PLSCR1 - phospholipid scramblase 1 Gene

Also Known as MMTRA1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5359

About PLSCR1

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:146,515,180-146,544,607 (from NCBI)

This gene has 19 transcripts (splice variants), 235 orthologues and 4 paralogues. Ubiquitous expression in appendix (RPKM 43.5), gall bladder (RPKM 33.7) and 25 other tissues.

Summary

This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of Phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced Antiviral responses. [provided by RefSeq, May 2022]

PLSCR1 Products (13)

mRNA	Protein	Name
NM_001363872.1	NP_001350801.1	phospholipid scramblase 1 isoform 2
NM_001363874.1	NP_001350803.1	phospholipid scramblase 1 isoform 3
NM_001406033.1	NP_001392962.1	phospholipid scramblase 1 isoform 4
NM_001406034.1	NP_001392963.1	phospholipid scramblase 1 isoform 1
NM_001406035.1	NP_001392964.1	phospholipid scramblase 1 isoform 1
NM_001406036.1	NP_001392965.1	phospholipid scramblase 1 isoform 5
NM_001406037.1	NP_001392966.1	phospholipid scramblase 1 isoform 6
NM_001406038.1	NP_001392967.1	phospholipid scramblase 1 isoform 3
NM_001406039.1	NP_001392968.1	phospholipid scramblase 1 isoform 3
NM_001406040.1	NP_001392969.1	phospholipid scramblase 1 isoform 3
NM_001406041.1	NP_001392970.1	phospholipid scramblase 1 isoform 3
NM_001406042.1	NP_001392971.1	phospholipid scramblase 1 isoform 7
NM_021105.3	NP_066928.1	phospholipid scramblase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CD4 receptor binding	IPI IPI: Inferred from physical interaction	19333378	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16091359	GOA
enables SH3 domain binding	IDA IDA: Inferred from direct assay	11390389	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	8663431	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	12586838	GOA
enables epidermal growth factor receptor binding	IPI IPI: Inferred from physical interaction	12009895	GOA
enables lead ion binding	IDA IDA: Inferred from direct assay	23659204	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	27206388	GOA
enables mercury ion binding	IDA IDA: Inferred from direct assay	23659204	GOA
enables nuclease activity	IMP IMP: Inferred from mutant phenotype	27206388	GOA
enables phospholipid scramblase activity	IDA IDA: Inferred from direct assay	8663431	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables virus receptor activity	IMP IMP: Inferred from mutant phenotype	21806988	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	27206388	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process	IDA IDA: Inferred from direct assay	10770950	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	15308695	GOA
involved in negative regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	26745724	GOA
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	15308695	GOA
involved in phosphatidylserine exposure on apoptotic cell surface	IMP IMP: Inferred from mutant phenotype	32110987	GOA
involved in plasma membrane phospholipid scrambling	IDA IDA: Inferred from direct assay	9218461	GOA
involved in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	IDA IDA: Inferred from direct assay	17567603	GOA
involved in positive regulation of chromosome separation	IDA IDA: Inferred from direct assay	27206388	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15308695	GOA
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	15308695	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16091359	GOA
involved in response to interferon-beta	IMP IMP: Inferred from mutant phenotype	15308695	GOA
involved in response to lead ion	IDA IDA: Inferred from direct assay	29748552	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12586838	GOA
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	20870722	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22052202	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17712045	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	12009895	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	17567603	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12564925	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22052202	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9218461	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLSCR1 Protein Structure

Scramblase

0
100
200
300
318 a.a.

Protein Preferred Names	Protein Names
phospholipid scramblase 1	PL scramblase 1

PLSCR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLSCR1	O15162	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	PLSCR1	O15162	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
Intra	PLSCR1	O15162	BCL6B	Homo sapiens	A8KA13	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	KRTAP10-11	Homo sapiens	P60412	Validated Y2H	25416956
Intra	PLSCR1	O15162	P2RY6	Homo sapiens	Q15077	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	P2RY6	Homo sapiens	Q15077	Y2H Array	25416956
Intra	PLSCR1	O15162	LCE4A	Homo sapiens	Q5TA78	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	LCE2D	Homo sapiens	Q5TA82	Y2H Array	25416956
Intra	PLSCR1	O15162	KRTAP5-6	Homo sapiens	Q6L8G9	Validated Y2H	25416956
Intra	PLSCR1	O15162	KRTAP4-11	Homo sapiens	Q9BYQ6	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	KRTAP4-11	Homo sapiens	Q9BYQ6	Y2H Array	25416956
Intra	PLSCR1	O15162	GDPD5	Homo sapiens	Q9HBR3	Y2H Array	25416956
Intra	PLSCR1	O15162	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
Intra	PLSCR1	O15162	NUFIP2	Homo sapiens	Q7Z417	Anti Tag CoIP	21653829
Intra	PLSCR1	O15162	NUFIP2	Homo sapiens	Q7Z417	Y2H Pooling	21653829
Cross	PLSCR1	O15162	yscY	Yersinia pestis	P61417	Y2H Array	21911467
Cross	PLSCR1	O15162	yscB	Yersinia pestis	Q56973	Y2H Array	21911467
Cross	PLSCR1	O15162	ompA	Yersinia pestis	Q8ZG77	Y2H Array	21911467
Intra	PLSCR1	O15162	RGS3	Homo sapiens	P49796	Validated Y2H	25416956
Intra	PLSCR1	O15162	RGS3	Homo sapiens	P49796	Y2H Array	25416956
Intra	PLSCR1	O15162	RGS3	Homo sapiens	P49796	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	VPS37C	Homo sapiens	A5D8V6	Validated Y2H	25416956
Intra	PLSCR1	O15162	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	25416956
Cross	PLSCR1	O15162	yscK	Yersinia pestis	P69974	Y2H Array	21911467
Intra	PLSCR1	O15162	OCLN	Homo sapiens	Q16625	Anti Tag CoIP	21806988
Intra	PLSCR1	O15162	SMARCC1	Homo sapiens	Q92922	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	TFG	Homo sapiens	Q92734	Y2H Pooling	16189514
Intra	PLSCR1	O15162	CPSF6	Homo sapiens	Q16630	Y2H Pooling	16189514
Intra	PLSCR1	O15162	GLRX3	Homo sapiens	O76003	Validated Y2H	25416956
Intra	PLSCR1	O15162	GLRX3	Homo sapiens	O76003	Y2H Pooling	16189514
Intra	PLSCR1	O15162	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	25416956
Cross	PLSCR1	O15162	Hoxa1	Mus musculus	P09022	BiFC	23088713
Cross	PLSCR1	O15162	Hoxa1	Mus musculus	P09022	Pull Down	23088713
Intra	PLSCR1	O15162	DOCK2	Homo sapiens	Q92608	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	25416956
Intra	PLSCR1	O15162	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	DAZAP2	Homo sapiens	Q15038	Validated Y2H	25416956
Intra	PLSCR1	O15162	DAZAP2	Homo sapiens	Q15038	Y2H Pooling	16189514
Intra	PLSCR1	O15162	FRS3	Homo sapiens	O43559	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	EWSR1	Homo sapiens	Q01844	Y2H Array	25416956
Intra	PLSCR1	O15162	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	25416956
Intra	PLSCR1	O15162	PRR13	Homo sapiens	Q9NZ81	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	PRR13	Homo sapiens	Q9NZ81	Validated Y2H	25416956
Intra	PLSCR1	O15162	PRR13	Homo sapiens	Q9NZ81	Y2H Array	25416956
Intra	PLSCR1	O15162	ILF3	Homo sapiens	Q9NXX0	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	ILF3	Homo sapiens	Q9NXX0	Validated Y2H	25416956
Intra	PLSCR1	O15162	CATSPER1	Homo sapiens	Q8NEC5	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	CATSPER1	Homo sapiens	Q8NEC5	Y2H Array	25416956
Intra	PLSCR1	O15162	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	25416956
Intra	PLSCR1	O15162	DEF6	Homo sapiens	Q9H4E7	Validated Y2H	25416956
Intra	PLSCR1	O15162	DEF6	Homo sapiens	Q9H4E7	Y2H Array	25416956
Intra	PLSCR1	O15162	DEF6	Homo sapiens	Q9H4E7	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	NEU4	Homo sapiens	Q8WWR8	Y2H Pooling	16189514
Intra	PLSCR1	O15162	SCNM1	Homo sapiens	Q9BWG6	Y2H Array	31515488
Intra	PLSCR1	O15162	SCNM1	Homo sapiens	Q9BWG6	Y2H Array	25416956
Intra	PLSCR1	O15162	STK16	Homo sapiens	O75716	Validated Y2H	25416956
Intra	PLSCR1	O15162	STK16	Homo sapiens	O75716	Y2H Array	25416956
Intra	PLSCR1	O15162	APP	Homo sapiens	P05067	Y2H Pooling	32814053
Intra	PLSCR1	O15162	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	PLSCR1	O15162	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	PLSCR1	O15162	PKD2	Homo sapiens	Q13563	Validated Y2H	25416956
Intra	PLSCR1	O15162	PKD2	Homo sapiens	Q13563	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	ESR2	Homo sapiens	Q92731	Validated Y2H	25416956
Intra	PLSCR1	O15162	SPATA8	Homo sapiens	Q6RVD6	Y2H Array	25416956
Intra	PLSCR1	O15162	SPATA8	Homo sapiens	Q6RVD6	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	CTSZ	Homo sapiens	Q9UBR2	Y2H Array	25416956
Intra	PLSCR1	O15162	CTSZ	Homo sapiens	Q9UBR2	Y2H Prey Pooling	25416956
Intra	PLSCR1	O15162	LGALS9C	Homo sapiens	Q6DKI2	Y2H Array	25416956
Intra	PLSCR1	O15162	LGALS9C	Homo sapiens	Q6DKI2	Validated Y2H	25416956
Intra	PLSCR1	O15162	CHRD	Homo sapiens	Q9H2X0	Validated Y2H	25416956
Intra	PLSCR1	O15162	CHRD	Homo sapiens	Q9H2X0	Y2H Array	25416956
Intra	PLSCR1	O15162	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	25416956
Intra	PLSCR1	O15162	DMRT3	Homo sapiens	Q9NQL9	Y2H Array	25416956
Cross	PLSCR1	O15162	polg_hcvco	Hepatitis C virus	Q9WMX2	Anti Tag CoIP	21806988
Cross	PLSCR1	O15162	polg_hcvco	Hepatitis C virus	Q9WMX2	Y2H	21806988
Cross	PLSCR1	O15162	polg_hcvco	Hepatitis C virus	Q9WMX2	Pull Down	21806988

Cross: Cross-species interaction Intra: Intraspecies interaction

PLSCR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82674	Scramblase 1 Antibody (YA2419)	WB, ICC/IF, FC, IP	Human

Related Diseases

Diseases	Alias
Scott Syndrome	SCTS Bdplt7 Prothrombin Consumption Deficiency Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X Bleeding Disorder, Platelet-Type, 7 Prothrombin Conversion Defect, Familial Prothrombin Consumption Inhibitor, Familial Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X Familial Prothrombin Consumption Inhibitor Familial Prothrombin Conversion Defect Platelet-Type Bleeding Disorder 7 Platelet Factor X Receptor Deficiency Bleeding Disorder Platelet-Type 7 Prothrombin Consumption Inhibitor Familial Prothrombin Conversion Defect Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10741	PLSCR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18201	Plscr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24677	Plscr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLSCR1	RGD	RGD:620521
Mus musculus	PLSCR1	MGD	MGI:893575
Others	PLSCR1	NCBI