50 Results for "

antioxidative stress

" in MedChemExpress (MCE) Product Catalog:
Products (50)

50 Results for "antioxidative stress" in MCE Product Catalog:

145
Melatonin
Melatonin
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145 Publications Verification
Cat. No.: HY-B0075
CAS No.: 73-31-4
Synonyms: N-Acetyl-5-methoxytryptamine
Category:  

Natural Products Neurological Disease Other disease Anti-aging Disease markers Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis PANoptosis Ligands for Target Protein for PROTAC Histone Acetyltransferase

Melatonin is a hormone made by the pineal gland that can activate melatonin receptor and inhibit PANoptosis. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .
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41
Paeoniflorin
Paeoniflorin
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41 Cited Publications
Cat. No.: HY-N0293
CAS No.: 23180-57-6
Synonyms: Peoniflorin
Category:  

Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Plants Paeoniaceae

Target:  

HSP

Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .
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19
Matrine
Matrine
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19 Cited Publications
Cat. No.: HY-N0164
CAS No.: 519-02-8
Synonyms: Matridin-15-one; Vegard; α-Matrine
Category:  

Plants Sophora flavescens Aiton Biological Pesticide Research Agricultural Research Alkaloids Piperidine Alkaloids Leguminosae Disease Research Fields Inflammation/Immunology Cancer

Target:  

PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis

Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .
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15
Cynaroside
Cynaroside
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15 Cited Publications
Cat. No.: HY-N0540
CAS No.: 5373-11-5
Synonyms: Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside
Category:  

Infection Flavonoids Flavones Centaurea ornata Phenols Polyphenols Plants Umbelliferae Disease Research Fields

Target:  

Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal

Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .
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10
Benzbromarone
Benzbromarone
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10 Cited Publications
Cat. No.: HY-B1135
CAS No.: 3562-84-3
Target:  

Xanthine Oxidase Apoptosis Interleukin Related Keap1-Nrf2 SOD Caspase Bcl-2 Family NF-κB JNK HSP

Research Areas:  

Metabolic Disease

Benzbromarone is an orally active anti-gout agent. Benzbromarone has anti-infammatory, anti-oxidative stress and nephroprotective effects. Benzbromarone can be used for the research of hyperuricemia and gout .
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8
Afzelin
Afzelin
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8 Cited Publications
Cat. No.: HY-N1441
CAS No.: 482-39-3
Synonyms: Kaempferol-3-O-rhamnoside
Category:  

Flavonols Saururaceae Flavonoids  Houttuynia cordata Thunb. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Mitochondrial Metabolism PTEN Autophagy Bacterial

Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .
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5
Calycosin-7-O-β-D-glucoside
Calycosin-7-O-β-D-glucoside
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5 Cited Publications
Cat. No.: HY-N0520
CAS No.: 20633-67-4
Synonyms: Calycosin-7-glucoside
Category:  

Flavonoids Monophenols Leguminosae Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Phenols Plants Disease Research Fields Isoflavones

Target:  

Reactive Oxygen Species (ROS)

Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects .
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5
Fraxin
Fraxin
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5 Cited Publications
Cat. No.: HY-N0579
CAS No.: 524-30-1
Synonyms: Fraxoside
Category:  

Oleaceae Fraxinus rhynchophylla Hance Coumarins Plants other families Monophenols Phenols Phenylpropanoids Disease Research Fields Inflammation/Immunology

Target:  

Phosphodiesterase (PDE)

Fraxin isolated from Cortex Fraxini, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action , anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme .
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5
Esculin sesquihydrate
Esculin sesquihydrate
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5 Cited Publications
Cat. No.: HY-W166297
CAS No.: 66778-17-4
Target:  

p38 MAPK

Research Areas:  

Cancer

Esculin sesquihydrate, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin sesquihydrate ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the MAPK signaling pathway .
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2
24-Methylenecholesterol
24-Methylenecholesterol
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2 Cited Publications
Cat. No.: HY-133968
CAS No.: 474-63-5
Purity:  99.48%
Synonyms: Ostreasterol
Category:  

other families Animals Anti-aging Marine natural products Other marine organisms Plants Disease Research Fields Inflammation/Immunology Steroids

Target:  

Acyltransferase Reactive Oxygen Species (ROS)

24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .
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1
Caftaric acid
Caftaric acid
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1 Cited Publications
Cat. No.: HY-N0321
CAS No.: 67879-58-7
Synonyms: trans-Caftaric acid
Category:  

other families Microorganisms Simple Phenylpropanols Other Diseases Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields

Target:  

Others

Caftaric acid (trans-Caftaric acid) is a polyphenolic antidiuretic, antioxidant and anti-apoptotic agent that can be hydrolyzed by intestinal microbial esterases. Caftaric acid exerts its antioxidant and potential anti-inflammatory effects mainly through intestinal microbial metabolism. Caftaric acid can reduce renal damage, restore electrolyte balance, renal function indicators and antioxidant enzyme activities in a rat albinism model, and further exert anti-oxidative stress and anti-inflammatory activities .
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1
(-)-Limonene
(-)-Limonene
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1 Cited Publications
Cat. No.: HY-Z0478
CAS No.: 5989-54-8
Synonyms: (S)-(-)-Limonene
Category:  

Cardiovascular Disease Other Monoterpenes Microorganisms Terpenoids Rutaceae Plants Disease Research Fields Citrus

Target:  

Bacterial Antibiotic CaMK

(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca 2+) and Ca 2+/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture .
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1
MOTS-c (human)
MOTS-c (human)
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1 Cited Publications
Cat. No.: HY-P2048
CAS No.: 1627580-64-6
Target:  

Apoptosis GLUT AMPK

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology

MOTS-c (human) is a blood-brain barrier-penetrating, mitochondrial-derived peptide that modulates the AMPK/PGC-1α pathway to enhance insulin sensitivity. MOTS-c (human) inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate AMPK, and then regulates the Nrf2/Keap1 antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .
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1
1-Caffeoylquinic acid
1-Caffeoylquinic acid
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1 Cited Publications
Cat. No.: HY-N0460
CAS No.: 1241-87-8
Category:  

Phyllodium pulchellum (L.) Desv. Phenols Polyphenols Plants Compositae Disease Research Fields Cancer

Target:  

NF-κB PD-1/PD-L1

1-Caffeoylquinic acid is an effective NF-κB inhibitor, shows significant binding affinity to the RH domain of p105 with Ki of 0.007 μM . 1-Caffeoylquinic acid has anti-oxidative stress ability . 1-Caffeoylquinic acid is the Inhibitor for PD-1/PD-L1 .
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1
MOTS-c(human) acetate
MOTS-c(human) acetate
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1 Cited Publications
Cat. No.: HY-P2048A
Target:  

AMPK GLUT

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology

MOTS-c (human) acetate is a blood-brain barrier-penetrating, mitochondrial-derived peptide that modulates the AMPK/PGC-1α pathway to enhance insulin sensitivity. MOTS-c (human) acetate inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate AMPK, and then regulates the Nrf2/Keap1 antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) acetate has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .
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1
Cynaroside (Standard)
Cynaroside (Standard)
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1 Cited Publications
Cat. No.: HY-N0540R
CAS No.: 5373-11-5
Synonyms: Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)
Category:  

Flavonoids Flavones Centaurea ornata Phenols Polyphenols Plants Umbelliferae

Target:  

Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal Reference Standards

Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .
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Silybin B
Silybin B
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Cat. No.: HY-N7046
CAS No.: 142797-34-0
Synonyms: Silibinin B
Category:  

Flavanonols Glycine soya Flavonoids Phenols Polyphenols Cyamopsis tetragonoloba (L.) Taub. Plants Compositae

Target:  

Amyloid-β Apoptosis JNK p38 MAPK

Silybin B (Silibinin B) is an orally active amyloid-β aggregation inhibitor and ATR pathway activator that can cross the blood-brain barrier. Silybin B inhibits Aβ fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin (HY-17394)-induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimer's disease and Cisplatin chemotherapy-related neurotoxicity .
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Melatonin-d3
Melatonin-d3
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Cat. No.: HY-B0075S1
CAS No.: 90735-69-6
Synonyms: N-Acetyl-5-methoxytryptamine-d3
Melatonin-d3 is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .
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Swertiajaponin
Swertiajaponin
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Cat. No.: HY-N2204
CAS No.: 6980-25-2
Category:  

other families Flavonoids Flavones Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Tyrosinase Reactive Oxygen Species (ROS)

Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity .
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Zeaxanthin dipalmitate
Zeaxanthin dipalmitate
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Cat. No.: HY-N9182
CAS No.: 144-67-2
Synonyms: Physalien
Category:  

Terpenoids Diterpenoids Plants Solanaceae Lycium chinense Miller Disease Research Fields Inflammation/Immunology

Target:  

Adiponectin Receptor P2X Receptor Autophagy

Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (Kd=81.2 nM) and adiponectin receptor 1 (AdipoR1; Kd=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP) .
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