NO Synthase
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NO Synthase Inhibitors
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NO Synthase Ligand
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NO Synthase Related Products (628)
Related Products (628)
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Kansuinine E
0 ImagesCat. No.: HY-N9376CAS No.: 672945-84-5Kansuinine E is a plant-derived nitric oxide inhibitor (IC50=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui.
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Antihypertensive agent 7
0 ImagesCat. No.: HY-184303Antihypertensive agent 7 is a vasodilator. Antihypertensive agent 7 acts on vascular endothelial cells to activate the PI3K/AKT signaling axis, increase phosphorylated eNOS, release NO, activate the sGC/cGMP pathway in smooth muscle cells, and synergistically activate multiple K+ channels in vascular smooth muscle (Kir/Kv/KCa/KATP, thereby inducing endothelium-dependent vasodilation. Antihypertensive agent 7 can be used in the research of hypertension.
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11-Deoxyalisol B
0 ImagesCat. No.: HY-117601CAS No.: 155073-73-711-Deoxyalisol B, a triterpene, shows the potent inhibitory activity on Lipopolysaccharide (LPS)-induced nitric oxide (NO) production.
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Isolupalbigenin
0 ImagesCat. No.: HY-N8477CAS No.: 162616-70-8Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC50 of 5.1 μM.
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O-Acetylschisantherin L
0 ImagesCat. No.: HY-N8631CAS No.: 149998-51-6Synonyms: Acetylschisantherin LO-Acetylschisantherin L (Acetylschisantherin L) is a natural lignan, which exhibits inhibitory effects on LPS-induced NO production in BV-2 cells with an IC50 of 23.1 μM.
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(±)-Eudesmin
0 ImagesCat. No.: HY-N2180ACAS No.: 25305-05-9Synonyms: (±)-Eudesmine(±)-Eudesmin ((±)-Eudesmine) is a natural compound found in Fragaria nubicola with in vitro anti-inflammatory activity. (±)-Eudesmin inhibits NO production in LPS-activated macrophages; suppresses myeloperoxidase-dependent ROS production in zymosan-activated phagocytes; and inhibits superoxide anion production in PMA-activated macrophages. (±)-Eudesmin can be used for the research of inflammation-related diseases.
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Anti-inflammatory agent 19
0 ImagesCat. No.: HY-143457CAS No.: 2873386-63-9Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.
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Sodium propionate-13C2
0 ImagesCat. No.: HY-B1773AS2CAS No.: 83587-75-1Sodium propionate-13C-2 is the 13C-labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease.
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Valeriandoid F
0 ImagesCat. No.: HY-N8174CAS No.: 1427162-60-4Valeriandoid F is an iridoid, which potently inhibits NO production with an IC50 value of 0.88 μM. Valeriandoid F has anti-inflammatory and antiproliferative activities.
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Antitumor agent-49
0 ImagesCat. No.: HY-145908CAS No.: 2763914-21-0Antitumor agent-49 (Compound 10) is a Harmine derivative-furoxan hybrids containing NO donor, with antitumor activities. Antitumor agent-49 shows cytotoxic activity against HepG2 cells with an IC50 of 1.79 µM. Antitumor agent-49 produces high levels of NO in vitro.
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Britannilactone diacetate
0 ImagesCat. No.: HY-N4190CAS No.: 1286694-67-4Synonyms: 1,6-O,O-Diacetylbritannilactone; Di-O-acetylbritannilactoneBritannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC50 value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property.
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Flavokawain A (Standard)
0 ImagesFlavokawain A is a chalcone compound and an orally active inhibitor of PRMT5 and cytochrome P450. Flavokawain A has anti-inflammatory, anti-tumor, and immunomodulatory effects. Flavokawain A can inhibit the proliferation of tumor cells and induce apoptosis. Flavokawain A can be used in the research of diseases such as bladder cancer.
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Desmethoxyyangonin (Standard)
0 ImagesCat. No.: HY-N0918RCAS No.: 15345-89-8Synonyms: Demethoxyyangonin (Standard); 5,6-Dehydrokavain (Standard)Desmethoxyyangonin (Standard) is one of the six major kavalactones found in the Piper methysticum (kava) plant. Desmethoxyyangonin (Standard) is a selective inhibitor of monoamine oxidase-B (MAO-B) (IC50: 0.123 µM). Desmethoxyyangonin (Standard) exerts anti-inflammatory effects by inhibiting Jak2/STAT3 and IKK signaling pathways. Desmethoxyyangonin (Standard) induces CYP3A23 expression and leads to skeletal muscle relaxation.
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Avanafil-13C5
0 ImagesCat. No.: HY-18252S3Synonyms: TA1790-13C5Avanafil-13C5 (TA1790-13C5) is 13C labeled Avanafil. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis.
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N-Isobutyl decanamide
0 ImagesN-Isobutyl decanamide is a plant growth regulator. N-Isobutyl decanamide promotes the development of adventitious roots in hypocotyl explants of A. thaliana and lateral roots in taproot explants. N-Isobutyl decanamide induces the accumulation of NO in the proliferative sites of adventitious roots.
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Mycosporine 2 glycine
0 ImagesCat. No.: HY-161612CAS No.: 149092-45-5Mycosporine 2 glycine is an anti-inflammatory agent and TYRP1 inhibitor. Mycosporine 2 glycine inhibits the expression of inflammatory genes and reduces nitric oxide production. Mycosporine 2 glycine binds tightly to the active pocket of TYRP1 and inhibits the activity of melanogenesis-related enzymes. Mycosporine 2 glycine can be used in the research of hyperpigmentation and inflammation-related diseases.
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SARS-CoV-2-IN-107
0 ImagesCat. No.: HY-169974CAS No.: 3087307-24-9SARS-CoV-2-IN-107 (Compound A7) is the inhibitor for SARS-CoV-2 3CLpro with an IC50 of 261.3 nM. SARS-CoV-2-IN-107 inhibits the SARS-CoV-2 replication with an EC50 of 11.7 μM. SARS-CoV-2-IN-107 exhibits anti-inflammatory activity with a NO inhibition rate of 68.6% in LPS (HY-D1056)-stimulated RAW264.7 macrophages.
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DETA NONOate (Standard)
0 ImagesCat. No.: HY-136278RCAS No.: 146724-94-9Synonyms: Diethylamine NONOate (Standard); NOC-18 (Standard)DETA NONOate (Standard) is the analytical standard of DETA NONOate (HY-136278). This product is intended for research and analytical applications. DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting.
