acids (M1-E123).

HY-P76714

	ACVR1 Protein, Canine (HEK293, Fc) Activin receptor Type-1; ACTR-I; SKR1; TSR-I; TSK-7L; Acvrlk2; Tgfb1	Canine	HEK293
	Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. ACVR1 Protein, Canine (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag.

HY-P75539

	ACVR1 Protein, Mouse (HEK293, His-hFc) Activin receptor Type-1; ACTR-I; SKR1; TSR-I; TSK-7L; Acvrlk2; Tgfb1	Mouse	HEK293
	Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. ACVR1 Protein, Mouse (HEK293, His-hFc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag . It consists of 123 amino acids (M1-E123).

HY-P705731

	Activin RIA Protein, Human (Q207E, sf9) Activin receptor Type-1; ACTR-I; ALK-2; SKR1; TSR-I; ACVR1; ACVRLK2	Human	sf9 insect cells

HY-P700262

	RSPO3/R-spondin-3 Protein, Human (HEK293, His) R-spondin-3; RSPO3; Protein with TSP Type-1 repeat; PWTSR; THSD2; CRISTIN1	Human	HEK293
	RSPO3 is a potent activator of the canonical Wnt pathway and can bind to LGR4-6 receptors to initiate a complex with phosphorylated LRP6 and Frizzled receptors. This interaction activates the canonical Wnt pathway and upregulates target genes. R-spondin 3 Protein, Human (HEK293, His) is the recombinant human-derived R-spondin 3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704873

	RSPO3/R-spondin-3 Protein, Human (HEK293, Fc) R-spondin-3; RSPO3; Protein with TSP Type-1 repeat; PWTSR; THSD2; CRISTIN1	Human	HEK293
	RSPO3 is a potent activator of the canonical Wnt pathway and can bind to LGR4-6 receptors to initiate a complex with phosphorylated LRP6 and Frizzled receptors. This interaction activates the canonical Wnt pathway and upregulates target genes. RSPO3/R-spondin-3 Protein, Human (HEK293, Fc) is the recombinant human-derived R-spondin 3 protein, expressed by HEK293 , with C-Fc labeled tag.

HY-P70286

	IL-1R1 Protein, Mouse (HEK293, His) rMuInterleukin-1 receptor Type 1/IL-1R1, His ; Interleukin-1 receptor Type 1; IL-1R-1; IL-1RT1; IL-1 RI; CD121a	Mouse	HEK293
	IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (K_d: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. IL-1R1 Protein, Mouse (HEK293, His) is a recombinant mouse extracellular region of IL-1R1 (L20-K338) with a C terminal 6*His tag, which is produced in HEK293 cells.

HY-P78044

	THSD7A Protein, Human (HEK293, His) Thrombospondin Type-1 domain-containing protein 7A; Gm837; KIAA0960; thrombospondin,Type I,domain containing 7A	Human	HEK293
	THSD7A Protein orchestrates actin cytoskeleton rearrangement, actively influencing cellular dynamics. Its soluble form facilitates endothelial cell migration and filopodia formation in sprouting angiogenesis, relying on Focal Adhesion Kinase (FAK) activation. This emphasizes THSD7A's role in modulating key cellular processes associated with angiogenesis, highlighting its potential as a regulator of vascular development. THSD7A Protein, Human (HEK293, His) is the recombinant human-derived THSD7A protein, expressed by HEK293 , with C-His labeled tag.

HY-P705732

	Activin RIA Protein, Human (G328V, sf9, His-GST) Activin receptor Type-1; ACTR-I; ALK-2; SKR1; TSR-I; ACVR1; ACVRLK2	Human	sf9 insect cells

HY-P705733

	Activin RIA Protein, Human (G328W, sf9, His-GST) Activin receptor Type-1; ACTR-I; ALK-2; SKR1; TSR-I; ACVR1; ACVRLK2	Human	sf9 insect cells

HY-P705734

	Activin RIA Protein, Human (Q207D, sf9, His-GST) Activin receptor Type-1; ACTR-I; ALK-2; SKR1; TSR-I; ACVR1; ACVRLK2	Human	sf9 insect cells

HY-P705735

	Activin RIA Protein, Human (R206H, sf9, His-GST) Activin receptor Type-1; ACTR-I; ALK-2; SKR1; TSR-I; ACVR1; ACVRLK2	Human	sf9 insect cells

HY-P705993

	HY-P705993 RIA Protein, Human (Active, sf9, His-GST) Activin receptor Type-1; ACTR-I; ALK-2; SKR1; TSR-I; ACVR1; ACVRLK2	Human	sf9 insect cells

HY-P74823

	IL-1R1 Protein, Human (HEK293) Interleukin-1 receptor Type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1	Human	HEK293
	IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (K_d: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. I IL-1R1 Protein, Human (HEK293) is a recombinant human extracellular region of IL-1R1 (M1-T332) without any tag, which is produced in HEK293 cells.

HY-P74822

	IL-1R1 Protein, Rat (HEK293, His) Interleukin-1 receptor Type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1	Rat	HEK293
	IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (K_d: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB, MAPK pathways . IL-1R1 Protein, Rat (HEK293, His) is a recombinant rat extracellular region of IL-1R1 (M1-K352) with a C terminal His tag, which is produced in HEK293 cells.

HY-P76995

	IL-1R1 Protein, Cynomolgus (HEK293, Fc) Interleukin-1 receptor Type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1	Cynomolgus	HEK293
	IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (K_d: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. IL-1R1 Protein, Cynomolgus (HEK293, Fc) is a recombinant cynomolgus extracellular region of IL-1R1 (M1-T332) with a C-Terminal hFc tag, which is produced in HEK293 cells.

HY-P76996

	IL-1R1 Protein, Cynomolgus (HEK293, His) Interleukin-1 receptor Type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1	Cynomolgus	HEK293
	IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (K_d: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. IL-1R1 Protein, Cynomolgus (HEK293, His) is a recombinant cynomolgus extracellular region of IL-1R1 (M1-T332) with a C-Terminal His tag, which is produced in HEK293 cells.

HY-P73185

	IL-1R1 Protein, Human (HEK293, Fc) Interleukin-1 receptor Type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1	Human	HEK293
	IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (K_d: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. IL-1R1 Protein, Human (HEK293, Fc) is a recombinant human extracellular region of IL-1R1 (M1-T332) with a C-Terminal hFc tag, which is produced in HEK293 cells.

HY-P74821

	IL-1R1 Protein, Rat (HEK293, His-mFc) Interleukin-1 receptor Type 1; IL-1R-1; CD121a; IL1R1; IL1R; IL1RA; IL1RT1	Rat	HEK293
	IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (K_d: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB, MAPK pathways. IL-1R1 Protein, Rat (HEK293, His-mFc) is a recombinant rat extracellular region of IL-1R1 (M1-K352) with C terminal His and hFc tags, which is produced in HEK293 cells.

HY-P72569

	IL-1R1 Protein, Human (HEK293, His) Interleukin-1 receptor Type 1; IL-1R-1; IL-1RT-1; Interleukin-1 receptor alpha; IL-1R-alpha; p80; CD121a	Human	HEK293
	IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (K_d: 0.1-1 nM). IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway. IL-1R1 Protein, Human (HEK293, His) is a recombinant human extracellular region of IL-1R1 (L18-T332) with a C-Terminal 6*His tag, which is produced in HEK293 cells.

HY-P72237

	HSD11B1 Protein, Human (His-SUMO) 11 beta HSD 1; 11 beta HSD1 ; 11 beta hydroxysteroid dehydrogenase 1; 11 DH ; 11-beta hydroxysteroid dehydrogenase; Type 1; 11-beta-HSD1; 11-DH; 11DH ; Corticosteroid 11 beta dehydrogenase isozyme 1; Corticosteroid 11-beta-dehydrogenase isozyme 1; CORTRD2; DHI1_HUMAN; HDL; HSD 11; HSD11; HSD11B; HSD11B1; HSD11L; member 1	Human	E. coli
	The proteins encoded by ED genes are involved in a variety of physiological processes. HSD11B1 Protein, Human (His-SUMO) is the recombinant human-derived HSD11B1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P701885

	FNTA Protein, Human FNTA; Protein farnesyltransferase/geranylgeranyltransferase Type-1 subunit alpha; CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha	Human	E. coli
	FNTA protein is a key subunit in the farnesyltransferase and geranylgeranyltransferase complexes, which can transfer farnesyl or geranylgeranyl moieties to proteins with Cys-aliphatic-aliphatic-X sequence cysteine residues in proteins. This enzymatic activity contributes to post-translational protein modifications. FNTA Protein, Human is the recombinant human-derived FNTA protein, expressed by E. coli , with tag free.

HY-P702528

	CD206/MMR Protein, Mouse (HEK293, His) CD206; CLEC13D; CLEC13Dmacrophage mannose receptor 1; C-Type lectin domain family 13 member D; mannose receptor, C Type 1; MMR; MMRCD206 antigen; MRC1	Mouse	HEK293
	The CD206/MMR protein acts as a multifunctional mediator in macrophages, promoting glycoprotein internalization. It has a broad binding capacity, interacting with both sulfated and non-sulfated polysaccharide chains. CD206/MMR Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD206/MMR protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P702654

	CAMK1 alpha/CAMK1 Protein, Human (Active, sf9, His, GST) CAMK1; calcium/calmodulin-dependent protein kinase I; calcium/calmodulin-dependent protein kinase Type 1; CaMKI; caM-KI; caMKI-alpha; caM kinase I alpha; CAMKI; MGC120317; MGC120318;	Human	Sf9 insect cells
	CAMK1 alpha/CAMK1 Protein, Human (sf9, His, GST) is the recombinant human-derived CAMK1 alpha, expressed by Sf9 insect cells , with His, GST labeled tag.

HY-P701886

	FNTA Protein, Human (His, StrepⅡ) FNTA; Protein farnesyltransferase/geranylgeranyltransferase Type-1 subunit alpha; CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha	Human	E. coli
	FNTA protein is a key subunit in the farnesyltransferase and geranylgeranyltransferase complexes, which can transfer farnesyl or geranylgeranyl moieties to proteins with Cys-aliphatic-aliphatic-X sequence cysteine residues in proteins. This enzymatic activity contributes to post-translational protein modifications. FNTA Protein, Human (His, Strep) is the recombinant human-derived FNTA protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

HY-P702570

	TRADD Protein, Human (His) TNFR1 associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; tradd; TRADD_HUMAN; Tumor necrosis factor receptor Type 1 associated DEATH domain protein; Tumor necrosis factor receptor Type 1-associated DEATH domain protein	Human	E. coli
	The TRADD protein acts as a linker for TNFRSF1A/TNFR1 and mediates its interaction with FADD. TRADD induces TNF-induced responses: apoptosis and NF-kappa-B activation. TRADD Protein, Human (His) is the recombinant human-derived TRADD protein, expressed by E. coli , with C-6*His labeled tag.

HY-P705249

	CD206/MMR Protein, Mouse (Biotinylated, HEK293, His-Avi) CD206; CLEC13D; CLEC13Dmacrophage mannose receptor 1; C-Type lectin domain family 13 member D; mannose receptor, C Type 1; MMR; MMRCD206 antigen; MRC1	Mouse	HEK293

HY-P705892

	TrkA Protein, Human (sf9, Flag, Avi) High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor Type 1; NTRK-1; NTRK1; Slow nerve growth factor receptor; p140-TrkA; Trk-A; Trk; Trka; TRK1-transforming tyrosine kinase protein; TRKAOncogene TRK; TRKTRK1; tyrosine kinase receptor A	Human	sf9 insect cells

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Host:	Mouse (9) Rabbit (40)
Reactivity:	Human (49) Rat (32) Mouse (30) Rabbit (1) Bovin (1)
Application:	IHC-P (31) ICC/IF (27) IF-Tissue (1) IP (12) IHC-F (10) WB (45) FC (12) ELISA (9)
Isotype:	IgG2a,IgG/Kappa (1) IgG (39) IgG1 (4) IgG/Kappa (1) IgG2b (1)
Conjugation:	Non-conjugated (49) Biotin (2)
Clonality:	Polyclonal (5) Monoclonal (34) Recombinant (21)
Modification:	Phosphorylated (2) Unmodified (36) Hydroxylated (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82099

	R Cadherin Antibody (YA1844) cadherin 4; Type 1; R-cadherin (retinal); CAD4; RCAD; R-CAD	WB, IP	Human, Mouse, Rat
	R Cadherin Antibody (YA1844) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to R Cadherin.

HY-P82099A

	R Cadherin Antibody (YA1844)(PBS only) cadherin 4; Type 1; R-cadherin (retinal); CAD4; RCAD; R-CAD	WB, IP	Human, Mouse, Rat
	R Cadherin Antibody (YA1844) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to R Cadherin.

HY-P83613

	*Angiotensin II Type 1* Receptor Antibody (YA3358)** AGTR1; AGTR1A; AGTR1B; AT2R1; AT2R1B; Type-1 angiotensin II receptor; AT1AR; AT1BR; Angiotensin II Type-1 receptor; AT1	WB	Human, Mouse, Rat
	Angiotensin II Type 1 Receptor Antibody (YA3358) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Angiotensin II Type 1 Receptor.

HY-P83613A

	*Angiotensin II Type 1* Receptor Antibody (YA3358)(PBS only)** AGTR1; AGTR1A; AGTR1B; AT2R1; AT2R1B; Type-1 angiotensin II receptor; AT1AR; AT1BR; Angiotensin II Type-1 receptor; AT1	WB	Human, Mouse, Rat
	Angiotensin II Type 1 Receptor Antibody (YA3358) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Angiotensin II Type 1 Receptor.

HY-P84988

	N Cadherin Antibody (YA4680) CADH2_HUMAN antibody; Cadherin 2 antibody; Cadherin 2 N cadherin neuronal antibody; Cadherin 2 Type 1 antibody; Cadherin 2 Type 1 N cadherin neuronal antibody; Cadherin 2; Type 1; N-cadherin; neuronal; antibody; Cadherin-2 antibody; Cadherin2 antibody; Calcium dependent adhesion protein neuronal antibody; CD325 antibody; CD325 antigen antibody; CDH2 antibody; CDHN antibody; CDw325 antibody; CDw325 antigen antibody; N cadherin 1 antibody; N-cadherin antibody; NCAD antibody; Neural cadherin antibody; OTTHUMP00000066304 antibody; OTTHUMP00000067378 antibody; CD325 nanobody;	FC, ELISA	Human
	N Cadherin Antibody (YA4680) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to N Cadherin.

HY-P83518

	*Dynein Light Chain Tctex Type 1* Antibody (YA3263)** CW-1; TCTEL1; tctex-1	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
	Dynein Light Chain Tctex Type 1 Antibody (YA3263) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dynein Light Chain Tctex Type 1.

HY-P810406

	*Angiotensin II Type 1* Receptor Antibody (YA9721)** AG2S, Agtr 1, Agtr1, AGTR1_HUMAN, Agtr1a, AGTR1B, Ang II, Angiotensin II receptor Type 1, Angiotensin II Type-1 receptor, Angiotensin receptor 1	WB, ICC/IF, FC	Human, Mouse, Rat
	Angiotensin II Type 1 Receptor Antibody (YA9721) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to Angiotensin II Type 1 Receptor.

HY-P83518A

	*Dynein Light Chain Tctex Type 1* Antibody (YA3263)(PBS only)** CW-1; TCTEL1; tctex-1	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
	Dynein Light Chain Tctex Type 1 Antibody (YA3263) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dynein Light Chain Tctex Type 1.

HY-P80573

	BRCA1 Antibody BRCA1; RNF53; Breast cancer Type 1 susceptibility protein; RING finger protein 53	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Rat
	BRCA1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to BRCA1.

HY-P85047

	Ataxin 1 Antibody (YA4739) ATXN1; ATX1; SCA1; Ataxin-1; Spinocerebellar ataxia Type 1 protein	WB, IHC-P, ICC/IF, FC, ELISA	Human
	Ataxin 1 Antibody (YA4739) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ataxin 1.

HY-P83718

	PSMB1 Antibody FLJ25321 antibody; HC5 antibody; KIAA1838 antibody; Macropain subunit C5 antibody; Multicatalytic endopeptidase complex subunit C5 antibody; Proteasome (prosome macropain) subunit beta Type 1 antibody; Proteasome beta 1 subunit antibody; Proteasome component C5 antibody; Proteasome gamma chain antibody; Proteasome subunit beta Type 1 antibody; Proteasome subunit beta Type-1 antibody; Proteasome subunit HC5 antibody; PSB1_HUMAN antibody; PSC5 antibody; PSMB 1 antibody; PSMB1 antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PSMB1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PSMB1.

HY-P86131

	Histone H2A (Ubiquityl Lys119) Antibody (YA5823) Histone H2A Type 1; H2A.1; Histone H2A/p;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Histone H2A (Ubiquityl Lys119) Antibody (YA5823) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H2A (Ubiquityl Lys119).

HY-P82031

	PTP1B Antibody (YA1776) PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor Type 1; Protein-tyrosine phosphatase 1B; PTP-1B	WB, IHC-F, IHC-P, ICC/IF	Human
	PTP1B Antibody (YA1776) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PTP1B.

HY-P82031A

	PTP1B Antibody (YA1776)(PBS only) PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor Type 1; Protein-tyrosine phosphatase 1B; PTP-1B	WB, IHC-F, IHC-P, ICC/IF	Human
	PTP1B Antibody (YA1776) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PTP1B.

HY-P81300A

	Phospho-PTP1B (Ser378) Antibody (YA1028) PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor Type 1; Protein-tyrosine phosphatase 1B; PTP-1B	WB, IHC-P	Human
	Phospho-PTP1B (Ser378) Antibody (YA1028) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PTP1B (Ser378).

HY-P81300

	Phospho-PTP1B (Ser352) Antibody (YA1027) PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor Type 1; Protein-tyrosine phosphatase 1B; PTP-1B	WB, ICC/IF, IP	Human
	Phospho-PTP1B (Ser352) Antibody (YA1027) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PTP1B (Ser352).

HY-P81300AA

	Phospho-PTP1B (Ser378) Antibody (YA1028)(PBS only) PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor Type 1; Protein-tyrosine phosphatase 1B; PTP-1B	WB, IHC-P	Human
	Phospho-PTP1B (Ser378) Antibody (YA1028) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PTP1B (Ser378).

HY-P80163

	Histone H2B Antibody (YA378) H2B GL105 antibody; H2B histone family member O antibody; H2B histone family member S antibody; H2B.1 antibody; H2B.1 B antibody; H2B.b antibody; H2B.c antibody; H2B.d antibody; H2B.e antibody; H2B.f antibody; H2B.j antibody; H2B.q antibody; H2B/b antibody; H2B/c antibody; H2B/d antibody; H2B/e antibody; H2B/f antibody; H2B/j antibody; H2B/o antibody; H2B/q antibody; H2BFB antibody; H2BFC antibody; H2BFD antibody; H2BFE antibody; H2BFF antibody; H2BFJ antibody; H2BFO antibody; H2BFQ antibody; H2BFS antibody; HIRIP2 antibody; HIST1H2BB antibody; HIST1H2BD antibody; HIST1H2BH antibody; HIST1H2BL antibody; HIST1H2BM antibody; HIST1H2BN antibody; HIST2H2BE antibody; Histone H2B antibody; Histone H2B Type 1 B antibody; Histone H2B Type 1 D antibody; Histone H2B Type 1 H antibody; Histone H2B Type 1 L antibody; Histone H2B Type 1 M antibody; Histone H2B Type 1 N antibody; Histone H2B Type 2 E antibody; histone protein antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
	Histone H2B Antibody (YA378) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H2B.

HY-P81744

	Trk-A Antibody (YA1489) NTRK1; MTC; TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor Type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Trk-A Antibody (YA1489) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Trk-A.

HY-P85396

	Trk-A Antibody (YA5088) NTRK1; MTC; TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor Type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A;	WB, IHC-P, IHC-F, IF-Tissue, ICC/IF	Mouse, Rat, Human
	Trk-A Antibody (YA5088) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Trk-A.

HY-P86247

	Trk pan Antibody (YA5939) NTRK1; MTC; TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor Type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Trk pan Antibody (YA5939) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Trk pan.

HY-P81193

	ADAMTS5 Antibody (YA3480) 1 Publications Verification A disintegrin and metalloproteinase with thrombospondin motifs 5; A disintegrin like and metalloprotease (reprolysin Type) with thrombospondin Type 1 motif 5; A Disintigrin And Metalloproteinase with ThromboSpondin motif-5; ADAM metallopeptidase with thrombospondin Type 1 motif 5; ADAM TS 11; ADAM TS 5; ADAM TS5; ADAMTS 11; ADAMTS 5; ADAMTS11; ADMP 2; ADMP2; Aggrecanase 2; aggrecanase-2; FLJ36738; Implantin; ThromboSpondin motif-5.	WB, ICC/IF, FC	Human, Mouse, Rat
	ADAMTS5 Antibody (YA3480) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADAMTS5.

HY-P81177

	CD163 Antibody 2 Publications Verification Scavenger receptor cysteine-rich Type 1 protein M130; CD 163; CD163 antigen; CD163 molecule; Hemoglobin Scavenger Receptor; M130; M130 antigen precursor; Macrophage associated antigen; MM130; C163A_HUMAN.	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse
	CD163 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CD163.

HY-P82414

	ERAP1 Antibody (YA2159) ERAP1; APPILS; ARTS1; KIAA0525; Endoplasmic reticulum aminopeptidase 1; ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis facto	WB, IHC-P	Human, Rat
	ERAP1 Antibody (YA2159) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERAP1.

HY-P82414A

	ERAP1 Antibody (YA2159)(PBS only) ERAP1; APPILS; ARTS1; KIAA0525; Endoplasmic reticulum aminopeptidase 1; ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis facto	WB, IHC-P	Human, Rat
	ERAP1 Antibody (YA2159) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERAP1.

HY-P80706

	Histone H2B Antibody (YA737) H2BK5ac; H2B 1A; H2B; H2B histone family; H2B2f; H2Ba; H2Bf; HIST2H2BF; histone H2B; histone H2B Type 1; Histone H2B Type 2-F	WB, IHC-P	Human, Mouse, Rat
	Histone H2B Antibody (YA737) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Histone H2B.

HY-P85977

	TGF β Receptor I Antibody (YA5669) TGF-beta receptor Type-1, TGFBR1, TGF-beta Type I receptor, ALK5 , SKR4	IHC-P, ICC/IF, ELISA	Human, Mouse, Rat, Bovin
	TGF β Receptor I Antibody (YA5669) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TGF β Receptor I.

HY-P81267

	Cytokeratin 7 Antibody (YA950) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k Type ii cytoskeletal; Keratin 7; Keratin simple epithelial Type 1 k7; Keratin Type II cytoskeletal 7	WB, ICC/IF	Human
	Cytokeratin 7 Antibody (YA950) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Cytokeratin 7.

HY-P81267A

	Cytokeratin 7 Antibody (YA951) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k Type ii cytoskeletal; Keratin 7; Keratin simple epithelial Type 1 k7; Keratin Type II cytoskeletal 7	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Cytokeratin 7 Antibody (YA951) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytokeratin 7.

HY-P81267B

	Cytokeratin 7 Antibody (YA952) CK 7; CK-7; ck7; Cytokeratin 7; Cytokeratin-7; Cytokeratin7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 55k Type ii cytoskeletal; Keratin 7; Keratin simple epithelial Type 1 k7; Keratin Type II cytoskeletal 7	WB, ICC/IF, IP	Human
	Cytokeratin 7 Antibody (YA952) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 7.

HY-P87077

	SMOC2 Antibody (YA6770) bA270C4A.1 antibody; bA37D8.1 (secreted modular calcium binding protein 2) antibody; bA37D8.1 antibody; dJ421D16.1 (novel thyroglobulin Type 1 repeat containing protein) antibody; dJ421D16.1 antibody; MST117 antibody; MSTP117 antibody; MSTP140 antibody; Secreted modular calcium binding protein 2 antibody; Secreted modular calcium-binding protein 2 antibody	WB, IHC-P	Human, Mouse, Rat
	SMOC2 Antibody (YA6770) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SMOC2.

HY-P83587

	Hydroxyl-Histone H2A Antibody (YA3332) H2A.1; H2A/c; H2A1; H2AFC:; H2AFD; H2AFI; H2AFN; H2AFP; HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM; histone cluster 1; H2ai; Histone H2A Type 1; Histone H2A/p	WB, IHC-P	Human, Mouse
	Hydroxyl-Histone H2A Antibody (YA3332) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hydroxyl-Histone H2A.

HY-P83587A

	Hydroxyl-Histone H2A Antibody (YA3332)(PBS only) H2A.1; H2A/c; H2A1; H2AFC:; H2AFD; H2AFI; H2AFN; H2AFP; HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM; histone cluster 1; H2ai; Histone H2A Type 1; Histone H2A/p	WB, IHC-P	Human, Mouse
	Hydroxyl-Histone H2A Antibody (YA3332) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hydroxyl-Histone H2A.

HY-P87142

	VILIP1 Antibody (YA6835) 21 kDa CABP antibody; Hippocalcin like protein 3 antibody; Hippocalcin-like protein 3 antibody; HLP 3 antibody; HLP3 antibody; HPCAL 3 antibody; HPCAL3 antibody; HUVISL1 antibody; Neural visinin-like protein 1 antibody; Neural visinin-like Type 1 protein antibody; 21 kDa CABP antibody; Hippocalcin like protein 3 antibody; Hippocalcin-like protein 3 antibody; HLP 3 antibody; HLP3 antibody; HPCAL 3 antibody; HPCAL3 antibody; HUVISL1 antibody; Neural visinin-like protein 1 antibody; Neural visinin-like Type 1 protein antibody; Neurocalcin alpha antibody; NVL 1 antibody; NVL1 antibody; Nvp1 antibody; OZ1 antibody; Ratnvp1 antibody; VIL; IP : antibody; VILIP-1 antibody; Visinin antibody; Visinin like 1 antibody; Visinin like protein 1 antibody; Visinin-like protein 1 antibody; VISL 1 antibody; VISL1 antibody; VISL1_HUMAN antibody; VLP-1 antibody; Vnsl1 antibody; Vsnl1 antibody;	WB, IHC-P	Human, Mouse, Rat
	VILIP1 Antibody (YA6835) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VILIP1.

HY-P81214

	Macrophage mannose receptor 1 Antibody (YA3531) 1 Publications Verification Mannose Receptor; C-Type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor; Mannose receptor C Type 1; MMR; MRC 1; MRC-1; MRC1_HUMAN; Macrophage mannose receptor 1; MRC1L1; C-Type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1.	WB	Human, Rat
	Macrophage mannose receptor 1 Antibody (YA3531) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Macrophage mannose receptor 1.

HY-P81214A

	Macrophage mannose receptor 1 Antibody (YA3531)(PBS only) Mannose Receptor; C-Type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor; Mannose receptor C Type 1; MMR; MRC 1; MRC-1; MRC1_HUMAN; Macrophage mannose receptor 1; MRC1L1; C-Type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1.	WB	Human, Rat
	Macrophage mannose receptor 1 Antibody (YA3531) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Macrophage mannose receptor 1.

HY-P86519

	Histone H2A Antibody (YA6211) HIST1H2AG; H2AFP; HIST1H2AI; H2AFC; HIST1H2AK; H2AFD; HIST1H2AL; H2AFI; HIST1H2AM; H2AFN; Histone H2A Type 1; H2A.1; Histone H2A/p; HIST1H2AB; H2AFM; HIST1H2AE; H2AFA; Histone H2A Type 1-B/E; Histone H2A.2; Histone H2A/a; Histone H2A/m; HIS	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Histone H2A Antibody (YA6211) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H2A.

HY-P81227

	Collagen I Antibody 3 Publications Verification Collagen Type I; Alpha 1 Type I collagen; Alpha 2 Type I collagen; COL1A1; COL1A2; Collagen I alpha 1 polypeptide; Collagen I alpha 2 polypeptide; Collagen Of Skin Tendon And Bone; Collagen Type 1; Collagen Type I alpha 1; Collagen Type I alpha 2; OI4; Osteogenesis Imperfecta Type IV; Pro alpha 1(I) collagen; Type I procollagen; CO1A1_HUMAN.	WB, IHC-P	Human, Mouse, Rat, Rabbit
	Collagen I Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Collagen I.

HY-P85894

	CD35 Antibody (YA5586) C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD 35; CD35; CD35 antigen; complement component; 3b/4b; receptor 1; Knops blood group; complement component; 3b/4b; receptor 1 including Knops blood group system; Complement component receptor 1; Complement receptor 1; Complement receptor Type 1; CR 1; CR1; CR1_HUMAN; KN; Knops blood group antigen	IHC-P, WB, ICC/IF, ELISA	Human
	CD35 Antibody (YA5586) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD35.

HY-P87011

	PIP5K1C Antibody (YA6704) Diphosphoinositide kinase antibody; LCCS3 antibody; Phosphatidylinositol-4-phosphate 5-kinase Type I gamma antibody; Phosphatidylinositol-4-phosphate 5-kinase Type-1 gamma antibody; PI51C antibody; PI51C_HUMAN antibody; PIP5K GAMMA antibody; PIP5K1-gamma antibody; Pip5k1c antibody; PIP5KIgamma antibody; Diphosphoinositide kinase antibody; LCCS3 antibody; Phosphatidylinositol-4-phosphate 5-kinase Type I gamma antibody; Phosphatidylinositol-4-phosphate 5-kinase Type-1 gamma antibody; PI51C antibody; PI51C_HUMAN antibody; PIP5K GAMMA antibody; PIP5K1-gamma antibody; Pip5k1c antibody; PIP5KIgamma antibody; PtdIns(4)P 5 kinase gamma antibody; PtdIns(4)P-5-kinase 1 gamma antibody; Type I P; IP : kinase antibody;	WB	Human
	PIP5K1C Antibody (YA6704) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIP5K1C.

HY-P810407

	*Activin A Receptor Type* IB Antibody (YA9722)** Activin A receptor Type 1B, Activin A receptor Type II like kinase 4, Activin A Type 1B receptor, Activin A Type IB receptor, Activin receptor like kinase 4, Activin receptor Type 1B, Activin receptor Type IB, Activin receptor Type-1B, Activin receptor-like kinase 4, ACTR IB	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Activin A Receptor Type IB Antibody (YA9722) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Activin A Receptor Type IB.

HY-P81196

	HSD3B1 Antibody (YA3519) 1 Publications Verification 3BHS1_HUMAN; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Type 1; beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase 1; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase 1; EC:1.1.1.145; 3-beta-hydroxysteroid 3-dehydrogenase 1; EC:1.1.1.270; Delta-5-3-ketosteroid isomerase; Dihydrotestosterone oxidoreductase. EC:1.1.1.210; Steroid Delta-isomerase 1; EC:5.3.3.1; Trophoblast antigen FDO161G; 3BH; HSDB3A;	WB, ICC/IF	Human
	HSD3B1 Antibody (YA3519) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HSD3B1.

HY-P81583

	CD35 Antibody (YA1328) C3BR,Complement receptor Type 1,C3b/C4b receptor,CD35	IHC-P	Human
	CD35 Antibody (YA1328) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD35.

HY-P81583A

	CD35 Antibody (YA1328)(PBS only) C3BR,Complement receptor Type 1,C3b/C4b receptor,CD35	IHC-P	Human
	CD35 Antibody (YA1328) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD35.

HY-P81119

	MTNR1A Antibody 1 Publications Verification MTR1A_HUMAN; Melatonin receptor Type 1A; Melatonin Receptor 1A; Mel-1A-R; Mel1a receptor; MT1; MT 1; Mel 1A R;	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	MTNR1A Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MTNR1A.

HY-P85684

	Histone H2B Antibody (YA5376) HIST1H2BB; H2BFF; Histone H2B Type 1-B; Histone H2B.1; Histone H2B.f; H2B/f	WB, ICC/IF	Human, Mouse, Rat
	Histone H2B Antibody (YA5376) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Histone H2B.

HY-P810513

	*Activin A Receptor Type* IB Antibody (YA9797)** ACVR1B, ACVRLK4, ALK4, Activin receptor Type-1B, Activin receptor Type IB, ACTR-IB, Activin receptor-like kinase 4, ALK-4, Serine/threonine-protein kinase receptor R2, SKR2	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Activin A Receptor Type IB Antibody (YA9797) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to Activin A Receptor Type IB.

HY-P82244

	*Activin A Receptor Type* IB Antibody (YA1989)** ACVR1B; ACVRLK4; ALK4; Activin receptor Type-1B; Activin receptor Type IB; ACTR-IB; Activin receptor-like kinase 4; ALK-4; Serine/threonine-protein kinase receptor R2; SKR2	WB, FC	Human, Mouse, Rat
	Activin A Receptor Type IB Antibody (YA1989) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Activin A Receptor Type IB.

HY-P82244A

	*Activin A Receptor Type* IB Antibody (YA1989)(PBS only)** ACVR1B; ACVRLK4; ALK4; Activin receptor Type-1B; Activin receptor Type IB; ACTR-IB; Activin receptor-like kinase 4; ALK-4; Serine/threonine-protein kinase receptor R2; SKR2	WB, FC	Human, Mouse, Rat
	Activin A Receptor Type IB Antibody (YA1989) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Activin A Receptor Type IB.

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Cat. No.	Product Name		Classification

HY-106203

Crinecerfont SSR-125543		Alkynes
Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency ^[1] . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-106203A

Crinecerfont hydrochloride SSR-125543 hydrochloride		Alkynes
Crinecerfont (SSR-125543) hydrochloride is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont hydrochloride blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont hydrochloride improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont hydrochloride can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency ^[1] . Crinecerfont hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15286

Sodium 4-pentynoate		Alkynes
Sodium 4-pentynoate is a alkynylacetate analogue, can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types . Sodium 4-pentynoate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-106203B

(R)-Crinecerfont (R)-SSR-125543		Alkynes
(R)-Crinecerfont is the R-enantiomer of Crinecerfont (HY-106203). Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency ^[1] . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-155772

LUF7690		Alkynes
LUF7690 (Compound 9) is a clickable and covalent affinity-based probe (AfBP) that targets the human A3AR (hA3AR). LUF7690 can be used in the detection and characterization of the hA3AR in different types of granulocytes, among other cell types .

HY-175421

ArMan		Alkynes
ArMan is an aryl mannoside ligand that can be chemically functionalized onto the surface of virus-like particles (VLPs) through click chemistry. VLPs can be used to target DC-SIGN dendritic cells, promote the selective co-binding of DC-SIGN and TLR7, and lead to a Th1-type immune response. VLP-ArMan-OvaI/II can significantly inhibit tumor growth in the mouse melanoma model ^[1].

Cat. No.	Product Name		Classification

HY-146244

Agatolimod 1 Publications Verification ODN 2006; PF-3512676; CpG 7909; ODN 7909		CpG ODNs
Agatolimod ((ODN 2006; PF-3512676; CpG 7909)) is a TLR9 agonist and immunomodulator with an EC₅₀ of 180 nM against human TLR9. Agatolimod activates and upregulates the expression of both TLR9 and TLR6, and mediates downstream signaling pathways via IRAK4, IRF5, IRF7. Agatolimod induces Th1-type innate and adaptive immune responses, activates various immune cells and promotes antigen presentation, regulates antibody levels and immune cell infiltration, upregulates the secretion of multiple cytokines, induces apoptosis and cell cycle arrest, enhances cytotoxicity, and clears intracellular Salmonella. Agatolimod is applicable to research on COVID-19, breast cancer, lung adenocarcinoma, HPV-related tumors, melanoma, and salmonellosis ^[1] .

HY-132588

Lumasiran ALN-G01		siRNAs siRNA drugs
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) ^[1] .

HY-132613

Lumasiran sodium		siRNAs siRNA drugs
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) ^[1] .

HY-145725A

Baliforsen ISIS 598769; IONIS 598769; BIIB 065; ISIS-DMPK-2.5Rx		Antisense Oligonucleotides
Baliforsen (ISIS 5987690) is an antisense oligonucleotide (ASO) that inhibits DMPK mRNA. Baliforsen binds within exon 9 of the human DMPK transcript to promote RNase H1-mediated degradation Baliforsen can be used for the research of myotonic dystrophy type 1 ^[1].

HY-171692

G3-YSD		CpG ODNs
G3-YSD is a cGAS agonist. G3-YSD directly interacts with cGAS to enhance its enzymatic activity, promote the conversion of ATP and GTP into cGAMP, and trigger STING-dependent IFN-α/β secretion. G3-YSD acts as a viral mimic to replace actual viral DNA . G3-YSD is applicable to research related to long COVID and type 1 human immunodeficiency virus infection ^[1] .

HY-147278

Manusiran Divesiran; SLN124		siRNAs siRNA drugs
Manusiran (Divesiran) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran increases hepatic Hepcidin synthesis and plasma levels by silencing TMPRSS6, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia ^[1] .

HY-177638

ISIS 1082		Antisense Oligonucleotides
ISIS 1082 is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-177638A

ISIS 1082 sodium		Antisense Oligonucleotides
ISIS 1082 sodium is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-174786

Human ACVR1 mRNA		mRNA
Human ACVR1 mRNA encodes the human activin A receptor type 1 (ACVR1) protein, a member of type I receptor which signals a particular transcriptional response in concert with activin type II receptors.

HY-174768

Human CCL15 mRNA		mRNA Chemokine & Receptors
Human CCL15 mRNA encodes the human C-C motif chemokine ligand 15 (CCL15) protein, a chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1).

HY-174775

Human BMPR1A mRNA		mRNA
Human BMPR1A mRNA encodes the human bone morphogenetic protein receptor type 1A (BMPR1A) protein, a family of transmembrane serine/threonine kinases. BMPR1A may play a role in positively regulating chondrocyte differentiation through GDF5 interaction and mediating induction of adipogenesis by GDF6.

HY-174781

Human ACVRL1 mRNA		mRNA
Human ACVRL1 mRNA encodes the human activin A receptor like type 1 (ACVRL1) protein. ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development.

HY-174784

Human ACVR1C mRNA		mRNA
Human ACVR1C mRNA encodes the human activin A receptor type 1C (ACVR1C) protein, a type I receptor for the TGFB family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.

HY-174604

Human IL4 mRNA		mRNA Interleukin & Receptors
Human IL4 mRNA encodes the human interleukin 4 (IL4) protein, a pleiotropic cytokine produced by activated T cells. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4 mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation.

HY-174564

Human NRG4 mRNA		mRNA
Human NRG4 mRNA encodes the human neuregulin 4 (NRG4) protein. The neuregulins, including NRG4, activate type-1 growth factor receptors to initiating cell-to-cell signaling through tyrosine phosphorylation.

HY-174530

Human TGFBR2 mRNA		mRNA
Human TGFBR2 mRNA encodes the human transforming growth factor beta receptor 2 (TGFBR2) protein, a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. TGFBR2/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis.

HY-174785

Human ACVR1B mRNA		mRNA
Human ACVR1B mRNA encodes the human activin A receptor type 1B (ACVR1B) protein, a type I receptor which is essential for signaling.

HY-174774

Human BMPR1B mRNA		mRNA
Human BMPR1B mRNA encodes the human bone morphogenetic protein receptor type 1B (BMPR1B) protein, a family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis.

HY-174626

Human IL1R1 mRNA		mRNA Interleukin & Receptors
Human IL1R1 mRNA encodes the human interleukin 1 receptor type 1 (IL1R1) protein, a cytokine receptor that belongs to the interleukin-1 receptor family. IL1R1 is an important mediator involved in many cytokine-induced immune and inflammatory responses.

HY-147262

Etedesiran		siRNAs siRNA drugs
Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1 ^[1].

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