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Results for "

polycyclic

" in MedChemExpress (MCE) Product Catalog:

88

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3

Fluorescent Dye

3

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9

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23

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12

Isotope-Labeled Compounds

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N6693
    Valinomycin
    5+ Cited Publications

    NSC 122023

    		 Apoptosis Antibiotic Autophagy Fungal Infection Others Cancer
    Valinomycin is a potassium-specific ionophore, the valinomycin-K + complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K + gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .
    Valinomycin
  • HY-W011845
    DMBA
    3 Publications Verification

    7,12-DMBA; 7,12-Dimethylbenzanthracene

    		 Environmental Pollutants c-Myc Cancer
    DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .
    DMBA
  • HY-N0823
    Lithospermic acid
    5+ Cited Publications

    (+)-Lithospermic acid

    		 NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis Cardiovascular Disease Inflammation/Immunology
    Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .
    Lithospermic acid
  • HY-W100026
    Galaxolide

    		Environmental Pollutants Estrogen Receptor/ERR Glutathione S-transferase Metabolic Disease
    Galaxolide is a polycyclic musk synthetic fragrance. Galaxolide possesses endocrine-disrupting activity and can exert anti-androgenic/estrogenic effects. Galaxolide exhibits in vivo androgenic activity in immature rats . Galaxolide can be used in studies related to endocrine disruption .
    Galaxolide
  • HY-121360
    Cylindrospermopsin

    		DNA/RNA Synthesis Reactive Oxygen Species (ROS) Cancer
    Cylindrospermopsin, a cyanotoxin, is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA. Cylindrospermopsin induces hepatocellular hypertrophy, renal cellular hypertrophy, intracellular reactive oxygen species (ROS), DNA strand breaks, mitochondrial hyperpolarisation, ultrastructural damage, and altered gene expression in liver, kidney, and intestinal cells. Cylindrospermopsin can be used in research including hepatocellular carcinoma and water quality testing .
    Cylindrospermopsin
  • HY-B1727
    Phenanthrene
    1 Publications Verification

    		 Environmental Pollutants Apoptosis Inflammation/Immunology Cancer
    Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
    Phenanthrene
  • HY-P10033
    SFTI-1

    		Ser/Thr Protease Others
    SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms .
    SFTI-1
  • HY-N2427
    Adamantane

    		Others Others
    Adamantane is a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be studied in pharmacological research to improve the lipophilicity and pharmacological properties of other active products .
    Adamantane
  • HY-103609
    Pyrene
    1 Publications Verification

    Benzo[def]phenanthrene

    		 Environmental Pollutants Biochemical Assay Reagents Others
    Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.
    Pyrene
  • HY-W014075
    1-Hydroxypyrene

    		Aryl Hydrocarbon Receptor Cytochrome P450 Collagen Inflammation/Immunology
    1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis .
    1-Hydroxypyrene
  • HY-W026772
    Fluorene
    1 Publications Verification

    		 Environmental Pollutants Fluorescent Dye TNF Receptor Interleukin Related SOD Reactive Oxygen Species (ROS) Inflammation/Immunology
    Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .
    Fluorene
  • HY-W007692
    Acetylpyrazine

    2-Acetylpyrazine

    		 Drug Intermediate Others
    Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) .
    Acetylpyrazine
  • HY-B1727S
    Phenanthrene-d10

    		Isotope-Labeled Compounds Inflammation/Immunology
    Phenanthrene-d10 is the deuterium labeled Phenanthrene. Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) and has been frequently used as an indicator for monitoring PAH contaminated matrices . Phenanthrene induces oxidative stress and inflammation .
    Phenanthrene-d10
  • HY-W013053
    Dibenz[a,h]anthracene

    DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene

    		 Environmental Pollutants DNA/RNA Synthesis MDM-2/p53 Apoptosis Cancer
    Dibenz[a,h]anthracene (DBA) is an orally active polycyclic aromatic hydrocarbon, a by-product of incomplete combustion of organic matter, a potent carcinogen, and an agonist of AhR. Dibenz[a,h]anthracene induces dose-dependent increases in DNA adduct formation and lacZ mutation frequency. Dibenz[a,h]anthracene upregulates St3gal5. Dibenz[a,h]anthracene can be used in cancer-related research .
    Dibenz[a,h]anthracene
  • HY-W013570
    Acenaphthylene
    1 Publications Verification

    		 Environmental Pollutants Drug Intermediate Others
    Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter .
    Acenaphthylene
  • HY-121107
    Chrysene
    1 Publications Verification

    		 Environmental Pollutants Cancer
    Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .
    Chrysene
  • HY-W090294
    Perylene

    Peri-dinaphthalene (purified by sublimation)

    		 Environmental Pollutants Biochemical Assay Reagents Others
    Perylene, which is a polycyclic aromatic hydrocarbon composed of four linearly fused benzene rings, is commonly used as a pigment and dye in a variety of applications, including printing inks, plastics, and textiles. In addition, Perylene has potential uses in solar cells as photosensitizers and as fluorescent probes in biochemistry and materials science. Perylene's rigid planar structure endows it with unique electronic and optical properties, making it a versatile and important compound in many fields of chemistry and materials science.
    Perylene
  • HY-P1206
    CH 275
    1 Publications Verification

    		 Somatostatin Receptor Neurological Disease
    CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM . CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively . CH 275 can be used for the research of alzheimer’s disease .
    CH 275
  • HY-124211
    Dibenzo(a,i)pyrene

    		Environmental Pollutants MDM-2/p53 Aryl Hydrocarbon Receptor Cancer
    Dibenzo (a,i) pyrene is a polycyclic aromatic hydrocarbon and also a carcinogenic ligand of the TCDD (Ah) receptor. Dibenzo (a,i) pyrene binds to the TCDD (Ah) receptor in rat liver. Dibenzo (a,i) pyrene induces DNA adduct formation and upregulates the protein levels of p53 and p21 WAF1 in diploid lung fibroblasts. Dibenzo (a,i) pyrene alters the cell cycle distribution of diploid lung fibroblasts, increasing the proportion of cells in the S phase, decreasing the proportions of cells in the G0/G1 and G2/M phases, and causing S phase delay/arrest. Dibenzo (a,i) pyrene is applicable for cancer research .
    Dibenzo(a,i)pyrene
  • HY-111441
    1,4-Chrysenequinone

    Chrysene-1,4-dione

    		 Aryl Hydrocarbon Receptor Cancer
    1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).
    1,4-Chrysenequinone
  • HY-W014075S
    1-Hydroxypyrene-d9

    		Isotope-Labeled Compounds Aryl Hydrocarbon Receptor Cytochrome P450 Collagen Inflammation/Immunology
    1-Hydroxypyrene-d9 is the deuterium labeled 1-Hydroxypyrene (HY-W014075). 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis .
    1-Hydroxypyrene-d9
  • HY-23499
    Indeno[1,2,3-cd]pyrene

    		Environmental Pollutants Aryl Hydrocarbon Receptor Inflammation/Immunology Cancer
    Indeno[1,2,3-cd]pyrene is a polycyclic aromatic hydrocarbon with moderate cytotoxicity in human pulmonary alveolar epithelial cells HPAEpiC. Indeno[1,2,3-cd]pyrene enhances allergic lung infammation via aryl hydrocarbon receptor .
    Indeno[1,2,3-cd]pyrene
  • HY-W103305
    Biphenylene

    Dibenzocyclobutadiene

    		 Biochemical Assay Reagents Others
    Biphenylene (Dibenzocyclobutadiene) is a two-dimensional allotrope of carbon. Biphenylene is a promising material with potential applications in many important fields, such as chemical catalysis .
    Biphenylene
  • HY-111450
    CB7993113

    		Aryl Hydrocarbon Receptor Cancer
    CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively .
    CB7993113
  • HY-W127705
    Quinacrine mustard dihydrochloride
    1 Publications Verification

    		 Fluorescent Dye Others
    Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes .
    Quinacrine mustard dihydrochloride
  • HY-167843
    Alborixin

    		Akt Autophagy PTEN Amyloid-β Antibiotic Bacterial Fungal Infection Neurological Disease
    Alborixin is a polycyclic polyether ionophore Antibiotic. Alborixin is isolated from cultures of Streptomyces albus. Alborixin induces Autophagy via PTEN-mediated inhibition of the AKT pathway, thereby clearing Amyloid-β. Alborixin exhibits activity against Gram-positive bacteria and fungi. Alborixin can be used in the research of Alzheimer's disease .
    Alborixin
  • HY-W016103
    1-Hydroxy-2-naphthoic acid

    		Bacterial Drug Intermediate Infection
    1-Hydroxy-2-naphthoic acid is a ubiquitous bicyclic intermediate metabolite in the microbial degradation process of polycyclic aromatic hydrocarbons (PAHs). 1-Hydroxy-2-naphthoic acid can be converted into 1,2-naphthalenediol, which enters the naphthalene degradation pathway and participates in the tricarboxylic acid (TCA) cycle to achieve complete mineralization .
    1-Hydroxy-2-naphthoic acid
  • HY-W016389
    2-Hydroxyfluorene

    2-OHFLU

    		 Endogenous Metabolite Metabolic Disease
    2-Hydroxyfluorene (2-OHFLU) is a polycyclic aromatic hydrocarbon metabolite. 2-Hydroxyfluorene is positively associated with cardiovascular disease (CVD) and hyperlipidemia.
    2-Hydroxyfluorene
  • HY-N11222
    Nonanoylcarnitine

    C9 carnitine

    		 Endogenous Metabolite Cardiovascular Disease Cancer
    Nonanoylcarnitine is a metabolite associated with chronic environmental exposure to polycyclic aromatic hydrocarbons (PAH) and fragmented QRS waves in acute myocardial infarction. Nonanoylcarnitine can be used as a potential biomarker for the metabolic outcome of PAH exposure and the prognosis of acute myocardial infarction .
    Nonanoylcarnitine
  • HY-W110980
    2-Aminoanthracene

    Anthracen-2-amine; 2-Anthramine

    		 DNA/RNA Synthesis Cancer
    2-Aminoanthracene (Anthracen-2-amine) is a nitrogen substituted polycyclic aromatic hydrocarbon. 2-Aminoanthracene is mutagenic and carcinogenic. 2-Aminoanthracene acts by intercalating into DNA, causing structural distortion and interfering with DNA replication and transcription .
    2-Aminoanthracene
  • HY-109542
    Cyclopenthiazide

    		Biochemical Assay Reagents Metabolic Disease
    Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney .
    Cyclopenthiazide
  • HY-23498
    Benzo[k]fluoranthene

    		Environmental Pollutants Endogenous Metabolite Others
    Benzo[k]fluoranthene is a polycyclic aromatic hydrocarbon (PAH) that is carcinogenic and genotoxic .
    Benzo[k]fluoranthene
  • HY-W012278
    Benz[a]anthracene

    Tetraphene

    		 Environmental Pollutants Aryl Hydrocarbon Receptor Others
    Benz[a]anthracene (Tetraphene) (Compound 92) is a ligand for the aryl hydrocarbon receptor (AhR) with a pIC50 of 7.319. Benz[a]anthracene is a polycyclic aromatic hydrocarbon (PAH) that can be detected in spruce needles near aluminum smelters .
    Benz[a]anthracene
  • HY-W017708
    Triphenylene

    		Drug Intermediate Others
    Triphenylene is a highly symmetrical polycyclic aromatic hydrocarbon. Triphenylene shows no carcinogenic activity in mouse skin application experiments. Triphenylene can be used as a drug intermediate for the synthesis of triphenyl polycyclic aromatic hydrocarbons (PAHs) .
    Triphenylene
  • HY-W103306
    3-Aminofluoranthene

    		Biochemical Assay Reagents Others
    3-Aminofluoranthene is a nitrated polycyclic aromatic hydrocarbon. 3-Aminofluoranthene exhibits weak mutagenic activity .
    3-Aminofluoranthene
  • HY-P3193A
    Cyclic nona-L-arginine hydrochloride

    		Biochemical Assay Reagents Others
    Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .
    Cyclic nona-L-arginine hydrochloride
  • HY-W004460
    9,10-Dimethylanthracene

    		Environmental Pollutants Biochemical Assay Reagents Cancer
    9,10-Dimethylanthracene is a polycyclic aromatic hydrocarbon that acts as a DNA-damaging agent. 9,10-Dimethylanthracene is promising for research of carcinogenic risks of environmental pollutants .
    9,10-Dimethylanthracene
  • HY-W013570S
    Acenaphthylene-d8

    Acenaphthylene-d8

    		 Isotope-Labeled Compounds Others
    Acenaphthylene-d8 is the deuterium labeled Acenaphthylene . Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter .
    Acenaphthylene-d8
  • HY-B1727R
    Phenanthrene (Standard)

    		Reference Standards Apoptosis Inflammation/Immunology Cancer
    Phenanthrene (Standard) is the analytical standard of Phenanthrene. This product is intended for research and analytical applications. Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
    Phenanthrene (Standard)
  • HY-N2427S
    Adamantane-d16

    		Isotope-Labeled Compounds Others
    Adamantane-d16is the deuterium labeled Adamantane (HY-N2427). Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .
    Adamantane-d16
  • HY-P10027A
    Clovibactin TFA

    		Antibiotic Bacterial Infection
    Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .
    Clovibactin TFA
  • HY-P10027
    Clovibactin

    		Antibiotic Bacterial Infection
    Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .
    Clovibactin
  • HY-W026772R
    Fluorene (Standard)

    		Fluorescent Dye Reference Standards Others
    Fluorene (Standard) is the analytical standard of Fluorene. This product is intended for research and analytical applications. Fluorene, a polycyclic aromatic hydrocarbon (PAH), is a precursor to other fluorene compounds. Fluorene and its derivative?can be used as a precursor to fluorene-based dyes .
    Fluorene (Standard)
  • HY-W011845R
    DMBA (Standard)

    7,12-DMBA (Standard); 7,12-Dimethylbenzanthracene (Standard)

    		 c-Myc Reference Standards Cancer
    DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .
    DMBA (Standard)
  • HY-35556
    9-Aminophenanthrene

    		Fluorescent Dye Cardiovascular Disease Metabolic Disease
    9-Aminophenanthrene is a type of polycyclic aromatic amine compound, which can be used as a fluorescent labeling reagent for free fatty acids (FFA) .
    9-Aminophenanthrene
  • HY-121107S
    Chrysene-d12

    		Isotope-Labeled Compounds Cancer
    Chrysene-d12 is the deuterium labeled Chrysene. Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .
    Chrysene-d12
  • HY-W777456
    Phenanthrene-13C6

    		Isotope-Labeled Compounds Others
    Phenanthrene- 13C6 is the 13C labeled Phenanthrene (HY-B1727). Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
    Phenanthrene-13C6
  • HY-Y1771
    2-Carboxybenzaldehyde

    Phthalaldehydic acid

    		 Drug Metabolite Bacterial Infection
    2-Carboxybenzaldehyde is a key intermediate metabolite in the biodegradation of polycyclic aromatic hydrocarbons (PAHs) such as fluoranthene and phenanthrene. 2-Carboxybenzaldehyde can be produced by the degradation of fluoranthene by Pasteurella sp. IFA and Mycobacterium sp. PYR-1. 2-Carboxybenzaldehyde can also be produced by the degradation of phenanthrene by Pseudomonas sp. PPD .
    2-Carboxybenzaldehyde
  • HY-W096906
    Naphthacene

    Benz[b]anthracene

    		 Biochemical Assay Reagents Endogenous Metabolite Others
    Naphthacene (Benz[b]anthracene) is a fused polycyclic aromatic compound exhibiting an electron field-effect mobility of approximately 10 cm2/Vs; it is an ethylnylated acene that functions as a conducting polymer, making it suitable for use as a donor material. Its exceptional photoluminescence and quantum yield position naphthacene as a highly promising candidate for the advancement of single crystal electronic materials.
    Naphthacene
  • HY-177739
    Antifibrotic agent 2

    		Drug Derivative Collagen Inflammation/Immunology
    Antifibrotic agent 2 (Compound 636) is a polycyclic pyridinone derivative with antifibrotic activity. Antifibrotic agent 2 reduces the pathological accumulation of fibrosis-related proteins such as fibronectin and collagen, prevents excessive fibrous connective tissue from depositing in organs or tissues, and reverses or delays the remodeling of tissue fibrosisby regulating the abnormal proliferation and activation of fibroblasts. Antifibrotic agent 2 can be used for research on pulmonary fibrosis .
    Antifibrotic agent 2

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