Microtubule/Tubulin

Related Products

Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.

Microtubule/Tubulin Related Products (951)
Antibodies (69)

By Effects:	Inhibitors (780) Agonists (2) Degraders (3) Controls (19) Ligands (5) Activators (12) Modulators (15) Inducers (5)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W013437

7-Benzoyloxindole	Inhibitor
7-Benzoyloxindole (Compound 4a) is a tubulin destabilizer. 7-Benzoyloxindole disrupts the structure of microtubulin, thereby inhibiting the growth of tumor cells. 7-Benzoyloxindole can be used in the research of gastric cancer and lung cancer.

HY-171683

Anti-CCL2 (Carlumab)-VcMMAE	Inhibitor
Anti-CCL2 (Carlumab)-VcMMAE is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated with valine-citrulline (vc) and the tubulin inhibitor MMAE (HY-15162). The ADC toxic molecule and linker part are McMMAE (HY-15575). Anti-CCL2 (Carlumab)-VcMMAE induces apoptosis and can be used in cancer research.

HY-164923

SPA107	Inhibitor
SPA107 (Hemiasterlin methyl ester) is a Hemiasterlin (HY-117371) analog. SPA107 inhibits the polymerization of tubulin, exhibits antimitotic activity (IC₅₀ of 0.5 nM) and cytotoxicity in p53 mutated MCF-7 cell with IC₅₀ of 0.5 nM.

HY-106021

Tasidotin	Inhibitor
Tasidotin (ILX651 free base) is a tubulin inhibitor and competitive Prolyl Endopeptidase (PREP) inhibitor, with an IC₅₀ of 10 μM against bovine tubulin. Tasidotin exhibits high cerebrospinal fluid penetration in non-human primates. Tasidotin antagonizes microtubule assembly and induces an extended assembly lag phase, thereby inhibiting mitosis and cell proliferation, and exerts cytotoxic and oncolytic effects on cancer cells. Tasidotin is metabolized into polypeptides and proline inside cells, and its in vivo metabolism is mediated by prolyl endopeptidase. Tasidotin can be applied in research related to Burkitt's lymphoma, breast cancer, leukemia, melanoma, central nervous system malignancies and various solid tumors.

HY-124624

PBOX-15	Inhibitor
PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells.

HY-180347

HD-800	Inhibitor
HD-800 is a tubulin inhibitor with an IC₅₀ of 4.3 nM and an EC₅₀ for depolymerization of 24 nM. HD-800 can be used to generate a radioactive tracer [11C]HD-800, and [11C]HD-800 can penetrate the blood-brain barrier and be used for positron emission tomography (PET) in various neurological diseases.

HY-172088

Tubulin/MMP-IN-3	Inhibitor
Tubulin/MMP-IN-3 (Compound 15j) is the dual inhibitor for tubulin polymerization and MMP, and inhibits MMP-2 and MMP-9 with IC₅₀ of 21.13 μM and 19.24 μM. Tubulin/MMP-IN-3 inhibits NF-κB signaling pathway, causes mitochondrial dysfunction and the apoptosis through a mitochondrial-dependent pathway. Tubulin/MMP-IN-3 exhibits antiproliferative activity in a variety of cancer cells, arrests the cell cycle at G2/M phase, and exhibits antitumor efficacy in mouse models.

HY-115957

Tubulin inhibitor 19	Inhibitor
Tubulin inhibitor 19 (compound 9b) is a potent inhibitor of tubulin. Tubulin inhibitor 19 is an indole chalcone compound. Tubulin inhibitor 19 has the potential for the research of cancer diseases.

HY-146506

isoCA-4	Inhibitor
isoCA-4, a Combretastatin A4 derivative, is a tubulin polymerization inhibitor. isoCA-4 has anti-proliferative activities.

HY-144132

αβ-Tubulin-IN-1	Inhibitor
αβ-Tubulin-IN-1 is a potent and orally active αβ-Tubulin inhibitor. αβ-Tubulin-IN-1 induces cell cycle arrest at G2/M and efficient apoptosis. αβ-Tubulin-IN-1 inhibits tumor cell migration and Metastasis. αβ-Tubulin-IN-1 shows significant antitumor efficacy in a dose dependent manner.

HY-151337

Aha1/Hsp90-IN-1	Inhibitor
Aha1/Hsp90-IN-1 (Compound 17) is an Aha1/Hsp90 complex inhibitor. Aha1/Hsp90-IN-1 disrupts Aha1/Hsp90 interactions with an IC₅₀ of 3.32 μM. Aha1/Hsp90-IN-1 inhibits tau aggregation.

HY-172611

Tubulin polymerization-IN-78	Inhibitor
Tubulin polymerization-IN-78 (compound 10a) is a tubulin polymerization inhibitor with an IC₅₀ value of 2.69 μM. Tubulin polymerization-IN-78 shows antiproliferative activity.

HY-N9842

Violanone	Inhibitor
Violanone, an isoflavanone compound, can inhibit tubulin polymerization. Violanone also exhibits larvicidal activity against A. aegypti.

HY-123266

D011-2120	Inhibitor
D011-2120 functions as an antiviral agent by inhibiting microtubule polymerization, disrupting the Golgi complex, and preventing viral trafficking to the plasma membrane during the virus egress process.

HY-N0488S2

Vincristine-d₆ sulfate	Inhibitor
Vincristine-d₆ (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas.

HY-162667

EX05	Inhibitor
EX05 is a potent KIF18A inhibitor with an IC₅₀ value of 8.2 nM. EX05 has the potential for the research of cancer.

HY-147848

Tubulin polymerization-IN-27	Inhibitor
Tubulin polymerization-IN-27 (compound 5j) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-27 can arrest cell cycle at G2/M phase and induce apoptosis.

HY-185269

2'-Deoxy-PTX	Activator
2'-Deoxy-PTX is a Paclitaxel (HY-B0015) derivative and microtubule assembly inducer. 2'-Deoxy-PTX binds to GMPcPP-stabilized microtubules, with a Ka_app of 0.50 × 10⁶ M^-1. 2′-Deoxy-PTX induces Tubulin to assemble into normal microtubules. 2'-Deoxy-PTX can be used for the research of prostate cancer.

HY-106399A

Acodazole hydrochloride	Inhibitor
Acodazole hydrochloride is an anticancer agent that exerts its anticancer activity by inhibiting microtubule polymerization.

HY-130273

HDAC/HSP90-IN-1	Inhibitor
HDAC/HSP90-IN-1 (compound 20) is a potent dual inhibitor of HDAC (IC₅₀ = 194 nM) and HSP90 (HSP90α IC₅₀ = 153 nM). HDAC/HSP90-IN-1 induces HSP70 expression, downregulates HSP90 client proteins, and promotes acetylation of α-tubulin and histone H3 in cancer cells. HDAC/HSP90-IN-1 reduces PD-L1 expression in IFN-γ treated H1975 cells. HDAC/HSP90-IN-1 can be used for cancer research, such as lung and colon cancer.

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Microtubule/Tubulin

Microtubule/Tubulin

Microtubule/Tubulin Related Products (951)

Antibodies (69)

Microtubule/Tubulin Related Products (951):