1. Anti-infection
  2. Antibiotic
    Bacterial
  3. Valnivudine

Valnivudine (Synonyms: FV-100 free base)

Cat. No.: HY-109016 Purity: 98.02%
Handling Instructions

Valnivudine (FV-100 free base), a prodrug of CF-1743, is an orally active anti-herpes zoster (HZ) nucleoside analogue. CF-1743, a bicyclic nucleoside analog (BCNA), has highly specific antiviral activity against varicella-zoster virus (VZV). Valnivudine is rapidly and extensively converted to CF-1743 in vivo.

For research use only. We do not sell to patients.

Valnivudine Chemical Structure

Valnivudine Chemical Structure

CAS No. : 956483-02-6

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10 mM * 1  mL in DMSO USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1800 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Valnivudine (FV-100 free base), a prodrug of CF-1743, is an orally active anti-herpes zoster (HZ) nucleoside analogue. CF-1743, a bicyclic nucleoside analog (BCNA), has highly specific antiviral activity against varicella-zoster virus (VZV). Valnivudine is rapidly and extensively converted to CF-1743 in vivo[1][2].

In Vitro

In vitro cytotoxicity studies in normal human primary hepatocytes, keratinocytes, and rapidly dividing HepG2 cells, Valnivudine (FV-100 free base) demonstrates mean 50% cytotoxic concentration values of >10 μM[2].
CF-1743 (compound 4f) has anti-varicella-zoster virus (VZV) activity in VZV OKA (EC50=0.3 nM), VZV YS (EC50=0.1 nM) in HEL cell[3].

Molecular Weight

497.58

Formula

C₂₇H₃₅N₃O₆

CAS No.

956483-02-6

SMILES

O=C1N=C2C(C=C(C3=CC=C(C=C3)CCCCC)O2)=CN1[[email protected]]4([H])O[[email protected]@H]([[email protected]](C4)O)COC([[email protected]@H](N)C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

ValnivudineFV-100FV100FV 100AntibioticBacterialCF-1743orallyanti-herpeszosterHZantiviralvaricella-zostervirusVZVInhibitorinhibitorinhibit

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Valnivudine
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