Infection

Oseltamivir-d₃ (phosphate)eis the deuterium labeled Oseltamivir phosphate. Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.

Antiviral agent 82 (example 1) is an anti-HCV agent. Antiviral agent 82 can be used to prevent infection with flaviviruses, particularly hepatitis C virus.

Spiroamantadine (DU-34569 maleate) is a compound related to Amantadine (HY-B0402) with anti-influenza virus activity.

Saflufenacil (Standard) is the analytical standard of Saflufenacil. This product is intended for research and analytical applications. Saflufenacil is a herbicide of the pyrimidinedione chemical class preplant burndown and selective preemergence dicot weed control in multiple crops, including corn. Saflufenacil is a potent inhibitor of protoporphyrinogen IX oxidase (PPO).

LSPN959 is a slow-acting indole peptidomimetic antiplasmodial agent with submicromolar activity against the Plasmodium falciparum 3D7 strain. LSPN959 does not inhibit plastid-dependent isoprenoid biosynthesis. The combination of LSPN959 with Artesunate (HY-N0193) exhibits an additive effect against Plasmodium falciparum. LSPN959 can be used in malaria research.

SMR efflux inhibitor targets the small multidrug resistance (SMR) efflux pump, blocks the interaction of TM4-TM4, and exhibits board-spectrum antibacterial activity.

Argifin (Standard) is the analytical standard of Argifin. This product is intended for research and analytical applications. Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

Dinitolmide (Zoalene) (Standard) is the analytical standard of Dinitolmide (HY-B1004). This product is intended for research and analytical applications. Dinitolmide is an orally active anticoccidial agent used as a fodder additive. Dinitolmide has a wide anticoccidial spectrum with no effect on host immunity. Dinitolmide mainly acts on the first generation merozoite stage of coccidia and also has an inhibitory effect on the sporulation process of oocysts. Dinitolmide has anti-Toxoplasma gondii effect in vitro with an EC₅₀ of 3.625 μg/mL. Dinitolmide can be used to inhibits infections caused by Eimeria tenella.

Premafloxacin is a potent antimicrobial agent that exhibits activity against Staphylococcus aureus, Corynebacterium bovis, and Corynebacterium amylocolatum. Premafloxacin demonstrated potent antimicrobial activity against S. aureus by targeting topoisomerase IV, and is a poor substrate for NorA efflux pump. Premafloxacin can be used for antimicrobial research.

LpxC-IN-15 ((S)-13j) is a potent LpxC inhibitor with K_i values of 9.05, 5.6 nM for EcLpxC C63A, PaLpxC, respectively. LpxC-IN-15 shows antibacterial activity.

SARS-CoV-2-IN-51 (S-10) is a potent lead compound of Omicron fusion inhibitor. SARS-CoV-2-IN-51 inhibits Omicron and other variants with EC₅₀s of 0.82-5.45 μM. SARS-CoV-2-IN-51 inhibits SARS-CoV-2 virus entry, by the direct interaction with S in the prefusion state.

Spergualin trihydrochloride is a natural occurring antibiotic initially identified from culture filtrates of Bacillus laterosporus BMG162-aF2.

Antibacterial agent 136 (compound 3) is an antibiotic of oxadiazolones. Antibacterial agent 136 have high antibacterial potency against Staphylococcus aureus (MRSA) with a MIC₅₀ value of 0.8 μM.

PLP_Snyder530 is a potent papain-like protease (PL^pro) inhibitor with an IC₅₀ value of 6.4 μM. PLP_Snyder530 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. PLP_Snyder530 can be used for SARS-CoV-2 research.

AcrB-IN-1 (Compound H6) is a potent AcrB inhibitor. AcrB-IN-1 can be used for the reversal of bacterial multidrug resistance.

Spinosyn D-¹³C,d₃ is the deuterium and ¹³C-labeled Spinosyn D (HY-125326). Spinosyn D is one of the major components of Spinosad (HY-138800). Spinosad is a natural pesticide that shows biological activity against a range of insects including Lepidoptera.

CXCR4 antagonist 1 is a potent CXCR4 antagonist. CXCR4 antagonist 1 has anti-HIV activity.

Amenamevir-d₆ (ASP2151-d₆) is the deuterium labeled Amenamevir (HY-14809). Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against HSVs with an EC₅₀ of 14 ng/mL.

Antibacterial agent 271 is an antibacterial agent with significant inhibition against Escherichia coli (MIC: 2.2 μM). Antibacterial agent 271 reduces metabolic activity by disrupting the integrity of bacterial membranes. Antibacterial agent 271 binds to DNA grooves to inhibit replication and induces accumulation of reactive oxygen species (ROS) , ultimately leading to bacterial death. Antibacterial agent 271 shows significant potential in combating bacterial infections.

Rehmaglupentasaccharide A is a pentasaccharide found in air-dried roots of Rehmannia glutinosa. Rehmaglupentasaccharide A promotes proliferation of Lactobacillus reuteri.