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Results for "

acid lipase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ATGL (6) DAGL (8) Hormone-Sensitive Lipase (HSL) (1) Lipase (98) MAGL (35) Acyltransferase (2) Akt (1) Amylases (4) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (10) ATP Synthase (1) Autophagy (7) Bacterial (14) Beta-lactamase (1) Biochemical Assay Reagents (22) Cannabinoid Receptor (2) Carboxylesterase (CES) (2) Cholinesterase (ChE) (3) Collagen (2) COX (2) Cytochrome P450 (2) Dipeptidyl Peptidase (2) Drug Metabolite (2) Endogenous Metabolite (28) Environmental Pollutants (7) ERK (1) Eukaryotic Initiation Factor (eIF) (1) Exosomes (1) FAAH (8) Fatty Acid Synthase (FASN) (3) Ferroptosis (1) Fluorescent Dye (7) Free Fatty Acid Receptor (1) Fungal (9) GLUT (1) Glycosidase (5) Histamine Receptor (1) Influenza Virus (1) Insecticide (2) Interleukin Related (3) Isotope-Labeled Compounds (4) LPL Receptor (1) mAChR (2) Melanocortin Receptor (2) MetAP (1) Mitochondrial Metabolism (1) MMP (1) MNK (1) NF-κB (2) NOD-like Receptor (NLR) (1) P2Y Receptor (1) p38 MAPK (1) PERK (1) Phosphatase (1) Phospholipase (4) PI3K (1) PPAR (3) PROTACs (1) Pyroptosis (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (2) Reference Standards (17) SARS-CoV (2) SOD (1) Stearoyl-CoA Desaturase (SCD) (2) TGF-β Receptor (2) TNF Receptor (3) VEGFR (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (8) Endocrinology (2) Infection (18) Inflammation/Immunology (25) Metabolic Disease (109) Neurological Disease (24)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Fluorescent Lipids (1) Emulsifiers (1) Solubilizing Agents (1) Cholesterol (1) pH Modifiers (1)

229

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Lipase DAGL MAGL Hormone-Sensitive Lipase (HSL) ATGL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0218

Orlistat 30+ Cited Publications Tetrahydrolipstatin; Ro-18-0647	Fatty Acid Synthase (FASN) Apoptosis	Metabolic Disease Cancer
Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric *lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN*), is used orally for long-term research of obesity . Anti-atherosclerotic effect .

HY-15859

Atglistatin Maximum Cited Publications 40 Publications Verification	ATGL	Metabolic Disease
Atglistatin is a selective adipose triglyceride lipase (ATGL) inhibitor which inhibits lipolysis with an IC₅₀ of 0.7 μM in vitro.

HY-N1937

Pristimerin Maximum Cited Publications 7 Publications Verification Celastrol methyl ester	Bacterial	Cancer
Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC₅₀ of 93 nM.

HY-Y1422D

Lipase,Candida antarctica (Immobilized)	Environmental Pollutants Lipase	Others
Lipase,Candida antarctica (Immobilized) is an immobilized lipase isolated from Candida antarctica fraction B. Lipase,Candida antarctica (Immobilized) features high stability and selectivity. Lipase,Candida antarctica (Immobilized) is widely used in fields such as chemical synthesis, food oil modification, and biodiesel production .

HY-128144

Lalistat 2 3 Publications Verification	Lipase	Metabolic Disease
Lalistat 2 is an inhibitor of many *lipases* especially Lysosomal acid lipase (LAL, IC₅₀ = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells .

HY-Y1422

Triacylglycerol lipase Alkaline lipase	Environmental Pollutants Lipase	Metabolic Disease
Triacylglycerol lipase is an enzyme catalyzing the hydrolysis of triacylglycerol. Triacylglycerol lipase promotes fat decomposition, providing energy and lipid precursors for cells. Triacylglycerol lipase is used in the research of metabolic diseases such as diabetes and obesity .

HY-119283

CAY10499 1 Publications Verification MAGL-IN-5	MAGL FAAH SARS-CoV Influenza Virus	Infection Metabolic Disease Inflammation/Immunology
CAY10499 (MAGL-IN-5) is a non-selective lipase inhibitor with IC₅₀ values of 144 nM and 14 nM for monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), respectively. Additionally, CAY10499 exhibits anti-inflammatory and antiviral activities .

HY-N7072

Grape seed extract 2 Publications Verification	Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .

HY-102056

BAY 59-9435 4 Publications Verification	Lipase	Metabolic Disease
BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC₅₀ of 0.023 μM.

HY-W013168

4-Nitrophenyl palmitate 4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate; pNpp	Lipase	Others
4-Nitrophenyl palmitate (4-Nitrophenyl hexadecanoate) is a chromogenic substrate for lipases and esterases. Upon enzymatic hydrolysis, 4-Nitrophenyl palmitate releases p-nitrophenol, which can be quantified by colorimetric detection at 410 nm as a measure of enzymatic activity. 4-Nitrophenyl palmitate is used to characterize the activity of various bacterial and mammalian enzymes, including those from Burkholderia and porcine pancreatic lipase .

HY-W004282

Undecanoic acid Undecanoate; Hendecanoic acid	Fungal Endogenous Metabolite Bacterial	Infection
Undecanoic acid (Undecanoate) is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum .

HY-E70313

Lipase,Candida antarctica (Immobilized on hydrophilic carrier) Candida antarctica lipase B	Biochemical Assay Reagents	Others
Lipase,Candida antarctica (Immobilized on hydrophilic carrier) (Candida antarctica lipase B) is a lipase derived from Candida antarctica and immobilized on a hydrophilic carrier. Lipase,Candida antarctica (Immobilized on hydrophilic carrier) is a green catalyst that can be used to catalyze polymer synthesis .

HY-15250

JZL195 4 Publications Verification	FAAH MAGL Autophagy	Neurological Disease
JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and *monoacylglycerol lipase* (MAGL) inhibitor with IC₅₀**s of 2 and 4 nM, respectively .

HY-P2752

*Lipoprotein lipase, Pseudomonas sp* LPL	Endogenous Metabolite	Metabolic Disease Cancer
Lipoprotein lipase, Pseudomonas sp (LPL) is a multifunctional enzyme from adipose tissue, heart and skeletal muscle, islets and macrophages. Lipoprotein lipase promotes normal lipoprotein metabolism, delivery and utilization of tissue-specific substrates. Lipoprotein lipase catalyzes the rate-limiting step of lipids in blood circulation .

HY-Y1422I

Lipase,Pseudomonas fluorescens (Immobilized)	Environmental Pollutants Biochemical Assay Reagents Lipase	Others
Lipase, Pseudomonas fluorescens (Immobilized) is an immobilized biocatalyst derived from Pseudomonas fluorescens. Lipase, Pseudomonas fluorescens (Immobilized) efficiently catalyzes the hydrolysis, esterification and transesterification of triacylglycerols in solvent-free systems, and is particularly suitable for biodiesel production from soybean oil and selective modification of oils rich in EPA and DHA. Lipase, Pseudomonas fluorescens (Immobilized) exhibits optimal activity at pH 8.5 and 45°C, and retains residual activity after repeated cycles of use. Lipase, Pseudomonas fluorescens (Immobilized) is activated by Ca ²⁺, but inhibited by Co ²⁺, Ni ²⁺, Fe ³⁺, Fe ²⁺ and EDTA .

HY-117095

4-Methylumbelliferyl oleate	Fluorescent Dye	Metabolic Disease
4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline *lipases. 4-Methylumbelliferyl oleate is cleaved by lipases*, liberating 4-Methylumbelliferyl (Ex/Em=320/450 nm) .

HY-14471

Cetilistat 1 Publications Verification ATL-962	Lipase	Metabolic Disease
Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC₅₀s of 54.8 nM, and 5.95 nM, respectively .

HY-153523

Hi 76-0079 1 Publications Verification NNC0076-0079; 76-0079	Lipase	Metabolic Disease
Hi 76-0079 (NNC0076-0079; 76-0079) is a lipase inhibitor that specifically targets hormone-sensitive lipase (HSL). Hi 76-0079 inhibits PNPB Hydrolysis in cell lysates of HEK293A cells overexpressing Lipe with an IC₅₀ value of 0.1 μM. Hi 76-0079 synergizes with the ATGL inhibitor Atglistatin (HY-15859) to block lipolysis in vitro. Hi 76-0079 can be used for the study of lipid metabolism .

HY-Y1422H

Lipase,Candida cylindracea (Immobilized)	Environmental Pollutants Biochemical Assay Reagents Lipase	Others
Lipase, Candida cylindracea (Immobilized) is an immobilized hydrolase and biocatalyst with relaxed positional and substrate specificity. Lipase, Candida cylindracea (Immobilized) can target primary and secondary ester bonds to completely hydrolyze triglycerides into fatty acids and glycerol, producing only trace amounts of monoglycerides. Lipase, Candida cylindracea (Immobilized) exhibits chain specificity, with a relatively fast hydrolysis rate for oleic acid and lauric acid chains, and the slowest hydrolysis rate for stearic acid chains. Lipase, Candida cylindracea (Immobilized) shows high catalytic activity toward long-chain triglycerides under the conditions of pH 8.0 and 37°C .

HY-117549

Ibrolipim NO-1886	Lipase	Cardiovascular Disease
Ibrolipim (NO-1886) is an orally active *lipoprotein lipase* (LPL)**-promoting agent. Ibrolipim decreases plasma triglycerides, increases high-density lipoprotein cholesterol levels. Ibrolipim has renoprotective and hypolipidemic effects .

HY-W392100A

Polycaprolactone diol (MW 530) PCL-diol (MW 530)	Biochemical Assay Reagents Fungal	Infection
Polycaprolactone diol (MW 530) (PCL-diol (MW 530)) is a poly (ε-caprolactone) diol with an average molecular weight of 530 g·mol ⁻¹, which serves as a monomer for biodegradable network elastic polyesters. Network polyester films undergo enzymatic hydrolysis by Rhizopus delemar lipase .

HY-P2879A

Cholesterol esterase, Porcine pancreas	Biochemical Assay Reagents	Metabolic Disease
Cholesterol esterase, Porcine pancreas is an enzyme that hydrolyzes cholesteryl esters into cholesterol and free fatty acids in the intestine. Cholesterol esterase, also known as bile salt-stimulated lipase or carboxyl ester lipase, functions to promote cholesterol absorption .

HY-23524

HSL-IN-3 1 Publications Verification	Lipase	Others
HSL-IN-3, a boronic acid ester derivative, is an inhibitor of *hormone-sensitive lipase* (HSL)** .

HY-E70332

Lipase, Aspergillus niger	Endogenous Metabolite	Others
Lipase, Aspergillus niger is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-E70277

Hexadecyl-CoA	ATGL	Metabolic Disease
Hexadecyl-CoA is a thioether analog of acyl-CoA that can inhibit adipose triglyceride lipase (ATGL) .

HY-Y1422B

Lipase (MS grade) 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Lipase (MS grade) catalyzes the hydrolysis of triacylglycerols to release long-chain fatty acids in a site-specific manner. Lipase (MS grade) is involved in a variety of biological processes, from fat metabolism to cell signaling and inflammation, and can be used to study diseases such as pancreatic insufficiency, celiac disease and cystic fibrosis .

HY-116583

Resorufin butyrate	Cholinesterase (ChE)	Metabolic Disease
Resorufin butyrate is a fluorogenic substrate for triglyceride lipases and cholinesterase (Ex=570 nm, Em=580 nm) .

HY-103372

GSK264220A 1 Publications Verification	Lipase	Cardiovascular Disease
GSK264220A is a potent endothelial lipase inhibitor with IC₅₀ of 16 nM. GSK264220A has the potential to decrease the risk of cardiovascular disease .

HY-W099648

4-Methylumbelliferyl octanoate	Lipase	Others
4-Methylumbelliferyl octanoate is a octoate. 4-Methylumbelliferyl octanoate can be used as a s ubstrate of hog pancreatic lipase .

HY-100792

URB602	Bacterial	Cancer
URB602 is a selective monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL with IC₅₀ of 28±4 μM through a noncompetitive mechanism.

HY-112911

*Endothelial lipase* inhibitor-1**	Lipase	Cardiovascular Disease
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC₅₀ of 49 nM.

HY-Y1422E

Lipase,Aspergillusniger (Immobilized)	Biochemical Assay Reagents Lipase	Others
Lipase, Aspergillus niger (Immobilized) is an immobilized triacylglycerol acyl hydrolase and biocatalyst. Lipase, Aspergillus niger (Immobilized) broadly catalyzes the hydrolysis of glycerol-long-chain fatty acid esters, exhibits positional selectivity for the 1,3-positions of glycerol, but shows low hydrolysis efficiency for castor oil. Lipase, Aspergillus niger (Immobilized) displays optimal activity at 45°C and pH 7.0, and remains stable at temperatures up to 60°C and over a broad pH range of 2.0-9.0. Lipase, Aspergillus niger (Immobilized) is activated by Ca ²⁺ and Mg ²⁺, but inhibited by Mn ²⁺, Fe ²⁺ and Zn ²⁺ .

HY-E70312

*High-efficiency lipase,Candida antarctica (Immobilized on hydrophilic carrier)*	Endogenous Metabolite	Others
High-efficiency lipase,Candida antarctica (Immobilized on hydrophilic carrier) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-119741

Salacinol	Glycosidase Lipase	Metabolic Disease
Salacinol, compound found in Salacia reticulata, is an orally active *α-glucosidase/lipase* inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC₅₀ = 3.2 μg/mL, K_i = 0.31 μg/mL), sucrase (IC₅₀ = 0.84 μg/mL, K_i = 0.32 μg/mL), and isomaltase (IC₅₀ = 0.59 μg/mL, K_i = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus .

HY-136562

N-Arachidonyl maleimide	MAGL	Metabolic Disease
N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC₅₀ value of 140 nM .

HY-Y1422J

Lipase,Burkholderiacepacia (Immobilized)	Biochemical Assay Reagents Lipase	Others
Lipase,Burkholderiacepacia (Immobilized) comes from Burkholderiacepacia and can be used for catalytic reaction .

HY-W010947

4-Methylumbelliferyl palmitate	Fluorescent Dye	Inflammation/Immunology
4-Methylumbelliferyl palmitate is an excellent fluorophore for measuring acid lipase in human leukocytes. Acidity and solvent have important influence on its fluorescence. 4-Methylumbelliferyl palmitate exists mainly as neutral molecular form which can be produced strong fluorescence at 445 nm in near neutral aqueous solutions, and exist mainly as anion form which can be produced stronger fluorescence at 445 nm in weak alkaline solutions .

HY-N16617

Platycodin V	Lipase	Metabolic Disease
Platycodin V is a triterpenoid saponin. Platycodin V has a relatively weak inhibitory effect on pancreatic lipase.

HY-138653

Lipase Substrate DGGR; 1,2-o-Dilauryl-rac-glycero-3-glutaric acid (6′-methylresorufin) ester	Lipase	Metabolic Disease
Lipase Substrate is a chromogenic substrate of lipase to detect activity . It is used in colorimetric methods to measure lipase activity. It produces a red-purple compound, methylresorufin, upon digestion by the lipase enzyme.

HY-144809

*Pancreatic lipase/Carboxylesterase 1-IN-1*	Carboxylesterase (CES)	Metabolic Disease
Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent dual inhibitor of *pancreatic lipase* (PL) and human carboxylesterase 1A (hCES1A) with IC₅₀** values of 2.13 µM and 0.055 µM against PL and hCES1A .

HY-E70888

Lipase, Candida antarctica, expressed in Aspergillus niger	Lipase	Others
Lipase, Candida antarctica, expressed in Aspergillus niger, is a serine hydrolase, which belongs to the α/β hydrolase fold family .

HY-135996A

Dilaurylglycerosulfate sodium	Lipase	Others
Dilaurylglycerosulfate sodium is a co-emulsifier in the diagnostic test for the determination of lipase.

HY-P2879B

Cholesterol esterase, Candida cylindracea	Endogenous Metabolite Biochemical Assay Reagents	Metabolic Disease
Cholesterol esterase, Candida cylindracea is an enzyme located in the intestines that hydrolyzes cholesterol esters into cholesterol and free fatty acids. Also known as bile salt-stimulated lipase or carboxylester lipase, this enzyme facilitates cholesterol metabolism and absorption in the body. It can also be used as a biochemical reagent, and is employed in conjunction with cholesterol oxidase (HY-P2848) to measure cholesterol levels .

HY-138959

4-Nitrophenyl octanoate p-Nitrophenyl caprylate	Lipase	Others
4-Nitrophenyl octanoate (p-Nitrophenyl caprylate) is an aromatic ester compound which can be used as a substrate for pancreatic lipase. 4-Nitrophenyl octanoate contains an ester bond that can be hydrolyzed under the action of lipase, releasing p-nitrophenol as a yellow product. 4-Nitrophenyl octanoate can be used to assay the activities of lipases and esterases .

HY-136124

Cetilistat impurity 1	Drug Metabolite	Others
Cetilistat impurity 1 is an impurity of Cetilistat. Cetilistat, an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC₅₀s of 54.8 nM, and 5.95 nM, respectively .

HY-N12292

Acanthopanaxoside A	Lipase	Metabolic Disease
Acanthopanaxoside A, a triterpenoid saponin, has pancreatic *lipase* inhibitory action .

HY-E70409

Diacetinase, bacillus subtilis	Endogenous Metabolite	Metabolic Disease
Diacetinase, Bacillus subtilis is a member of the esterase family and is responsible for catalyzing the hydrolysis of diacetin. This enzyme is used in the measurement of lipase activity .

HY-E70311

*1,3-specific lipase,Bacillus lanolin (Immobilized)* Thermomyces lanuginosus lipase	Endogenous Metabolite	Others
1,3-specific lipase,Bacillus lanolin (Immobilized)(Thermomyces lanuginosus lipase) is a high-efficiency biocatalyst, a lipase from Thermomyces lanuginosus. 1,3-specific lipase,Bacillus lanolin (Immobilized) can be conjugated to magnetic nanoparticles and coupled to the surface of Fe(3)O(4)-COOH to obtain better temperature resistance and pH resistance. The activity unit (U) of lipase is defined as the amount of enzyme that produces 1 μmol of fatty acid per minute under experimental conditions .

HY-157313

*Pancreatic lipase-IN-1*	Lipase	Metabolic Disease
Pancreatic lipase-IN-1 (compound 8) ia a pancreatic lipase inhibitor with the K_i of 1.288 μM .

HY-E70310

Lipase (Immobilized,Used for biodiesel production) lipase for biodiesel production	Endogenous Metabolite	Others
Lipase (Immobilized,Used for biodiesel production) is a methanol-resistant lipase with high catalytic activity and can be used for the production of biodiesel. The reaction conditions of Lipase (Immobilized,Used for biodiesel production) are mild, which can avoid the oxidation of hydroxyl groups and the opening of double bonds, and prevent the production of by-products other than glycerol .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1937

Pristimerin Maximum Cited Publications 7 Publications Verification Celastrol methyl ester	Triterpenes Classification of Application Fields Terpenoids Celastraceae Tripterygium wilfordii Hook. f. Plants Disease Research Fields Source Classification Cancer	Bacterial
Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC₅₀ of 93 nM.

HY-B0998

Dehydrocholic acid sodium Dehydrocholate sodium	Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Amylases Lipase Autophagy
Dehydrocholic acid (Dehydrocholate) sodium is an orally active hydrocholeretic agent. Dehydrocholic acid sodium modulates Autophagy, reduces serum amylase and *lipase* levels. Dehydrocholic acid sodium has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid sodium can be used in the study of acute biliary pancreatitis and obstructive jaundice .

HY-N0777

Isorhamnetin-3-O-glucoside 3 Publications Verification	Flavonols Cruciferous vegetables Flavonoids Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Brassicaceae Disease Research Fields Source Classification	Others PERK ERK Akt PI3K Lipase
Isorhamnetin-3-O-glucoside is an orally active natural compound. Isorhamnetin 3-O-glucoside increases P-ERK, ERK, P-Akt (Ser473), P-PI3K, and PDX-1. Isorhamnetin 3-O-glucoside downregulates C/EBPα and inhibits *lipase*. Isorhamnetin 3-O-glucoside reduces lipids and inhibits obesity .

HY-N7072

Grape seed extract 2 Publications Verification	Natural Products Classification of Application Fields Vitis vinifera cv. Zalema Metabolic Disease Plants Vitaceae Disease Research Fields Inflammation/Immunology Source Classification	Apoptosis
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .

HY-W004282

Undecanoic acid Undecanoate; Hendecanoic acid	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Fungal Endogenous Metabolite Bacterial
Undecanoic acid (Undecanoate) is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum .

HY-N0313

Euphol	Triterpenes Classification of Application Fields Terpenoids Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	MAGL Endogenous Metabolite
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the *monoacylglycerol lipase* (MGL) activity via a reversible mechanism (IC₅₀**=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .

HY-N6667

Glucovanillin	Vanilla planifolia Classification of Application Fields Ketones, Aldehydes, Acids Orchidaceae Other Diseases Plants Disease Research Fields Source Classification	Lipase
Glucovanillin, found in vanilla, is a potential *lipase* inhibitor. Glucovanillin can be converted into vanillin through an enzyme-coupled process involving cell wall degradation and glucovanillin hydrolysis .

HY-126411

Peonidin-3-O-galactoside chloride	Structural Classification Anthocyans Flavonoids other families Classification of Application Fields Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Lipase ATP Synthase
Peonidin-3-O-galactoside chloride is an anthocyanin with antioxidant properties and blood-brain barrier permeability. Peonidin-3-O-galactoside chloride inhibits pancreatic lipase, with an IC₅₀ value of 23.2 μg/mL against porcine pancreatic lipase. Peonidin-3-O-galactoside chloride mediates neuroprotection, regulates glucose metabolism, protects cells from high glucose-induced damage, promotes glucose uptake and increases ATP production. Peonidin-3-O-galactoside (chloride) can be used in the research of obesity and neurodegenerative diseases .

HY-N8599

Cichoriin 2 Publications Verification	Infection Structural Classification Monophenols other families Classification of Application Fields Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB
Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC₅₀ values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y₁₄R (IC₅₀ = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .

HY-119741

Salacinol	Structural Classification Natural Products Salacia reticulata Wight Celastraceae Plants Source Classification	Glycosidase Lipase
Salacinol, compound found in Salacia reticulata, is an orally active *α-glucosidase/lipase* inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC₅₀ = 3.2 μg/mL, K_i = 0.31 μg/mL), sucrase (IC₅₀ = 0.84 μg/mL, K_i = 0.32 μg/mL), and isomaltase (IC₅₀ = 0.59 μg/mL, K_i = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus .

HY-N0555

Escin IB	Triterpenes Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Metabolic Disease Plants Disease Research Fields Source Classification	Lipase
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity .

HY-N4167

3-O-Methylgalangin 1 Publications Verification Galangin 3-methyl ether; 3-Methylgalangin	Infection Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields Source Classification Zingiberaceae	Bacterial
3-O-Methylgalangin (Galangin 3-methyl ether) is a natural flavonoid compound from the rhizome of Alpinia officinarum (AO) with antibacterial activities, which also inhibits pancreatic lipase .

HY-N16617

Platycodin V	Triterpenes Structural Classification Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Source Classification	Lipase
Platycodin V is a triterpenoid saponin. Platycodin V has a relatively weak inhibitory effect on pancreatic lipase.

HY-N3797A

Echitamine chloride Ditaine chloride	Apocynaceae Alkaloids Classification of Application Fields Alstonia scholaris (L.) R. Br. Plants Disease Research Fields Indole Alkaloids Cancer Source Classification	Apoptosis
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC₅₀ of 10.92 μM .

HY-126564

Ebelactone A	Natural Products Microorganisms Source Classification	Lipase MetAP
Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, *lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC₅₀s of 56, 3, 8 and 7.5 μM, respectively . Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis* .

HY-N2330

Lipstatin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Lipase
Lipstatin is a pancreatic lipase inhibitor (IC₅₀=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM) .

HY-N0241

Rhodionin	Flavonols Structural Classification Classification of Application Fields Crassulaceae Metabolic Disease Plants Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Flavonoids Rhodiola rosea Linn. Phenols Polyphenols Disease Research Fields Source Classification	Cholinesterase (ChE) Lipase Bacterial Cytochrome P450
Rhodionin is an orally active, multifunctional antivirulence and cytoprotective agent that targets and inhibits Lipase, sortase A (SrtA), CYP2D6 (IC₅₀=0.761 μM), AChE (IC₅₀=2.43-57.5 μM), and DPPH free radicals (IC₅₀=19.49 μM). Rhodionin is isolable from the roots of Rhodiola crenulata. Rhodionin reduces postprandial serum triglyceride levels in mice by inhibiting lipase activity. Rhodionin also binds directly to SrtA to inhibit its transpeptidase activity, thereby reducing the fibrinogen adhesion and surface protein A levels of MRSA, effectively inhibiting biofilm formation and protecting against MRSA-induced cell damage. Rhodionin improves the survival rate of infected mice without affecting MRSA growth, and finds wide application in studies related to hyperlipidemia, exogenous obesity, and pneumonia induced by methicillin-resistant Staphylococcus aureus (MRSA) .

HY-N6667R

Glucovanillin (Standard)	Structural Classification Vanilla planifolia Ketones, Aldehydes, Acids Orchidaceae Plants Source Classification	Reference Standards Lipase
Glucovanillin, found in vanilla, is a potential lipase inhibitor. Glucovanillin can be converted into vanillin through an enzyme-coupled process involving cell wall degradation and glucovanillin hydrolysis .

HY-N15385

Hericenone D	Structural Classification Monophenols Microorganisms Phenols Source Classification	Lipase
Hericenone D, an orally active pancreatic lipase inhibitor, can be found in Hericium erinaceus. Hericenone D reduces lipid absorption and stimulates nerve growth factor NGF gene expression. Hericenone D can be used for the research of menopausal obesity .

HY-N4298

Epitheaflagallin 3-O-gallate	Classification of Application Fields Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Inflammation/Immunology Source Classification Theaceae	MMP
Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts .

HY-N0313R

Euphol (Standard)	Triterpenes Structural Classification Terpenoids Euphorbiaceae Plants	MAGL Endogenous Metabolite Reference Standards
Euphol (Standard) is the analytical standard of Euphol. This product is intended for research and analytical applications. Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .

HY-N11546

Sapindoside B	Structural Classification Eleutherococcus sieboldianus Makino Terpenoids Diterpenoids Plants Araliaceae Source Classification	Cytochrome P450 Bacterial Fungal
Sapindoside B is a substance with hepatoprotective activity, and also acts as a cytochrome P-450 (cytochrome P-450) inhibitor, antibacterial agent and membrane-disrupting agent. Sapindoside B reversibly inhibits the content of cytochrome P-450 in liver microsomes, suppresses the phenobarbital-induced increase in enzyme content, reduces the production of active metabolites mediated by cytochrome P-450, and alleviates hepatotoxic injury. Sapindoside B binds to Cutibacterium acnes lipase, reduces lipase activity, inhibits biofilm formation, and decreases bacterial adhesion. Sapindoside B exhibits cytotoxicity against human cancer, liver cancer, leukemia and glioblastoma cells. Sapindoside B inhibits mycelial growth of phytopathogenic fungal strains, possesses antibacterial activity against dermatophytes, and also has hemolytic/membrane-lytic activity. Sapindoside B can be used in research related to liver injury, Cutibacterium acnes biofilm-associated infections, gastric cancer, carcinoma, promyelocytic leukemia, glioblastoma, apple scab and grape gray mold .

HY-N12292

Acanthopanaxoside A	Triterpenes Structural Classification Tetracyclic Triterpenoids Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae Source Classification	Lipase
Acanthopanaxoside A, a triterpenoid saponin, has pancreatic *lipase* inhibitory action .

HY-W004282R

Undecanoic acid (Standard) Undecanoate (Standard); Hendecanoic acid (Standard)	Infection Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Reference Standards Fungal Endogenous Metabolite Bacterial
Undecanoic acid (Standard) (Undecanoate (Standard)) is the analytical standard of Undecanoic acid (HY-W004282). This product is intended for research and analytical applications. Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum .

HY-N8362

1-Isomangostin	Natural Products Guttiferae Garcinia mangostana Linn. Plants Source Classification	Lipase
1-Isomangostin is an inhibitor of pancreatic lipase. 1-Isomangostin inhibits porcine pancreatic lipase with an IC₅₀ of 34.5 μM. 1-Isomangostin has anti-obesity activity .

HY-N14641

Panclicin A	Natural Products Microorganisms Source Classification	Lipase
Panclicin A is a potent pancreatic lipase inhibitor .

HY-N14643

Panclicin C	Natural Products Microorganisms Source Classification	Lipase
Panclicin C is a potent pancreatic lipase inhibitor .

HY-N14647

Panclicin E	Natural Products Microorganisms Source Classification	Lipase
Panclicin E is a potent pancreatic lipase inhibitor .

HY-N14646

Panclicin D	Natural Products Microorganisms Source Classification	Lipase
Panclicin D is a potent pancreatic lipase inhibitor .

HY-N14642

Panclicin B	Natural Products Microorganisms Source Classification	Lipase
Panclicin B is a potent pancreatic lipase inhibitor .

HY-N7668

Neotheaflavin	Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Metabolic Disease Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae	Lipase
Neotheaflavin, from black tea, inhibits pancreatic lipase .

HY-N12294

Ciwujianoside D2	Triterpenes Structural Classification Tetracyclic Triterpenoids Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae Source Classification	Lipase
Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N12296

Ciwujianoside C4	Triterpenes Structural Classification Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Pentacyclic Triterpenoids Araliaceae Source Classification	Lipase
Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N14194

Esterastin	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Lipase
Esterastin is a lipase inhibitor with an IC₅₀ value of 2 ng/mL when p-nitrophenyl acetate is used as a substrate .

HY-N7163

(2S)-5,7,3',5'-Tetrahydroxyflavanone (2S)-3',5,5'7-Tetrahydroxyflavanone	Viguiera dentata (Cav.) Spreng. Structural Classification Flavonoids Labiatae Flavonones Plants Source Classification	Lipase
(2S)-5,7,3',5'-Tetrahydroxyflavanone ((2S)-3',5,5'7-Tetrahydroxyflavanone) is a porcine pancreatic lipase modulator with an IC₅₀ of >200 μM against porcine pancreatic lipase. (2S)-5,7,3',5'-Tetrahydroxyflavanone interacts with an enzyme involved in triglyceride hydrolysis .

HY-N2087

Ligupurpuroside A	Oleaceae Simple Phenylpropanols Phenylpropanoids Ligustrum expansum Rehder Plants Source Classification	Lipase
Ligupurpuroside A is an active product that can be extracted from Ligustrum robustum. Ligupurpuroside A acts as a natural inhibitor of lipase in a competitive manner .

HY-N12297

Ciwujianoside C2	Triterpenes Structural Classification Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Pentacyclic Triterpenoids Araliaceae Source Classification	Lipase
Ciwujianoside C2 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C2 enhances pancreatic lipase activity in vitro .

HY-N1937R

Pristimerin (Standard) Celastrol methyl ester (Standard)	Triterpenes Structural Classification Terpenoids Celastraceae Tripterygium wilfordii Hook. f. Plants Source Classification	Reference Standards Bacterial
Pristimerin (Standard) is the analytical standard of Pristimerin. This product is intended for research and analytical applications. Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC₅₀ of 93 nM.

HY-N12298

Ciwujianoside C1	Triterpenes Structural Classification Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Pentacyclic Triterpenoids Araliaceae Source Classification	Lipase
Ciwujianoside C1 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C1 inhibits pancreatic lipase activity in vitro .

HY-N12893

Sclerodione	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal Lipase
Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a *lipase* inhibitor (IC₅₀: 1 μM) .

HY-N10606

Uvagrandol	Natural Products Uvaria grandiflora Roxb. Plants Annonaceae	Glycosidase
Uvagrandol potently inhibits α-glucosidase and porcine lipase (IC₅₀: 15.2 μM, 11.2 μM respectively). Uvagrandol can be used in the research of Type 2 diabetes and obesity .

HY-N0555R

Escin IB (Standard)	Triterpenes Structural Classification Terpenoids Hippocastanaceae Aesculus hippocastanum Plants Source Classification	Lipase Reference Standards
Escin IB (Standard) is the analytical standard of Escin IB. This product is intended for research and analytical applications. Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity .

HY-N8989

(1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate	Natural Products Classification of Application Fields Metabolic Disease Plants Compositae Disease Research Fields Source Classification Erythrina sigmoidea Hua	Lipase
(1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate, isolated from the ethanol extract of Atractylodes lancea rhizome, displays significant lipase inhibition with an IC₅₀ value of 23.9 µg/mL. Antiobesity Effect .

HY-N11999

5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl	Orchidaceae Phenols Polyphenols Dendrobium wattii (J. D. Hooker) H. G. Reichenbach Plants Source Classification	Glycosidase
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) can be isolated from Dendrobium infundibulum (D. infundibulum). 5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl has no inhibitory activity against α-glucosidase and pancreatic lipase .

HY-N13198

4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside	Rhodiola sacra (Prain ex Raym.-Hamet) S. H. Fu Crassulaceae Phenols Polyphenols Plants Source Classification	Endogenous Metabolite
4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside is a pancreatic lipase inhibitor, with an IC₅₀ value of 2.91 μM. 4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside can effectively reduce lipid absorption and regulate obesity-related metabolic disorders, making it useful for research on obesity .

HY-N17567

Morusalnol A	Structural Classification Monophenols Phenols Plants Moraceae Morus alba Linn. Source Classification	Lipase
Morusalnol A is a arylbenzofuran derivative found in the root bark of Morus alba. Morusalnol A is a pancreatic lipase inhibitor with a porcine pancreatic lipase IC₅₀ of 0.71 μM. Morusalnol A inhibits pancreatic lipase activity. Morusalnol A can be used for the research of obesity .

HY-N11721

5-Hydroxyaloin A	Structural Classification Liliaceae Aloe microstigma Salm-Dyck Phenols Polyphenols Plants Source Classification	SOD Lipase
5-Hydroxyaloin A is a polyphenolic antioxidant agent. 5-Hydroxyaloin A forms hydrogen bonding interactions at *lipase’s active site and SOD*’s active site with low binding energy. 5-Hydroxyaloin A inhibits microsomal lipid peroxidation induced by ferrous-cysteine, reducing malondialdehyde production. 5-Hydroxyaloin A can be used for the research of obesity .

HY-N17876

Royleanonic acid	Quinones Structural Classification Labiatae Pteris semipinnata L. Sp. Plants Phenanthrenequinones Source Classification	Lipase
Royleanonic acid is an abietan-type diterpene found in the leaves of Salvia officinalis L. Royleanonic acid is a porcine pancreatic lipase inhibitor with an IC₅₀ of 35 μg/mL .

HY-W719455

Pungenin	Structural Classification Pinaceae Picea obovata Ledeb. Plants Saccharides Monosaccharides Source Classification	Lipase
Pungenin is a compound that can be isolated from Leontopodium leontopodioides. Pungenin exhibits lipase inhibitory activity. Pungenin reuduces triglyceride absorption .

HY-W015310

Isoamyl isovalerate	Structural Classification Natural Products Animals Source Classification	Environmental Pollutants Biochemical Assay Reagents
Isoamyl isovalerate is an ester and flavor compound. Isoamyl isovalerate has a unique apple-like flavor. Isoamyl isovalerate can be isolated from fruits such as bananas and apples. Isoamyl isovalerate can be used as a flavor compound in beverages, convenience foods and desserts .

Cat. No.	Product Name	Chemical Structure

HY-W004282S

Undecanoic acid-d21
Undecanoic acid-d₂₁ (Undecanoate-d₂₁) is the deuterium labeled Undecanoic acid (HY-W004282). Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum .

HY-B0218S

Orlistat-d3
Orlistat-d3 is a deuterated labeled Orlistat . Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric *lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN*), is used orally for long-term research of obesity .?Anti-atherosclerotic?effect .

HY-W004282S2

Undecanoic acid-d2
Undecanoic acid-d₂ (Undecanoate-d₂) is the deuterium labeled Undecanoic acid (HY-W004282). Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum .

HY-W004282S1

Undecanoic acid-d3
Undecanoic acid-d₃ (Undecanoate-d₃) is the deuterium labeled Undecanoic acid (HY-W004282). Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum .

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Species:	Human (11) Mouse (2) Rat (2) Dog (1)
Tag:	SUMO (2) His (15) Tag Free (1)
Source:	HEK293 (6) Sf9 insect cells (3) P. pastoris (3) E. coli (4)


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Host:	Mouse (4) Rabbit (13)
Reactivity:	Human (16) Rat (6) Mouse (6) human (1)
Application:	IHC-P (7) ICC/IF (3) IF-Tissue (4) IP (3) IHC-F (2) WB (15) ELISA (5)
Isotype:	IgG3 (1) IgG (13) IgG2 (1) IgG2a (2)
Conjugation:	Non-conjugated (17)
Clonality:	Monoclonal (10) Recombinant (8)
Modification:	Phosphorylated (2) Unmodified (10)


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