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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
bone defects
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "bone defects" in MCE Product Catalog:
6
6 Publications Verification
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AS2863619 is an orally active CDK8/19 inhibitor that also inhibits BMP2, MDA5 and RIG-I receptors. AS2863619 targets Stat5a-CDK8/19 to promote the differentiation of CD4 + T cells into regulatory T cells and induce FOXP3 expression, thereby restoring immune homeostasis and establishing transplant immune tolerance. AS2863619 also enhances the BMP2/SMAD signaling pathway to promote osteogenic differentiation and inhibit adipogenic differentiation. AS2863619 exerts osteoprotective effects by alleviating inflammation-induced impairment of osteogenic function and inducing neutrophil apoptosis (apoptosis). AS2863619 can be applied to research in related fields such as periodontitis-induced bone defects .
6
6 Publications Verification
Cat. No.: HY-18312
CAS No.: 1166393-85-6
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PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration .
6
6 Publications Verification
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AS2863619 free base is an orally active CDK8/19 inhibitor that also inhibits BMP2, MDA5 and RIG-I receptors. AS2863619 free base targets Stat5a-CDK8/19 to promote the differentiation of CD4 + T cells into regulatory T cells and induce FOXP3 expression, thereby restoring immune homeostasis and establishing transplant immune tolerance. AS2863619 free base also enhances the BMP2/SMAD signaling pathway to promote osteogenic differentiation and inhibit adipogenic differentiation. AS2863619 free base exerts osteoprotective effects by alleviating inflammation-induced impairment of osteogenic function and inducing neutrophil apoptosis (apoptosis). AS2863619 free base can be applied to research in related fields such as periodontitis-induced bone defects .
2
2 Cited Publications
Synonyms: CP-533536 free acid
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Cardiovascular Disease Inflammation/Immunology Endocrinology
Evatanepag (CP-533536) is a non-prostanoid, potent and selective EP2 receptor agonist. Evatanepag can induce local bone formation in vivo. Evatanepag can be used in the research of fractures, bone defects, asthma .
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Synonyms: ENB-0040
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Cat. No.: HY-P5558
CAS No.: 917760-16-8
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Cat. No.: HY-W014410
CAS No.: 526-99-8
Category:
Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
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Cat. No.: HY-P11328
CAS No.: 245120-10-9
Cat. No.: HY-P5832
CAS No.: 836606-84-9
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Cat. No.: HY-P2263
CAS No.: 800379-47-9
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Cat. No.: HY-P99720A
CAS No.: 1373715-00-4
Synonyms: RAP-536
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Cat. No.: HY-P2612
CAS No.: 199999-60-5
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Cat. No.: HY-15893G
CAS No.: 89464-63-1
Synonyms: Dimethyloxallyl Glycine (GMP)
Cat. No.: HY-158223
Synonyms: CMCSMA
Application: cell culture, biological 3D printing, tissue engineering, etc.
Cat. No.: HY-P3637
CAS No.: 2640019-27-6
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Cat. No.: HY-155705
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BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research .
Cat. No.: HY-W584165
CAS No.: 13983-17-0
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Wollastonite is a white, chain-structured pyroxene silicate mineral with biocompatibility, biodegradability, osteogenicity and antibacterial properties. Wollastonite induces transient pulmonary inflammatory responses, reversible alveolar macrophage responses, early inflammatory/proliferative mesothelial cell responses, ROS production, and mild chronic pulmonary interstitial inflammation in rats. Wollastonite induces osteogenic differentiation, promotes bone growth, supports angiogenesis, and facilitates the formation of hydroxycarbonate apatite on its surface. Wollastonite enhances the strength, bioactivity and biodegradability of hydroxyapatite scaffolds, and is used to construct porous bone tissue engineering scaffolds. Wollastonite is applied in research related to diseases such as bronchitis, decreased lung function and bone defects .
Cat. No.: HY-P4684
CAS No.: 138949-73-2
Synonyms: PTHrP (107–111)
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Cat. No.: HY-N0976
CAS No.: 210537-04-5
Synonyms: 11b-Hydroxy-11b,1-dihydromedicarpin
Category:
Natural Products Leguminosae Derris robusta Plants Disease Research Fields Inflammation/Immunology
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
