Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
184 Results for "
nuclear transcription
" in MedChemExpress (MCE) Product Catalog:
Products (184)
184 Results for "nuclear transcription" in MCE Product Catalog:
162
162 Publications Verification
Target:
Research Areas:
JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .
150
150 Cited Publications
Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA
13
Target:
Research Areas:
Darolutamide (ODM-201) is an orally active competitive androgen receptor (AR) antagonist. Darolutamide has a Ki of 11 nM for rat wild-type AR (wtAR) and IC50 of 26 nM for human wild-type AR (hAR)-mediated transcriptional activation . Darolutamide inhibits testosterone-induced AR nuclear translocation and transcriptional activation . Darolutamide exerts selective effects on AR-positive cells by inhibiting AR-dependent signaling pathways, and its active metabolite retains full antagonistic activity against AR mutants . Darolutamide can be used for the research of prostate cancer, including androgen receptor-dependent prostate cancer .
9
9 Cited Publications
Synonyms: Isoquercetin; Quercetin 3-glucoside
Category:
Flavonols Flavonoids Phenols Polyphenols Plants Apocynum venetum Linn. Disease Research Fields Cancer Apocynaceae Extract
Target:
8
8 Cited Publications
AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML) .
7
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 . Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM .
7
7 Cited Publications
Cat. No.: HY-N0010
CAS No.: 27741-01-1
Category:
Iridoids Terpenoids Plants Other Families Extract Endogenous metabolite Disease Research Fields Cancer
Target:
6
6 Cited Publications
Research Areas:
XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections .
5
5 Cited Publications
Cat. No.: HY-N0866
CAS No.: 54706-99-9
Category:
Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Plants Disease Research Fields Inflammation/Immunology Euphorbiaceae Extract
Target:
5
PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle . CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.
4
4 Cited Publications
Cat. No.: HY-N2593
CAS No.: 32507-66-7
4
4 Cited Publications
Cat. No.: HY-P81238
Synonyms: Phospho-NF-KB p65 (Ser536) ;
NF-kB p65 (phospho S536); p-NF-κB p65(Phospho-Ser536); RELA(phospho S536); NF kB P65; NF-kB p65; NFKBp65; NF-κBp65; p65 NF kappaB; p65 NFkB; NFKBp65; RELA; transcription Factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; nuclear Factor NF Kappa B p65 Subunit; nuclear factor of kappa light polypeptide gene enhancer in B cells 3; nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B Cells; TF65_HUMAN. NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;
3
3 Cited Publications
Synonyms: Abequolixron
Target:
Research Areas:
RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
3
3 Cited Publications
Target:
Research Areas:
CCG-100602 is a specific inhibitor of myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) signaling. CCG-100602 specifically block MRTF-A nuclear localization and thus inhibit the fibrogenic transcription factor SRF .
3
3 Cited Publications
Cat. No.: HY-P1832A
Research Areas:
3
3 Cited Publications
Cat. No.: HY-P73681
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: RELA; NF-Kappa-B transcription Factor P65; Prev. NFKB3; P65 Iso5 Isoform Delta 10; nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 3; Alternative Protein RELA; P65; NF-Kappa-B P65delta3; V-Rel Avian Reticuloendotheliosis Viral Oncogene
Species:
Human
Source:
E. coli
2
2
2 Cited Publications
Target:
Research Areas:
BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC50 of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription .
2
2 Cited Publications
Cat. No.: HY-N1921
CAS No.: 32685-93-1
2
2 Cited Publications
Cat. No.: HY-P702844
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NFE2L2; nuclear Factor (Erythroid-Derived 2)-Like 2; NFE2 Like BZIP transcription Factor 2; nuclear Factor, Erythroid Derived 2, Like 2; NRF2; nuclear Factor Erythroid-Derived 2-Like 2; nuclear Factor Erythroid 2-Related Factor 2; nuclear Factor, Erythroi
Species:
Mouse
Source:
E. coli
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
