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Results for "

heme-iron

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (4) Biochemical Assay Reagents (5) Cytochrome P450 (3) Ferroportin (1) Ferroptosis (2) Guanylate Cyclase (1) Heme Oxygenase (HO) (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Lipoxygenase (1) MMP (1) Reference Standards (1) Tyrosinase (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (5) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-W698249

Ferrous gluconate	Ferroptosis Bacterial	Cardiovascular Disease Infection
Ferrous gluconate is a highly water-soluble iron-containing agent with high bioavailability and bactericidal activity. As a non-heme iron, Ferrous gluconate is used for meat product fortification and improvement of iron deficiency anemia. Ferrous gluconate induces ferroptosis in E. coli through Fe ²⁺ infiltration, reactive oxygen species burst, lipid peroxidation and direct interaction with DNA. Ferrous gluconate also downregulates the SOS responsive transcriptional repressor LexA. In addition, Ferrous gluconate regulates multiple key pathways in E. coli such as fatty acid metabolism, iron-sulfur cluster assembly and pyruvate metabolism, and is applied in studies related to E. coli infection and iron deficiency anemia .

HY-17500

Ataciguat 1 Publications Verification HMR-1766	Guanylate Cyclase	Cardiovascular Disease
Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects .

HY-P2915

Protocatechuate 3,4-dioxygenase 1 Publications Verification	Biochemical Assay Reagents Bacterial	Infection
Protocatechuate 3,4-dioxygenase is a dioxygenase. Protocatechuate 3,4-dioxygenase belongs to the non-heme iron dioxygenase class. Protocatechuate 3,4-dioxygenase catalyzes the cleavage of the aromatic ring of 3,4-dihydroxybenzoate, attaching two atoms of molecular oxygen to the compound to generate β-carboxy-cis,cis-muconate. Protocatechuate 3,4-dioxygenase is a key enzyme in the β-ketoadipic acid pathway. It is found in marine bacteria associated with Roseobacter. Protocatechuate 3,4-dioxygenase can be isolated from Pseudomonas aeruginosa .

HY-126301

DMT1 blocker 1 3 Publications Verification	Ferroportin	Metabolic Disease
DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC₅₀ of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia .

HY-W041193

3-Hydroxy-2-pyrone	MMP Lipoxygenase Tyrosinase	Infection Inflammation/Immunology Cancer
3-Hydroxy-2-pyrone (Compound 12d) is a metalloenzyme inhibitor. 3-Hydroxy-2-pyrone shows an inhibition rate of approximately 50% for matrix metalloproteinases (MMP) and the inhibition rate for non-heme iron enzyme 5-lipoxygenase (5-LOX) was over 70% at 1 mM. 3-Hydroxy-2-pyrone also has certain inhibitory activity against copper-dependent enzyme tyrosinase. 3-Hydroxy-2-pyrone can be used for the research of cancer, infection and inflammation .

HY-B1610K

Sodium Citrate Buffer, 0.5M, pH 5.5	Biochemical Assay Reagents	Others
Sodium Citrate Buffer, 0.5M, pH 5.5 is a metal chelator and buffering agent. Sodium Citrate Buffer, 0.5M, pH 5.5 requires oxygen to participate in the oxidation process to reduce pink defects in cooked ground turkey, and it does not function via heme iron chelation or iron complex interaction. When mixed with 50% (by vol.) 1,3-dimethylimidazolium methyl sulfate, Sodium Citrate Buffer, 0.5M, pH 5.5 can serve as an aqueous buffering medium to maintain the catalytic efficiency of the hyperthermophilic β-glycosidase CelB for lactose hydrolysis at 80°C, while also acting as a reaction medium for CelB-catalyzed lactose hydrolysis and galactosyltransferase assays .

HY-N12196

Terretonin	Cytochrome P450	Infection
Terretonin is a fungal terpenoid isolated from Aspergillus terreus. The complete biosynthetic pathway of terretonin includes: cytochrome P450 Trt6 catalyzes the oxidation of terrenoid to obtain an unstable intermediate; then it is catalyzed by isomerase Trt14 and processed by non-heme iron-dependent dioxygenase Trt7 to complete the biosynthesis of terretonin .

HY-184104

IDO1/TDO-IN-17	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1/TDO-IN-17 is an IDO1/TDO inhibitor with human IDO1 IC₅₀ ~280 μmol/L and human TDO IC₅₀ 204 μmol/L. IDO1/TDO-IN-17 binds to the heme-iron of IDO1. IDO1/TDO-IN-17 can be used for the research of cancer .

HY-W698249R

Ferrous gluconate (Standard)	Reference Standards Ferroptosis Bacterial
Ferrous gluconate (Standard) is the analytical standard of Ferrous gluconate. This product is intended for research and analytical applications. Ferrous gluconate is a highly water-soluble iron-containing agent with high bioavailability and bactericidal activity. As a non-heme iron, Ferrous gluconate is used for meat product fortification and improvement of iron deficiency anemia. Ferrous gluconate induces ferroptosis in E. coli through Fe ²⁺ infiltration, reactive oxygen species burst, lipid peroxidation and direct interaction with DNA. Ferrous gluconate also downregulates the SOS responsive transcriptional repressor LexA. In addition, Ferrous gluconate regulates multiple key pathways in E. coli such as fatty acid metabolism, iron-sulfur cluster assembly and pyruvate metabolism, and is applied in studies related to E. coli infection and iron deficiency anemia .

HY-E71170

1,8-Cineole 2-endo-monooxygenase	Biochemical Assay Reagents	Others
1,8-Cineole 2-endo-monooxygenase (EC 1.14.13.156) is a heme-thiolate protein (P-450) which uses a flavodoxin-like redox partner to reduce the heme iron.

HY-136745

Aromatase-IN-1	Cytochrome P450	Cancer
Aromatase-IN-1 is a competitive aromatase (P450arom) inhibitor with a human IC₅₀ of 40 nM and a K_i of 1.05 nM. Aromatase-IN-1 binds via coordination of imidazole nitrogen to the heme iron of aromatase. Aromatase-IN-1 can be used for the research of breast cancer .

HY-E71109

(S)-2-Hydroxypropylphosphonic acid epoxidase	Biochemical Assay Reagents	Others
(S)-2-Hydroxypropylphosphonic acid epoxidase (EC 1.11.1.23) is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. Contains non heme iron that forms a iron (IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate.

HY-182604

QC-308	Heme Oxygenase (HO)	Cancer
QC-308 is a HO-1/HO-2 inhibitor with an HO-1 IC₅₀ of 0.27 μM and an HO-2 IC₅₀ of 0.46 μM. QC-308 coordinates heme iron(II) to disrupt catalysis. QC-308 can be used for research of HO-1 inhibition mechanisms in cancer .

HY-174332

Cholesterol 24-hydroxylase-IN-3	Cytochrome P450	Neurological Disease
Cholesterol 24-hydroxylase-IN-3 is an orally active, selective, and blood-brain barrier-penetrant CH24H inhibitor (IC₅₀ = 23 nM) belonging to 1,3-oxazole derivatives. Cholesterol 24-hydroxylase-IN-3 competitively inhibits CH24H enzyme activity by using the 1,3-oxazole nitrogen atom to coordinate the heme iron and the cyclopropyl group occupying the hydrophobic pocket. Cholesterol 24-hydroxylase-IN-3 can be used for research on epilepsy and other neurological diseases.

HY-P2915A

Protocatechuate 3,4-Dioxygenase, Bacteria	Biochemical Assay Reagents Bacterial	Infection
Protocatechuate 3,4-Dioxygenase, Bacteria is a dioxygenase. Protocatechuate 3,4-Dioxygenase, Bacteria belongs to the non-heme iron dioxygenase class. Protocatechuate 3,4-Dioxygenase, Bacteria catalyzes the cleavage of the aromatic ring of 3,4-dihydroxybenzoate, attaching two atoms of molecular oxygen to the compound to generate β-carboxy-cis,cis-muconate. Protocatechuate 3,4-Dioxygenase, Bacteria is a key enzyme in the β-ketoadipic acid pathway. Protocatechuate 3,4-Dioxygenase, Bacteria is found in marine bacteria associated with Roseobacter. Protocatechuate 3,4-Dioxygenase, Bacteria can be isolated from Pseudomonas aeruginosa .

Cat. No.	Nombre del producto	Type

HY-B1610K

Sodium Citrate Buffer, 0.5M, pH 5.5	Biochemical Assay Reagents
Sodium Citrate Buffer, 0.5M, pH 5.5 is a metal chelator and buffering agent. Sodium Citrate Buffer, 0.5M, pH 5.5 requires oxygen to participate in the oxidation process to reduce pink defects in cooked ground turkey, and it does not function via heme iron chelation or iron complex interaction. When mixed with 50% (by vol.) 1,3-dimethylimidazolium methyl sulfate, Sodium Citrate Buffer, 0.5M, pH 5.5 can serve as an aqueous buffering medium to maintain the catalytic efficiency of the hyperthermophilic β-glycosidase CelB for lactose hydrolysis at 80°C, while also acting as a reaction medium for CelB-catalyzed lactose hydrolysis and galactosyltransferase assays .

Sodium Citrate Buffer, 0.5M, pH 5.5

Biochemical Assay Reagents

Sodium Citrate Buffer, 0.5M, pH 5.5 is a metal chelator and buffering agent. Sodium Citrate Buffer, 0.5M, pH 5.5 requires oxygen to participate in the oxidation process to reduce pink defects in cooked ground turkey, and it does not function via heme iron chelation or iron complex interaction. When mixed with 50% (by vol.) 1,3-dimethylimidazolium methyl sulfate, Sodium Citrate Buffer, 0.5M, pH 5.5 can serve as an aqueous buffering medium to maintain the catalytic efficiency of the hyperthermophilic β-glycosidase CelB for lactose hydrolysis at 80°C, while also acting as a reaction medium for CelB-catalyzed lactose hydrolysis and galactosyltransferase assays .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-W041193

3-Hydroxy-2-pyrone	Structural Classification Productos naturales Actinidia chinensis Planch. Plants Actinidiaceae Source Classification	MMP Lipoxygenase Tyrosinase
3-Hydroxy-2-pyrone (Compound 12d) is a metalloenzyme inhibitor. 3-Hydroxy-2-pyrone shows an inhibition rate of approximately 50% for matrix metalloproteinases (MMP) and the inhibition rate for non-heme iron enzyme 5-lipoxygenase (5-LOX) was over 70% at 1 mM. 3-Hydroxy-2-pyrone also has certain inhibitory activity against copper-dependent enzyme tyrosinase. 3-Hydroxy-2-pyrone can be used for the research of cancer, infection and inflammation .

HY-N12196

Terretonin	Other Monoterpenes Microorganisms Terpenoids Source Classification	Cytochrome P450
Terretonin is a fungal terpenoid isolated from Aspergillus terreus. The complete biosynthetic pathway of terretonin includes: cytochrome P450 Trt6 catalyzes the oxidation of terrenoid to obtain an unstable intermediate; then it is catalyzed by isomerase Trt14 and processed by non-heme iron-dependent dioxygenase Trt7 to complete the biosynthesis of terretonin .

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heme-iron

Inhibitors & Agonists

Biochemical Assay Reagents

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