264 Results for "

Tyrosinase Inhibitor

" in MedChemExpress (MCE) Product Catalog:
Products (264)

264 Results for "Tyrosinase Inhibitor" in MCE Product Catalog:

7
2-Ketoglutaric acid
2-Ketoglutaric acid
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7 Publications Verification
Cat. No.: HY-W013636
CAS No.: 328-50-7
Synonyms: Alpha-Ketoglutaric acid; 2-Oxoglutaric acid
Category:  

Anti-aging Endocrine diseases Endogenous metabolite Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Other Diseases Disease markers Nervous System Disorder Disease Research Fields

Target:  

Tyrosinase Endogenous Metabolite

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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2-Ketoglutaric acid Sodium
2-Ketoglutaric acid Sodium
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7 Publications Verification
Cat. No.: HY-W013636A
CAS No.: 22202-68-2
Synonyms: Alpha-Ketoglutaric acid Sodium
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Tyrosinase Endogenous Metabolite

2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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7
Calcium 2-oxoglutarate
Calcium 2-oxoglutarate
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7 Publications Verification
Cat. No.: HY-W013636B
CAS No.: 71686-01-6
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Tyrosinase Endogenous Metabolite

Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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2-Ketoglutaric acid potassium
2-Ketoglutaric acid potassium
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7 Publications Verification
Cat. No.: HY-W013636C
CAS No.: 997-43-3
Synonyms: Alpha-Ketoglutaric acid potassium
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) (potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium is a reversible and orally active inhibitor of tyrosinase with an IC50 value of 15 mM. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium significantly suppresses abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cells, expression of TNFα in vitro and in vivo. 2-Ketoglutaric acid potassium directly binds to TAK1, and inhibits the TRAF6-TAK1 interaction. 2-Ketoglutaric acid potassium also alleviates inflammatory bowel disease (IBD) symptoms and gut microbiota dysbiosis, evident by the improvements in the intestine length .
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N-Acetylneuraminic acid
N-Acetylneuraminic acid
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6 Cited Publications
Cat. No.: HY-I0400
CAS No.: 131-48-6
Synonyms: NANA; Lactaminic acid
Category:  

Cardiovascular Disease Endogenous metabolite Disease Research Fields Saccharides Monosaccharides

Target:  

Tyrosinase Ras Influenza Virus Endogenous Metabolite

N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .
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5
Arbutin
Arbutin
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5 Cited Publications
Cat. No.: HY-N0192
CAS No.: 497-76-7
Synonyms: β-Arbutin
Category:  

Bergenia purpurascens (Hook. f. et Thoms.) Engl. Human Gut Microbiota Metabolites Microorganisms Phenols Plants Saxifragaceae Endogenous metabolite Disease Research Fields Cancer

Target:  

Tyrosinase Endogenous Metabolite

Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Ki app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .
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5
Decanoic acid
Decanoic acid
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5 Cited Publications
Cat. No.: HY-W015309
CAS No.: 334-48-5
Category:  

Neurological Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Biological Pesticide Research Agricultural Research

Target:  

Environmental Pollutants Endogenous Metabolite iGluR Glutaminase c-Met/HGFR Tyrosinase

Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces tyrosinase activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy .
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Mulberroside A
Mulberroside A
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5 Cited Publications
Cat. No.: HY-N0619
CAS No.: 102841-42-9
Category:  

Stilbenes Morus alba L. Phenols Polyphenols Plants Moraceae Disease Research Fields Inflammation/Immunology

Target:  

TNF Receptor Interleukin Related Tyrosinase

Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM .
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Kushenol A
Kushenol A
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4 Cited Publications
Cat. No.: HY-N2278
CAS No.: 99217-63-7
Synonyms: Leachianone E
Category:  

Flavonoids Leguminosae Flavonones Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Cancer

Target:  

Tyrosinase Glycosidase

Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .
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3
Oxyresveratrol
Oxyresveratrol
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3 Cited Publications
Cat. No.: HY-N1430
CAS No.: 29700-22-9
Synonyms: trans-Oxyresveratrol
Category:  

other families Stilbenes Anti-aging Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Free Radical Scavengers Tyrosinase HSV Autophagy

Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .
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Phenylthiourea
Phenylthiourea
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3 Cited Publications
Cat. No.: HY-Y0351
CAS No.: 103-85-5
Synonyms: Phenylthiocarbamide
Target:  

Tyrosinase Endogenous Metabolite

Research Areas:  

Others

Phenylthiourea (Phenylthiocarbamide) is an inhibitor for phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki = 0.21 μM). Phenylthiourea is an effective inhibitor for tyrosinase. Phenylthiourea can lead to graying of hair in black rats due to the interference with melanin formation .
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p-Anisic acid
p-Anisic acid
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3 Cited Publications
Cat. No.: HY-N1394
CAS No.: 100-09-4
Synonyms: 4-Methoxybenzoic acid; Draconic acid
Category:  

Infection Acacia mearnsii Leguminosae Ketones, Aldehydes, Acids Cosmetic Research Plants Endogenous metabolite Disease Research Fields

Target:  

Bacterial Endogenous Metabolite Tyrosinase

p-Anisic acid (4-Methoxybenzoic acid) is an orally available tyrosinase inhibitor that has antioxidant, anti-anxiety, anti-inflammatory, anti-tumor, anti-diabetic, and preservative properties. p-Anisic acid can be used as a preservative in the cosmetics field .
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2
Kojic acid
Kojic acid
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2 Cited Publications
Cat. No.: HY-W050154
CAS No.: 501-30-4
Category:  

Infection Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields

Target:  

Parasite Tyrosinase NF-κB CDK

Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .
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Pedalitin
Pedalitin
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2 Cited Publications
Cat. No.: HY-N3101
CAS No.: 22384-63-0
Category:  

other families Flavonoids Flavones Phenols Polyphenols Plants Disease Research Fields Endocrinology

Target:  

Endogenous Metabolite Tyrosinase Glycosidase

Pedalitin is a inhibitor of tyrosinase（IC50=0.28 mM） and α-glucosidase（IC50=0.29 mM） .
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2
Brassinin
Brassinin
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2 Cited Publications
Cat. No.: HY-111334
CAS No.: 105748-59-2
Purity:  99.74%
Synonyms: Brassinine
Category:  

Beassica pekinensis (Lour. ) Rupr. Alkaloids Cruciferae Cosmetic Research Plants Disease Research Fields Cancer Indole Alkaloids

Target:  

Endogenous Metabolite Indoleamine 2,3-Dioxygenase (IDO) Apoptosis Autophagy Paraptosis Reactive Oxygen Species (ROS) Tie Akt PERK PI3K mTOR Ribosomal S6 Kinase (RSK)

Brassinin is an indole derivative found in cruciferous plants. Brassinin acts as an IDO inhibitor (Ki = 97.7 μM). Brassinin inhibits angiogenesis and induces apoptosis, autophagy, paraptosis, ROS production, and ER stress. Brassinin selectively stimulates lysosomal degradation of Tie2 and promotes lysosomal and proteasomal degradation of FGFR1 in endothelial cells, downregulating AKT and ERK phosphorylation. Brassinin inhibits endothelial cell proliferation, migration, tube formation, spheroid sprouting, and angiogenesis. Brassinin inhibits PI3K/Akt/mTOR/S6K1 signaling, upregulates p21 and p27, and induces G1 phase cell cycle arrest through RB hypophosphorylation. Brassinin inhibits tyrosinase catalytic activity, reduces tyrosinase mRNA, and inhibits MITF nuclear translocation. Brassinin is used for research on triple-negative breast cancer, chronic myeloid leukemia, colon cancer, glioma, atherosclerosis, and skin cancer .
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Methyl cinnamate
Methyl cinnamate
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2 Cited Publications
Cat. No.: HY-W017212
CAS No.: 103-26-4
Synonyms: Methyl 3-phenylpropenoate
Category:  

Simple Phenylpropanols Rutaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zanthoxylum armatum DC.

Target:  

Environmental Pollutants AMPK Bacterial Tyrosinase

Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .
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Glycolic acid
Glycolic acid
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1 Cited Publications
Cat. No.: HY-W015967
CAS No.: 79-14-1
Synonyms: Hydroxyethanoic acid
Category:  

Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer

Target:  

Endogenous Metabolite Tyrosinase PROTAC Linkers

Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
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Swertiajaponin
Swertiajaponin
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1 Cited Publications
Cat. No.: HY-N2204
CAS No.: 6980-25-2
Category:  

other families Flavonoids Flavones Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Tyrosinase Reactive Oxygen Species (ROS)

Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity .
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Dihydromorin
Dihydromorin
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1 Cited Publications
Cat. No.: HY-N3748
CAS No.: 18422-83-8
Category:  

Flavanonols other families Flavonoids Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

Tyrosinase

Dihydromorin, a natural flavanonol compound, is a tyrosinase inhibitor .
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Aloesin
Aloesin
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1 Cited Publications
Cat. No.: HY-N2460
CAS No.: 30861-27-9
Synonyms: Aloeresin
Category:  

Liliaceae Monophenols Ketones, Aldehydes, Acids Aloe vera (L.) Burm. f. Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Tyrosinase Apoptosis

Aloesin (Aloeresin) is a tyrosinase inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research .
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