2. Signaling Pathways
  3. Immunology/Inflammation
  4. IKZF Family

IKZF Family

Ikaros zinc finger protein family

IKZF family is a group of transcription factor families that play a crucial role in processes such as lymphopoiesis, differentiation, and functional regulation of lymphocytes. The proteins of its members have specific zinc finger domains in their structures, which can interact with DNA or other proteins, thus regulating the gene transcription process. As transcriptional repressors and activators, members of the IKZF family are of great significance in the differentiation of hematopoietic stem cells into lymphocytes, as well as in the differentiation and function exertion of T and B cells. In addition, members of the IKZF family can regulate gene expression through various mechanisms, including remodeling chromatin structure, promoting the activity of the RNA Pol II transcription initiation complex, and inducing chromosome conformational changes, etc. Mutations or abnormal functions of the members of the IKZF family are associated with a variety of diseases, such as B cell deficiency, leukemia, and autoimmune diseases[1].

IKZF Family Isoform Specific Products:

IKZF Family Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-179064
    IKZF1/3 ligand-1
    		Degrader
    IKZF1/3 ligand-1 is a PROTAC target protein ligand that can be used for synthesis of PROTACs, such as PROTAC IKZF1/3 Degrader-1 (HY-179075). PROTAC IKZF1/3 Degrader-1 is a potent IKZF1/3 PROTAC degrader with neuroprotective activity.
    IKZF1/3 ligand-1
  • HY-175600
    MI-2-80
    		Degrader
    MI-2-80 is a molecular glue degrader. MI-2-80 induces proteins (such as IKZF1/3 and CSNK1A1) to bind to CRBN, promoting their ubiquitination and degradation.
    MI-2-80
  • HY-179077
    PROTAC BTK/IKZF1/3 Degrader-1
    		Degrader
    PROTAC BTK/IKZF1/3 Degrader-1 is a selective and orally active BCL6 and IKZF1/3 PROTAC degrader. PROTAC BTK/IKZF1/3 Degrader-1 exhibits antitumor activity. PROTAC BTK/IKZF1/3 Degrader-1 can be used for the research of cancer, such as lymphoma. (Structure Note: Pink: BCL6/IKZF1/3 ligand (HY-179076); Blue: CRBN ligand (HY-41547))
    PROTAC BTK/IKZF1/3 Degrader-1
  • HY-182797
    NHWL071065
    		Degrader
    NHWL071065 is a CRBN-targeting IKZF1/IKZF3 molecular glues degrader. NHWL071065 selectively degrades IKZF1 and IKZF3 in lymphoma cells via the ubiquitin-proteasome pathway. NHWL071065 inhibits the proliferation of lymphoma cells. NHWL071065 downregulates proteins involved in cytoskeleton assembly, cell adhesion and immune regulation in cells, while upregulating proteins related to the type I IFN signaling pathway. NHWL071065 can be used in the research of lymphoma.
    NHWL071065
  • HY-172368
    PROTAC CARM1/IKZF3 degrader-1
    		Degrader
    PROTAC CARM1/IKZF3 degrader-1 (Compound 074) inhibits CARM1, reduces the methylation level of its substrate BAF155. PROTAC CARM1/IKZF3 degrader-1 is the PROTAC degrader for IKZF 1/3 through a CRBN-dependent pathway. PROTAC CARM1/IKZF3 degrader-1 inhibits the expression of MYC protein, thereby inhibiting the proliferation of a variety of multiple myeloma cells. PROTAC CARM1/IKZF3 degrader-1 induces apoptosis in cell H929. PROTAC CARM1/IKZF3 degrader-1 overcomes immunomodulatory drugs (IMiD, such as pomalidomide) resistance. PROTAC CARM1/IKZF3 degrader-1 can be used in cancer and immunology research. (Pink: ligand for target protein CARM1/IKZF3 ligand 1 (HY-172369); Active form of target protein ligand: EZM 2302 (HY-111109); Black: linker (HY-21999); Blue: ligand for E3 ligase Cereblon Thalidomide 4-fluoride (HY-41547))
    PROTAC CARM1/IKZF3 degrader-1
  • HY-185300
    IKZF2-degrader 4
    		Degrader
    IKZF2-degrader 4 (Page 650, third compound from the top in the right column) is an IKZF2 Molecular glue degrader. IKZF2-degrader 4 degrades IKZF2 protein. IKZF2-degrader 4 can be used in the research of cancer.
    IKZF2-degrader 4
  • HY-103484R
    GATA4-NKX2-5-IN-1 (Standard)
    		Inhibitor
    GATA4-NKX2-5-IN-1 (Standard) is the analytical standard of GATA4-NKX2-5-IN-1 (HY-103484). This product is intended for research and analytical applications. GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression.
    GATA4-NKX2-5-IN-1 (Standard)
  • HY-160531
    IKZF1-degrader-1
    		Degrader
    IKZF1-degrader-1 (Compound 9-B) is a IKZF1 molecular glue degrader with the DC50 value of 0.134 nM. IKZF1-degrader-1 can be used to degrader tumors.
    IKZF1-degrader-1
IKZF Family Isoform Comparison

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