Sodium Channel
Na channels; Na+ channels
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.
Sodium Channel Isoform Specific Products
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Sodium Channel
(634)
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Nav1.1
(12)
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Nav1.2
(19)
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Nav1.3
(17)
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Nav1.4
(16)
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Nav1.5
(28)
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Nav1.6
(14)
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Nav1.7
(64)
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Nav1.8
(43)
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Nav1.9
(3)
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All Product Categories
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Sodium Channel Inhibitors
(638)
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Sodium Channel Agonists
(10)
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Sodium Channel Antagonists
(29)
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Sodium Channel Activators
(36)
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Sodium Channel Modulators
(31)
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Sodium Channel Controls
(5)
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Sodium Channel Ligands
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Sodium Channel Related Products (821)
Related Products (821)
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Antibodies (9)
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Related Compound Screening Libraries (1)
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Sodium Channel Isoform Comparison
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Bupivacaine hydrochloride solution
0 ImagesCat. No.: HY-FLW415121CAS No.: 73360-54-0Bupivacaine hydrochloride solution is mainly composed of Bupivacaine hydrochloride monohydrate (HY-W415121). Bupivacaine hydrochloride monohydrate is a NMDA receptor inhibitor. Bupivacaine hydrochloride monohydrate can block sodium, L-calcium, and potassium channels. Bupivacaine hydrochloride monohydrate potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride monohydrate can be used for the research of chronic pain.
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Lidocaine hydrochloride hydrate (Standard)
0 ImagesSynonyms: Lignocaine hydrochloride hydrate (Standard)Lidocaine (hydrochloride hydrate) (Standard) is the analytical standard of Lidocaine (hydrochloride hydrate). This product is intended for research and analytical applications. Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia.
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Fluphenazine dimaleate
0 ImagesCat. No.: HY-119980ACAS No.: 3093-66-1Fluphenazine dimaleate is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dimaleate blocks neuronal voltage-gated sodium channels. Fluphenazine dimaleate acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dimaleate can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dimaleate can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.
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Mexiletine hydrochloride (Standard)
0 ImagesMexiletine (hydrochloride) (Standard) is the analytical standard of Mexiletine (hydrochloride). This product is intended for research and analytical applications. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research.
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Cofirasersen sodium scrambled negative control
0 ImagesCat. No.: HY-139786CCofirasersen sodium scrambled negative control is the sequence scrambled negative control of Cofirasersen sodium.
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Detajmium L-tartrate
0 ImagesCat. No.: HY-115839ACAS No.: 33774-52-6Synonyms: Detajmium bitartrate; TachmalcorDetajmium (L-tartrate) is an antiarrhythmic compound. Detajmium has effect on V max in both dog ventricular muscle and Purkinje fibers was frequency dependent.
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Fomocaine
0 ImagesCat. No.: HY-B1656CAS No.: 17692-39-6Synonyms: P 652Fomocaine (P 652) is an orally active local agent that can suppress or relieve pain. Fomocaine shows antiarrhythmic activity.
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Kalmanol
0 ImagesCat. No.: HY-N21743CAS No.: 118997-92-5Kalmanol is a kalmane-type diterpenoid found in Rhododendri Mollis Flos and the leaves of Schinus terebinthifolius. Kalmanol is a state-dependent inhibitor of NaV1.4 channels, and upon binding to inactivated channels, it shifts the fast inactivation curve toward hyperpolarized potentials. Kalmanol exhibits analgesic activity and is used in pain-related research.
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Nav1.2-IN-2
0 ImagesNav1.2-IN-2 is a Nav1.2 inhibitor with a human IC50 of 0.18 μM. Nav1.2-IN-2 preferentially binds to the inactivated state of Nav1.2, reduces window current, suppresses neuronal depolarization and action potential generation. Nav1.2-IN-2 suppresses Veratridine (HY-N6691)-induced Ca2+ influx. Nav1.2-IN-2 can be used for the research of epilepsy.
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U 92032
0 ImagesCat. No.: HY-105415CAS No.: 142223-92-5U 92032 is a T-type Ca2+ channel antagonist. U 92032 inhibits Na+ channels. U-92032 inhibits thalamic oscillations. U 92032 can be used in the research of neurological diseases.
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Jingzhaotoxin XI
0 ImagesCat. No.: HY-P5872CAS No.: 921955-96-6Synonyms: JZTX-XIJingzhaotoxin XI (JZTX-XI) is a sodium conductance inhibitor with an IC50 of 124 nM. Jingzhaotoxin XI slows the fast inactivation (EC50=1.18±0.2 μM) of Nav1.5 expressed in Chinese hamster ovary (CHO-K1) cells.
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Metaflumizone (Standard)
0 ImagesCat. No.: HY-116448RCAS No.: 139968-49-3Synonyms: BAS-320I (Standard)Metaflumizone (Standard) is the analytical standard of Metaflumizone. This product is intended for research and analytical applications. Metaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker.
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Licarbazepine-d4-1
0 ImagesSynonyms: BIA 2-005-d4-1; GP 47779-d4-1Licarbazepine-d4-1 is deuterium labeled Licarbazepine. Licarbazepine (BIA 2-005; GP 47779)?is a?voltage-gated sodium channel?blocker?with?anticonvulsant?and?mood-stabilizing?effects.
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Dexnafenodone hydrochloride
0 ImagesCat. No.: HY-105521ACAS No.: 94096-42-1Synonyms: (S)-Nafenodone; LU-43706Dexnafenodone hydrochloride ((S)-Nafenodone; LU-43706) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone hydrochloride inhibits the fast inward Na+ current and slow inward Ca2+ current in cardiomyocytes. Dexnafenodone hydrochloride inhibits voltage-gated and receptor-activated Ca2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca2+ stores, suppresses agonist-stimulated Ca2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone hydrochloride can be used in the research of depression.
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Indecainide
0 ImagesCat. No.: HY-121306CAS No.: 74517-78-5Synonyms: Ricainide; LY 135837 free baseIndecainide (Ricainide) is an orally active antiarrhythmic agent. Indecainide can be used in the research of ventricular dysfunction. Indecainide has Na+-channel-blocking activity.
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Propylparaben-d7
0 ImagesCat. No.: HY-N2026SCAS No.: 1246820-92-7Synonyms: Propyl parahydroxybenzoate-d7; Propyl 4-hydroxybenzoate-d7Propylparaben-d7 (Propyl parahydroxybenzoate-d7) is the deuterium labeled Propylparaben (HY-N2026). Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is an orally active weak estrogen receptor agonist. Propylparaben regulates the PI3K-AKT and JNK signaling pathways, and induces oxidative stress. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods, and can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury.
