Glycosidase
Glycosidase
Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].
References:
- [1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.
- [2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]
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Glycosidase Inhibitors
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Glycosidase Antagonist
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Glycosidase Activators
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Glycosidase Modulators
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Glycosidase Chemical
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Glycosidase Inducers
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Glycosidase Degrader
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Glycosidase Controls
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Glycosidase Substrates
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Glycosidase Ligands
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Glycosidase Related Products (696)
Related Products (696)
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Antibodies (3)
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MDL-25637
0 ImagesCat. No.: HY-105528CAS No.: 104343-33-1MDL-25637 is an α-glucosidase inhibitor. MDL-25637 can inhibit the activity of sucrose enzyme, maltase, isomaltase, glucose amylase, and trehalose in the intestinal tract of rats. MDL-25637 can be used in the research of diabetes.
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DNJ-20
0 ImagesCat. No.: HY-173411CAS No.: 3081926-49-7DNJ-20 is an α-glucosidase inhibitor (IC50: 55.3 μg/mL). DNJ-20 has broad-spectrum anti-SARS-CoV-2 activity. DNJ-20 inhibits the correct processing of viral glycoproteins by interfering with the endoplasmic reticulum-associated glycoprotein folding process (ERQC), thereby blocking the formation and infection of viral particles. DNJ-20 has IC50 values up to 1.49 uM against several SARS-CoV-2 variants, as well as HCoV-229E and HCoV-0C43。DNJ-20 can be used for pan-coronavirus research.
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α-Amylase/α-Glucosidase-IN-22
0 ImagesCat. No.: HY-178170α-Amylase/α-Glucosidase-IN-22 is an inhibitor of α-Amylase and α-Glucosidase with IC50 values of 1.71 and 10.36 nM (5 and 23.8 folds more potent than Acarbose (HY-B0089)). α-Amylase/α-Glucosidase-IN-22 can be used for the researches of metabolic disease, such as diabetes.
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α-Amylase/α-Glucosidase-IN-1
0 ImagesCat. No.: HY-147711CAS No.: 329783-03-1α-Amylase/α-Glucosidase-IN-1 (compound 33) is a potent α-amylase/α-glucosidase inhibitor with IC50s of 2.01, 2.09 µM for α-amylase and α-glucosidase, respectively. Kinetic studies predict that α-Amylase/α-Glucosidase-IN-1 has the potential of anti hyperglycemia.
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β-Galactosidase 1A, Sulfolobus solfataricus
0 ImagesCat. No.: HY-E71296β-Galactosidase 1A, Sulfolobus solfataricus (EC 3.2.1.23) is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.
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α-glucosidase/PTP1B-IN-1
0 ImagesCat. No.: HY-168185α-glucosidase/PTP1B-IN-1 (compound 8a) is a potent α-glucosidase and PTP1B inhibitor with an IC50 value of 66.3 μM and 47.0 μM, respectively. α-glucosidase/PTP1B-IN-1 exhibits excellent activities against α-amylase with an IC50 of 30.62 μM. α-glucosidase/PTP1B-IN-1 can dock into the active pockets of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 has potential to reduce the postprandial blood glucose and is used for Type 2 diabetes mellitus.
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Maltose solution, 20% in H2O
0 ImagesMaltose solution, 20% in H2O is a 20% aqueous maltose solution. Maltose is a disaccharide composed of two glucose molecules linked together. Maltose is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders.
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α-Amylase/α-Glucosidase-IN-7
0 ImagesCat. No.: HY-162036CAS No.: 1038094-94-8α-Amylase/α-Glucosidase-IN-7 (Compound 3f) is a competitive α-glucosidase and α-amylase enzyme inhibitor with IC50 values of 18.52 and 20.25 µM, respectively. α-Amylase/α-Glucosidase-IN-7 can also effectively inhibit AChE and BChE, with IC50 values of 9.25 and 10.06 µM respectively. α-Amylase/α-Glucosidase-IN-7 can be used in diabetes and Alzheimer’s research.
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Endo-1,4-β-D-glucanase
0 ImagesCat. No.: HY-E71366Endo-1,4-β-D-glucanase is a glycoside hydrolase that cleaves internal β-1,4-glycosidic bonds in cellulose and related β-D-glucans (β-D-Glucan) (HY-139413). Endo-1,4-β-D-glucanase randomly cuts long, insoluble cellulose polymer chains into shorter, soluble fragments such as oligosaccharides, thereby paving the way for further digestion into glucose.
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β-glycosidase-IN-1
0 ImagesCat. No.: HY-135670ACAS No.: 176485-27-1β-glycosidase-IN-1 (Compound 33) is a piperidine derivative and a β-glycosidase inhibitor. β-glycosidase-IN-1 has hypoglycemic activity.
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26-Degluco-torvoside H
0 ImagesCat. No.: HY-N18350CAS No.: 437988-00-626-Degluco-torvoside H (Compound 4) is a Furostanol glycoside derivative. 26-Degluco-torvoside H forms via hydrolysis of Torvoside H by β-glucosidase from Solanum torvum leaves.
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DEL-C1
0 ImagesCat. No.: HY-179214DEL-C1 is a CHI3L1 inhibitor. DEL-C1 can restore the ability to clear Amyloid-β and repair lysosomal function of astrocytes. DEL-C1 can inhibit NF-κB signaling and IL-6 secretion. DEL-C1 can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease.
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α-Glucosidase-IN-85
0 ImagesCat. No.: HY-173035α-Glucosidase-IN-85 (Compound 8D1) is the inhibitor for α-Glucosidase with an IC50 of 5.43 μM. α-Glucosidase-IN-85 can be used in research of type 2 diabetes.
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α-Amylase/α-Glucosidase-IN-8
0 ImagesCat. No.: HY-162169α-Amylase/α-Glucosidase-IN-8 (Compound 7p) is a potent dual inhibitor of α-amylase and α-glucosidase, with IC50s of 10.19 and 10.33 μM, respectively. α-Amylase/α-Glucosidase-IN-8 has good anti-oxidant activity(IC50 = 14.93 μM). α-Amylase/α-Glucosidase-IN-8 can be used for the research of diabetes.
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PTP1B-IN-27
0 ImagesCat. No.: HY-162480PTP1B-IN-27 (Compound 7i) is an inhibitor of protein tyrosine phosphatase 1-B (PTP‐1B)(IC50=8.2 µM). PTP1B-IN-27 also inhibits α-Glucosidase (IC50=120 µM) and shows competitive inhibition (Ki=118 µM).
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α-Glucosidase-IN-55
0 ImagesCat. No.: HY-158037α-Glucosidase-IN-55 (Compound 8g) is an orally active and competitive alpha-glucosidase inhibitor, with IC50 and Ki values of 12.1 and 9.66 µM, respectively. α-Glucosidase-IN-55 can be used for the research into type 2 diabetes mellitus (T2DM) to improve blood sugar control and metabolic health.
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α-Glucosidase-IN-103
0 ImagesCat. No.: HY-179508α-Glucosidase-IN-103 (compound 5u) is a potent and competitive α-Glucosidase inhibitor with an IC50 of 5.38 µM and a Ki of 3.57 µM. α-Glucosidase-IN-103 can be used for type 2 diabetes (T2DM) research.
