Topoisomerase
Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes that act on the topology of DNA. Type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and then the cut strand is reannealed. Type I topoisomerases are subdivided into two subclasses: type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases, and type IB topoisomerases, which utilize a controlled rotary mechanism. Type II topoisomerase cuts both strands of one DNA double helix, pass another unbroken DNA helix through it, and then reanneal the cut strands. This class is also split into two subclasses: type IIA and type IIB topoisomerases, which possess similar structure and mechanisms.
Topoisomerase Isoform Specific Products
All Product Categories
-
Topoisomerase Inhibitors
(769)
View all products
-
Topoisomerase Agonists
(2)
View all products
-
Topoisomerase Modulator
(1)
View all products
-
Topoisomerase Inducer
(1)
View all products
-
Topoisomerase Degraders
(3)
View all products
-
Topoisomerase Controls
(3)
View all products
-
Topoisomerase Ligands
(2)
View all products
-
Topoisomerase Proteins
(1)
View all products
-
DNA topoisomerase II Proteins
(1)
View all products
-
Topoisomerase Related Products (847)
Related Products (847)
-
Recombinant Proteins (1)
-
Antibodies (4)
-
Topoisomerase Isoform Comparison
-
Topoisomerase II-IN-24
0 ImagesCat. No.: HY-175853CAS No.: 613254-63-0Topoisomerase II-IN-24 is a Topoisomerase IIα inhibitor with an IC50 of 41.67 μM. Topoisomerase II-IN-24 can inhibit cancer cells proliferation, induce G2/M phase arrest and induce apoptosis. Topoisomerase II-IN-24 can be used for the research of cancer, such as colon cancer.
-
Icariside E3
0 ImagesCat. No.: HY-N19832CAS No.: 117613-74-8Icariside E3 is a Leishmania donovani DNA Topoisomerase IB (LdTOP1LS) inhibitor. Icariside E3 can be used for the research of leishmaniasis.
-
Levofloxacin mesylate
0 ImagesCat. No.: HY-W338859CAS No.: 226578-51-4Levofloxacin mesylate is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin mesylate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin mesylate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin mesylate shows anti-orthopoxvirus activity.
-
Topoisomerase IIα-IN-7
0 ImagesCat. No.: HY-152479Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC50 value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability.
-
MDM2-IN-27
0 ImagesCat. No.: HY-180508MDM2-IN-27 (Compound 20k) is an MDM2 inhibitor. MDM2-IN-27 can effectively block the inhibitory effect of MDM2 on p53, thereby activating the p53 pathway. MDM2-IN-27 has a certain topoisomerase I inhibitory activity and has a very weak inhibitory effect on topoisomerase IIα. MDM2-IN-27 exhibits significant anti-proliferative activity against breast cancer, colon cancer, and cutaneous squamous cell carcinoma.
-
MGB4
0 ImagesCat. No.: HY-178174MGB4 is a DNA minor groove binder. MGB4 binds to ARE-containing DNA and inhibition of topoisomerase I activity. MGB4 can impacts key cellular pathways, including inhibition oftranslation and alterations in sphingolipid and amino acid metabolism. MGB4 also reduces spermine and spermidine metabolism companied with Doxorubicin (HY-15142A). MGB4 can be used for the research of cancer, such as Prostate cancer.
-
Chimmitecan
0 ImagesSynonyms: (S)-9-Allyl-10-HydroxycamptothecinChimmitecan ((S)-9-Allyl-10-Hydroxycamptothecin), a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560), is a potent inhibitor of topoisomerase I. Chimmitecan exhibits anticancer activity.
-
Niranthin
0 ImagesCat. No.: HY-N6054CAS No.: 50656-77-4Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.
-
(R)-Amrubicin
0 ImagesCat. No.: HY-B0067BCAS No.: 92395-36-3Synonyms: (R)-SM-5887(R)-Amrubicin ((R)-SM-5887) is an anthracycline that effectively treats lung cancer by intercalating into DNA and inhibiting topoisomerase II activity, which consequently hampers DNA replication as well as RNA and protein synthesis, leading to cell growth inhibition and apoptosis. This compound exhibits superior anti-tumor efficacy compared to traditional anthracycline drugs while lacking the cumulative cardiac toxicity typically associated with this drug class.
-
Luotonin A
0 ImagesLuotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity.
-
Mitoxantrone-d8
0 ImagesCat. No.: HY-13502SCAS No.: 1189974-82-0Synonyms: Mitozantrone-d8; NSC 301739-d8Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM.
-
Elomotecan TFA
0 ImagesCat. No.: HY-13622BSynonyms: BN 80927 TFAElomotecan TFA (BN 80927 TFA) is an orally active, potent inhibitor of topoisomerases I and II and a homocamptothecin (hCPT) analogue. Elomotecan TFA possesses a dual inhibitory mechanism: it acts as a topoisomerase I poison by stabilizing the DNA-enzyme complex while simultaneously serving as a catalytic inhibitor of topoisomerase II. Elomotecan TFA is used in research concerning various advanced and multidrug-resistant (MDR) solid tumors (such as prostate, colon, and breast cancers).
-
Gatifloxacin-d3 hydrochloride
0 ImagesCat. No.: HY-10581ASSynonyms: AM-1155-d3 hydrochloride; BMS-206584-d3 hydrochloride; PD135432-d3 hydrochlorideGatifloxacin-d3 (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
-
Topoisomerase I inhibitor 3
0 ImagesCat. No.: HY-143266CAS No.: 2588211-50-9Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase.
-
NBTIs-IN-6
0 ImagesCat. No.: HY-146816CAS No.: 2422893-97-6NBTIs-IN-6 is a bacterial topoisomerase inhibitor with certain antibacterial activity. Among them, the MIC90 for fluoroquinolone-resistant MRSA was 2 μg/mL.
-
Topoisomerase II inhibitor 12
0 ImagesCat. No.: HY-147877CAS No.: 2304527-20-4Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity.
-
Topoisomerase II inhibitor 19
0 ImagesCat. No.: HY-162381Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and topoisomerase II inhibitor (IC50 value of 0.34 μM). Topoisomerase II inhibitor 19 would induce detectable potent damage in ctDNA.
-
TopoII/Tubulin-IN-3
0 ImagesCat. No.: HY-187099TopoII/Tubulin-IN-3 is a Tubulin and Topoisomerase II inhibitor. TopoII/Tubulin-IN-3 induces G2 and M phase cell cycle arrest and promotes cell Apoptosis. TopoII/Tubulin-IN-3 exhibits anticancer activity against breast adenocarcinoma and liver cancer. TopoII/Tubulin-IN-3 can be used in studies related to breast adenocarcinoma and liver cancer.
-
OSUAB-0284
0 ImagesCat. No.: HY-173478CAS No.: 3053515-60-6OSUAB-0284 is a bacterial topoisomerase inhibitor. OSUAB-0284 has significant anti-staphylococcal activity, especially against methicillin-resistant Staphylococcus aureus (MRSA). OSUAB-0284 exerts its antibacterial effect by inhibiting bacterial topoisomerase. OSUAB-0284 can be used to study infections caused by drug-resistant bacteria such as MRSA.
-
Flumequine-13C3
0 ImagesCat. No.: HY-B0526SCAS No.: 1185049-09-5Flumequine-13C3 is the 13C3 labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).
