Sodium Channel
Na channels; Na+ channels
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.
Sodium Channel Isoform Specific Products
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Sodium Channel
(634)
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Nav1.1
(12)
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Nav1.2
(19)
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Nav1.3
(17)
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Nav1.4
(16)
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Nav1.5
(28)
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Nav1.6
(14)
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Nav1.7
(64)
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Nav1.8
(43)
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Nav1.9
(3)
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All Product Categories
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Sodium Channel Inhibitors
(638)
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Sodium Channel Agonists
(10)
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Sodium Channel Antagonists
(29)
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Sodium Channel Activators
(36)
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Sodium Channel Modulators
(31)
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Sodium Channel Controls
(5)
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Sodium Channel Ligands
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Sodium Channel Related Products (821)
Related Products (821)
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Antibodies (9)
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Related Compound Screening Libraries (1)
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Sodium Channel Isoform Comparison
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Sodium Channel inhibitor 2
0 ImagesCat. No.: HY-100257CAS No.: 653573-60-5Sodium Channel inhibitor 2 is a sodium channel blocker extracted from patent WO 2004011439 A2, compound 3c.
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Nav1.8-IN-19
0 ImagesCat. No.: HY-172999CAS No.: 3003829-05-5Nav1.8-IN-19 (Compound 122) is a Nav1.8 inhibitor with an IC50 of 0.44 nM in HEK cells. Nav1.8-IN-19 can be used for the study of pain.
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Brompheniramine maleate (Standard)
0 ImagesBrompheniramine (maleate) (Standard) is the analytical standard of Brompheniramine (maleate). This product is intended for research and analytical applications. Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research.
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Articaine
0 ImagesCat. No.: HY-B0516ACAS No.: 23964-58-1Synonyms: Hoe-045 free baseArticaine (Hoe-045) is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 μM for open-state Na+ channels, and IC50 of 40.6 μM and 378 μM for inactivated and resting-state Na+ channels, respectively. Articaine exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury).
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BN-82451 dihydrochloride
0 ImagesCat. No.: HY-119274CAS No.: 663172-95-0BN-82451 dihydrochloride, an orally active and CNS-penetrated antioxidant and a multitargeting neuroprotective agent, exert a significant protection in experimental animal models mimicking aspects of cerebral ischemia, Parkinson disease, Huntington disease, and more particularly amyotrophic lateral sclerosis.
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HNS-32
0 ImagesCat. No.: HY-117135CAS No.: 186086-10-2HNS-32 is a compound with antiarrhythmic and vasodilatory effects in canine hearts, showing superior protective effects against ischemic and reperfusion arrhythmias compared to an equivalent dose of Mexiletine hydrochloride (HY-A0093). Furthermore, HNS-32 exhibits significant negative chronotropic effects on mammalian ventricular myocardium, indicating its potential application value in the study of acute coronary syndrome.
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DA-0218
0 ImagesCat. No.: HY-182710CAS No.: 1081317-31-8DA-0218 is a Nav1.7 inhibitor. DA-0218 exerts state-dependent inhibitory effects. DA-0218 alleviates formalin-induced inflammatory pain behavior and Paclitaxel-induced mechanical hyperalgesia in mice. DA-0218 inhibits Histamine-induced acute pruritus and lymphoma-induced chronic pruritus in mice. DA-0218 can be used in research related to inflammatory pain, neuropathic pain, acute pruritus and chronic pruritus.
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Oxcarbazepine-d10
0 ImagesCat. No.: HY-B0114S3CAS No.: 2749432-28-6Synonyms: GP 47680-d10Oxcarbazepine-d10 (GP 47680-d10) is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects.
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Riluzole hydrochloride (Standard)
0 ImagesSynonyms: PK 26124 hydrochloride (Standard)Riluzole hydrochloride (Standard) is the analytical standard of Riluzole hydrochloride. This product is intended for research and analytical applications. Riluzole hydrochloride is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
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Oxcarbazepine-d4
0 ImagesCat. No.: HY-B0114SCAS No.: 1020719-71-4Synonyms: GP 47680-d4Oxcarbazepine-d4 (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects.
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Dexnafenodone
0 ImagesCat. No.: HY-105521CAS No.: 92629-87-3Synonyms: (S)-Nafenodone free base; LU-43706 free baseDexnafenodone ((S)-Nafenodone free base; LU-43706 free base) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone inhibits the fast inward Na+ current and slow inward Ca2+ current in cardiomyocytes. Dexnafenodone inhibits voltage-gated and receptor-activated Ca2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca2+ stores, suppresses agonist-stimulated Ca2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone can be used in the research of depression.
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Riluzole-13C6
0 ImagesCat. No.: HY-B0211S1Synonyms: PK 26124-13C6Riluzole-13C6 (PK 26124-13C6) is 13C labeled Riluzole. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
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Ropivacaine hydrochloride monohydrate (Standard)
0 ImagesRopivacaine (hydrochloride monohydrate) (Standard) is the analytical standard of Ropivacaine (hydrochloride monohydrate). This product is intended for research and analytical applications. Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is widely used for regional anesthesia and neuropathic pain management in vivo.
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Eslicarbazepine-d4
0 ImagesCat. No.: HY-114703S1Synonyms: BIA 2-194-d4Eslicarbazepine-d4 (BIA 2-194-d4) is deuterium labeled Eslicarbazepine. Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.
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Permethrin-d6
0 ImagesCat. No.: HY-W774926CAS No.: 82523-59-9Synonyms: NRDC-143-d6Permethrin-d6 (NRDC-143-d6) is deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes).
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NAV 26
0 ImagesNAV 26 (Compound 26) is a selective NaV1.7 inhibitor with an IC50 of 0.37 μM. NAV 26 is applicable for pain-related research.
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A-803467 (Standard)
0 ImagesCat. No.: HY-11079RCAS No.: 944261-79-4A-803467 (Standard) is the analytical standard of A-803467 (HY-11079). This product is intended for research and analytical applications. A-803467 is a potent and selective tetrodotoxin-resistant Nav1.8 sodium channel blocker (IC50=8 nM). A-803467 has shown significant anti-nociception in neuropathic and inflammatory pain models. A-803467 enhances the chemosensitivity of conventional anticancer agents through interaction with the ATP-binding cassette subfamily G member 2 (ABCG2) transporter.
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Dexpramipexole-d3 dihydrochloride
0 ImagesCat. No.: HY-17355BSCAS No.: 1432230-09-5Synonyms: (R)-Pramipexole-d3 dihydrochloride; R-(+)-Pramipexole-d3 dihydrochloride; KNS-760704-d3 dihydrochlorideDexpramipexole-d3 ((R)-Pramipexole-d3) dihydrochloride is the deuterium labeled Dexpramipexole. Dexpramipexole ((R)-Pramipexole) dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.
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Amiloride hydrochloride dihydrate (Standard)
0 ImagesSynonyms: MK-870 hydrochloride dihydrate (Standard)Amiloride hydrochloride dihydrate (Standard) is the analytical standard of Amiloride hydrochloride dihydrate. This product is intended for research and analytical applications. Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2) channel.
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Gonyautoxin II
0 ImagesCat. No.: HY-19605CAS No.: 60508-89-6Gonyautoxin II is a paralytic shellfish poisoning toxin. Gonyautoxin II can block of the voltage-gated sodium channels at axonal level, impeding nerve impulse propagation. Gonyautoxin II has killing activity against mouse neuroblastoma cells. Gonyautoxin II can be used for the researches of cancer and neurological disease.
