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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
85 Results for "
bidentate chelation
" in MedChemExpress (MCE) Product Catalog:
Products (85)
85 Results for "bidentate chelation" in MCE Product Catalog:
7
7 Publications Verification
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Cu(II)-Elesclomol is a complex formed by Elesclomol (HY-12040) and Cu 2+ (copper ions). Cu(II)-Elesclomol is also a weak inhibitor of DNA topoisomerase I. Cu(II)-Elesclomol exerts anticancer effects by inducing oxidative stress and DNA damage through copper chelation. Cu(II)-Elesclomol can inhibit tumor cell proliferation and induce cell cycle arrest and apoptosis. Cu(II)-Elesclomol can be used in the study of cancer .
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Category:
Natural Products Plants Other Families Extract Disease Research Fields Inflammation/Immunology
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4
4 Cited Publications
Synonyms: 8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol
Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research .
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Ditiocarb sodium (Sodium diethyldithiocarbamate) is an orally active copper reagent. Ditiocarb sodium exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium can be used in the research of tumors, inflammatory, and immune-related diseases .
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4 Cited Publications
Synonyms: Sodium diethyldithiocarbamate,98%
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Ditiocarb sodium,98% (Sodium diethyldithiocarbamate,98%) is an orally active copper reagent. Ditiocarb sodium,98% exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium,98% can be used in the research of tumors, inflammatory, and immune-related diseases .
1
1 Cited Publications
Cat. No.: HY-Y0395
CAS No.: 25487-66-5
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8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.
Cat. No.: HY-Y0091
CAS No.: 161265-03-8
Synonyms: 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene
Cat. No.: HY-W017289
CAS No.: 553-26-4
Cat. No.: HY-N4084
CAS No.: 271579-11-4
Category:
Thonningia sanguinea Phenols Polyphenols Plants Disease Research Fields Cancer Balanophoraceae Extract
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Cat. No.: HY-126404
CAS No.: 65072-00-6
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Casein hydrolysate is an orally effective, multi-functional mixture of bioactive peptides, a hydrolysis product of casein (HY-125865), containing ACE inhibitors and immunomodulatory target regulators, among others. Casein hydrolysate releases short-chain bioactive peptides through enzymatic hydrolysis of casein, increasing cellular glutathione and catalase levels, enhancing ConA-induced IL-2 production, and exhibiting metal ion chelation, free radical scavenging, antibacterial, and mineral absorption-promoting effects. Casein hydrolysate lowers blood pressure by inhibiting angiotensin-converting enzyme (ACE) and reducing bradykinin degradation .
Category:
Human Gut Microbiota Metabolites Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields
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Cat. No.: HY-W110927
CAS No.: 130-22-3
Cat. No.: HY-W012161
CAS No.: 3061-90-3
Synonyms: L-Alanyl-L-phenylalanine; H-Ala-Phe-OH
Cat. No.: HY-W096079
CAS No.: 1702356-19-1
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BCN-endo-PEG4-NHS is an ADC Linker containing 4 PEG units. BCN-endo-PEG4-NHS contains the lyophilic bidentate macrocyclic ligand endo-BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.
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DOTA-GA-maleimide is a bifunctional chelator with protein conjugation and radiometal chelation capabilities. DOTA-GA-maleimide forms stable complexes with 111In and conjugates with proteins via maleimide chemistry. DOTA-GA-maleimide conjugates with LFn, enabling 111In radiolabeling of LFn through direct or pre-labeling strategies. Radiolabeled LFn is applicable to MMP activity imaging studies. DOTA-GA-maleimide is used in cancer research .
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BCN-endo-PEG2-maleimide is an ADC Linker containing 4 PEG units. BCN-endo-PEG2-maleimide contains the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
Cat. No.: HY-W035520
CAS No.: 35369-53-0
Cat. No.: HY-162386
CAS No.: 324530-92-9
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UM4118 is a potent copper-selective non-genotoxic copper ionophore that induces cuproptosis in acute myeloid leukemia cells. UM4118 exhibits stronger activity against SF3B1G12C mutant acute myeloid leukemia cells. UM4118 transports extracellular copper into cells, elevates intracellular and mitochondrial copper levels, and triggers lipoylated DLAT aggregation, proteotoxic stress, iron-sulfur cluster protein depletion, reduced lipoylated protein levels, and maximal mitochondrial respiratory damage. UM4118 cytotoxicity can be enhanced by supplementation with extracellular copper, abolished by copper chelation, and shows synthetic lethal effects in the absence of iron-sulfur cluster biosynthesis/transport genes. UM4118 can be used for the study of acute myeloid leukemia .
Cat. No.: HY-Y0982
CAS No.: 76189-56-5
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(S)-BINAP is an isomer of (R)-BINAP (HY-W017757), as well as a chiral chelating diphosphine ligand and enantioselective catalyst precursor. (S)-BINAP acts as a bidentate ligand, transferring chiral information via its binaphthyl backbone to achieve stereodiscrimination of substrates. (S)-BINAP is used for the enantioselective hydrogenation of prochiral carboxylic acids, N-acyltetrahydroisoquinolines, allylic alcohols, functionalized ketones, cyclic anhydrides, and styrenes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
