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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
vATPase
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "vATPase" in MCE Product Catalog:
885
885 Publications Verification
Synonyms: BafA1
Category:
Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Anticancer Disease Research Fields
Target:
28
28 Cited Publications
Cat. No.: HY-N1724
CAS No.: 80890-47-7
Synonyms: Antibiotic X 4357B; Folimycin; X 4357B
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28
28 Cited Publications
Cat. No.: HY-N1724A
CAS No.: 80890-47-7
Synonyms: Antibiotic X 4357B (purity≥70%); Folimycin (purity≥70%); X 4357B (purity≥70%)
Category:
Target:
10
Target:
Na+/K+ ATPase Proton Pump Bacterial Cytochrome P450 Apoptosis Autophagy Atg8/LC3 TNF Receptor Interleukin Related
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Omeprazole (H 16868) is an orally active H +,K +-ATPase inhibitor and a proton pump inhibitor. Omeprazole competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole aslo has neuroprotective and antibacterial effects .
5
5 Cited Publications
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Research Areas:
EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner .
3
3 Cited Publications
Cat. No.: HY-N2532
CAS No.: 22055-22-7
Category:
Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Plants Infection Monophenols Phenols Phenylpropanoids Berberidaceae Disease Research Fields Inflammation/Immunology
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2
2 Cited Publications
Target:
Research Areas:
KM91104 is a cell-permeable V-ATPase a3-b2 inhibitor (IC50 = 2.3 µM). KM91104 reduces the metabolic activity, cell proliferation capacity and V-ATPase subunit protein expression levels of primary human hepatic stellate cells, increases intracellular ATP levels and decreases cytoplasmic pH. KM91104 reduces TLR4 expression on the surface of oligodendrocyte precursor cells, blocks the ENV-TLR4 interaction, and reverses oligodendrocyte myelination defects induced by ENV protein .
1
1 Cited Publications
Category:
Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Antibacterial Anticancer Disease Research Fields Cancer
Target:
1
1 Cited Publications
Cat. No.: HY-N6738
CAS No.: 88899-56-3
Category:
Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Antibacterial Disease Research Fields
Target:
Cat. No.: HY-P2657
CAS No.: 138067-14-8
Research Areas:
Cat. No.: HY-176954
CAS No.: 2171015-78-2
Target:
Research Areas:
RSC-1255 is a potent and selective Vacuolar H⁺-ATPase (V-ATPase) inhibitor that directly binds the mammalian V-ATPase complex with a Kd = 23 nM. RSC-1255 exhibits preferential cytotoxicity toward KRAS-mutant cancer cells, especially KRAS G13D and KRAS G12V cells. RSC-1255 induces apoptosis and blocks lysosomal acidification, autophagy, and macropinocytosis in cancer cells. RSC-1255 can be used for the study of KRAS-driven lung and colon cancers .
Research Areas:
Aldolase, Rabbit muscle (Fructose-diphosphate aldolase) is a glycolytic enzyme and glucose availability sensor. Aldolase, Rabbit muscle catalyzes the reversible carbon-carbon cleavage of fructose-1,6-bisphosphate to produce dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Aldolase, Rabbit muscle is an essential component for v-ATPase activity. Aldolase, Rabbit muscle participates in processes such as gluconeogenesis, the Calvin cycle and glycolysis .
Cat. No.: HY-162935
CAS No.: 1243603-61-3
Target:
Research Areas:
V-ATPase-IN-1 (Compound 3b-03) is a Vacuolar-type H +-ATPases (V-ATPase) inhibitor (IC50 = 194.80 μM) that can effectively target the V-ATPase subunit A (Kd = 0.803 μM). V-ATPase-IN-1 exhibits insecticidal activity against M. separata (LC50 = 2.64 mM) and contributes to research in the development of chemical insecticides .
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Cat. No.: HY-W436428
CAS No.: 69570-95-2
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V-161 is the orally active inhibitor for Na +-V-ATPase with an IC50 of 144 nM. V-161 inhibits Enterococcus hirae and Vancomycin-resistant Enterococcus faecium (VRE) under alkaline condition with MIC of 4 µg/mL and 4 µg/mL. V-161 inhibits colonization of VRE in mouse small intestine .
Cat. No.: HY-123095
CAS No.: 1314486-37-7
Synonyms: JBIR 100
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Cat. No.: HY-N12413
CAS No.: 220757-06-2
Category:
Target:
Cat. No.: HY-162264
CAS No.: 3032401-72-9
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Research Areas:
Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a Tubulin polymerization/V-ATPase inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
