Phospholipase
-
Phospholipase Related Products (235)
Related Products (235)
-
KARI 201
0 ImagesCat. No.: HY-171962CAS No.: 2376132-22-6KARI 201 is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC50 of 338.3?nM. KARI 201 is a ghrelin receptor agonist. KARI 201 improves neuropathological features of Alzheimer's disease.
-
DS07551382
0 ImagesCat. No.: HY-177450CAS No.: 2488609-68-1DS07551382 is a potent phosphatidylserine synthase 1 (PTDSS1) inhibitor, thereby blocking intracellular phosphatidylserine synthesis. DS07551382 has antitumor activity.
-
cPLA2α-IN-derivative 1
0 ImagesCat. No.: HY-138871CAS No.: 1233706-89-2cPLA2α-IN-derivative 1 is an inactive alcohol derivative of a highly potent Cytosolic phospholipase A2α (cPLA2α) inhibitor.
-
A4333
0 ImagesCat. No.: HY-155343CAS No.: 3025827-56-6A4333 is biotinylated compound of A3373 (HY-155342) that inhibits Phospholipase D1 (PLD1), but not PLD2. A4333 plays an important role in antitumor activity.
-
Avicin G
0 ImagesCat. No.: HY-134505CAS No.: 197787-17-0Avicin G is a sphingomyelinase inhibitor and plasma membrane disruptor. Avicin G inhibits the enzymatic activities of neutral sphingomyelinases (SMPD2/3) and acid sphingomyelinase (SMPD1), elevates intracellular sphingomyelin levels, and alters the distribution of sphingomyelin. Avicin G interferes with the lateral segregation of GTP- and GDP-bound H-Ras, inhibits the signal output of oncogenic K-Ras and H-Ras, reduces the phosphorylation of ERK and Akt, increases lysosomal pH, and inhibits the endocytic recycling of epidermal growth factor receptor. Avicin G can be used in research related to pancreatic ductal adenocarcinoma and non-small cell lung cancer.
-
Lp-PLA2-IN-16
0 ImagesCat. No.: HY-153561ACAS No.: 1865780-73-9Lp-PLA2-IN-16 (example 1) is a lipoprotein-associated phospholipase A2 (Lp-PLA 2) inhibitor, which can be used in the research of Alzheimer's disease, etc.
-
DPTIP hydrochloride
0 ImagesCat. No.: HY-131002ACAS No.: 2361799-64-4DPTIP hydrochloride is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM.
-
Fuzapladib calcium
0 ImagesCat. No.: HY-19151CCAS No.: 141284-77-7Synonyms: IS-741 calciumFuzapladib calcium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib calcium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib calcium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site.
-
7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
0 ImagesCat. No.: HY-23909CAS No.: 89560-01-0Synonyms: DEDA7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA), a phospholipase inhibitor, is a non-metabolizable analog of arachidonic or eicosadienoic acid. 7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA) inhibits P388D1 cell phospholipase A2 (PLA2) (IC50 = 16 µM) and snake venom PLA2 (IC50 = 14 µM).
-
GK563
0 ImagesCat. No.: HY-138990CAS No.: 2351820-19-2GK563 is a selective Ca2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes.
-
Heptanoyl thio-PC
0 ImagesCat. No.: HY-176085Heptanoyl thio-PC is a sn-2 thiol-labeled Phospholipase A2 (HY-P3029) (PLA2) substrate that can be used to detect the activity of Phospholipase A2.
-
U-26384
0 ImagesCat. No.: HY-187602CAS No.: 112646-88-5U-26384 is a Phospholipase A2 inhibitor. U-26384 reduces Sodium iodoacetate (HY-D0849)-induced Arachidonic acid (HY-109590) release and cell damage. U-26384 can be used for research on Graves' disease and ischemic brain injury.
-
RHC 80267 (Standard)
0 ImagesCat. No.: HY-107416RCAS No.: 83654-05-1Synonyms: U-57908 (Standard)RHC 80267 (Standard) is the analytical standard of RHC 80267 (HY-107416). This product is intended for research and analytical applications. RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC50 of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC50 of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC).
-
CRM-51005
0 ImagesCat. No.: HY-187640CAS No.: 203051-01-8CRM-51005 is a phospholipase C (PLC)γ1 inhibitor with a bovine IC50 of 13.0 μg/mL. CRM-51005 inhibits PLCγ1 enzymatic activity and platelet-derived growth factor-induced phosphoinositide turnover. CRM-51005 acts as a cell growth inhibitor via suppression of PLC, phosphoinositide turnover, DNA synthesis, and cell proliferation.
-
LCL521 dihydrochloride (Standard)
0 ImagesCat. No.: HY-103593ARCAS No.: 1226759-47-2LCL521 dihydrochloride (Standard) is the analytical standard of LCL521 dihydrochloride (HY-103593A). This product is intended for research and analytical applications. LCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).
-
Varespladib sodium (Standard)
0 ImagesCat. No.: HY-13402ARCAS No.: 172733-42-5Synonyms: LY315920 sodium (Standard)Varespladib (sodium) (Standard) is the analytical standard of Varespladib (sodium). This product is intended for research and analytical applications. Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.
-
ST271 (Standard)
0 ImagesCat. No.: HY-103097RCAS No.: 106392-48-7ST271 (Standard) is the analytical standard of ST271 (HY-103097). This product is intended for research and analytical applications. ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively.
-
ML349 (Standard)
0 ImagesML349 (Standard) is the analytical standard of ML349 (HY-100737). This product is intended for research and analytical applications. ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM.
-
CGP-35949 sodium
0 ImagesCat. No.: HY-19041CAS No.: 111130-13-3CGP-35949 sodium is a LTD4 antagonist with phospholipase inhibitory activity. CGP-35949 sodium can be used for research of asthma.
