Tamoxifen-d5
Based on 1 Customer Validation
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.77%
- CAS 番号: 157698-32-3
- 分子式: C26H24D5NO
- 分子量:376.55
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-13757A
TamoxifenEstrogen Receptor Modulator -
HY-B0257S1
Norgestrel-d6Stable Isotope -
HY-N0791
TectoridinPhytoestrogen -
HY-16950BS
(E)-4-Hydroxytamoxifen-d5Stable Isotope -
HY-N0791R
Tectoridin (Standard)Phytoestrogen -
HY-18719ES
Endoxifen-d5Stable Isotope -
HY-B0261S
Meloxicam-d3Stable Isotope -
HY-N6769
RadicicolHsp90 Inhibitor -
HY-B0847S
Propiconazole-d7Stable Isotope -
HY-N1986
Cucurbitacin DHSP Inhibitor -
HY-103000
HSF1AHSF1 Activator -
HY-100110
KNK437HSP Inhibitor
生物活性
製品説明
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Estrogen receptor |
HSP90 |
体外実験
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 157698-32-3
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非標識Cas 10540-29-1
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性状 Solid
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分子量 376.55
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分子式 C26H24D5NO
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Color White to off-white
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SMILES
[2H]C([2H])([2H])C([2H])([2H])/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3
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別名
ICI 47699-d5; (Z)-Tamoxifen-d5; trans-Tamoxifen-d5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 83.33 mg/mL (221.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
純度とドキュメンテーション
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データシート (273 KB)
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SDS (701 KB)
- English - EN (701 KB)
- Français - FR (701 KB)
- Deutsch - DE (701 KB)
- Norwegian - NO (701 KB)
- Español - ES (701 KB)
- Swedish - SV (701 KB)
- Italian - IT (701 KB)
- Korean - KR (701 KB)
- Portuguese - PT (701 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.6557 mL | 13.2784 mL | 26.5569 mL | 66.3922 mL |
| 5 mM | 0.5311 mL | 2.6557 mL | 5.3114 mL | 13.2784 mL | |
| 10 mM | 0.2656 mL | 1.3278 mL | 2.6557 mL | 6.6392 mL | |
| 15 mM | 0.1770 mL | 0.8852 mL | 1.7705 mL | 4.4261 mL | |
| 20 mM | 0.1328 mL | 0.6639 mL | 1.3278 mL | 3.3196 mL | |
| 25 mM | 0.1062 mL | 0.5311 mL | 1.0623 mL | 2.6557 mL | |
| 30 mM | 0.0885 mL | 0.4426 mL | 0.8852 mL | 2.2131 mL | |
| 40 mM | 0.0664 mL | 0.3320 mL | 0.6639 mL | 1.6598 mL | |
| 50 mM | 0.0531 mL | 0.2656 mL | 0.5311 mL | 1.3278 mL | |
| 60 mM | 0.0443 mL | 0.2213 mL | 0.4426 mL | 1.1065 mL | |
| 80 mM | 0.0332 mL | 0.1660 mL | 0.3320 mL | 0.8299 mL | |
| 100 mM | 0.0266 mL | 0.1328 mL | 0.2656 mL | 0.6639 mL |
Tamoxifen-d5 関連分類
HY-13757AS 関連分類
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