105 Results for "

flavone

" in MedChemExpress (MCE) Product Catalog:
Products (105)

105 Results for "flavone" in MCE Product Catalog:

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Flavone
Flavone
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Cat. No.: HY-N2424
CAS No.: 525-82-6
Synonyms: 2-Phenyl-4-chromone
Category:  

Flavonoids Flavones Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

CDK Apoptosis Caspase

Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21waf1, PIG3). Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer .
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28
Nobiletin
Nobiletin
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28 Publications Verification
Cat. No.: HY-N0155
CAS No.: 478-01-3
Category:  

Rutaceae Extract Flavonoids Neurological Disease Flavones Plants Disease Research Fields Inflammation/Immunology Citrus reticulata Blanco

Target:  

ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy

Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .
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24
Scutellarin
Scutellarin
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24 Cited Publications
Cat. No.: HY-N0751
CAS No.: 27740-01-8
Category:  

Infection Flavonoids Flavones Phenols Polyphenols Plants Disease Research Fields Medicago truncatula Gaertn. Labiatae Extract

Target:  

STAT Akt HIV

Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively.
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14
Vitexin
Vitexin
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14 Cited Publications
Cat. No.: HY-N0013
CAS No.: 3681-93-4
Category:  

Cardiovascular Disease Neurological Disease Anti-aging Flavones Metabolic Disease Leguminosae Extract Plants Flavonoids Phenols Polyphenols Disease Research Fields Trigonella foenum-graecum Linn. Cancer

Target:  

Autophagy

Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .
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7
Hispidulin
Hispidulin
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7 Cited Publications
Cat. No.: HY-N1950
CAS No.: 1447-88-7
Synonyms: Dinatin
Category:  

Flavonoids Flavones Cassia Phenols Polyphenols Plants Disease Research Fields Cancer Labiatae Extract

Target:  

Pim

Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.
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3
Cirsilineol
Cirsilineol
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3 Cited Publications
Cat. No.: HY-119347
CAS No.: 41365-32-6
Purity:  ≥98.0%
Category:  

Laburnum anagyroides Medic. Flavonoids Monophenols Flavones Phenols Plants Compositae Extract Disease Research Fields Inflammation/Immunology

Target:  

IFNAR STAT

Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4 + T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice .
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5-Hydroxyflavone
5-Hydroxyflavone
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2 Cited Publications
Cat. No.: HY-22024
CAS No.: 491-78-1
Synonyms: 5-OH-flavone
Category:  

Flavonoids Monophenols Flavones Phenols Plants Other Families Extract Disease Research Fields Cancer

Target:  

Cytochrome P450

5-Hydroxyflavone (5-OH-Flavone) is a flavonoid compound that undergoes oxidation-mediated conversion to 5,7-dihydroxyflavone and 5,6,7-trihydroxyflavone by human cytochrome P450 enzymes .
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2
Ginkgolide C
Ginkgolide C
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2 Cited Publications
Cat. No.: HY-N0785
CAS No.: 15291-76-6
Synonyms: BN-52022
Category:  

Ginkgoaceae Extract Terpenoids Ginkgo biloba L. Diterpenoids Plants Endogenous metabolite

Target:  

AMPK Sirtuin MMP Endogenous Metabolite

Ginkgolide C is a flavone isolated from Ginkgo biloba leaves, possessing multiple biological functions, such as decreasing platelet aggregation and ameliorating Alzheimer disease.
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2
Licoflavonol
Licoflavonol
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2 Cited Publications
Cat. No.: HY-N6583
CAS No.: 60197-60-6
Category:  

Infection Flavonols Flavonoids Phenols Polyphenols Leguminosae Extract Plants Disease Research Fields Glycyrrhiza uralensis Fisch.

Target:  

Bacterial

Licoflavonol, a minor flavone from the roots of Glycyrrhiza uralensis, is an inhibitor of the Salmonella type III secretion system (T3SS) .
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2
Vitexin (Standard)
Vitexin (Standard)
0 Images
2 Cited Publications
Cat. No.: HY-N0013R
CAS No.: 3681-93-4
Category:  

Flavonoids Flavones Phenols Polyphenols Leguminosae Extract Plants Trigonella foenum-graecum Linn.

Target:  

Reference Standards Autophagy

Vitexin (Standard) is the analytical standard of Vitexin. This product is intended for research and analytical applications. Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .
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Rhoifolin
Rhoifolin
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1 Cited Publications
Cat. No.: HY-N0755
CAS No.: 17306-46-6
Category:  

Rhus succedanea Flavonoids Anacardiaceae Extract Flavones Plants Disease Research Fields Endocrinology Cancer

Target:  

Insulin Receptor GLUT NF-κB p38 MAPK Autophagy

Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .
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Flavanone
Flavanone
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1 Cited Publications
Cat. No.: HY-N7128
CAS No.: 487-26-3
Category:  

Flavonoids Flavonones Leguminosae Extract Plants Sophora flavescens Aiton Disease Research Fields Cancer

Target:  

Cytochrome P450 ERK p38 MAPK NF-κB MMP PAI-1

Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase). Flavanone is the inhibitor for ERK/p38/NF-κB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy .
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Kuwanon A
Kuwanon A
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1 Cited Publications
Cat. No.: HY-N2300
CAS No.: 62949-77-3
Category:  

Flavones Moraceae Extract Metabolic Disease Plants Other Families Extract Flavonoids Morus alba L. Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

NO Synthase

Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.
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Isosaponarin
Isosaponarin
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1 Cited Publications
Cat. No.: HY-N2589
CAS No.: 19416-87-6
Category:  

Caryophyllaceae Extract Vaccaria segetalis (Neck.) Garcke Flavonoids Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

TGF-β Receptor Collagen

Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects .
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Ginkgolide J
Ginkgolide J
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1 Cited Publications
Cat. No.: HY-N0786
CAS No.: 107438-79-9
Category:  

Ginkgoaceae Extract Terpenoids Ginkgo biloba L. Diterpenoids Plants

Target:  

Others

Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC50 range of 12-54 µM, has neuroprotective and anti neuronal apoptotic ability .
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5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone
5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone
0 Images
1 Cited Publications
Cat. No.: HY-N6259
CAS No.: 78417-26-2
Category:  

Flavonoids Flavones Other Diseases Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:  

Others

5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a methylated flavones from Artemisia frigida.
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Tricetin 3',4',5'-trimethyl ether
Tricetin 3',4',5'-trimethyl ether
0 Images
1 Cited Publications
Cat. No.: HY-N7150
CAS No.: 18103-42-9
Synonyms: 5,7-Dihydroxy-3',4',5'-trimethoxyflavone
Category:  

Flavonols Chrysanthemum × morifolium (Ramat.) Hemsl. Flavonoids Paracryphiaceae Extract Pteridaceae Extract Plants Compositae Extract

Target:  

Xanthine Oxidase

Tricetin 3',4',5'-trimethyl ether (5,7-Dihydroxy-3',4',5'-trimethoxyflavone) is a flavone glucoside, that can be isolated the flowers of Chrysanthemum sinensea. Tricetin 3',4',5'-trimethyl ether displays xanthine oxidase competitive-type inhibitory activity, with an IC50 of 0.51 μM and a Ki of 0.37 μM .
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3',4'-Dimethoxyflavone
3',4'-Dimethoxyflavone
0 Images
1 Cited Publications
Cat. No.: HY-N8572
CAS No.: 4143-62-8
Category:  

Flavonoids Flavones Coniogramme japonica (Thunb.) Diels Plants Other Families Extract

Target:  

PARP Reactive Oxygen Species (ROS) Aryl Hydrocarbon Receptor

3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .
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Gossypin
Gossypin
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Cat. No.: HY-125911
CAS No.: 652-78-8
Purity:  98.04%
Category:  

Cardiovascular Disease Flavonols Malvaceae Extract Plants Flavonoids Abelmoschus manihot (Linn.) Medicus Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Aurora Kinase Ribosomal S6 Kinase (RSK) Apoptosis Caspase Bcl-2 Family PARP Cryptochrome

Gossypin is an orally active flavone isolated from Hibiscus vitifolius. Gossypin has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits AURKA and RSK2. Gossypin inhibits invasion and induces apoptosis. Gossypin can be used for gastric cancer study .
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Neodiosmin
Neodiosmin
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Cat. No.: HY-N4122
CAS No.: 38665-01-9
Category:  

Rutaceae Extract Citrus × aurantium Linnaeus Flavones Plants Other Families Extract Infection Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

Others

Neodiosmin is a flavone glycoside isolated from the leaves of Citrus aurantium .
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