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Referencia número: HY-184949

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XY-06-005

XY-06-005 is a modified selective inhibitor of BET bromodomain that binds to BRD4 BD1 L94V, BRD4 BD2 L387V and BRD2 BD2 L383V. XY-06-005 serves as a Ligand for Target Protein for PROTAC for studies related to PROTAC synthesis, such as acting as the target protein ligand structure of XY-06-007 (HY-145226).

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No. CAS: 1642783-78-5
Fòrmula: C₂₂H₂₁ClN₄O₃
Peso molecular:424.88

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

XY-06-005 Chemical Structure

No. CAS: 1642783-78-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

BRD4 BD1

BRD4 BD2

BRD4 BD1L94V

Ver todos los productos específicos de isoformas Epigenetic Reader Domain :

In Vitro

XY-06-005 (compound 3) potently binds to mutant bromodomains (BRD4 BD1 L94V, BRD4 BD2 L387V, BRD2 BD2 L383V) with IC₅₀ values ranging from 62 nM to 231 nM. In contrast, it shows significantly weaker binding affinity to wild-type BRD4 BD1 (39 nM) and BRD4 BD2 (863 nM), indicating its selectivity for mutant bromodomains over wild-type counterparts^[1].
XY-06-005 can serve as the target protein ligand structure of XY-06-007 (HY-145226). XY-06-007 is a potent and selective B&H-PROTAC BRD4 BD1 L94V degrader with a DC₅₀ of 10 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1642783-78-5
Peso molecular 424.88
Fòrmula C₂₂H₂₁ClN₄O₃
SMILES

ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C=C(C=C4)OC)C)[C@H](C(OC)=O)C)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Nowak RP, et al. Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag. Journal of medicinal chemistry. 2021 Aug 12;64(15):11637-11650. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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XY-06-005

Ver todos los productos específicos de isoformas Epigenetic Reader Domain