E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
E3 Ligase Ligand-Linker Conjugates Isoform Specific Products
All Product Categories
-
E3 Ligase Ligand-Linker Conjugates Related Products (1117)
Related Products (1117)
-
Antibodies (1)
-
E3 Ligase Ligand-Linker Conjugates Isoform Comparison
-
Thalidomide-ethyne-C5-COOH
0 ImagesCat. No.: HY-W935330CAS No.: 2600541-17-9
-
(S,R,S)-AHPC-C2-NH2
0 ImagesCat. No.: HY-136163ACAS No.: 2241643-69-4(S,R,S)-AHPC-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.
-
(S,R,S)-AHPC-C3-COOH
0 ImagesCat. No.: HY-141651CAS No.: 2172819-73-5
-
Thalidomide-NH-amido-C6-NH2
0 ImagesCat. No.: HY-138852CAS No.: 2763827-13-8Thalidomide-NH-amido-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
-
E3 Ligase Ligand-linker Conjugate 197
0 ImagesCat. No.: HY-W1008330CAS No.: 2766179-02-4E3 Ligase Ligand-linker Conjugate 197 is an E3 ubiquitinase ligand-linker conjugate that can be used to synthesize the PROTAC Androgen receptor degrader-1 (HY-175652).
-
Thalidomide-5-O-C8-NH2 hydrochloride
0 ImagesCat. No.: HY-149565Thalidomide-5-O-C8-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C8-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
-
Thalidomide-4-C3-NH2 hydrochloride
0 ImagesCat. No.: HY-139545CAS No.: 2357110-84-8Thalidomide-4-C3-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
-
Thalidomide-4-O-C9-Br
0 ImagesCat. No.: HY-181321CAS No.: 2653338-56-6
-
Me-SJ46411-PEG1-Piperazine-Boc
0 ImagesCat. No.: HY-159974Me-SJ46411-PEG1-Piperazine-Boc is a conjugate of E3 ubiquitin ligase and PROTAC linker, which can be used for the synthesis of PROTAC molecules. For example, Me-SJ46411-PEG1-Piperazine-Boc combined with target protein ligand (+)-JQ-1 (HY-13030) can be used to synthesize the selective BRD3 PROTAC degrader SJ46420 (HY-168635)..
-
Thalidomide-5-O-C3-NH2 hydrochloride
0 ImagesThalidomide-5-O-C3-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
-
Thalidomide-piperidine-O-piperidine-C2-OH
0 ImagesCat. No.: HY-161202Thalidomide-piperidine-O-piperidine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-O-piperidine-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
-
Thalidomide-5-NH-CH2-COO(t-Bu)
0 ImagesCat. No.: HY-W584516CAS No.: 2412056-28-9Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-NH-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-NH-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
