Phospholipase
Phospholipase is a member of a very complex group of enzymes that break down phospholipids into fatty acids and other compounds. Phospholipases are defined by the enzymatic reaction they catalyze. The classes are phospholipase A, which has members A1 and A2; phospholipase B, which can carry out the reactions of both A1 and A2; phospholipase C; and phospholipase D.
Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular processes and are also substrates for synthesis of other important signaling molecules. PLC is thus central to many important interlocking regulatory networks. Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival.
Phospholipase Isoform Specific Products
All Product Categories
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Phospholipase Related Products (339)
Related Products (339)
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Antibodies (9)
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Phospholipase Isoform Comparison
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(+)-β-Pinene
0 ImagesCat. No.: HY-W716339CAS No.: 19902-08-0Synonyms: d-β-Pinene(+)-β-Pinene (d-β-Pinene) acts as an Antifungal and Antibacterial agent. (+)-β-Pinene inhibits Phospholipase. (+)-β-Pinene interferes with fungal cell wall function, reduces Candida biofilm adhesion, inhibits Candida albicans biofilm formation, and suppresses the growth of various Candida species. Combined with Ciprofloxacin (HY-B0356), (+)-β-Pinene exerts synergistic antibacterial activity against Methicillin (HY-121544)-resistant Staphylococcus aureus. (+)-β-Pinene can be used in research related to candidiasis and Staphylococcus aureus infections.
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CAY10650 (Standard)
0 ImagesCat. No.: HY-10801RCAS No.: 1233706-88-1CAY10650 (Standard) is the analytical standard of CAY10650 (HY-10801). This product is intended for research and analytical applications. CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.
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Compound 48/80 (Standard)
0 ImagesCat. No.: HY-115768RCAS No.: 94724-12-6Synonyms: Poly-p-methoxyphenethylmethylamine (Standard)Compound 48/80 (Standard) is the analytical standard of Compound 48/80 (HY-115768). This product is intended for research and analytical applications. Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways.
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BAPTA (Standard)
0 ImagesCat. No.: HY-100168RCAS No.: 85233-19-8BAPTA (Standard) is the analytical standard of BAPTA. This product is intended for research and analytical applications. BBAPTA is a selective and cell-impermeant chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
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SMS2-IN-1 (Standard)
0 ImagesCat. No.: HY-102041RCAS No.: 2098890-15-2SMS2-IN-1 (Standard) is the analytical standard of SMS2-IN-1 (HY-102041). This product is intended for research and analytical applications. SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM).
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Alminoprofen (Standard)
0 ImagesCat. No.: HY-17485RCAS No.: 39718-89-3Synonyms: EB-382 (Standard)Alminoprofen (Standard) is the analytical standard of Alminoprofen. This product is intended for research and analytical applications. Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A2 (sPLA2) and COX-2.
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D-Erythro-dihydrosphingosine (Standard)
0 ImagesCat. No.: HY-W019838RCAS No.: 764-22-7Synonyms: Sphinganine (d18:0) (Standard)D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.
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Isosalvianolic acid C
0 ImagesCat. No.: HY-122967CAS No.: 142115-17-1Isosalvianolic acid C is a naturally derived phenolic compound that acts as a signal modulator, antioxidant, and enzyme inhibitor. Isosalvianolic acid C induces the phosphorylation of PLC-γ, IP3R, PKC, and P38, triggering Ca2+ mobilization, degranulation, and chemokine release. Isosalvianolic acid C activates MRGPRX2 and its murine homolog MrgprB2, leading to pseudo-allergic reactions in vivo. Isosalvianolic acid C inhibits Cu2+-induced LDL peroxidation. Isosalvianolic acid C can be used in studies related to pseudo-allergy, diabetes, and atherosclerosis.
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Tris(2,4-di-tert-butylphenyl)phosphate (Standard)
0 ImagesTris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking.
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5-Bromo-4-chloro-3-indoxyl myo-inositol-1-phosphate ammonium
0 ImagesCat. No.: HY-W568087CAS No.: 212515-11-25-Bromo-4-chloro-3-indoxyl myo-inositol-1-phosphate ammonium is a chromogenic substrate that can be used to detect the activity of phosphatidylinositol-specific phospholipase C (PI-PLC).
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AVX001
0 ImagesCat. No.: HY-19920CAS No.: 300553-18-8Synonyms: AKH-217AVX001 is an inhibitor of phospholipase A2 (cPLA2α) that can be used in the research of psoriasis.
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Rilapladib (Standard)
0 ImagesCat. No.: HY-102004RCAS No.: 412950-08-4Synonyms: SB 659032 (Standard)Rilapladib (Standard) is the analytical standard of Rilapladib (HY-102004). This product is intended for research and analytical applications. Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM. Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist.
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PACOCF3 (Standard)
0 ImagesCat. No.: HY-108607RCAS No.: 141022-99-3Synonyms: Palmityltrifluoromethylketone (Standard)PACOCF3 (Standard) is the analytical standard of PACOCF3. This product is intended for research and analytical applications. PACOCF3 (Palmityltrifluoromethylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells.
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PF-04217903 phosphate
0 ImagesCat. No.: HY-12017CCAS No.: 1159490-83-1PF-04217903 phosphate is an orally active, highly selective ATP-competitive c-Met kinase inhibitor with a Ki value of 4.8 nM and a Kd value of 4.5 nM. PF-04217903 phosphate blocks c-Met and HGF signaling pathways, inhibits MET phosphorylation, and blocks downstream MAPK, PI3K/AKT and PLCγ1 pathways. PF-04217903 phosphate suppresses tumor proliferation, survival, migration, invasion, angiogenesis and metastasis, induces apoptosis, and enhances efferocytosis, Annexin A1 expression and resolution of inflammation. PF-04217903 phosphate retains activity against several c-Met mutants (M1131T, V1220I, H1094R). PF-04217903 phosphate increases the incidence of subarachnoid hemorrhage and reduces survival rate without altering aneurysm formation, and also prevents lymph node metastasis induced by VEGF inhibition. PF-04217903 phosphate is applicable to research related to tumors (pancreas, stomach, lung, brain, colon, breast, kidney, melanoma, etc.), intracranial aneurysms and inflammatory diseases (gouty arthritis, neutrophilic pleuritis).
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(S)-Albuterol
0 ImagesCat. No.: HY-137311ACAS No.: 34271-50-6(S)-Albuterol is a muscarinic receptor and phospholipase C activator. (S)-Albuterol increases intracellular free calcium in airway smooth muscle.
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U-73343 (Standard)
0 ImagesCat. No.: HY-108630RCAS No.: 142878-12-4U-73343 (Standard) is the analytical standard of U-73343 (HY-108630). This product is intended for research and analytical applications. U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC.
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Chlorogentisylquinone
0 ImagesCat. No.: HY-N15058CAS No.: 333344-08-4Chlorogentisylquinone is found in the strain of FOM-8108. The IC50 of inhibitory rat meningeal nSMase is 1.2 μM, and the IC50 of P388 cells is 7.6 μM.
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Phosphatidylinositol 4,5-bisphosphate
0 ImagesCat. No.: HY-114457CAS No.: 245126-95-8Synonyms: L-alpha-Phosphatidylinositol-4,5-bisphosphate; (PtdIns)-(4,5)-P2Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate) is a plasma membrane lipid that is enriched in the cytoplasmic leaflet of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate serves as a substrate for phospholipase C and class I PI3K, generating diacylglycerol, inositol (1,4,5)-trisphosphate, and phosphatidylinositol (3,4,5)-trisphosphate. Phosphatidylinositol 4,5-bisphosphate contributes to lamellipodial protrusion, directional cell migration, focal adhesion lipid generation, and trafficking of the GABAA receptor. Phosphatidylinositol 4,5-bisphosphate can be used in research related to acute lung injury and pulmonary edema.
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Cambinol (Standard)
0 ImagesCambinol (Standard) is the analytical standard of Cambinol. This product is intended for research and analytical applications. Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
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1-Linoleoyl Glycerol (Standard)
0 ImagesCat. No.: HY-111346RCAS No.: 2277-28-3Synonyms: 1-Linoleoyl-rac-glycerol (Standard); 1-Monolinolein (Standard)1-Linoleoyl Glycerol (Standard) is the analytical standard of 1-Linoleoyl Glycerol. This product is intended for research and analytical applications. 1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6).
