mAChR
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mAChR Related Products (484)
Related Products (484)
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VU6036864
0 ImagesCat. No.: HY-159578SCAS No.: 2746406-36-8VU6036864 (compound 45) is an orally active, selective mAChR M5 antagonist with IC50=20 nM for human M5. VU6036864 is >500-fold selective for human M1-4, with BBB characteristic and high oral bioavailability (%F>100%).
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Pirenzepine (Standard)
0 ImagesSynonyms: LS 519 free base (Standard); Pirenzepin (Standard); Gastrozepin (Standard)Pirenzepine (Standard) is the analytical standard of Pirenzepine. This product is intended for research and analytical applications. Pirenzepine (LS 519 free base) is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine shows anti-proliferative activity to cancer cells.
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(R)-Oxybutynin
0 ImagesCat. No.: HY-B0267CCAS No.: 119618-21-2Synonyms: Aroxybutynin(R)-Oxybutynin (Aroxybutynin), an enantiomer of Oxybutynin, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin exhibits antispasmodic and anticholinergic activities, and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used in the research of urinary incontinence caused by neurogenic bladder dysfunction.
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CHF-6366
0 ImagesCat. No.: HY-151198CAS No.: 1615208-41-7CHF-6366 is a potent M3 muscarinic antagonist and β2-adrenergic receptors agonist with pKi values of 10.4 and 11.4, respectively. CHF-6366 is also a weak calcium channel inhibitor (IC50~50 μM). CHF-6366 inhibits bronchoconstriction in guinea pigs. CHF-6366 can be used to research chronic obstructive pulmonary disease (COPD).
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Bethanechol chloride (Standard)
0 ImagesSynonyms: Carbamyl-β-methylcholine chloride (Standard)Bethanechol (chloride) (Standard) is the analytical standard of Bethanechol (chloride). This product is intended for research and analytical applications. Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system.
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Arecoline hydrochloride
0 ImagesArecoline hydrochloride, a naturally brain-penetrant and orally active occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrochloride exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrochloride also can induce oxidative stress.
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VU6005806
0 ImagesCat. No.: HY-128584CAS No.: 2180914-37-6Synonyms: AZN-00016130VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders.
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VU6021625
0 ImagesCat. No.: HY-160440ACAS No.: 2803696-99-1VU6021625 is a selective antagonist muscarinic acetylcholine receptors (mAChRs), with the IC50 value of 0.44 nM, 57 nM for human M4 and rat M4, respectively.
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TD-6301
0 ImagesCat. No.: HY-171843CAS No.: 690999-15-6TD-6301 is a bladder-selective M2/4 muscarinic receptor antagonist. TD-6301 binds to and blocks M2/4 muscarinic receptors with high selectivity, especially human M2 receptors with strong affinity (Ki = 0.36 nM). TD-6301 inhibits volume-induced bladder contractions (ID50 = 0.075 mg/kg). TD-6301 can be used in the research of overactive bladder.
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Pargeverine hydrochloride
0 ImagesCat. No.: HY-W742955CAS No.: 2765-97-1Pargeverine hydrochloride is an antispasmodic opioid alkaloid. Pargeverine hydrochloride has a moderate and non-selective blockade of muscarinic cholinergic fibers. Pargeverine hydrochloride can be used in the research of painful spasms.
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Batefenterol Succinate
0 ImagesCat. No.: HY-12980ACAS No.: 945905-37-3Synonyms: GSK961081 Succinate; TD-5959 SuccinateBatefenterol Succinate (GSK961081 Succinate) is a first-of-its-kind inhaled bifunctional bronchodilator with smooth muscle relaxant properties. The activities of Batefenterol Succinate include acting as a smooth muscle parasympathetic antagonist and a beta2-adrenoceptor agonist. Batefenterol Succinate is used to improve respiratory function, especially in patients with chronic obstructive pulmonary disease (COPD).
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VU6016235
0 ImagesCat. No.: HY-169178CAS No.: 2344787-70-6VU6016235 is a highly selective, orally available, positive allosteric modulator of the M4 mAChR with in vivo inhibitory potency in animal models of psychosis..
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Telenzepine
0 ImagesCat. No.: HY-B1789CAS No.: 80880-90-6Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM).
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Desalkylquazepam
0 ImagesCat. No.: HY-W664824CAS No.: 1645-32-5Synonyms: N-DesmethylquazepamDesalkylquazepam (Compound 23; N-Desmethylquazepam) is a precursor in the synthesis of triazolobenzodiazepines. Desalkylquazepam is a mAChR modulator (EC 50 = 0.317 µM).
![[D-Trp7,9,10]-Substance P TFA](https://file.medchemexpress.com/product_pic/hy-p1375a.gif "Click to View [D-Trp7,9,10]-Substance P TFA Product Detail")
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Sabcomeline-d3 hydrochloride
0 ImagesCat. No.: HY-106432ASSynonyms: SB-202026-d3 hydrochloride; Memric-d3 hydrochlorideSabcomeline-d3 (SB-202026-d3) hydrochloride is the deuterated-labeled Sabcomeline hydrochloride (HY-106432A). Sabcomeline (SB-202026; Memric) hydrochloride is a muscarinic receptor agonist capable of crossing the blood-brain barrier. Sabcomeline hydrochloride exhibits affinity for all hM1 to hM5 subtypes (pKi=6.72-7.23), and shows near-full agonism at the hM3 receptor, inducing extracellular acidification. Sabcomeline hydrochloride alters the binding kinetics of dopamine D2 receptors through neural network regulation. Sabcomeline hydrochloride also causes minimal cardiovascular changes, effectively reverses spatial memory deficits in rodents and induces conditioned taste aversion. Sabcomeline hydrochloride is an important tool compound in studies of Alzheimer's disease and related neurodegenerative diseases.
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VU6007678
0 ImagesCat. No.: HY-123778CAS No.: 2222737-15-5VU6007678 is a CNS-penetrant muscarinic acetylcholine receptor (mAChR) modulator. VU6007678 potentiates acetylcholine-mediated signaling at human M1, M3, M5 and rat M1, M3, M4, M5 muscarinic acetylcholine receptors. VU6007678 is applicable to research related to Alzheimer's disease, schizophrenia, and ischemic stroke.
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Bibn 140
0 ImagesCat. No.: HY-117966CAS No.: 145301-79-7Bibn 140 is a pyridine derivative substituted with a benzene ring, which has high affinity (Ki: 12 nM) and selectivity for M2 mAChR receptors over M1 receptors.
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Promethazine-d4
0 ImagesCat. No.: HY-B1296S1CAS No.: 1173147-64-2Synonyms: (±)-Promethazine-d4; N,N-dimethyl-1-phenothiazin-10-yl-propan-2-amine-d4
