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Results for "

intermediate type

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Intermediate (17) Amylin Receptor (1) Amyloid-β (1) Angiotensin Receptor (1) Apoptosis (2) Bacterial (2) Biochemical Assay Reagents (7) CGRP Receptor (1) Cytochrome P450 (2) Drug Metabolite (2) Endogenous Metabolite (26) ERK (2) Fluorescent Dye (2) Glucocorticoid Receptor (1) Glutathione S-transferase (1) Interleukin Related (2) Isotope-Labeled Compounds (2) Melanocortin Receptor (1) Mineralocorticoid Receptor (1) Mitosis (1) MOFs (1) NF-κB (3) Potassium Channel (1) Proteasome (1) Ras (2) Reactive Oxygen Species (ROS) (1) Reference Standards (9) Ser/Thr Protease (1) STAT (2) YAP (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (4) Endocrinology (1) Infection (2) Inflammation/Immunology (9) Metabolic Disease (29) Neurological Disease (5)
Oligonucleotides:	Cationic Lipids (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

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Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Drug Intermediate C-type Lectin-like Receptors (CTLRs) PCSK9 Scavenger Receptor Class B type I (SR-BI）

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011474

Geranylgeraniol	NF-κB	Inflammation/Immunology
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-113381

2-Hydroxybutyric acid 1 Publications Verification α-Hydroxybutyric acid	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia . 2-Hydroxybutyric acid prevents the acetaminophen (AP)-induced liver injury .

HY-126370A

Geranylgeranyl pyrophosphate triammonium	Endogenous Metabolite YAP Apoptosis Interleukin Related STAT ERK Ras	Cancer
Geranylgeranyl pyrophosphate triammonium is a type of isoprenoid metabolic intermediate, mainly synthesized through the mevalonate pathway. Geranylgeranyl pyrophosphate triammonium is a key precursor in various biological synthesis processes, especially as a necessary substrate for post-translational modification of proteins - geranylgeranyl phosphorylation. Geranylgeranyl pyrophosphate triammonium regulates various cellular processes and disease progression through protein geranylgeranyl phosphorylation, such as activating the YAP signaling pathway, promoting cell proliferation and inhibiting apoptosis; promoting IL-2 production and STAT5 phosphorylation; and influencing metabolic homeostasis and cancer, etc .

HY-113166

Dodecanoylcarnitine 1 Publications Verification (-)-Lauroylcarnitine	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome .

HY-113004

3-Hydroxyvaleric acid	Endogenous Metabolite	Metabolic Disease
3-Hydroxyvaleric acid is a five-carbon ketone body byproduct that can undergo an anaplerotic reaction to replenish the intermediates of the tricarboxylic acid cycle. 3-Hydroxyvaleric acid is one of the important monomers for the synthesis of polyhydroxyalkanoates (PHA). PHA is a type of biodegradable plastic that is widely used in environmentally friendly packaging, disposable products, and medical materials .

HY-151424

Vimentin-IN-1	Proteasome Mitosis	Cancer
Vimentin-IN-1 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin (VIM), to induce hyperphosphorylation of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Vimentin-IN-1 shows better oral bioavailability and pharmacokinetic profiles than FiVe1 .

HY-W008820

Glutaric acid	MOFs Endogenous Metabolite	Metabolic Disease
Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-W010040

4-Hydroxyphenylpyruvic acid 1 Publications Verification	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase (HPPA). 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria .

HY-34596

4-Hydroxyindole	Biochemical Assay Reagents Amyloid-β	Neurological Disease Metabolic Disease
4-Hydroxyindole is a type of hydroxyindole in which the 1H-indole at position 4 is substituted by a hydroxyl group. 4-Hydroxyindole serves as an important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. 4-Hydroxyindole inhibits amyloid fibrillization and induces liver function impairment, thyroid abnormalities, and blood glucose fluctuations in mice. 4-Hydroxyindole holds potential for research in neurodegenerative diseases and metabolic disorders .

HY-W002339

3-Hydroxy-2-methylpyridine	Drug Intermediate	Others
3-Hydroxy-2-methylpyridine is a pharmaceutical intermediate that can be used in the synthesis of pyrimidines. 3-Hydroxy-2-methylpyridine acts as a corrosion inhibitor, serving as a mixed-type corrosion inhibitor for carbon steel in HCl medium .

HY-Y0973

BOP hexafluorophosphate	Biochemical Assay Reagents Drug Intermediate	Others
BOP hexafluorophosphate is a phosphonium-type condensing agent. BOP hexafluorophosphate activates the carboxylic acid component to form a highly reactive O-benzotriazole ester (active ester) intermediate, which then reacts with the amino component to form an amide bond (peptide bond). BOP hexafluorophosphate is applicable to solid-phase polypeptide synthesis and nucleoside modification .

HY-126370

Geranylgeranyl pyrophosphate	Endogenous Metabolite YAP Apoptosis Interleukin Related STAT ERK Ras	Cancer
Geranylgeranyl pyrophosphate is a type of isoprenoid metabolic intermediate, mainly synthesized through the mevalonate pathway. Geranylgeranyl pyrophosphate is a key precursor in various biological synthesis processes, especially as a necessary substrate for post-translational modification of proteins - geranylgeranyl phosphorylation. Geranylgeranyl pyrophosphate regulates various cellular processes and disease progression through protein geranylgeranyl phosphorylation, such as activating the YAP signaling pathway, promoting cell proliferation and inhibiting apoptosis; promoting IL-2 production and STAT5 phosphorylation; and influencing metabolic homeostasis and cancer, etc .

HY-W008820S

Glutaric acid-d6 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Glutaric acid-d₆ is the deuterium labeled Glutaric acid. Glutaric acid is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-N0348

Dexamethasone 9,11-epoxide	Glucocorticoid Receptor Drug Intermediate	Inflammation/Immunology
Dexamethasone 9,11-epoxide is a type of glucocorticoid. Dexamethasone 9,11-epoxide can be used as a drug intermediate to prepare Dexamethasone (HY-14648) and Betamethasone (HY-13570). Dexamethasone 9,11-epoxide can be employed in the research of inflammation and immune diseases .

HY-W012790

Sodium 2-hydroxybutanoate 1 Publications Verification 2-Hydroxybutyric acid sodium	Endogenous Metabolite	Metabolic Disease
Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-W587796

6-Phosphoglucono-δ-lactone 6-PGδL; 6-Phosphonoglucono-D-lactone	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Cancer
6-Phosphoglucono-δ-lactone (6-PGδL), a reversal substrate of glucose-6-phosphate dehydrogenase (G6PD), is an intermediate compound in the oxidative branch of the pentose phosphate pathway (PPP). 6-Phosphoglucono-δ-lactone produced from D-glucose-6-phosphate by glucose-6-phosphate dehydrogenase (G6PDH) and is converted to 6-phosphoglutonate by lactonase. 6-Phosphoglucono-δ-lactone can be used for heart failure, type 2 diabetes and cancers research .

HY-CE02028

Glutaconyl-CoA Glutaconyl-coenzyme A	Endogenous Metabolite	Metabolic Disease
Glutaconyl-CoA (Glutaconyl-coenzyme A) is a key metabolic intermediate in the mitochondrial catabolic pathways of lysine, hydroxylysine and tryptophan. Glutaconyl-CoA competitively inhibits wild-type glutaryl-CoA dehydrogenase (GCDH) with a K_i value of 1.1 µM. Glutaconyl-CoA is generated via the oxidative decarboxylation of glutaryl-CoA catalyzed by GCDH, and is subsequently further metabolized. Glutaconyl-CoA can be used in the research of type I glutaric aciduria .

HY-W130074

α-Pinene oxide	Endogenous Metabolite Drug Intermediate Cytochrome P450	Metabolic Disease
α-Pinene oxide is a type of monoterpene epoxidation intermediate. α-Pinene oxide is produced via the cytochrome P-450-mediated oxidation pathway in Dendroctonus terebrans body microsomes and rat liver microsomes, and can be further converted into alcohols, ketones and insect pheromone derivatives. α-Pinene oxide can generate the perfume intermediate myrtenal. α-Pinene oxide is used in studies related to terpenoid metabolism and perfume synthesis .

HY-114327

D-Ribose 1,5-diphosphate R15P	Endogenous Metabolite Drug Intermediate Biochemical Assay Reagents	Others
D-Ribose 1,5-diphosphate (R15P) is a metabolic intermediate and enzyme substrate. Purified Tk-E2b2 converts D-Ribose 1,5-diphosphate into Ribulose-1,5-bisphosphate, with a specific activity of 32.3 μmol min ^-1 mg ^-1[1] .

HY-164804

N-Lactylvaline	Endogenous Metabolite	Metabolic Disease
N-Lactylvaline is an endogenous metabolite that can be identified in patients with the intermediate type of maple syrup urine disease .

HY-W035904

Tropone Cycloheptatrienone	Drug Intermediate	Others
Tropone (Cycloheptatrienone) is a non-benzene aromatic natural product and a derivative of a tropane-type compound. Tropone is the direct precursor of various tropane-type natural products, such as Tropolone (HY-N7135) and Tropodithietic acid (HY-N6705), and can be used as a drug intermediate in their biosynthesis .

HY-W011474R

Geranylgeraniol (Standard)	Reference Standards NF-κB	Inflammation/Immunology
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-W003222

N-tert-Boc-cis-4-fluoro-L-proline	Drug Intermediate	Metabolic Disease
N-tert-Boc-cis-4-fluoro-L-proline (Compound 11) is a drug intermediate for the synthesis of 4-fluoropyrrolidine-2-carbonitrile DPP-4 inhibitor. N-tert-Boc-cis-4-fluoro-L-proline can be used to study type 2 diabetes .

HY-W015229R

3-Indolepropionic acid (Standard) Indole-3-propionic acid (Standard); 3-IPA (Standard)	Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease
3-Indolepropionic acid (Standard) is the analytical standard of 3-Indolepropionic acid. This product is intended for research and analytical applications. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease. In Vitro: 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease . 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds . It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function .

HY-164805

N-Lactylleucine	Endogenous Metabolite	Others
N-Lactylleucine is an endogenous metabolite that can be identified in patients with the intermediate type of maple syrup urine disease .

HY-W002734

(3-Hydroxyphenyl)boronic acid 3-Hydroxybenzeneboronic acid	Drug Intermediate	Endocrinology
(3-Hydroxyphenyl)boronic acid (3-Hydroxybenzeneboronic acid) is a drug intermediate that can be used for the synthesis of 17β-hydroxysteroid dehydrogenase type 1 inhibitors .

HY-44087

Ethyl (E)-3-(1-pyrrolidinyl)crotonate	Drug Intermediate	Others
Ethyl (E)-3-(1-pyrrolidinyl)crotonate is an organic synthetic intermediate of the enamine ester type. Ethyl (E)-3-(1-pyrrolidinyl)crotonate has a stable structure and strong reactivity, and is mainly used for the construction of heterocyclic compounds and drug molecules.

HY-W010040R

4-Hydroxyphenylpyruvic acid (Standard)	Reference Standards Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
4-Hydroxyphenylpyruvic acid (Standard) is the analytical standard of 4-Hydroxyphenylpyruvic acid (HY-W010040). This product is intended for research and analytical applications. 4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase (HPPA). 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria .

HY-W014226

4,4'-Dihydroxybenzophenone	Drug Intermediate Ser/Thr Protease	Others
4,4'-Dihydroxybenzophenone is a type of phenolic ultraviolet absorber and a drug intermediate for synthesis of various anticancer active compounds (such as Sivifene (HY-14801)). 4,4'-Dihydroxybenzophenone binds to the active site of trypsin with binding constants (K_A = 7.59 x 10 ⁵ L/moL) and leads to abnormal structure of trypsin, suggesting that long-term intake may affect the digestive function of the human body. 4,4’-dihydroxybenzophenone has a relatively low toxicity to Chlorella vulgaris and a moderate toxicity to Daphnia magna .

HY-W008820R

Glutaric acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I . In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM .

HY-W008820S1

Glutaric acid-d4	Endogenous Metabolite	Metabolic Disease
Glutaric acid-d₄ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-W012790S

Sodium 2-hydroxybutanoate-d3	Endogenous Metabolite	Metabolic Disease
Sodium 2-hydroxybutanoate-d₃ is the deuterium labeled Sodium 2-hydroxybutanoate . Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-77642

4-(Methylsulfonyl)phenylboronic acid	Biochemical Assay Reagents Drug Intermediate	Metabolic Disease
4-(Methylsulfonyl)phenylboronic acid is an intermediate. 4-(Methylsulfonyl)phenylboronic acid can be used to synthesize GPR119 agonists via Suzuki coupling reaction. 4-(Methylsulfonyl)phenylboronic acid can be used in the research of type 2 diabetes .

HY-59320

4-Thiazolecarboxylic acid	Biochemical Assay Reagents Drug Intermediate	Metabolic Disease
4-Thiazolecarboxylic acid (Compound 1e) is an intermediate. 4-Thiazolecarboxylic acid can be used in the synthesis of MGL-IN-2 (HY-177534). MGL-IN-2 inhibits wild-type MGL enzyme activity with an IC₅₀ of 0.0121 μM. 4-Thiazolecarboxylic acid can be used in the research of metabolic diseases .

HY-165569

AU-1421	Potassium Channel	Neurological Disease
AU-1421 is a potassium ion (K⁺) site-directed regulator that specifically acts on various cation transport ATPases. AU-1421 can distinguish between two different K⁺-sensitive phosphorylation intermediate (E2P) states: for non-K⁺ transport type ATPases (such as the sarcoplasmic reticulum Ca²⁺-ATPase), after binding to AU-1421, it mimics the agonistic effect of K⁺, significantly accelerating the hydrolysis (dephosphorylation) of E2P. For K⁺ transport type ATPases (such as the gastric mucosa H⁺/K⁺-ATPase and the renal Na⁺/K⁺-ATPase), after binding to AU-1421, it inhibits the hydrolysis of E2P, stabilizing the phosphorylated intermediate, thereby blocking the ion transport cycle. AU-1421 can be used to study the mechanism of the potassium ion pump .

HY-W019780

Bromodichloromethane Dichlorobromomethane	Glutathione S-transferase	Metabolic Disease Cancer
Bromodichloromethane (Dichlorobromomethane) is a type of trihalomethane, commonly found in chlorinated drinking water for disinfection, and is a disinfection by-product. The bromination of bromodichloromethane can cause the formation of mutagenic intermediates through the transformation mediated by glutathione S-transferase (GST). Bromodichloromethane inhibits the differentiation of human placental trophoblast cells and reduces the secretion of chorionic gonadotropin (CG). Bromodichloromethane has potential reproductive toxicity and carcinogenicity .

HY-P2883A

Recombinant Human Keratin2	Biochemical Assay Reagents	Others
Recombinant Human Keratin2 is a type II or neutral basic keratin intermediate filament protein that protects against collagen loss .

HY-W011474S

Geranylgeraniol-d5	Isotope-Labeled Compounds NF-κB	Inflammation/Immunology
Geranylgeraniol-d₅ is the deuterium labeled Geranylgeraniol (HY-W011474). Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-W012790R

Sodium 2-hydroxybutanoate (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Sodium 2-hydroxybutanoate is an endogenous metabolite. Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-113004R

3-Hydroxyvaleric acid (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease
3-Hydroxyvaleric acid (Standard) is the analytical standard of 3-Hydroxyvaleric acid. This product is intended for research and analytical applications. 3-Hydroxyvaleric acid is a five-carbon ketone body byproduct that can undergo an anaplerotic reaction to replenish the intermediates of the tricarboxylic acid cycle. 3-Hydroxyvaleric acid is one of the important monomers for the synthesis of polyhydroxyalkanoates (PHA). PHA is a type of biodegradable plastic that is widely used in environmentally friendly packaging, disposable products, and medical materials .

HY-W205529

RO 16-6491 free base	Fluorescent Dye	Neurological Disease
RO 16-6491 Free base is a selective, reversible inhibitor of monoamine oxidase type B (MAO-B), exhibiting high affinity and specificity for binding sites in human frontal cortex mitochondria and platelet membranes. RO 16-6491 demonstrates a fast dissociation of bound radioactivity at 20 degrees C, indicating its dynamic binding properties. RO 16-6491 also acts as a substrate for MAO-B, suggesting that its oxidation may produce a stable intermediate responsible for its potent inhibitory effects. RO 16-6491 serves as an excellent radioligand probe for investigating the regional tissue distribution of MAO-B in various physiological and pathological states.

HY-W738639

18-Hydroxy-11-deoxy corticosterone 18-OH-DOC; 11-Deoxy-18-hydroxycorticosterone	Melanocortin Receptor Angiotensin Receptor Drug Metabolite Mineralocorticoid Receptor	Cardiovascular Disease Metabolic Disease
18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields .

HY-113166R

Dodecanoylcarnitine (Standard) (-)-Lauroylcarnitine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Dodecanoylcarnitine (Standard) is the analytical standard of Dodecanoylcarnitine (HY-113166). This product is intended for research and analytical applications. Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome .

HY-22204

3,2'-Dihydroxyflavone	Drug Intermediate	Others
3,2'-Dihydroxyflavone (Compound 4) is a type of flavonol compound that can be used as a drug intermediate for the synthesis of tetracyclic compounds .

HY-176028

N-Stearoyl-DPPE ammonium NAPE(16:0/16:0/18:0); N-Stearoyl-1,3-dipalmitoyl-3-PE	Drug Intermediate	Inflammation/Immunology
N-Stearoyl-DPPE ammonium is a type of N-acylphosphatidylethanolamine (NAPE). N-Stearoyl-DPPE ammonium is an important intermediate in the endocannabinoid biosynthesis pathway .

HY-N17787

Labdanolic acid	Drug Intermediate	Inflammation/Immunology
Labdanolic acid is a labdane-type diterpenoid compound that can be isolated from Cistus ladaniferus, a plant growing in Portugal. Labdanolic acid is a key intermediate in the synthesis of anti-inflammatory molecules and has both medicinal and industrial applications .

HY-W008820S2

Glutaric acid-d2	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Glutaric acid-d₂ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-W035904R

Tropone (Standard) Cycloheptatrienone (Standard)	Drug Intermediate Reference Standards	Others
Tropone (Standard) is the analytical standard of Tropone (HY-W035904). This product is intended for research and analytical applications. Tropone (Cycloheptatrienone) is a non-benzene aromatic natural product and a derivative of a tropane-type compound. Tropone is the direct precursor of various tropane-type natural products, such as Tropolone (HY-N7135) and Tropodithietic acid (HY-N6705), and can be used as a drug intermediate in their biosynthesis .

HY-W738465

N,N-Dimethylamidino Urea N-Carbonylguanidine	Endogenous Metabolite	Metabolic Disease
N,N-Dimethylamidino Urea (N-Carbonylguanidine) is an intermediate in the electrochemical oxidation of Metformin (HY-B0627). Metformin can be used in the study of type 2 diabetes. N,N-Dimethylamidino Urea can be used as a marker to study the metabolic pathway of metformin in vivo .

HY-185226

γ-Linolenic acid NHS ester	Drug Metabolite	Cancer
γ-Linolenic acid NHS ester is a lipid metabolite of γ-Linolenic acid (GLA) (HY-N7140), which can serve as a synthetic intermediate or probe labeling reagent for the preparation of GLA conjugates. In practical applications, γ-Linolenic acid NHS ester can be conjugated with taxanes and polysaccharides to form dual-type conjugates for drug delivery purposes .

Cat. No.	Product Name

HY-L123

Human Metabolite Library

6,744 compounds

Human metabolism is an integral part of cellular function that reflects individual differences in health, disease, diet, and lifestyle. Many health conditions such as obesity, diabetes, hypertension, heart disease, and cancer are associated with abnormal metabolic states. In the pathological state of the human body, metabolic pathways are significantly altered, resulting in aberrant levels of intermediates or end-products that can be viewed as potential diagnostic biomarkers or even therapeutic targets. Therefore, detection, identification and quantification of human metabolites are very important for drug metabolism research in drug development.

MCE offers a unique collection of 6,744 human metabolites, including endogenous metabolites and exogenous metabolites, covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins,. MCE Human Metabolites Library is a helpful tool for studying the relationship between diseases and metabolism.

Cat. No.	Product Name	Type

HY-D1737

RADA

Fluorescent Dyes

RADA is a fluorescent D-amino acid (FDAA) with high photostability and thermostability, which emits yellow-to-orange fluorescence. RADA shows low outer membrane permeability in wild-type Gram-negative Escherichia coli, but it targets penicillin-binding proteins and L,D-transpeptidases, mimics the interaction between acyl acceptors and enzyme intermediates, and integrates into peptidoglycan during biosynthesis. As a peptidoglycan labeling reagent, RADA metabolically integrates into the nascent peptidoglycan of live bacterial cells, labels the peptidoglycan at the poles and lateral walls of mycobacteria, and enables visualization of peptidoglycan synthesis and remodeling processes. RADA serves as a non-specific stain for fixed cells, is non-toxic to bacterial cells, and its red-shifted excitation/emission spectra reduce phototoxicity. RADA also supports virtual pulse-chase labeling experiments and stochastic optical reconstruction microscopy for sub-diffraction-limited imaging of bacterial cell walls .

Cat. No.	Product Name	Type

HY-Y0973

BOP hexafluorophosphate	Biochemical Assay Reagents
BOP hexafluorophosphate is a phosphonium-type condensing agent. BOP hexafluorophosphate activates the carboxylic acid component to form a highly reactive O-benzotriazole ester (active ester) intermediate, which then reacts with the amino component to form an amide bond (peptide bond). BOP hexafluorophosphate is applicable to solid-phase polypeptide synthesis and nucleoside modification .

HY-W002734

(3-Hydroxyphenyl)boronic acid 3-Hydroxybenzeneboronic acid	Biochemical Assay Reagents
(3-Hydroxyphenyl)boronic acid (3-Hydroxybenzeneboronic acid) is a drug intermediate that can be used for the synthesis of 17β-hydroxysteroid dehydrogenase type 1 inhibitors .

HY-44087

Ethyl (E)-3-(1-pyrrolidinyl)crotonate	Biochemical Assay Reagents
Ethyl (E)-3-(1-pyrrolidinyl)crotonate is an organic synthetic intermediate of the enamine ester type. Ethyl (E)-3-(1-pyrrolidinyl)crotonate has a stable structure and strong reactivity, and is mainly used for the construction of heterocyclic compounds and drug molecules.

HY-W014226

4,4'-Dihydroxybenzophenone

Biochemical Assay Reagents

4,4'-Dihydroxybenzophenone is a type of phenolic ultraviolet absorber and a drug intermediate for synthesis of various anticancer active compounds (such as Sivifene (HY-14801)). 4,4'-Dihydroxybenzophenone binds to the active site of trypsin with binding constants (K_A = 7.59 x 10 ⁵ L/moL) and leads to abnormal structure of trypsin, suggesting that long-term intake may affect the digestive function of the human body. 4,4’-dihydroxybenzophenone has a relatively low toxicity to Chlorella vulgaris and a moderate toxicity to Daphnia magna .

HY-77642

4-(Methylsulfonyl)phenylboronic acid	Biochemical Assay Reagents
4-(Methylsulfonyl)phenylboronic acid is an intermediate. 4-(Methylsulfonyl)phenylboronic acid can be used to synthesize GPR119 agonists via Suzuki coupling reaction. 4-(Methylsulfonyl)phenylboronic acid can be used in the research of type 2 diabetes .

HY-59320

4-Thiazolecarboxylic acid	Biochemical Assay Reagents
4-Thiazolecarboxylic acid (Compound 1e) is an intermediate. 4-Thiazolecarboxylic acid can be used in the synthesis of MGL-IN-2 (HY-177534). MGL-IN-2 inhibits wild-type MGL enzyme activity with an IC₅₀ of 0.0121 μM. 4-Thiazolecarboxylic acid can be used in the research of metabolic diseases .

HY-P2883A

Recombinant Human Keratin2	Biochemical Assay Reagents
Recombinant Human Keratin2 is a type II or neutral basic keratin intermediate filament protein that protects against collagen loss .

Cat. No.	Product Name	Target	Research Area

HY-138126

Dansyl-Tyr-Val-Gly	Peptides	Others
Dansyl-Tyr-Val-Gly is a substrate of peptidylglycine monooxygenase (PHM), with a K_D of 22 μM for PHM. Dansyl-Tyr-Val-Gly can be used to investigate the catalytic mechanism, kinetics and inactivation characteristics of PHM .

HY-164804

N-Lactylvaline	Endogenous Metabolite	Metabolic Disease
N-Lactylvaline is an endogenous metabolite that can be identified in patients with the intermediate type of maple syrup urine disease .

HY-W003222

N-tert-Boc-cis-4-fluoro-L-proline	Drug Intermediate	Metabolic Disease
N-tert-Boc-cis-4-fluoro-L-proline (Compound 11) is a drug intermediate for the synthesis of 4-fluoropyrrolidine-2-carbonitrile DPP-4 inhibitor. N-tert-Boc-cis-4-fluoro-L-proline can be used to study type 2 diabetes .

HY-164805

N-Lactylleucine	Endogenous Metabolite	Others
N-Lactylleucine is an endogenous metabolite that can be identified in patients with the intermediate type of maple syrup urine disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W011474

Geranylgeraniol	Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-113381

2-Hydroxybutyric acid 1 Publications Verification α-Hydroxybutyric acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Source Classification	Endogenous Metabolite
2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia . 2-Hydroxybutyric acid prevents the acetaminophen (AP)-induced liver injury .

HY-126370A

Geranylgeranyl pyrophosphate triammonium	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite YAP Apoptosis Interleukin Related STAT ERK Ras
Geranylgeranyl pyrophosphate triammonium is a type of isoprenoid metabolic intermediate, mainly synthesized through the mevalonate pathway. Geranylgeranyl pyrophosphate triammonium is a key precursor in various biological synthesis processes, especially as a necessary substrate for post-translational modification of proteins - geranylgeranyl phosphorylation. Geranylgeranyl pyrophosphate triammonium regulates various cellular processes and disease progression through protein geranylgeranyl phosphorylation, such as activating the YAP signaling pathway, promoting cell proliferation and inhibiting apoptosis; promoting IL-2 production and STAT5 phosphorylation; and influencing metabolic homeostasis and cancer, etc .

HY-113166

Dodecanoylcarnitine 1 Publications Verification (-)-Lauroylcarnitine	Structural Classification Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome .

HY-113004

3-Hydroxyvaleric acid	Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-Hydroxyvaleric acid is a five-carbon ketone body byproduct that can undergo an anaplerotic reaction to replenish the intermediates of the tricarboxylic acid cycle. 3-Hydroxyvaleric acid is one of the important monomers for the synthesis of polyhydroxyalkanoates (PHA). PHA is a type of biodegradable plastic that is widely used in environmentally friendly packaging, disposable products, and medical materials .

HY-W008820

Glutaric acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	MOFs Endogenous Metabolite
Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-W010040

4-Hydroxyphenylpyruvic acid 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase (HPPA). 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria .

HY-W002339

3-Hydroxy-2-methylpyridine	Alkaloids Structural Classification other families Classification of Application Fields Leguminosae Other Diseases Pyridine Alkaloids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Source Classification	Drug Intermediate
3-Hydroxy-2-methylpyridine is a pharmaceutical intermediate that can be used in the synthesis of pyrimidines. 3-Hydroxy-2-methylpyridine acts as a corrosion inhibitor, serving as a mixed-type corrosion inhibitor for carbon steel in HCl medium .

HY-126370

Geranylgeranyl pyrophosphate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite YAP Apoptosis Interleukin Related STAT ERK Ras
Geranylgeranyl pyrophosphate is a type of isoprenoid metabolic intermediate, mainly synthesized through the mevalonate pathway. Geranylgeranyl pyrophosphate is a key precursor in various biological synthesis processes, especially as a necessary substrate for post-translational modification of proteins - geranylgeranyl phosphorylation. Geranylgeranyl pyrophosphate regulates various cellular processes and disease progression through protein geranylgeranyl phosphorylation, such as activating the YAP signaling pathway, promoting cell proliferation and inhibiting apoptosis; promoting IL-2 production and STAT5 phosphorylation; and influencing metabolic homeostasis and cancer, etc .

HY-W012790

Sodium 2-hydroxybutanoate 1 Publications Verification 2-Hydroxybutyric acid sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-W130074

α-Pinene oxide	Structural Classification Natural Products Pinaceae Picea abies (L.) H. Karsten Plants Source Classification	Endogenous Metabolite Drug Intermediate Cytochrome P450
α-Pinene oxide is a type of monoterpene epoxidation intermediate. α-Pinene oxide is produced via the cytochrome P-450-mediated oxidation pathway in Dendroctonus terebrans body microsomes and rat liver microsomes, and can be further converted into alcohols, ketones and insect pheromone derivatives. α-Pinene oxide can generate the perfume intermediate myrtenal. α-Pinene oxide is used in studies related to terpenoid metabolism and perfume synthesis .

HY-114327

D-Ribose 1,5-diphosphate R15P	Microorganisms Source Classification	Endogenous Metabolite Drug Intermediate Biochemical Assay Reagents
D-Ribose 1,5-diphosphate (R15P) is a metabolic intermediate and enzyme substrate. Purified Tk-E2b2 converts D-Ribose 1,5-diphosphate into Ribulose-1,5-bisphosphate, with a specific activity of 32.3 μmol min ^-1 mg ^-1[1] .

HY-W035904

Tropone Cycloheptatrienone	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields Source Classification	Drug Intermediate
Tropone (Cycloheptatrienone) is a non-benzene aromatic natural product and a derivative of a tropane-type compound. Tropone is the direct precursor of various tropane-type natural products, such as Tropolone (HY-N7135) and Tropodithietic acid (HY-N6705), and can be used as a drug intermediate in their biosynthesis .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	Reference Standards NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-W015229R

3-Indolepropionic acid (Standard) Indole-3-propionic acid (Standard); 3-IPA (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS)
3-Indolepropionic acid (Standard) is the analytical standard of 3-Indolepropionic acid. This product is intended for research and analytical applications. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease. In Vitro: 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease . 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds . It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function .

HY-W010040R

4-Hydroxyphenylpyruvic acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
4-Hydroxyphenylpyruvic acid (Standard) is the analytical standard of 4-Hydroxyphenylpyruvic acid (HY-W010040). This product is intended for research and analytical applications. 4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase (HPPA). 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria .

HY-W008820R

Glutaric acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I . In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM .

HY-W012790R

Sodium 2-hydroxybutanoate (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Sodium 2-hydroxybutanoate is an endogenous metabolite. Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-113004R

3-Hydroxyvaleric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
3-Hydroxyvaleric acid (Standard) is the analytical standard of 3-Hydroxyvaleric acid. This product is intended for research and analytical applications. 3-Hydroxyvaleric acid is a five-carbon ketone body byproduct that can undergo an anaplerotic reaction to replenish the intermediates of the tricarboxylic acid cycle. 3-Hydroxyvaleric acid is one of the important monomers for the synthesis of polyhydroxyalkanoates (PHA). PHA is a type of biodegradable plastic that is widely used in environmentally friendly packaging, disposable products, and medical materials .

HY-113166R

Dodecanoylcarnitine (Standard) (-)-Lauroylcarnitine (Standard)	Structural Classification Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Dodecanoylcarnitine (Standard) is the analytical standard of Dodecanoylcarnitine (HY-113166). This product is intended for research and analytical applications. Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome .

HY-N17787

Labdanolic acid	Structural Classification Ketones, Aldehydes, Acids Talinum calycinum Engelm. in Wisl. Plants Talinaceae Source Classification	Drug Intermediate
Labdanolic acid is a labdane-type diterpenoid compound that can be isolated from Cistus ladaniferus, a plant growing in Portugal. Labdanolic acid is a key intermediate in the synthesis of anti-inflammatory molecules and has both medicinal and industrial applications .

HY-W035904R

Tropone (Standard) Cycloheptatrienone (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Plants Source Classification	Drug Intermediate Reference Standards
Tropone (Standard) is the analytical standard of Tropone (HY-W035904). This product is intended for research and analytical applications. Tropone (Cycloheptatrienone) is a non-benzene aromatic natural product and a derivative of a tropane-type compound. Tropone is the direct precursor of various tropane-type natural products, such as Tropolone (HY-N7135) and Tropodithietic acid (HY-N6705), and can be used as a drug intermediate in their biosynthesis .

HY-W130074R

α-Pinene oxide (Standard)	Structural Classification Natural Products Pinaceae Picea abies (L.) H. Karsten Plants Source Classification	Reference Standards Endogenous Metabolite Drug Intermediate Cytochrome P450
α-Pinene oxide (Standard) is the analytical standard of α-Pinene oxide (HY-W130074). This product is intended for research and analytical applications. α-Pinene oxide is a type of monoterpene epoxidation intermediate. α-Pinene oxide is produced via the cytochrome P-450-mediated oxidation pathway in Dendroctonus terebrans body microsomes and rat liver microsomes, and can be further converted into alcohols, ketones and insect pheromone derivatives. α-Pinene oxide can generate the perfume intermediate myrtenal. α-Pinene oxide is used in studies related to terpenoid metabolism and perfume synthesis .

Cat. No.	Product Name	Chemical Structure

HY-W008820S

Glutaric acid-d6 1 Publications Verification
Glutaric acid-d₆ is the deuterium labeled Glutaric acid. Glutaric acid is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-W008820S1

Glutaric acid-d4
Glutaric acid-d₄ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

HY-W012790S

Sodium 2-hydroxybutanoate-d3

Sodium 2-hydroxybutanoate-d₃ is the deuterium labeled Sodium 2-hydroxybutanoate . Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-W011474S

Geranylgeraniol-d5
Geranylgeraniol-d₅ is the deuterium labeled Geranylgeraniol (HY-W011474). Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-W008820S2

Glutaric acid-d2
Glutaric acid-d₂ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .

Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Mouse (1)
Application:	IHC-P (4) ICC/IF (4) IHC-F (3) WB (4) FC (2) ELISA (3)
Isotype:	IgG (3) IgG1 (1)
Conjugation:	Non-conjugated (4)
Clonality:	Polyclonal (2) Monoclonal (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81183

	Cytokeratin 19 Antibody 40 kDa keratin intermediate filament; CK 19; ck19; CK19; CK-19; KRT19; Cytokeratin19; Cytokeratin-19; k19; k1cs; Keratin 19; Keratin-19; Keratin type I 40 kD; Keratin type i 40kD; Keratin type I cytoskeletal 19; krt19; mgc15366; K1C19_HUMAN; Keratin, type I cytoskeletal 19; Keratin, type I, 40 kd.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human
	Cytokeratin 19 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Cytokeratin 19.

HY-P85943

	Cytokeratin 19/10 Antibody (YA5635) 40 kDa keRatin intermediate filament; CK 19; CK-19; CK19; Cytokeratin 19; CytokeRatin-19; K19; K1C19_HUMAN; K1CS; KeRatin 19; KeRatin type I 40 kD; KeRatin type I 40kD; KeRatin type I cytoskeletal 19; KeRatin, type I cytoskeletal 19; KeRatin, type I, 40 kd; KeRatin-19; KRT19; MGC15366	IHC-P, WB, ICC/IF, ELISA	Human
	Cytokeratin 19/10 Antibody (YA5635) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytokeratin 19/10.

HY-P81183A

	Cytokeratin 19 Antibody(PBS only) 40 kDa keratin intermediate filament; CK 19; ck19; CK19; CK-19; KRT19; Cytokeratin19; Cytokeratin-19; k19; k1cs; Keratin 19; Keratin-19; Keratin type I 40 kD; Keratin type i 40kD; Keratin type I cytoskeletal 19; krt19; mgc15366; K1C19_HUMAN; Keratin, type I cytoskeletal 19; Keratin, type I, 40 kd.	WB, IHC-P, IHC-F, ICC/IF, FC, ELISA	Human, Mouse
	Cytokeratin 19 Antibody(PBS only) is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Cytokeratin 19.

HY-P81250

	Cytokeratin 19 Antibody (YA924) 40 kDa keratin intermediate filament; CK 19; ck19; CK19; CK-19; KRT19; Cytokeratin19; Cytokeratin-19; k19; k1cs; Keratin 19; Keratin-19; Keratin type I 40 kD; Keratin type i 40kD; Keratin type I cytoskeletal 19; krt19; mgc15366; K1C19_HUMAN; Keratin, type I cytoskeletal 19; Keratin, type I, 40 kd	WB, IHC-P, IHC-F, ICC/IF	Human
	Cytokeratin 19 Antibody (YA924) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 19.

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Cat. No.	Product Name		Classification

HY-113166

Dodecanoylcarnitine 1 Publications Verification (-)-Lauroylcarnitine		Cationic Lipids
Dodecanoylcarnitine ((-)-Lauroylcarnitine) is a medium long-chain acylcarnitine, an intermediate product in key energy metabolic pathways of fatty acid β-oxidation and amino acids catabolism. The abnormal decrease in the Dodecanoylcarnitine levels indicats that mitochondrial fuel metabolism, including fatty acid oxidation is significantly disturbed. Changes in plasma concentrations of Dodecanoylcarnitine are not only associated with type II diabetes, but also with pre-diabetes status. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease. Dodecanoylcarnitine deomonstrates high sensitivities and specificities in predicting asthma. Combined model of Decanoylcarnitine (HY-113069), Dodecanoylcarnitine, PC (16:0/0:0), and Asp Arg Pro can be used as a potential biomarker for the diagnosis of Yin-deficiency-heat syndrome .

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