Sodium Channel
Na channels; Na+ channels
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.
Sodium Channel Isoform Specific Products
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Sodium Channel
(634)
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Nav1.1
(12)
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Nav1.2
(19)
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Nav1.3
(17)
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Nav1.4
(16)
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Nav1.5
(28)
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Nav1.6
(14)
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Nav1.7
(64)
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Nav1.8
(43)
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Nav1.9
(3)
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All Product Categories
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Sodium Channel Inhibitors
(638)
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Sodium Channel Agonists
(10)
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Sodium Channel Antagonists
(29)
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Sodium Channel Activators
(36)
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Sodium Channel Modulators
(31)
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Sodium Channel Controls
(5)
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Sodium Channel Ligands
(3)
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Sodium Channel Related Products (821)
Related Products (821)
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Antibodies (9)
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Related Compound Screening Libraries (1)
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Sodium Channel Isoform Comparison
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Methocarbamol-d5
0 ImagesCat. No.: HY-B0262SCAS No.: 1189699-70-4Methocarbamol-d5 is deuterium labeled Methocarbamol. Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel.
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Dronedarone-d6 hydrochloride
0 ImagesCat. No.: HY-A0016SCAS No.: 1329809-23-5Dronedarone-d6 (hydrochloride) is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4.
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PD-85639
0 ImagesCat. No.: HY-135628CAS No.: 149838-21-1PD-85639 is a voltage-gated sodium (Na+) channel blocker that has neuroprotective effects.
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Nav1.7-IN-13
0 ImagesCat. No.: HY-162347CAS No.: 2776235-57-3Nav1.7-IN-13 (compound 3g) is a sodium channel inhibitor that significantly inhibits Veratridine (HY-N6691)-induced neuronal activity. Nav1.7-IN-13 inhibits total Na+ current in DRG neurons in a concentration-dependent manner; slows down the activation of Navs. Nav1.7-IN-13 significantly alleviated mechanical pain behavior in a rat model of nerve injury (SNI) and had analgesic activity.
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GrTx1
0 ImagesCat. No.: HY-P5164GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel, with IC50s of 0.63 μM, 0.23 μM, 0.77 μM, 1.29 μM, 0.63 μM and 0.37 μM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively. GrTx1 can be used for neurological disease research.
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Eslicarbazepine acetate (Standard)
0 ImagesSynonyms: BIA 2-093 (Standard)Eslicarbazepine acetate (Standard) is the analytical standard of Eslicarbazepine acetate. This product is intended for research and analytical applications. Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
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GTx1-15
0 ImagesCat. No.: HY-P5793GTx1-15 is an inhibitor cystine knot (ICK) peptide that inhibits the voltage-dependent calcium channel Cav3.1 and the voltage-dependent sodium channels Nav1.3 and Nav1.7.
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Veratridine (Standard)
0 ImagesVeratridine (Standard) is the analytical standard of Veratridine. This product is intended for research and analytical applications. Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39?μM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow.
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BDS-II
0 ImagesCat. No.: HY-P5818BDS-II is a peptide toxin, and is composed of 43 amino acids. BDS-II is a selective Kv3.4 channel inhibitor.
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Buratrigine
0 ImagesCat. No.: HY-187893SCAS No.: 2864428-32-8Buratrigine is a Sodium channel blocker with analgesic properties.
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Ranolazine-d8 dihydrochloride
0 ImagesSynonyms: CVT 303-d8 dihydrochloride; RS 43285-d8Ranolazine-d8 (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor.
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GS-462808
0 ImagesCat. No.: HY-120774CAS No.: 1354198-41-6GS-462808 is an oral active late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with the IC50 of 1.33 μM. GS-462808 can be used for study of arrhythmia.
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Budiodarone-d10 tartrate
0 ImagesCat. No.: HY-14834ASSynonyms: ATI-2042-d10 tartrateBudiodarone-d10 tartrate (ATI-2042-d10 tartrate) is the deuterium labeled Budiodarone tartrate (HY-14834A). Budiodarone (ATI-2042) tartrate is a chemical analogue of Amiodarone (HY-14187) with balanced, multiple cardiac ion channel (potassium, sodium and calcium channels) inhibiting activity. Budiodarone tartrate is an antiarrhythmic agent.
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Sulcardine
0 ImagesCat. No.: HY-156976CAS No.: 343935-60-4Sulcardine is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 µM and 69.2 µM, respectively. Sulcardine is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine has anti-arrhythmic effects.
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Antiarrhythmic agent-4
0 ImagesCat. No.: HY-189366Antiarrhythmic agent-4 is an orally active cardiac ion channel modulator. Antiarrhythmic agent-4 selectively inhibits pathological late sodium current of the cardiac NaV1.5 channel (IC50 = 2.5 μM) while blocking the hERG (IKr) channel (IC50 = 1.5 μM). Antiarrhythmic agent-4 reduces intracellular sodium/calcium overload, prolongs the cardiac action potential, and avoids conduction block and negative inotropic effects. Antiarrhythmic agent-4 exhibits antiarrhythmic efficacy in an isoproterenol-induced atrial fibrillation model in isolated rabbit hearts and improves survival and cardiac function in a Doxorubicin (HY-15142A)-induced heart failure mouse model. Antiarrhythmic agent-4 can be used for research on atrial fibrillation and heart failure.
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Topiramate D12 (Standard)
0 ImagesCat. No.: HY-110234RCAS No.: 1279037-95-4Synonyms: McN 4853 D12 (Standard); RWJ 17021 D12 (Standard)Topiramate D12 (Standard) is the analytical standard of Topiramate D12. This product is intended for research and analytical applications. Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
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NIP 142
0 ImagesCat. No.: HY-W705705CAS No.: 203002-58-8NIP-142 is a benzopyran derivative with multiple ion channel-blocking effects. NIP-142 selectively blocks the potassium ion channels enriched in atrial muscle, prolonging the effective refractory period (ERP) and action potential duration (APD) of the atrium, while having minimal effect on ventricular repolarization. NIP-142 also inhibits L-type/T-type calcium channels and sodium channels, further contributing to its anti-arrhythmic effect. NIP-142 shows significant efficacy in various atrial fibrillation models. NIP-142 can be used for research on arrhythmias.
