17β-Hydroxywortmannin
17β-Hydroxywortmannin (Wortmannin-17β-ol) is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM. 17β-Hydroxywortmannin exhibits antitumor activity.
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- No. CAS: 58053-83-1
- Fòrmula: C23H26O8
- Peso molecular:430.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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PI3K 0.5 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| LNCaP | IC50 |
1.464 μM
Compound: 2, 17-hydroxywortmannin
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Growth inhibition of human LNCap cells
Growth inhibition of human LNCap cells
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[PMID: 18269228] |
17β-Hydroxywortmannin (2.5 mg/kg/week, i.v. for 2 weeks) exhibits antitumor efficacy towards U87MG glioma with a therapeutic index of 26 in human tumor xenografted nude mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 58053-83-1
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Peso molecular 430.45
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Fòrmula C23H26O8
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SMILES
C[C@@]12C3=C(C(C4=C1C(C(O[C@@H]2COC)=O)=CO4)=O)[C@@]5([H])[C@](C[C@H]3OC(C)=O)([C@H](CC5)O)C
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Synonyms
Wortmannin-17β-ol
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Hall TJ, et al., Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro. Calcif Tissue Int. 1995 Apr;56(4):336-8. [Content Brief]
[2]. Zask A, et al., Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51(5):1319-23. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
17β-Hydroxywortmannin Related Classifications
HY-126083 Related Classifications
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