2 Results for "

cochlear explants

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "cochlear explants" in MCE Product Catalog:

5,7-Dihydroxy-4-methylcoumarin
5,7-Dihydroxy-4-methylcoumarin
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Cat. No.: HY-N4102
CAS No.: 2107-76-8
Category:  

Infection other families Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields

Target:  

Apoptosis JNK FOXO Reactive Oxygen Species (ROS) Caspase

5,7-Dihydroxy-4-methylcoumarin is an antioxidant. 5,7-Dihydroxy-4-methylcoumarin protects mouse cochlear hair cells from Cisplatin-induced damage, enhances cell viability and inhibits apoptosis. 5,7-Dihydroxy-4-methylcoumarin downregulates phosphorylated JNK levels, increases the ratio of phosphorylated FoxO1 to total FoxO1, scavenges free radicals, reduces ROS accumulation, maintains mitochondrial membrane potential and alleviates mitochondrial dysfunction. 5,7-Dihydroxy-4-methylcoumarin downregulates the expression of caspase-3 and improves cell viability. 5,7-Dihydroxy-4-methylcoumarin can be used in studies related to ototoxicity .
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Ombuoside
Ombuoside
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Cat. No.: HY-N3138
CAS No.: 20188-85-6
Category:  

Infection Flavonols Flavonoids Cucurbitaceae Phenols Polyphenols Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino

Target:  

Bacterial Apoptosis Reactive Oxygen Species (ROS) ERK JNK Caspase SOD Fungal

Ombuoside has antioxidant properties, inhibiting ROS production and apoptosis. Ombuoside exerts neuroprotective effects through the ERK-JNK-caspase-3 system. Ombuoside promotes Dopamine biosynthesis through TH and CREB activation. Ombuoside exhibits antimicrobial activity against several Gram-positive and Gram-negative bacteria, as well as Candida albicans
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