Search Result

Results for "

Tyrosinase Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Tyrosinase (210) Akt (2) AMPK (6) Antibiotic (5) AP-1 (1) Apoptosis (15) Autophagy (4) Bacterial (19) Bcl-2 Family (3) Beta-lactamase (1) Biochemical Assay Reagents (2) c-Met/HGFR (3) Casein Kinase (1) Caspase (4) CD38 (1) CDK (1) Cholinesterase (ChE) (4) COX (2) DNA/RNA Synthesis (1) Drug Derivative (2) Drug Intermediate (1) EGFR (1) Endogenous Metabolite (34) Environmental Pollutants (7) ERK (4) Estrogen Receptor/ERR (1) Fluorescent Dye (1) Fungal (11) Glutaminase (3) Glutathione Reductase (GR) (1) Glycosidase (4) GSK-3 (1) HBV (1) HDAC (1) Heme Oxygenase (HO) (1) HIV (1) HSV (2) iGluR (3) Influenza Virus (2) Interleukin Related (7) Isotope-Labeled Compounds (16) JAK (1) JNK (2) Keap1-Nrf2 (1) Lipoxygenase (2) MAPKAPK2 (MK2) (1) MEK (1) Melanocortin Receptor (4) Microphthalmia Associated Transcription Factor (MITF) (1) MMP (2) mTOR (1) NADPH Oxidase (2) NF-κB (8) NO Synthase (1) NOD-like Receptor (NLR) (1) P2X Receptor (1) p38 MAPK (6) Parasite (4) PARP (2) PERK (3) Phosphatase (3) Phosphodiesterase (PDE) (1) Phospholipase (2) PI3K (2) PKA (3) PPAR (1) Prokineticin Receptor (1) Pyroptosis (1) Raf (1) Ras (4) Reactive Oxygen Species (ROS) (11) Reference Standards (33) SARS-CoV (4) Sirtuin (1) SOD (1) STAT (1) TGF-beta/Smad (1) TNF Receptor (5) Toll-like Receptor (TLR) (1) Xanthine Oxidase (1) β-catenin (1)
By Research Areas:	Cancer (79) Cardiovascular Disease (9) Endocrinology (6) Infection (36) Inflammation/Immunology (52) Metabolic Disease (82) Neurological Disease (35)

By Targets:

Tyrosinase (210)

Akt (2)

AMPK (6)

Antibiotic (5)

AP-1 (1)

Apoptosis (15)

Autophagy (4)

Bacterial (19)

Bcl-2 Family (3)

Beta-lactamase (1)

Biochemical Assay Reagents (2)

c-Met/HGFR (3)

Casein Kinase (1)

Caspase (4)

CD38 (1)

CDK (1)

Cholinesterase (ChE) (4)

COX (2)

DNA/RNA Synthesis (1)

Drug Derivative (2)

Drug Intermediate (1)

EGFR (1)

Endogenous Metabolite (34)

Environmental Pollutants (7)

ERK (4)

Estrogen Receptor/ERR (1)

Fluorescent Dye (1)

Fungal (11)

Glutaminase (3)

Glutathione Reductase (GR) (1)

Glycosidase (4)

GSK-3 (1)

HBV (1)

HDAC (1)

Heme Oxygenase (HO) (1)

HIV (1)

HSV (2)

iGluR (3)

Influenza Virus (2)

Interleukin Related (7)

Isotope-Labeled Compounds (16)

JAK (1)

JNK (2)

Keap1-Nrf2 (1)

Lipoxygenase (2)

MAPKAPK2 (MK2) (1)

MEK (1)

Melanocortin Receptor (4)

Microphthalmia Associated Transcription Factor (MITF) (1)

MMP (2)

mTOR (1)

NADPH Oxidase (2)

NF-κB (8)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

P2X Receptor (1)

p38 MAPK (6)

Parasite (4)

PARP (2)

PERK (3)

Phosphatase (3)

Phosphodiesterase (PDE) (1)

Phospholipase (2)

PI3K (2)

PKA (3)

PPAR (1)

Prokineticin Receptor (1)

Pyroptosis (1)

Raf (1)

Ras (4)

Reactive Oxygen Species (ROS) (11)

Reference Standards (33)

SARS-CoV (4)

Sirtuin (1)

SOD (1)

STAT (1)

TGF-beta/Smad (1)

TNF Receptor (5)

Toll-like Receptor (TLR) (1)

Xanthine Oxidase (1)

β-catenin (1)

By Research Areas:

Cancer (79)

Cardiovascular Disease (9)

Endocrinology (6)

Infection (36)

Inflammation/Immunology (52)

Metabolic Disease (82)

Neurological Disease (35)

244

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

136

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Targets Recommended: Tyrosinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W050154

Kojic acid 2 Publications Verification	Parasite Tyrosinase NF-κB CDK	Infection Inflammation/Immunology Cancer
Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a *Tyrosinase* inhibitor with an Mushroom Tyrosinase IC₅₀ of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .

HY-N1430

Oxyresveratrol 3 Publications Verification trans-Oxyresveratrol	Tyrosinase HSV Autophagy	Others
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive *tyrosinase* inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

HY-W015967

Glycolic acid 1 Publications Verification Hydroxyethanoic acid	Environmental Pollutants Endogenous Metabolite Tyrosinase	Metabolic Disease
Glycolic acid is an inhibitor of *tyrosinase*, suppressing melanin formation and lead to a lightening of skin colour.

HY-126052

Gnetol	COX Tyrosinase HDAC	Metabolic Disease Cancer
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent *tyrosinase* inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities .

HY-107369

4-Butylresorcinol Butylresorcinol	Tyrosinase	Others
4-Butylresorcinol is a phenol derivative which can inhibit *tyrosinase* with IC₅₀ of 11.27 μM.

HY-N2204

Swertiajaponin	Tyrosinase Reactive Oxygen Species (ROS)	Inflammation/Immunology
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC₅₀ of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity .

HY-Y0135

Tropinone	Drug Intermediate	Cancer
Tropinone is an organic synthesis intermediate and a skeleton for constructing derivatives containing thiazole rings and other structures. Tropinone derivatives have anticancer activities such as inducing tumor cell apoptosis and inhibiting tyrosinase activity, and can be used in research such as anticancer drug development and tyrosinase inhibitor design .

HY-101445A

(R)-Trolox	Tyrosinase	Cancer
(R)-Trolox is a vitamin E analogue and a competitive *tyrosinase* inhibitor with a K_i value of 0.83 mM and a ID₅₀ value of 1.88 mM . The (R)-Trolox has stronger *tyrosinase* affinity than the (S) enantiomer (K_i value of 0.61 mM) .

HY-N1386

2-Methoxycinnamic acid	Tyrosinase	Metabolic Disease
2-Methoxycinnamic acid is a noncompetitive inhibitor of *tyrosinase* .

HY-P3452

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

HY-N3200

Neorauflavane	Tyrosinase	Cancer
Neorauflavane is a potent *tyrosinase* inhibitor derived from Campylotropis hirtella, with an IC₅₀ value of 30 nM for tyrosinase monophenolase activity and an IC₅₀ value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells .

HY-W015967S

Glycolic acid-d2	Endogenous Metabolite Tyrosinase	Metabolic Disease
Glycolic acid-d₂ is the deuterium labeled Glycolic acid. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-N2101

Benzoyloxypaeoniflorin	Tyrosinase NF-κB	Inflammation/Immunology
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a *tyrosinase* inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation .

HY-W115529

Geranic acid Geranate; NSC 229335; GAGE	Environmental Pollutants Fungal Tyrosinase	Infection Cancer
Geranic acid (Geranate) acts as a *tyrosinase* inhibitor and antifungal agent, with an IC₅₀ value of 0.14-2.3 mM against mushroom *tyrosinase. Geranic acid reduces the viability of human pancreatic cancer cells and B-lymphoma cells. Geranic acid inhibits* mycelial growth of the maize pathogens Colletotrichum graminicola and Fusarium graminearum. Geranic acid is applicable to research related to fungal infections, pancreatic cancer and B-lymphoma .

HY-W037976

Tyrosinase-IN-22 5-Chloro-2-mercaptobenzimidazole	Reactive Oxygen Species (ROS) Tyrosinase	Cancer
Tyrosinase-IN-22 (compound 4) is an inhibitor of tyrosinase substrates (L-tyrosine and L-dopa) with IC₅₀s of 60 nM and 30 nM, respectively. Tyrosinase-IN-22 also shows potent antioxidant and anti-melanogenic properties, thus can be used for relevant researches .

HY-N3748

Dihydromorin 1 Publications Verification	Tyrosinase	Cancer
Dihydromorin, a natural flavanonol compound, is a *tyrosinase* inhibitor .

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-N3425

Kazinol U	AMPK	Others
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

HY-152194

Tyrosinase-IN-10	Tyrosinase	Cancer
Tyrosinase-IN-10 (Compound 23) is a partially competitive *tyrosinase* inhibitor with an IC₅₀ of 1.6 μM against tyrosinase activity from human melanoma cell lysates .

HY-125762

Tyrosinase-IN-16	Tyrosinase	Cancer
Tyrosinase-IN-16 (compound 19a) is a tyrosine kinase (Tyrosinase) inhibitor with Ki=470 nM. Tyrosinase-IN-16 is cytotoxic to B16F10 cells, with >90% inhibition at 20 μM .

HY-N6244

Isolindleyin	Tyrosinase	Inflammation/Immunology
Isolindleyin, a butyrophenone, is a *tyrosinase* inhibitor, with a K_d of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities .

HY-N12810

Sanggenon O	Tyrosinase	Others
Sanggenon O is a mushroom tyrosinase inhibitor that can be isolated from Morus nigra, with an IC₅₀ value of 1.15 μM .

HY-N2134

Mirificin Puerarin apioside	Tyrosinase	Endocrinology
Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix. Mirificin inhibits tyrosinase (TYR) with an IC₅₀ of 12.66 μM .

HY-N8223

Viscumneoside III	Tyrosinase	Cardiovascular Disease
Viscumneoside III, a dihydroflavone O-glycoside, is a potent *tyrosinase* inhibitor with an IC₅₀ of 0.5 mM. Viscumneoside III has anti-angina pectoris .

HY-151977

Tyrosinase-IN-7	Tyrosinase	Cancer
Tyrosinase-IN-7 is a potent *tyrosinase* inhibitor with an IC₅₀ value of 1.57 µM. Tyrosinase-IN-7 inhibits cell growth with low cytotoxicity .

HY-151979

Tyrosinase-IN-8	Tyrosinase	Cancer
Tyrosinase-IN-8 is a potent *tyrosinase* inhibitor with an IC₅₀ value of 1.6 µM. Tyrosinase-IN-8 inhibits cell growth with low cytotoxicity .

HY-149207

Tyrosinase-IN-11	Tyrosinase	Metabolic Disease
Tyrosinase-IN-11 is a potent *tyrosinase* inhibitor with IC₅₀s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research .

HY-143459

Tyrosinase-IN-5	Tyrosinase	Cancer
Tyrosinase-IN-5 (compound 16c) is a potent inhibitor of *tyrosinase* with an IC₅₀ of 0.02 μM. Tyrosinase-IN-5 efficiently suppresses the melanogenesis without significant toxicity on cells .

HY-N5118

Chimonanthine (-)-Chimonanthine	Tyrosinase	Cancer
Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis .

HY-N3101

Pedalitin 2 Publications Verification	Endogenous Metabolite Tyrosinase Glycosidase	Endocrinology
Pedalitin is a inhibitor of tyrosinase（IC₅₀=0.28 mM） and α-glucosidase（IC₅₀=0.29 mM） .

HY-N3943

Glabrene	Tyrosinase	Neurological Disease
Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a *tyrosinase* inhibitor with an IC₅₀ of 3.5 μM .

HY-W012092

Ethyl 3,4,5-trimethoxybenzoate	Tyrosinase Reactive Oxygen Species (ROS)	Metabolic Disease Inflammation/Immunology
Ethyl 3,4,5-trimethoxybenzoate is a melanogenesis inhibitor. Ethyl 3,4,5-trimethoxybenzoate does not directly target tyrosinase activity, but inhibits melanin synthesis in a dose-dependent manner by downregulating α-MSH (HY-P0252)-induced tyrosinase protein expression and scavenging ROS. Ethyl 3,4,5-trimethoxybenzoate scavenges DPPH free radicals. Ethyl 3,4,5-trimethoxybenzoate can be used in the research of hyperpigmentation .

HY-N1386R

2-Methoxycinnamic acid (Standard)	Reference Standards Tyrosinase	Metabolic Disease
2-Methoxycinnamic acid is a noncompetitive inhibitor of tyrosinase .

HY-N10219

Dihydroaltenuene B	Tyrosinase Fungal	Infection
Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC₅₀ of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase .

HY-W046353A

(E)-2-Methoxycinnamaldehyde (E)-O-Methoxycinnamaldehyde	Tyrosinase	Neurological Disease
(E)-2-Methoxycinnamaldehyde ((E)-o-Methoxycinnamaldehyde) is a *tyrosinase* inhibitor with an IC₅₀ of 0.42 mM for mushroom tyrosinase. (E)-2-Methoxycinnamaldehyde is found in the twigs of Cinnamomum cassia. (E)-2-Methoxycinnamaldehyde can be used for the research of Parkinson's disease .

HY-P6294

Pseudostellarin G	Tyrosinase	Others
Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin .

HY-157124

Tyrosinase-IN-19	Tyrosinase	Metabolic Disease
Tyrosinase-IN-19 (compound 9) is a competitive *tyrosinase* inhibitor. Tyrosinase-IN-19 has strong antioxidant activities against ROS, ABTS+, and DPPH radicals. Tyrosinase-IN-19 suppresses tyrosinase expression in a dose-dependent manner .

HY-162909

Tyrosinase-IN-38	Tyrosinase	Metabolic Disease
Tyrosinase-IN-38 (compound 6b) is a competitive *Tyrosinase* inhibitor with IC₅₀ value of 25.82 μM. Tyrosinase-IN-38 has antioxidant activity .

HY-161241

Tyrosinase-IN-23	Tyrosinase	Cancer
Tyrosinase-IN-23 (Compd 11m) is a *tyrosinase* inhibitor with an IC₅₀ of 55.39±4.93 µM. Tyrosinase-IN-23 can be used for research of melanin biosynthesis .

HY-162140

Tyrosinase-IN-21	Tyrosinase	Others
Tyrosinase-in-21 (compound 3g) is a *tyrosinase* inhibitor with IC₅₀ value of 80.93 μM .

HY-155247

Tyrosinase-IN-14	Tyrosinase	Others
Tyrosinase-IN-14 (compound 7m) is a tyrosinase inhibitor that reduces the catalytic activity of tyrosinase by changing its secondary structure. Tyrosinase-IN-14 has low cytotoxicity and anti-browning activity in fruits. Tyrosinase-IN-14 effectively inhibits banana browning during storage .

HY-N3091

Persiconin	Tyrosinase	Others
Persiconin is a tyrosinase Inhibitor. Persiconin can be isolated from Prunus persica. Persiconin has tyrosinase inhibitory activity of 46% at 500 μM. Persiconin can be used in whitening research .

HY-157123

Tyrosinase-IN-18	Tyrosinase	Metabolic Disease
Tyrosinase-IN-18 (compound 6) is a potent *tyrosinase* inhibitor. Tyrosinase-IN-18 inhibits melanogenesis in B16F10 mammalian cells. Tyrosinase-IN-18 has strong antioxidant activities against ROS, ABTS ⁺, and DPPH radicals .

HY-175349

Tyrosinase-IN-43	Tyrosinase	Metabolic Disease
Tyrosinase-IN-43 (Compound 12j) is a competitive Tyrosinase inhibitor with an IC₅₀ of 10.49 ?μM for tyrosinase. Tyrosinase-IN-43 has significant antioxidant activity. Tyrosinase-IN-43 can be used for hyperpigmentation-related complications such as melasma, freckles, age spots and post-inflammatory hyperpigmentation research .

HY-N2962

Broussonin C	Tyrosinase	Inflammation/Immunology
Broussonin C is a competitive inhibitor of *Tyrosinase* that can be isolated from Broussonetia kazinoki. Broussonin C inhibits monophenolase and diphenolase with IC₅₀s of 0.43 and 0.57 μM, respectively .

HY-161289

Tyrosinase-IN-24	Tyrosinase	Cancer
Tyrosinase-IN-24 (compound 3b) is a tyrosinase inhibitor with inhibitory activity against mushroom tyrosinase .

HY-149404

Tyrosinase-IN-12	Reactive Oxygen Species (ROS) Tyrosinase	Others
Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) is a potent, non-competitive *tyrosinase* inhibitor with an IC₅₀ value of 49.33 ± 2.64 µM and K_i value of 31.25 ± 0.25 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) have the highest radical scavenging activity to reduce the production of reactive oxygen species (ROS) with an IC₅₀ value of 25.39 ± 0.77 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) can be used for anti-browning substances in the food and agricultural sectors .

HY-161846

Tyrosinase-IN-31	Tyrosinase	Neurological Disease
Tyrosinase-IN-31 (compound 2-06) is a central-targeting tyrosinase inhibitor (tyrosinase: monophenolase IC₅₀=70.44 μM, diphenolase IC₅₀=1.89 μM). Tyrosinase-IN-31 can inhibit the tyrosinase and melanogenesis. Tyrosinase-IN-31 can penetrate the BBB and enter the central nervous system (CNS). Tyrosinase-IN-31 shows neuroprotective effects and Parkinsonism behavior improving function .

HY-158021

Tyrosinase-IN-26	Tyrosinase	Cancer
Tyrosinase-IN-26 (compound 13) is a uncompetitive *tyrosinase* inhibitor with the an IC₅₀ value of 68.86 µM. Tyrosinase-IN-26 can suppresses melanogenesis .

HY-173223

Tyrosinase-IN-41	Tyrosinase	Others
Tyrosinase-IN-41 (compound 7) is a *Tyrosinase* inhibitor, with an IC₅₀ of 9.45 μM .

Cat. No.	Product Name	Type

HY-D0168

Orcinol

3,5-Dihydroxytoluene

Fluorescent Dyes

Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

HY-W013636AG

2-Ketoglutaric acid Sodium

Alpha-Ketoglutaric acid Sodium

Fluorescent Dyes

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) Sodium (GMP) is 2-Ketoglutaric acid Sodium (HY-W013636A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 2-Ketoglutaric acid Sodium is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

Cat. No.	Product Name	Type

HY-W013636C

2-Ketoglutaric acid potassium

5+ Cited Publications

Alpha-Ketoglutaric acid potassium

Biochemical Assay Reagents

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) (potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium is a reversible and orally active inhibitor of tyrosinase with an IC₅₀ value of 15 mM. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium significantly suppresses abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cells, expression of TNFα in vitro and in vivo. 2-Ketoglutaric acid potassium directly binds to TAK1, and inhibits the TRAF6-TAK1 interaction. 2-Ketoglutaric acid potassium also alleviates inflammatory bowel disease (IBD) symptoms and gut microbiota dysbiosis, evident by the improvements in the intestine length .

HY-78700

4-Bromobenzoic acid	Biochemical Assay Reagents
4-Bromobenzoic acid is a *tyrosinase* inhibitor (IC₅₀ range 0-0.3 mg/mL). 4-Bromobenzoic acid can be metabolized through the protocatechuic acid (PCA) pathway. 4-Bromobenzoic acid can be used for research on cosmetic whitening or pigmentation conditions .

HY-W015715

5-Methylresorcinol monohydrate Orcinol monohydrate	Biochemical Assay Reagents
5-Methylresorcinol monohydrate (Orcinol monohydrate) is a *tyrosinase* inhibitor. 5-Methylresorcinol monohydrate shows cytotoxicity. 5-Methylresorcinol monohydrate also is an oral active and cross the blood-brain barrier anxiolytic agent .

HY-NP192

Sericin

Biochemical Assay Reagents

Sericin is an orally active globular protein produced by silkworm cocoons. Sericin inhibits the expression of COX2, iNOS, TLR4, MAPK and NF-κB; reduces the levels of IL-18, IL-1 and CCL2; antagonizes the activity of AChE; and downregulates the expression of Bcl-2. Sericin enhances the PI3K/AKT-mediated insulin signaling pathway. Sericin inhibits the activity of tyrosinase (Tyrosinase), scavenges ROS, chelates metal ions, and increases the levels of antioxidant enzymes. Sericin induces apoptosis and arrests the cell cycle. Sericin exhibits antibacterial, moisturizing, cardioprotective and anticoagulant properties. Sericin can be used in research related to type 2 diabetes, hyperlipidemia, obesity, Alzheimer's disease, colon cancer, peripheral nerve injury and ischemic myocardial infarction .

HY-W013636AG

2-Ketoglutaric acid Sodium

Alpha-Ketoglutaric acid Sodium

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P10533

Cysteine peptide	Tyrosinase	Others
Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses .

HY-P3452

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

HY-P0096

Decapeptide-12	Tyrosinase Sirtuin	Inflammation/Immunology Endocrinology
Decapeptide-12, a small oligopeptide, is a *tyrosinase* inhibitor that interacts with C-terminal residue of tyrosinase (K_d: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC₅₀: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .

HY-P6294

Pseudostellarin G	Tyrosinase	Others
Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin .

HY-P4497

Prolylserine	ERK	Cancer
Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and *tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB)* .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990149

Anti-Mouse/Human TYRP1 Antibody (TA99)	Tyrosinase	Cancer
Anti-Mouse/Human TYRP1 Antibody (TA99) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human TYRP1. Anti-Mouse/Human TYRP1 Antibody (TA99) binds to Tyrp1 (tyrosinase related protein-1) on tumor. Anti-Mouse/Human TYRP1 Antibody (TA99) enhances infiltration of the tumor by CD8 ⁺ T cells. Anti-Mouse/Human TYRP1 Antibody (TA99) can be used for the research of melanoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W013636

2-Ketoglutaric acid Maximum Cited Publications 6 Publications Verification Alpha-Ketoglutaric acid; 2-Oxoglutaric acid	Immune System Disorder Microorganisms Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Tyrosinase Endogenous Metabolite
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM) .

HY-W050154

Kojic acid 2 Publications Verification	Infection Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Parasite Tyrosinase NF-κB CDK
Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a *Tyrosinase* inhibitor with an Mushroom Tyrosinase IC₅₀ of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .

HY-N0192

Arbutin 3 Publications Verification β-Arbutin	Bergenia purpurascens (Hook. f. et Thoms.) Engl. Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Phenols Saxifragaceae Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Tyrosinase Endogenous Metabolite
Arbutin (β-Arbutin) is a competitive inhibitor of *tyrosinase, with K_i ^app* values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .

HY-W015309

Decanoic acid 4 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Biological Pesticide Research Source Classification Agricultural Research	Environmental Pollutants Endogenous Metabolite iGluR Glutaminase c-Met/HGFR Tyrosinase
Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces *tyrosinase* activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy .

HY-N1430

Oxyresveratrol 3 Publications Verification trans-Oxyresveratrol	other families Stilbenes Classification of Application Fields Anti-aging Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Tyrosinase HSV Autophagy
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive *tyrosinase* inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

HY-N6006

1,3,6-Tri-O-galloyl-beta-D-glucose 1,3,6-Tri-O-galloyl-β-D-glucose	other families Classification of Application Fields Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Others
1,3,6-Tri-O-galloyl-beta-D-glucose is a non-covalent inhibitor of tyrosinase (TYR), which can block the rate-limiting step of melanin synthesis and inhibit melanin deposition. 1,3,6-Tri-O-galloyl-beta-D-glucose has antioxidant and anti-inflammatory activities and can be used as a natural active ingredient to develop anti-freckle and whitening skin care products .

HY-W015967

Glycolic acid 1 Publications Verification Hydroxyethanoic acid	Structural Classification Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Environmental Pollutants Endogenous Metabolite Tyrosinase
Glycolic acid is an inhibitor of *tyrosinase*, suppressing melanin formation and lead to a lightening of skin colour.

HY-W013571

4-Isopropylbenzoic acid Cuminic acid; p-Isopropyl benzoic acid	Infection other families Bridelia retusa Classification of Application Fields Ketones, Aldehydes, Acids Euphorbiaceae Plants Disease Research Fields Source Classification	Fungal
4-Isopropylbenzoic acid (Cuminic acid; p-Isopropyl benzoic acid) an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of mushroom tyrosinase .

HY-N3002

α-Arbutin 4-Hydroxyphenyl α-D-glucopyranoside	Monophenols Classification of Application Fields Phenols Metabolic Disease Cosmetic Research Ericaceae Plants Disease Research Fields Source Classification	Tyrosinase
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is a *tyrosinase* inhibitor, which is used as an effective skin whiteners. α-Arbutin is promising for research of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes .

HY-126052

Gnetol	Stilbenes Classification of Application Fields Phenols Polyphenols Gnetaceae Metabolic Disease Plants Disease Research Fields Gnetum montanum Markgr. Source Classification	COX Tyrosinase HDAC
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent *tyrosinase* inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities .

HY-N2460

Aloesin 1 Publications Verification Aloeresin	Monophenols Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Phenols Aloe vera (L.) Burm. f. Plants Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase Apoptosis
Aloesin (Aloeresin) is a *tyrosinase* inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research .

HY-Y0444

D-Tyrosine	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Tyrosinase
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting *tyrosinase* activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth .

HY-N10503

Norartocarpetin	Flavonoids Flavones Plants Moraceae	Tyrosinase Ras Raf MAPKAPK2 (MK2) Apoptosis
Norartocarpetin is a *tyrosinase* inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC₅₀ value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC₅₀ value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells .

HY-B0856

Validamycin A 1 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Fungal Tyrosinase Antibiotic
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1?μg/mL . Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC₅₀ of 72 μM . Validamycin A is a reversible *tyrosinase* inhibitor, with a K_i of 5.893 mM .

HY-N0445

2-Hydroxy-4-methoxybenzaldehyde	Monophenols other families Classification of Application Fields Simple Phenylpropanols Other Diseases Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Tyrosinase Bacterial
2-hydroxy-4-methoxybenzaldehyde is a potent *tyrosinase* inhibitor . 2-Hydroxy-4-methoxybenzaldehyde, an isomer of Vanillin, could be used to synthesis Urolithin M7

HY-N1394

p-Anisic acid 3 Publications Verification 4-Methoxybenzoic acid; Draconic acid	Infection Structural Classification Acacia mearnsii Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Cosmetic Research Plants Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite Tyrosinase
p-Anisic acid (4-Methoxybenzoic acid) is an orally available *tyrosinase* inhibitor that has antioxidant, anti-anxiety, anti-inflammatory, anti-tumor, anti-diabetic, and preservative properties. p-Anisic acid can be used as a preservative in the cosmetics field .

HY-W013636A

2-Ketoglutaric acid Sodium Maximum Cited Publications 6 Publications Verification Alpha-Ketoglutaric acid Sodium	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Tyrosinase Endogenous Metabolite
2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM) .

HY-N2204

Swertiajaponin	Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase Reactive Oxygen Species (ROS)
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC₅₀ of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity .

HY-127170

3-Hydroxycoumarin	Structural Classification other families Classification of Application Fields Other Diseases Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification	Lipoxygenase Tyrosinase
3-Hydroxycoumarin is an inhibitor of *tyrosinase* and lipoxygenase with an IC₅₀ for recombinant human tyrosinase (rHT) of 26 μM, and a K_i of 3.39 μM; its IC₅₀ for LOX is 9.5 μM. 3-Hydroxycoumarin has DPPH free radical scavenging activity (IC₅₀ = 31.2 μM). 3-Hydroxycoumarin has photoprotective effects on sea urchin zygotes and embryos .

HY-N1750

3-(2,4-Dihydroxyphenyl)propanoic acid	Structural Classification Natural Products Classification of Application Fields Plants Moraceae Endogenous metabolite Human Gut Microbiota Metabolites Ficus carica L. Other Diseases Phenols Polyphenols Disease Research Fields Source Classification	Tyrosinase
3-(2,4-Dihydroxyphenyl) propanoic acid (DPPacid) is a competitive *Tyrosinase* inhibitor. It exhibits an IC₅₀ value of 3.02 μM against mushroom tyrosinase with L-tyrosine as the substrate, an IC₅₀ value of 62 μM with DL-DOPA as the substrate, and a K_i value of 11.5 μM. 3-(2,4-Dihydroxyphenyl) propanoic acid shows no DPPH radical scavenging activity. It can be used in studies related to ultraviolet B (UVB)-induced hyperpigmentation .

HY-W012595

Benzylideneacetone Benzalacetone	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Endogenous Metabolite Phospholipase Bacterial Tyrosinase
Benzylideneacetone (Benzalacetone) is an orally active antibiotic, *tyrosinase* inhibitor, phospholipase A₂ inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods .

HY-133680

β-Tocopherol	Monophenols Classification of Application Fields Phenols Metabolic Disease Palmae Plants Disease Research Fields Trachycarpus fortunei (Hook.) H. Wendl. Source Classification	Tyrosinase
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit *tyrosinase* activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-129997

Luteolinidin chloride 1 Publications Verification	Anthocyans Flavonoids Sorghum bicolor (Linn.) Moench Classification of Application Fields Gramineae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	CD38 NADPH Oxidase Tyrosinase
Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor (K_i=11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of *tyrosinase* (IC₅₀=3.7 μM) and blocks the production of melanin .

HY-W017212

Methyl cinnamate 2 Publications Verification Methyl 3-phenylpropenoate	Structural Classification Classification of Application Fields Simple Phenylpropanols Rutaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zanthoxylum armatum DC. Source Classification	Environmental Pollutants AMPK Bacterial Tyrosinase
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a *tyrosinase* inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N1386

2-Methoxycinnamic acid	Classification of Application Fields Simple Phenylpropanols Ranunculaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel Source Classification	Tyrosinase
2-Methoxycinnamic acid is a noncompetitive inhibitor of *tyrosinase* .

HY-N3200

Neorauflavane	Leguminosae Campylotropis hirtella (Franch.) Schindl. Phenols Polyphenols Plants Source Classification	Tyrosinase
Neorauflavane is a potent *tyrosinase* inhibitor derived from Campylotropis hirtella, with an IC₅₀ value of 30 nM for tyrosinase monophenolase activity and an IC₅₀ value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells .

HY-B1461

Deoxyarbutin	Natural Products Monophenols other families Classification of Application Fields Other Diseases Phenols Plants Disease Research Fields Source Classification	Tyrosinase Apoptosis
Deoxyarbutin is an orally active *tyrosinase* inhibitor that can promote apoptosis of melanoma cells, enhance the vitality of mouse acinar cells, and has skin whitening and anti-tumor activity ^[1][2][3].

HY-N3103

p-Coumaric Acid Ethyl Ester Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate	Monophenols other families Classification of Application Fields Simple Phenylpropanols Phenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase
p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate) is a non-competitive, reversible inhibitor of *tyrosinase* (IC₅₀=4.89 μg/mL, K_i=1.83 μg/mL), which can quench the intrinsic fluorescence of the enzyme. p-Coumaric Acid Ethyl Ester changes the binding affinity of L-tyrosine by inducing conformational changes in the catalytic domain of tyrosinase, and does not bind to the copper ion of the enzyme. p-Coumaric Acid Ethyl Ester is used in the development of medicines, cosmetics and fruit preservation products using pollen .

HY-N3239

Mulberrofuran G	Phenols Polyphenols Plants Moraceae Morus alba Linn. Source Classification	Tyrosinase NADPH Oxidase HBV SARS-CoV Reactive Oxygen Species (ROS) JAK STAT Apoptosis Caspase PARP
Mulberrofuran G is a NOX inhibitor (IC₅₀: 6.9 μM) and *tyrosinase* inhibitor. Mulberrofuran G exhibits anti-inflammatory, antioxidant, antiviral, antitumor, and neuroprotective effects. Mulberrofuran G can be used in the research of tumors, nervous system diseases, and other conditions .

HY-W013636B

Calcium 2-oxoglutarate Maximum Cited Publications 6 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Tyrosinase Endogenous Metabolite
Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM) .

HY-N7929

5-Feruloylquinic acid	Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Other Phenylpropanoids Phenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Tyrosinase
5-Feruloylquinic acid (5-FQA) is a hydroxycinnamic acid derivative. 5-Feruloylquinic acid can be isolated from green coffee beans. 5-Feruloylquinic acid inhibits *tyrosinase* activity. 5-Feruloylquinic acid has antioxidant properties. 5-Feruloylquinic acid has anticancer activity against lymphoma, oral epidermal cancer, and breast cancer .

HY-N2101

Benzoyloxypaeoniflorin	Other Monoterpenes Monophenols Classification of Application Fields Paeonia lactiflora Pall. Terpenoids Phenols Plants Paeoniaceae Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase NF-κB
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a *tyrosinase* inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation .

HY-W115529

Geranic acid Geranate; NSC 229335; GAGE	Structural Classification Ketones, Aldehydes, Acids Plants Lauraceae Litsea cubeba (Lour.) Pers. Source Classification	Environmental Pollutants Fungal Tyrosinase
Geranic acid (Geranate) acts as a *tyrosinase* inhibitor and antifungal agent, with an IC₅₀ value of 0.14-2.3 mM against mushroom *tyrosinase. Geranic acid reduces the viability of human pancreatic cancer cells and B-lymphoma cells. Geranic acid inhibits* mycelial growth of the maize pathogens Colletotrichum graminicola and Fusarium graminearum. Geranic acid is applicable to research related to fungal infections, pancreatic cancer and B-lymphoma .

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Stilbenes Classification of Application Fields Polygonaceae Whitening Agent Reynoutria japonica Houtt. Phenols Polyphenols Metabolic Disease Cosmetic Research Plants Disease Research Fields Source Classification	Tyrosinase
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective *tyrosinase* inhibitor with an IC₅₀ of 1.64 μM .

HY-N6829

Retusin Quercetin-3,3',4',7-tetramethylether	Flavonols Structural Classification Monophenols Flavonoids Entada phaseoloides (L.) Merr. Classification of Application Fields Labiatae Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase Fungal SARS-CoV Apoptosis Reactive Oxygen Species (ROS)
Retusin (Quercetin-3,3',4',7-tetramethylether) is a *tyrosinase* inhibitor, with IC₅₀ values of 50.9 μM and 51.8 μM against mushroom and intracellular tyrosinase, respectively. Retusin also acts as a free radical scavenger, melanogenesis inhibitor, anti-apoptosis agent, neuroprotective agent, antiemetic, antifungal agent, and antiviral agent. Retusin scavenges ABTS• ⁺ and DPPH• free radicals. Retusin can be used in studies related to hyperpigmentation, vomiting, Aspergillus niger infection, and COVID-19 infection .

HY-134046

(-)-Isodocarpin Isodocarpin	Labiatae Erythrina sacleuxii Hua Plants Source Classification	Melanocortin Receptor
(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC₅₀ of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA .

HY-W015782

4-Ethylresorcinol	Classification of Application Fields Phenols Polyphenols Metabolic Disease Umbelliferae Plants Disease Research Fields Echinacea angustifolia DC. Source Classification	Tyrosinase PKA
4-Ethylresorcinol is a derivative of resorcinol and can serve as a substrate for *tyrosinase. 4-Ethylresorcinol has anti-hyperpigmentation and antioxidant effects and can inhibit* melanin synthesis. 4-Ethylresorcinol has potential whitening value .

HY-N4005

Isoastilbin	Flavanonols Flavonoids other families Phenols Polyphenols Plants Source Classification	Bacterial Tyrosinase
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits *tyrosinase* activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .

HY-N3748

Dihydromorin 1 Publications Verification	Flavanonols Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Cancer Source Classification	Tyrosinase
Dihydromorin, a natural flavanonol compound, is a *tyrosinase* inhibitor .

HY-N3425

Kazinol U	Flavonoids other families Classification of Application Fields Flavanols Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	AMPK
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Stilbenes Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Moraceae Disease Research Fields Source Classification Morus alba Linn.	Tyrosinase
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective *tyrosinase* inhibitor with an IC₅₀ of 29.75 μM .

HY-W015616

Benzylacetone 4-Penylbutan-2-one	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Thymelaeaceae Metabolic Disease Plants Aquilaria sinensis (Lour.) Spreng. Disease Research Fields Source Classification	Environmental Pollutants Tyrosinase
Benzylacetone (4-Penylbutan-2-one) is an aromatic compound. Benzylacetone is a mushroom *tyrosinase* inhibitor with an IC₅₀ of 2.8 mM, a K_i of 1.25 mM for monophenolase and an IC₅₀ of 0.6 mM, a K_i of 0.39 mM for diphenolase. Benzylacetone inhibits free mushroom tyrosinase and enzyme-substrate complex. Benzylacetone acts as an appetite enhancer via olfactory stimulation, reduces spontaneous locomotor activity, induces weight gain. Benzylacetone exhibits repellent, fumigant, and contact toxicity against Tribolium castaneum adults .

HY-N10016

Chlorogenic acid butyl ester	Lysimachia davurica Ledeb. Phenols Polyphenols Plants Primulaceae Source Classification	Tyrosinase
Chlorogenic acid butyl ester, a caffeoylquinic acid, is a potent melanogenesis inhibitor. Chlorogenic acid butyl ester inhibits the expression of microphtalmia-associated transcription factor (MITF), *tyrosinase, tyrosinerelated protein 1 (TRP-1), and TRP-2*. Chlorogenic acid butyl ester also shows antioxidant activity .

HY-N11063

Obtusifolin-2-O-glucoside	Cassia tora (L.) Roxb. Quinones Monophenols Leguminosae Anthraquinones Phenols Plants Source Classification	Tyrosinase
Obtusifolin-2-O-glucoside (compound 7) is a *Tyrosinase* inhibitor (IC₅₀=9.2 μM). Obtusifolin-2-O-glucoside can be isolated from cassia seed .

HY-129137

Cyanidin 3-sophoroside chloride Cy 3-soph	Rosaceae Plants Prunus cerasus L.	Tyrosinase
Cyanidin 3-sophoroside chloride is a potent non-competitive reversible polyphenol oxidase (PPO)/Tyrosinase inhibitor. Also, Cyanidin 3-sophoroside chloride can be used as an anti-browning agent to inhibit the degree of PPO browning, enhance the antioxidant damage capacity of fruits and prolong the storage period .

HY-N0192R

Arbutin (Standard) β-Arbutin (Standard)	Bergenia purpurascens (Hook. f. et Thoms.) Engl. Structural Classification Human Gut Microbiota Metabolites Microorganisms Phenols Saxifragaceae Plants Endogenous metabolite Source Classification	Reference Standards Tyrosinase Endogenous Metabolite
Arbutin (Standard) is the analytical standard of Arbutin. This product is intended for research and analytical applications. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .

HY-N6244

Isolindleyin	Classification of Application Fields Polygonaceae Rheum officinale Baill. Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase
Isolindleyin, a butyrophenone, is a *tyrosinase* inhibitor, with a K_d of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities .

HY-N12810

Sanggenon O	Morus nigra Linn. Phenols Polyphenols Plants Moraceae Source Classification	Tyrosinase
Sanggenon O is a mushroom tyrosinase inhibitor that can be isolated from Morus nigra, with an IC₅₀ value of 1.15 μM .

HY-N2134

Mirificin Puerarin apioside	Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Endocrinology Isoflavones Source Classification	Tyrosinase
Mirificin (Puerarin apioside) is a isoflavone in Puerariae Lobatae Radix. Mirificin inhibits tyrosinase (TYR) with an IC₅₀ of 12.66 μM .

HY-N8223

Viscumneoside III	Cardiovascular Disease Flavonoids Viscum coloratum (Kom.) Nakai Classification of Application Fields Flavonones Phenols Polyphenols Plants Loranthaceae Disease Research Fields Source Classification	Tyrosinase
Viscumneoside III, a dihydroflavone O-glycoside, is a potent *tyrosinase* inhibitor with an IC₅₀ of 0.5 mM. Viscumneoside III has anti-angina pectoris .

Cat. No.	Product Name	Chemical Structure

HY-W013636S

2-Ketoglutaric acid-13C5

2-Ketoglutaric acid- ¹³C₅ (Alpha-Ketoglutaric acid- ¹³C₅) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-W015967S

Glycolic acid-d2
Glycolic acid-d₂ is the deuterium labeled Glycolic acid. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

HY-W013636S1

2-Ketoglutaric acid-d4

2-Ketoglutaric acid-d₄ (Alpha-Ketoglutaric acid-d₄) is the deuterium labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid Sodium is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-Y0444S2

D-Tyrosine-d7
D-Tyrosine-d₇ is the deuterium labeled D-Tyrosine (HY-Y0444) . D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth .

HY-W013636S2

2-Ketoglutaric acid-d6
2-Ketoglutaric acid-d₆ (Alpha-Ketoglutaric acid-d₆) is the deuterium labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM) .

HY-W266188

Decanoic acid-13C

Decanoic acid- ¹³C is the ¹³C-labeled Decanoic acid (HY-W015309). Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces tyrosinase activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy .

HY-W013636S3

2-Ketoglutaric acid-13C

2-Ketoglutaric acid- ¹³C (Alpha-Ketoglutaric acid- ¹³C) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-W013636S4

2-Ketoglutaric acid-13C2

2-Ketoglutaric acid- ¹³C₂ (Alpha-Ketoglutaric acid- ¹³C₂) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-W050154S

Kojic acid-13C6

Kojic acid- ¹³C₆ is ¹³C labeled Kojic acid (HY-W050154). Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .

HY-W778203

Glycolic acid-13C2
Glycolic acid- ¹³C₂ is the ¹³C-labeled Glycolic acid (HY-W015967). Glycolic acid- ¹³C₂ is an inhibitor of *tyrosinase*, suppressing melanin formation and lead to a lightening of skin colour.

HY-Y0444S1

D-Tyrosine-d4
D-Tyrosine-d₄ is the deuterium labeled D-Tyrosine (HY-Y0444) . D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth .

HY-Y0444S

D-Tyrosine-d2
D-Tyrosine-d₂ is the deuterium labeled D-Tyrosine (HY-Y0444) . D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth .

HY-113068S

β-Tocopherol-d3
β-Tocopherol-d₃ is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-N0192S

Arbutin-d4

Arbutin-d₄ is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with K_iapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .

HY-W017212S

Methyl cinnamate-d7

Methyl cinnamate-d₇ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-133680S

β-Tocopherol-d4
β-Tocopherol-d4 is a deuterium labeled β-Tocopherol (HY-133680). β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit *tyrosinase* activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-W723952

p-Anisic acid-d7
p-Anisic acid-d₇ (4-Methoxybenzoic acid-d₇) is the deuterium labeled p-Anisic acid (HY-N1394). p-Anisic acid (4-Methoxybenzoic acid) is an orally available tyrosinase inhibitor that has antioxidant, anti-anxiety, anti-inflammatory, anti-tumor, anti-diabetic, and preservative properties. p-Anisic acid can be used as a preservative in the cosmetics field .

Targets Recommended: Tyrosinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013636AG

2-Ketoglutaric acid Sodium Alpha-Ketoglutaric acid Sodium	Tyrosinase Endogenous Metabolite	Neurological Disease Metabolic Disease
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) Sodium (GMP) is 2-Ketoglutaric acid Sodium (HY-W013636A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 2-Ketoglutaric acid Sodium is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of *tyrosinase* (IC₅₀=15 mM) .

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Tyrosinase Inhibitor

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