DNA Alkylator/Crosslinker
DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.
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DNA Alkylator/Crosslinker Inhibitors
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DNA Alkylator/Crosslinker Activator
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DNA Alkylator/Crosslinker Chemicals
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DNA Alkylator/Crosslinker Inducers
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DNA Alkylator/Crosslinker Controls
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DNA Alkylator/Crosslinker Ligand
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DNA Alkylator/Crosslinker Related Products (298)
Related Products (298)
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Antibodies (3)
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Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA
0 ImagesCat. No.: HY-171685Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated with the linker MC-Vc-PAB-DMEA-PEG2 and the DNA alkylator Duocarmycin SA (HY-12456). Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA can be used in cancer research.
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Duocarmycin analog-2
0 ImagesCat. No.: HY-148091CAS No.: 1164275-01-7Duocarmycin analog-2 is a potent DNA alkylating agent. Duocarmycin analog-2 can be used of synthetic immunoconjugate. Duocarmycin analog-2 has antitumor activity.
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Temozolomide-15N
0 ImagesCat. No.: HY-17364S1Synonyms: NSC 362856-15N; CCRG 81045-15N; TMZ-15NTemozolomide-15N (NSC 362856-15N) is the 15N-labeled Temozolomide (HY-17364). Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects.
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Heptaplatin
0 ImagesCat. No.: HY-106588CAS No.: 146665-77-2Synonyms: SKI 2053RHeptaplatin (SKI 2053R) is a platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant tumor cell lines. SKI-2053R is active in the research of gastric adenocarcinoma and has favorable toxicity profiles.
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seco-CBI dimer
0 ImagesCat. No.: HY-185488CAS No.: 2592397-70-9seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma.
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MC-cBu-Cit-seco-CBI dimer
0 ImagesCat. No.: HY-185492CAS No.: 1799659-90-7MC-cBu-Cit-seco-CBI dimer (Compound 10) is a conjugate of an ADC drug toxin molecule and a linker, which consists of a DNA alkylating agent connected to a reactive maleimide via a protease-cleavable peptidomimetic linker.
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Bendamustine hydrochloride hydrate
0 ImagesCat. No.: HY-13567ACAS No.: 1374784-02-7Synonyms: SDX-105 hydrateBendamustine hydrochloride hydrate (SDX-105 hydrate), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride hydrate activates DNA-damage stress response and apoptosis. Bendamustine hydrochloride hydrate has potent alkylating, anticancer and antimetabolite properties.
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DMS-612
0 ImagesCat. No.: HY-19412CAS No.: 56967-08-9Synonyms: NSC-281612DMS-612 (NSC-281612) is an alkylating agent with anti-renal cell carcinoma activity. DMS-612 can be used in cancer research.
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WP836
0 ImagesCat. No.: HY-160915CAS No.: 266000-09-3WP836 is a potent antitumor agent. WP836 shows cytoxicity.
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Galarubicin hydrochloride
0 ImagesCat. No.: HY-105178ACAS No.: 140637-82-7Synonyms: DA 125Galarubicin hydrochloride (DA 125) is a novel Anthracycline derivative. Galarubicin hydrochloride shows high-affinity DNA binding and topoisomerase II inhibitory activities. Galarubicin hydrochloride induces Apoptosis. Galarubicin hydrochloride exerts cytotoxicity via JNK pathway. Galarubicin hydrochloride can be used in the research of hepatocellular carcinoma.
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Ambamustine hydrochloride
0 ImagesCat. No.: HY-19577ACAS No.: 83996-50-3Synonyms: PTT119 hydrochlorideAmbamustine (PTT119) hydrochloride is a bifunctional alkylating agent and induces DNA damage by alkylating mechanisms. Ambamustine interferes with late steps in murine mammary tumor virus (MuMTV) processing and maturation and reduces production of the B-type retrovirus MuMTV. Ambamustine possesses cytolytic and antiviral activities.
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Bromofosfamide
0 ImagesCat. No.: HY-W1057999CAS No.: 104149-14-6Bromofosfamide is a prodrug-type alkylating agent and also an analog of Ifosfamide (HY-17419). Bromofosfamide exhibits potent in vivo anti-tumor activity against lymphoid leukemia and can be used for the research of lymphoid leukemia.
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Chlorambucil-d8
0 ImagesCat. No.: HY-13593SCAS No.: 2748247-26-7Synonyms: CB-1348-d8; WR-139013-d8Chlorambucil-d8 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease.
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YL0441
0 ImagesCat. No.: HY-182050Purity: 98.94%YL0441 is an inhibitor of ΔFOSB/JUND heterodimers and ΔFOSB homomultimers, with IC50 values of 13.7 μM and 12.3 μM, respectively. YL0441 blocks the binding of ΔFOSB to DNA. YL0441 reduces ΔFOSB bound to genomic DNA in the hippocampal tissues of APP mice. YL0441 is applicable to the research of Alzheimer's disease.
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IOB-82
0 ImagesIOB-82 is a bifunctional alkylating agent. IOB‑82 induces marked nuclear and cytoplasmic alterations, elicits severe chromatid and chromosome aberrations, and remodels chromosome ploidy. IOB-82 exerts dose-dependent radiomimetic effects and preferentially cytotoxic to large A-type rat ascites cells. IOB-82 can be applied in the research of melanoma‑derived tumors and leukemia.
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Vezf1-IN-1
0 ImagesCat. No.: HY-153099CAS No.: 2640149-52-4Vezf1-IN-1 (Compound T4) is a Vezf1 inhibitor. Vezf1-IN-1 blocks Vezf1-DNA binding. Vezf1-IN-1 inhibits the network formation by MSS31. Vezf1-IN-1 has ability to block angiogenesis.
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Phosphoramide mustard cyclohexanamine (Standard)
0 ImagesCat. No.: HY-137316ARCAS No.: 1566-15-0Phosphoramide mustard (cyclohexanamine) (Standard) is the analytical standard of Phosphoramide mustard (cyclohexanamine). This product is intended for research and analytical applications. Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage[1][2].
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Duocarmycin A
0 ImagesCat. No.: HY-12455CAS No.: 118292-34-5Duocarmycin A is an antitumor antibiotic and DNA alkylating agent with broad-spectrum antibacterial activity, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). Duocarmycin A selectively binds to the AT-rich minor groove of DNA, forms covalent adducts by alkylating the adenine N3 residue, thereby disrupting DNA structure and inhibiting its replication and transcription. Duocarmycin A induces apoptosis, sub-G1 phase accumulation and chromatin condensation, reduces the levels of pro-caspase-3/9, and induces p53-independent p21 expression. Duocarmycin A is widely used in the research of various malignancies, including leukemia, sarcoma, glioblastoma, as well as multiple solid tumor models such as lung cancer, breast cancer, and colorectal cancer.
