2. Search Result
Search Result
Results for "

dsDNA

" in MedChemExpress (MCE) Product Catalog:

49

Inhibitors & Agonists

16

Fluorescent Dye

1

Biochemical Assay Reagents

3

Peptides

1

MCE Kits

1

Inhibitory Antibodies

2

Natural
Products

7

Isotope-Labeled Compounds

1

Click Chemistry

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114180
    RU.521
    80+ Cited Publications

    RU320521

    		 Cyclic GMP-AMP Synthase Metabolic Disease
    RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) .
    RU.521
  • HY-101879
    Acridine Orange hydrochloride
    35+ Cited Publications

    		 DNA Stain Parasite Fluorescent Dye Others
    Acridine Orange hydrochloride is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .
    Acridine Orange hydrochloride
  • HY-W013049
    Docosanoic acid

    Behenic acid

    		 Endogenous Metabolite DNA/RNA Synthesis Metabolic Disease Cancer
    Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .
    Docosanoic acid
  • HY-128583
    G150
    5+ Cited Publications

    		 Cyclic GMP-AMP Synthase Inflammation/Immunology
    G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory .
    G150
  • HY-D0952
    Acridine Orange base
    35+ Cited Publications

    		 Parasite Others
    Acridine Orange base is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. Acridine Orange base fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644), also can be used in cell cycle assays .
    Acridine Orange base
  • HY-D0093
    Ethidium homodimer
    4 Publications Verification

    EthD-1

    		 DNA Stain Others
    Ethidium homodimer (EthD-1) is a high-affinity fluorescent nucleic acid dye commonly used to stain mammals, bacteria, yeast, and fungi. Ethidium homodimer binds to DNA or RNA, enhancing fluorescence more than 30 times. The Ethidium homodimer has a strong positive charge, so it cannot cross cell membranes and stain living cells; But the Ethidium homodimer can cross the disordered region of the dead cell membrane to reach the nucleus and embed the DNA double strand to produce red fluorescence. Therefore, Ethidium homodimer is a relatively sensitive nucleic acid stain that can accurately detect nucleic acids in solution or in decomposing cells. Ethidium homodimer binds DNA, Ex/Em=528/617 nm .
    Ethidium homodimer
  • HY-D1738
    DAPI dilactate
    Maximum Cited Publications
    115 Publications Verification

    4',6-Diamidino-2-phenylindole dilactate

    		 Fluorescent Dye Others
    DAPI (4',6-Diamidino-2-phenylindole) dilactate is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. DAPI cannot penetrate intact cell membranes and is commonly used for staining both live and fixed cells . DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment (Ex/Em = 356/451 nm) .
    DAPI dilactate
  • HY-108882B
    DNase I RNase & Protease free
    25+ Cited Publications

    		 DNA/RNA Synthesis Inflammation/Immunology
    DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune responses. Decreased DNase I activity may be associated with the onset and progression of systemic lupus erythematosus (SLE). DNase I (RNase & Protease free) is a molecular biology-grade DNase I purified by chromatography to remove RNase and protease .
    DNase I RNase & Protease free
  • HY-W018587
    TBPH

    		Mitochondrial Metabolism Cytochrome P450 TNF Receptor Interleukin Related HSP LDLR Eukaryotic Initiation Factor (eIF) ClpP Metabolic Disease Inflammation/Immunology
    TBPH is a brominated flame retardant. TBPH enhances hepatic steatosis, inflammation, and fibrosis in mice with nonalcoholic steatohepatitis (NASH). TBPH induces dysregulation of phospholipid metabolism, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH leads to impaired endoplasmic reticulum-mitochondria (ER-Mito) contacts, subsequently causing mitochondrial dysfunction. TBPH induces lung injury through an inflammatory response mediated by mitochondria-derived ds-DNA. TBPH can be used to study the role of MFN2-mediated ER-mitochondria contacts in lipid metabolism homeostasis .
    TBPH
  • HY-D0942
    Acridine Orange zinc chloride salt
    35+ Cited Publications

    Euchrysine 3RX

    		 Parasite Fluorescent Dye DNA Stain Others
    Acridine Orange (Euchrysine 3RX) zinc chloride salt is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange zinc chloride salt produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .
    Acridine Orange zinc chloride salt
  • HY-172208
    PROTAC cGAS degrader-1

    		PROTACs Cyclic GMP-AMP Synthase Inflammation/Immunology
    PROTAC cGAS degrader-1 is a potent and selective cGAS PROTAC degrader, with DC50 values of 0.9 μM and 4.6 μM in THP-1 and RAW 264.7 cells, respectively. PROTAC cGAS degrader-1 induces proteasome-mediated degradation of cGAS, inhibits the cGAS signaling pathway, and attenuates double-stranded DNA-induced activation of cGAS in human and mouse cells. PROTAC cGAS degrader-1 is applicable to research related to ulcerative colitis .
    PROTAC cGAS degrader-1
  • HY-120951
    PFM39
    1 Publications Verification

    		 Endonuclease Cancer
    PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity .
    PFM39
  • HY-DY1038
    Acridine Orange hydrochloride (solution)

    		Fluorescent Dye Others
    Acridine Orange hydrochloride (solution) is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .
    Solvent and Concentration: Sterile water: 10 mg/mL
    The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
    Acridine Orange hydrochloride (solution)
  • HY-138155
    NSC15520

    		DNA/RNA Synthesis Cancer
    NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling .
    NSC15520
  • HY-W013049S3
    Docosanoic acid-d3

    Behenic acid-d3

    		 Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Metabolic Disease Cancer
    Docosanoic acid-d3 (Behenic acid-d3) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .
    Docosanoic acid-d3
  • HY-D1444
    Propidium monoazide
    1 Publications Verification

    		 Fluorescent Dye Bacterial Infection
    Propidium monoazide is a cell-impermeant photoreactive DNA-binding dye that preferentially binds to dsDNA. Propidium monoazide (PMA) prevents DNA from dead bacteria from being amplified during the PCR. PMA-PCR enhanced both the specificity and the sensitivity of PCR . Propidium monoazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Propidium monoazide
  • HY-D1191
    SYBR green I chloride
    3 Publications Verification

    		 Fluorescent Dye DNA/RNA Synthesis Others
    SYBR Green I chloride is a highly sensitive fluorescent nucleic acid dye that binds specifically to the minor groove of double-stranded DNA or intercalates between base pairs. SYBR Green I chloride exhibits weak fluorescence in the unbound state but emits bright fluorescence upon binding, and it preferentially binds to large-fragment DNA and DNA with high G+C content. SYBR Green I chloride is suitable for real-time PCR technology; its fluorescence intensity correlates with the amount and size of amplification products, enabling accurate quantification of gene expression and discrimination of amplicons via melting curve analysis without additional post-processing. SYBR Green I chloride is widely used in preclinical in vitro nucleic acid detection .
    SYBR green I chloride
  • HY-D1773
    YOYO-3

    		Fluorescent Dye DNA Alkylator/Crosslinker Others
    YOYO-3 is a trimethine cyanine homodimer dye. YOYO-3 intercalates into AF488-tagged dsDNA molecules at the single-molecule level. YOYO-3 has a greater affinity for DNA than do EB and other Cyanine dyes .
    YOYO-3
  • HY-D0916
    Thiazole orange dimer YOYO 1

    YOYO 1; YOYO1

    		 Fluorescent Dye Others
    Thiazole orange dimer YOYO 1 (YOYO 1) is a cell-impermeable cyanine dimer with no inherent fluorescence, and its fluorescence intensity increases significantly upon binding to double-stranded DNA (dsDNA) . Thiazole orange dimer YOYO 1 can serve as a nuclear counterstain or a dead cell indicator (Ex/Em = 505/512 nm).
    Thiazole orange dimer YOYO 1
  • HY-D3010
    VF dsDNA Green Dye

    		Fluorescent Dye Others
    VF dsDNA Green Dye is a fluorescent dye for detecting and quantifying double-stranded DNA (dsDNA). VF dsDNA Green Dye fluoresces only when bound to dsDNA, and the fluorescence intensity is proportional to the DNA concentration. VF dsDNA Green Dye does not fluoresce when bound to ssDNA, RNA, or free nucleotides. VF dsDNA Green Dye can detect dsDNA within the range of 25 pg/mL to 1000 ng/mL (Ex/Em = 480/520 nm).
    VF dsDNA Green Dye
  • HY-P2754
    Micrococcal nuclease

    		Endonuclease Infection
    Micrococcal nuclease is an endonuclease derived from Staphylococcus aureus. Micrococcal nuclease is able to digest both single and double-stranded DNA (ssDNA and dsDNA) and RNA, and can cleave and hydrolyze the AT or AU-rich regions specifically. Micrococcal nuclease could be used as an indicator of Staphylococcus aureus contamination .
    Micrococcal nuclease
  • HY-D2208
    SYTM Green
    1 Publications Verification

    		 Fluorescent Dye Others
    SYTM Green is a cell impermeant DNA dye that fluoresces green by binding to dsDNA (Ex/Em=503/530 nm). SYTM Green can also be used to stain bacteria, including Gram-positive and Gram-negative bacteria. Note: SYTM Green cannot penetrate living cells, and this product is equivalent to (Ex/Em=488/530 nm) .
    SYTM Green
  • HY-E70579
    Exonuclease III

    		DNA/RNA Synthesis Others
    Exonuclease III is a nuclease for specifically targeting double-stranded DNA (dsDNA). Exonuclease III is a DNA repair-associated nuclease with apurinic/apyrimidinic (AP)-endonuclease and 3'→5' exonuclease activities. Exonuclease III cleaves the ssDNA at 5'-bond of phosphodiester from 3' to 5' end by both exonuclease and endonuclease activities .
    Exonuclease III
  • HY-W013049S1
    Docosanoic acid-d43

    Behenic acid-d43

    		 Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Metabolic Disease Cancer
    Docosanoic acid-d43 (Behenic acid-d43) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .
    Docosanoic acid-d43
  • HY-W013049S4
    Docosanoic acid-d4-1

    Behenic acid-d4-1

    		 Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Metabolic Disease Cancer
    Docosanoic acid-d4-1 (Behenic acid-d4-1) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .
    Docosanoic acid-d4-1
  • HY-E70381
    dsDNase

    		Endonuclease Cancer
    dsDNase is a highly specific double-strand DNA (dsDNA) endonuclease that quickly and efficiently removes contaminating DNA from PCR master mixes .
    dsDNase
  • HY-148411
    Abetimus

    LJP 394 free base

    		 DNA/RNA Synthesis Inflammation/Immunology
    Abetimus (LJP 394 free base) is an immunosuppressant consisting of four double-stranded DNA (dsDNA) oligonucleotides. Abetimus is capable of crosslinking anti-dsDNA antibodies on the surface of B cells, and decreases anti-dsDNA antibodies levels. Abetimus has the potential for research of systemic lupus erythematosus .
    Abetimus
  • HY-W013049S6
    Docosanoic acid-13C4

    Behenic acid-13C4

    		 Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Metabolic Disease
    Docosanoic acid- 13C4 (Behenic acid- 13C4) is the 13C-labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in vivo .
    Docosanoic acid-13C4
  • HY-P11351
    Precursor-HhH

    		DNA/RNA Synthesis Cancer
    Precursor-HhH is a nucleic acid-binding peptide capable of non-specific interactions with RNA and double-stranded DNA (dsDNA). Precursor-HhH is promising for research of nucleic acid-targeted therapeutics .
    Precursor-HhH
  • HY-P5768
    2× ST-tag II

    		Biochemical Assay Reagents Others
    2× ST-tag II is an oligopeptide that can link proteins and dsDNA molecules in an efficient, rapid and specific manner. 2× ST-tag II is a peptide ligand of ST Tactin (STN). 2× ST-tag II specifically binds to ST Tactin. 2× ST-tag II can be used to construct DNA-protein hybrids .
    2× ST-tag II
  • HY-P5768A
    2× ST-tag II TFA

    		Biochemical Assay Reagents Cancer
    2× ST-tag II TFA is an oligopeptide that can link proteins and dsDNA molecules in an efficient, rapid and specific manner. 2× ST-tag II is a peptide ligand of ST Tactin (STN). 2× ST-tag II TFA specifically binds to ST Tactin. 2× ST-tag II TFA can be used to construct DNA-protein hybrids .
    2× ST-tag II TFA
  • HY-149900
    Antiviral agent 33

    		Biochemical Assay Reagents Infection
    Antiviral agent 33 (compound 1c) is a double-stranded DNA (dsDNA) virus inhibitor with IC50 values of 0.0790 and 0.1572 µM for VACV and AdV5, respectively. Antiviral agent 33 also has potential for oral administration .
    Antiviral agent 33
  • HY-E70604
    E. coli DNA ligase

    		DNA/RNA Synthesis Others
    E. coli DNA ligase is a NAD +-dependent DNA ligase that catalyzes the formation of a phosphodiester bond between the complementary 3′-OH and 5′-P ends of dsDNA .
    E. coli DNA ligase
  • HY-162852
    OAF89

    		G-quadruplex Cancer
    OAF89 is a small molecule that interacts with G-Quadruplexes (G4s) and dsDNA with an IC50 of 1.07 μM in normal lung epithelial cells BEAS-2B .
    OAF89
  • HY-W013049R
    Docosanoic acid (Standard)

    Behenic acid (Standard)

    		 Reference Standards Endogenous Metabolite DNA/RNA Synthesis Metabolic Disease Cancer
    Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .
    Docosanoic acid (Standard)
  • HY-W190974
    3-Ethynylperylene

    Perylene, 3-ethynyl-

    		 Biochemical Assay Reagents Others
    3-Ethynylperylene (Perylene, 3-ethynyl-) is a polyaromatic hydrocarbon with five fused rings and has a terminal propargyl group. 3-Ethynyl perylene possesses intrinsic fluorescence and pyrene derivatives are known for their ability to intercalate dsDNA. The propargyl group can react with azide-bearing compounds to form stable triazole rings.
    3-Ethynylperylene
  • HY-W013049S
    Docosanoic acid-d4

    Behenic acid-d4

    		 Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Metabolic Disease Cancer
    Docosanoic acid-d4 (Behenic acid-4) is deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .
    Docosanoic acid-d4
  • HY-W013049S2
    Docosanoic acid-d2

    Behenic acid-d2

    		 Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Metabolic Disease Cancer
    Docosanoic acid-d2 (Behenic acid-d2) is deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .
    Docosanoic acid-d2
  • HY-W013049S5
    Docosanoic acid-d4-2

    Behenic acid-d4-2

    		 Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Metabolic Disease Cancer
    Docosanoic acid-d4-2 (Behenic acid-d4-2) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .
    Docosanoic acid-d4-2
  • HY-D0150A
    (Z)-Thiazole Orange iodide

    		Fluorescent Dye Others
    (Z)-Thiazole Orange iodide is an asymmetric cyanine dye whose fluorescence highly depends on the local environment.(Z)-Thiazole Orange iodide is essentially dark in solution; however, its fluorescence increases a thousandfold when (Z)-Thiazole Orange iodide is introduced into double-stranded DNA and RNA (dsDNA or dsRNA). The maximum absorption of Thiazole Orange in complex with DNA is 509 nm, and the maximum emission is 532 nm. Thiazole Orange solution is widely used for determining the percentage of reticulocytes in human peripheral blood with microscopy and flow cytometry.
    (Z)-Thiazole Orange iodide
  • HY-165400
    TODi-1

    		Fluorescent Dye DNA Alkylator/Crosslinker Others
    TODi-1 (TOTO) is a double-stranded DNA binder and Fluorescence enhancer (with a lambda max of 513 nm for dsDNA-TOTO). TODi-1 forms stable bis-intercalation complexes with double-stranded DNA. TODi-1 shows almost no fluorescence in free solution, but its fluorescence intensity increases significantly upon binding to double-stranded DNA .
    TODi-1
  • HY-101879R
    Acridine Orange hydrochloride (Standard)

    		DNA Stain Reference Standards Parasite Fluorescent Dye Others
    Acridine Orange hydrochloride (Standard) is the analytical standard of Acridine Orange hydrochloride (HY-101879). This product is intended for research and analytical applications. Acridine Orange hydrochloride is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .
    Acridine Orange hydrochloride (Standard)
  • HY-D3404
    BODi-1

    		DNA Stain Others
    BODi-1 is a fluorescent modulator targeting dsDNA, which binds to dsDNA via a bis-intercalation mechanism (Ex=465 nm, Em=490 nm). BODi-1 exhibits a fluorescence enhancement effect upon binding to nucleic acids, but its fluorescence intensity, anisotropy and average lifetime decrease at higher dye/DNA ratios. When BODi-1 binds to DNA in liposome complexes, it also shows red-shifted emission spectra, along with reduced quantum yield and average lifetime. BODi-1 does not induce significant DNA conformational changes when the dye/DNA ratio is below 0.01. BODi-1 can be used as a fluorescent probe for the characterization of liposome complexes and FRET studies at this ratio .
    BODi-1
  • HY-E70608
    PcrA spirase

    		DNA/RNA Synthesis Others
    PcrA spirase is an ATP-driven 3′ to 5′ helicase responsible for unwinding double-stranded DNA (dsDNA). PcrA spirase binds to dsDNA and unwinds it into two single-stranded DNAs (ssDNA).
    PcrA spirase
  • HY-E70607
    MutS protein, thermophilic bacteria

    		DNA/RNA Synthesis Others
    MutS protein, thermophilic bacteria is a DNA mismatch-binding protein that can be used to detect mismatched double-stranded DNA (dsDNA) .
    MutS protein, thermophilic bacteria
  • HY-181440
    TDG-IN-1

    		DNA Glycosylase DNA/RNA Synthesis Cancer
    TDG-IN-1 is an orally active, selective small-molecule inhibitor of thymine DNA glycosylase (TDG) with a Ka of 1.46 nM. TDG-IN-1 impairs the DNA-binding ability of TDG, induces downregulated expression of DHX9, accumulation of double-stranded RNA, and activation of the RIG-I/MDA5-MAVS pathway, while acting as a tumor suppressor, innate immune activator and immunostimulant. TDG-IN-1 inhibits the growth of p53-deficient tumor cells and xenograft tumors, and exerts a synthetic lethal effect with p53. TDG-IN-1 is applicable to the research of p53-deficient cancers .
    TDG-IN-1
  • HY-185129
    Headpiece

    		Biochemical Assay Reagents Others
    Headpiece is a short, covalently linked double-stranded DNA (dsDNA). It is designed as the starting point of DNA-Encoded Libraries (DELs) synthesis. In each chemical synthesis step, the compounds are encoded by enzymatically ligating the respective DNA tags to the Headpiece. Finally, a closing primer containing the distal primer-binding site for PCR amplification is added to complete the library synthesis/encoding.
    Headpiece
  • HY-P992101
    Aritinercept

    AUR-200

    		 TNF Receptor IFNAR Interleukin Related Inflammation/Immunology
    Aritinercept (AUR-200) is a recombinant fusion protein targeting TNFSF13B/BAFF/CD257. Aritinercept neutralizes BAFF and APRIL (TNFSF13), reduces B cell proliferation, suppresses peripheral B cells, lowers serum immunoglobulins. Aritinercept reduces renal damage markers, decreases IFNγ, IL-17A, and anti-dsDNA autoantibodies, and improves survival in a mouse model of SLE. ritinercept can be used for the research of systemic lupus erythematosus .
    Aritinercept
  • HY-147129
    cGAS-IN-9

    		Guanylate Cyclase Adenylate Cyclase CXCR NF-κB Inflammation/Immunology
    cGAS-IN-9 is a cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) inhibitor, with IC50 values of 27.5 nM and 5.15 μM against human and murine cGAS, respectively. cGAS-IN-9 shows weak inhibitory activity against human soluble adenylate cyclase, with an IC50 of 26.4 μM. cGAS-IN-9 inhibits dsDNA-induced expression of IFNB1 and CXCL10, as well as activation of the NF-κB pathway, in human immune cells. cGAS-IN-9 can be used in research related to cGAS-dependent inflammatory diseases .
    cGAS-IN-9

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: