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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
304 Results for "
superoxide
" in MedChemExpress (MCE) Product Catalog:
Products (304)
304 Results for "superoxide" in MCE Product Catalog:
328
328 Publications Verification
Cat. No.: HY-D1055
CAS No.: 1003197-00-9
Excitation/emission wavelength: 510/580 nm.
49
49 Cited Publications
Cat. No.: HY-165529
CAS No.: 59721-28-7
Target:
Research Areas:
Camostat is an orally active trypsin inhibitor. Camostat can reduce pancreatic fibrosis induced by repeated administration of superoxide dismutase inhibitors in rats, and decrease the proliferation and activation of pancreatic stellate cells (PSCs) .
33
33 Cited Publications
Synonyms: 2-ME2; NSC-659853
29
29 Cited Publications
Synonyms: 4-Hydroxy-TEMPO; MBM-02
Research Areas:
Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS).
22
Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite
Target:
20
20 Cited Publications
Cat. No.: HY-B0581
CAS No.: 24584-09-6
Synonyms: ICRF-187; ADR-529; NSC-169780
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Dexrazoxane, as an intracellular iron chelating agent, reduces the formation of superoxide radicals and has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities. Dexrazoxane inhibits ferroptosis of H9c2 cells by inhibiting HMGB1. Dexrazoxane induces DNA damage and apoptosis in human fibrosarcoma cells .
17
17 Cited Publications
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Research Areas:
NF-κΒ activator 1 (compound 32) is a potent NF-κΒ activator with an EC50 of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD)2 mRNA expression .
16
16 Cited Publications
Cat. No.: HY-W001187
CAS No.: 2564-83-2
Research Areas:
Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .
12
Category:
Monophenols Stilbenes Phenols Plants Other Families Extract Disease Research Fields Inflammation/Immunology
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10
10 Cited Publications
Cat. No.: HY-19619
CAS No.: 200933-14-8
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Research Areas:
m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .
8
Research Areas:
DMPO is a cell permeable hydrophillic spin trap agent for superoxide detection .
8
6
6 Cited Publications
Synonyms: MitoParaquat
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Research Areas:
MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study .
6
ATN-224 is an orally active Cu 2+/Zn 2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5 nM.
6
6 Cited Publications
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Research Areas:
MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research .
6
6 Cited Publications
Cat. No.: HY-18743
CAS No.: 55779-48-1
Category:
Alkaloids Monophenols Animals Other Alkaloids Phenols Polyphenols Disease Research Fields Cancer
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6
6 Cited Publications
Cat. No.: HY-18743A
Target:
Research Areas:
Coelenterazine TFA is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate Coelenterazine TFA has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine TFA is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm) .
6
6 Cited Publications
Research Areas:
HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases .
5
Target:
5
5 Cited Publications
Category:
Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
