NO Synthase
Nitric oxide synthases; NOS
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.
NO Synthase Isoform Specific Products
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NO Synthase Inhibitors
(755)
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NO Synthase Agonists
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NO Synthase Antagonists
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NO Synthase Activators
(111)
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NO Synthase Modulators
(14)
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NO Synthase MDM2 Inhibitor
(1)
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NO Synthase Inducers
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NO Synthase Controls
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NO Synthase Substrates
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NO Synthase Ligand
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NO Synthase Related Products (1009)
Related Products (1009)
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Antibodies (6)
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NO Synthase Isoform Comparison
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Nalmefene (Standard)
0 ImagesCat. No.: HY-107744RCAS No.: 55096-26-9Nalmefene (Standard) is the analytical standard of Nalmefene. This product is intended for research and analytical applications. Nalmefene is a long acting opioid (MOR and DOR antagonist), and a partial KOR agonist. Nalmefene is used for opioid overdose and alcohol dependence.
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Tricrozarin A
0 ImagesCat. No.: HY-N15334CAS No.: 107817-60-7Tricrozarin A is a Naphthazarin (HY-N7526) derivative, which is found in fresh bulbs of Tritonia crocosmaeflora. Tricrozarin A exhibits antimicrobial activity against gram-positive bacteria, fungi, and yeast.
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DHEA Benzophenone-biotin
0 ImagesCat. No.: HY-183342CAS No.: 1216903-70-6DHEA Benzophenone-biotin is a photoactive DHEA (HY-14650) analog containing Biotin (HY-B0511) and Benzophenone (HY-Y0546) groups. DHEA Benzophenone-biotin inhibits plasma membrane binding of DHEA, activates endothelial NO synthase. DHEA Benzophenone-biotin cross-links to plasma membrane DHEA binding sites upon UV irradiation to identify associated proteins.
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Piceatannol 3'-O-glucoside (Standard)
0 ImagesCat. No.: HY-N2237RCAS No.: 94356-26-0Synonyms: Quzhaqigan (Standard)Piceatannol 3'-O-glucoside (Standard) is the analytical standard of Piceatannol 3'-O-glucoside. This product is intended for research and analytical applications. Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC50s of 11.22 μM and 11.06 μM against arginase I and arginase II, respectively.
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Aminoguanidine-13C,15N4 hemisulfate
0 ImagesCat. No.: HY-W020772AS1Purity: 99.0%Synonyms: Pimagedine-13C,15N4 hemisulfate; GER-11-13C,15N4 hemisulfate; Aminoguanidinium-13C,15N4 hemisulfateAminoguanidine-13C,15N4 (Pimagedine-13C,15N4) hemisulfate is the 13C,15N4-labeled Aminoguanidine hemisulfate (HY-W020772). Aminoguanidine hemisulfate is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hemisulfate can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hemisulfate has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hemisulfate has antioxidant properties. Aminoguanidine hemisulfate can be used in the research of diabetic nephropathy.
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Rubranol
0 ImagesCat. No.: HY-N1330CAS No.: 211126-61-3Rubranol is an inhibitor of NO Synthase. Rubranol inhibits LPS-induced NO production in activated macrophages with 74% inhibition.
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trans-Isoferulic acid (Standard)
0 ImagesSynonyms: trans-3-Hydroxy-4-methoxycinnamic acid (Standard)trans-Isoferulic acid (Standard) is the analytical standard of trans-Isoferulic acid. This product is intended for research and analytical applications. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity.trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1).
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α-Humulene (Standard)
0 ImagesSynonyms: Humulene (Standard); α-Caryophyllene (Standard)α-Humulene (Standard) is the analytical standard of α-Humulene. This product is intended for research and analytical applications. α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC50=15±2 μg/mL). α-Humulene inhibits COX-2 and iNOS expression.
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Quinocetone (Standard)
0 ImagesCat. No.: HY-123581RCAS No.: 81810-66-4Quinocetone (Standard) is the analytical standard of Quinocetone (HY-123581). This product is used for research and analytical purposes. Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage.
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3β,15α-Dihydroxy-7,11,23-trioxo-lanost-8-dien-26-oic acid
0 ImagesCat. No.: HY-N13706CAS No.: 117354-72-03β,15α-Dihydroxy-7,11,23-trioxo-lanost-8-dien-26-oic acid is a triterpene compound that can be found in Ganoderma lucidum, and it inhibits nitric oxide (NO) production in BV-2 microglial cells induced by lipopolysaccharide (LPS, HY-D1056), with an IC50 of 6.50 μM, making it a potential candidate for anti-inflammatory research.
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Artocarpesin
0 ImagesArtocarpesin is a flavonoid compound. Artocarpesin has inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA). Artocarpesin inhibits the production of NO, PGE2 and ROS by inhibiting COX-2 and iNOS expression, and plays an anti-inflammatory role. In addition, Artocarpesin inhibits platelet aggregation by inhibiting cyclic nucleotides and MAPKs, which can be used in the study of cardiovascular diseases.
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1-O-Caffeoylglycerol
0 ImagesCat. No.: HY-N16632CAS No.: 123134-23-61-O-Caffeoylglycerol is a compound with anti-inflammatory activity found in Sorghum bicolor. 1-O-Caffeoylglycerol significantly inhibits LPS (HY-D1056) induced NO production (IC50 = 18.5 μM) and dose dependently inhibits iNOS protein expression. 1-O-Caffeoylglycerol can be used for research on inflammatory conditions.
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GYY4137 (Standard)
0 ImagesCat. No.: HY-107632RCAS No.: 106740-09-4GYY4137 (Standard) is the analytical standard of GYY4137 (HY-107632). This product is intended for research and analytical applications. GY4137 is a sustained-release H2S donor possessing vasodilatory, antihypertensive, and anti-inflammatory activities. GY4137 can inhibit cell growth, induce apoptosis, and cause cell cycle arrest by blocKing the STAT3 pathway, demonstrating potent anticancer activity.
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Cinnamyl Alcohol-d9
0 ImagesCat. No.: HY-Y0078S1CAS No.: 3028869-57-7
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Valeriandoid B
0 ImagesCat. No.: HY-133198CAS No.: 1380399-57-4Valeriandoid B is a Iridoids product that can be isolated from the herbs of Valeriana jatamansi.
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H-D-Tpi-OH
0 ImagesCat. No.: HY-W269285CAS No.: 72002-54-1Synonyms: D-1,2,3,4-Tetrahydronorharman-3-carboxylic acidH-D-Tpi-OH (D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid) is a tetrahydro-β-carboline derivative. H-D-Tpi-OH only slightly upregulates QR1, mildly inhibits the aromatase and NO synthesis pathways, and shows no significant in vitro anti-breast tumor proliferation activity. H-D-Tpi-OH can be used in cancer-related research.
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Apiin (Standard)
0 ImagesCat. No.: HY-N0577RCAS No.: 26544-34-3Synonyms: Apigenin 7-O-apiosylglucoside (Standard); Apigenin 7-(2-O-apiosylglucoside) (Standard)Apiin (Standard) is the analytical standard of Apiin. This product is intended for research and analytical applications. Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells.
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Sulpho NONOate
0 ImagesCat. No.: HY-155224CAS No.: 61142-90-3Synonyms: Sulfi/NOSulpho NONOate (Sulfi/NO) does not produce NO at physiological pH. Sulpho NONOate can be used in the experiments about other NO-donor regents as a negative control.
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L-Arginine-15N4,d7 hydrochloride
0 ImagesCat. No.: HY-N0455AS9Synonyms: (S)-(+)-Arginine-15N4,d7 hydrochlorideL-Arginine-15N4,d7 (hydrochloride) is the deuterium and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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Aminopicoline (Standard)
0 ImagesSynonyms: Ascensil (Standard); 2-Amino-4-methylpyridine (Standard)Aminopicoline (Standard) is the analytical standard of Aminopicoline. Aminopicoline (Ascensil) is a potent and non-selective inhibitor of nitric oxide synthase (NOS) isoenzymes (iNOS, nNOS, eNOS). Aminopicoline competes with arginine at the substrate-binding site of nitric oxide synthase, reduces cellular nitric oxide production, inhibits the elevation of plasma nitrate, increases mean arterial pressure at high doses, and also serves as a basis for radiolabeled ligands to localize nitric oxide synthase binding sites. Aminopicoline can be used in the research of diseases associated with septic shock, joint inflammation, intestinal inflammation, and CNS inflammation。
