Transmembrane Glycoprotein
Transmembrane Glycoprotein
Transmembrane glycoproteins are important components of cell membranes and are characterized by oligosaccharide chains covalently linked to polypeptide chains. Glycosylation sites are mainly located in their extracellular regions, achieved by N-linked glycosylation (linked to asparagine residues) or O-linked glycosylation (linked to serine or threonine residues). Sugar chains not only provide structural stability to proteins but also confer functional specificity. Many transmembrane glycoproteins are receptors, such as G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Most （clusters of differentiation）CD molecules are also transmembrane glycoproteins expressed on the surface of antigen-presenting cells[1][2].
References:
- [1]. L Franco, et al. The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes. FASEB J. 1998 Nov;12(14):1507-20. [Content Brief]
- [2]. Kumi Oshima, et al. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 2002 May 22;519(1-3):1-7. [Content Brief]
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Transmembrane Glycoprotein Inhibitors
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Transmembrane Glycoprotein Agonists
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Transmembrane Glycoprotein Antagonists
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Transmembrane Glycoprotein Activators
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Transmembrane Glycoprotein Modulators
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Transmembrane Glycoprotein Ligands
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Transmembrane Glycoprotein Related Products (380)
Related Products (380)
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E8431
0 ImagesCat. No.: HY-180801CAS No.: 2419580-01-9E8431 is a DCSTAMP antagonist with an IC50 value of 775.8 nM for osteoclastogenesis. E8431 selectively binds to the endoplasmic reticulum domain of DCSTAMP, disrupts its interaction with RAP1B, and inhibits downstream cytoskeleton rearrangement mediated by the RAP1-RAC1 signaling pathway, thereby impeding osteoclast precursor fusion, suppressing bone resorption, and stimulating PDGFBB secretion to promote osteogenesis and angiogenesis. E8431 can be used in the research of osteoporosis.
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AE105 TFA
0 ImagesCat. No.: HY-P11446AAE105 TFA is a 9-mer peptide probe targeting the urokinase-type plasminogen activator receptor (uPAR). AE105 TFA binds tightly to the uPA-binding cavity of uPAR. AE105 TFA can be used for the study of cancer.
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GPR110 peptide agonist P12
0 ImagesCat. No.: HY-P10495CAS No.: 1778685-49-6GPR110 peptide agonist P12 is a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 can be used in the study of developmental disorders and cancers related to GPR110.
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Anti-CEACAM1/CD66a Antibody
0 ImagesCat. No.: HY-P990364Anti-CEACAM1/CD66a Antibody is a human antibody expressed in CHO cells that targets CEACAM1/CD66a. The Anti-CEACAM1/CD66a Antibody is equipped with huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 144.98 kDa. The isotype control for the Anti-CEACAM1/CD66a Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Zomepirac acyl-O-β-D-glucuronide
0 ImagesCat. No.: HY-W121887CAS No.: 75871-31-7Synonyms: Zomepirac glucuronideZomepirac acyl-O-β-D-glucuronide (Zomepirac glucuronide) is a dipeptidyl peptidase IV Inhibitor. Zomepirac acyl-O-β-D-glucuronide is an unstable and chemically reactive metabolite of Zomepirac (HY-B0890A). Zomepirac acyl-O-β-D-glucuronide forms covalent adducts with cell membrane glycoproteins. Zomepirac acyl-O-β-D-glucuronide can be used for research on immunotoxicity.
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Anti-Mouse CD18 Antibody (M18/2)
0 ImagesCat. No.: HY-P990288Anti-Mouse CD18 Antibody (M18/2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD18. Anti-Mouse CD18 Antibody (M18/2) can neutralize lymphocyte function-associated antigen 1 (LFA-1). Anti-Mouse CD18 Antibody (M18/2) can be used for the researches of immunology, such as heart transplantation.
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BAT-6005
0 ImagesCat. No.: HY-P991389BAT-6005 is a human monoclonal antibody (mAb) targeting TIGIT. BAT-6005 can be used in Tumor Immunity research.
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ZV05
0 ImagesCat. No.: HY-P992488Purity: ≥99.0%Synonyms: ZV0501 AntibodyZV05 (ZV0501 Antibody) is an anti-5T4 monoclonal antibody with an EC50 of 4.3 ng/mL against h5T4. ZV05 does not induce apoptosis or interfere with cell cycle progression. ZV05 accumulates specifically in 5T4-positive tumor xenografts. ZV05 can serve as the antibody component of antibody-active molecule conjugates (ADCs) to bind the 5T4 glycoprotein, thereby enabling targeted delivery of toxins. ZV05 is used in studies of 5T4-positive cancers, including triple-negative breast cancer.
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Anti-Mouse CD8α Antibody (YTS 105.18)
0 ImagesCat. No.: HY-P992063Purity: 99.9%Anti-Mouse CD8α Antibody (YTS 105.18) is a non-depleting rat IgG2a monoclonal antibody that binds to CD8α on mouse CD8+ T cells. When used in combination with a non-depleting anti-CD4 antibody, Anti-Mouse CD8α Antibody (YTS 105.18) does not deplete CD8+ T cells, but instead promotes the induction of peripheral tolerance in this cell subset. Anti-Mouse CD8α Antibody (YTS 105.18) can be used for research on graft rejection. The recommended isotype control is Mouse IgG2a kappa, Isotype Control (HY-P99978).
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Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1)
0 ImagesCat. No.: HY-P990168Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse Podoplanin/glycoprotein 38. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) blocks podoplanin binding to C-type lectin receptor CLEC-2. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) can be used for the research of cancer and inflammation, such as lung inflammation.
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Anti-Mouse CD326/EpCAM Antibody (G8.8)
0 ImagesCat. No.: HY-P990275Anti-Mouse CD326/EpCAM Antibody (G8.8) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD326/EpCAM. Anti-Mouse CD326/EpCAM Antibody (G8.8) reacts with CD326 also known as EpCAM (Epithelial Cell Adhesion Molecule). Anti-Mouse CD326/EpCAM Antibody (G8.8) can be used for cancer research, such as lung carcinoma and colorectal carcinoma. Anti-Mouse CD326/EpCAM Antibody (G8.8) can be used for detections of western blot, immunohistochemistry, immunofluorescence and flow cytometry.
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CD63-1 aptamer sodium
0 ImagesCat. No.: HY-160050CD63-1 aptamer sodium is a high-affinity and specific DNA aptamer targeting the CD63 protein (Kd = 38.71 nM). CD63-1 aptamer sodium effectively binds to CD63-positive cells and serves as an exosome isolation reagent. CD63-1 aptamer sodium is applicable to breast cancer-related research.
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Anafiltamig
0 ImagesCat. No.: HY-P991671CAS No.: 3009026-69-8Synonyms: JNJ-80948543Anafiltamig is a trivalent monoclonal antibody inhibitor targeting CD79B, CD3E and MS4A1. Anafiltamig consists of a humanized IgG1κ anti-CD79B arm and a bispecific scFv-based arm targeting CD3E and MS4A1. Anafiltamig simultaneously bridges T and B cells, activating T cells and specifically killing B cell tumors. Anafiltamig can be used for B cell malignancies such as non-Hodgkin lymphoma research.
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Anti-Rat CD4 Antibody (OX-38)
0 ImagesCat. No.: HY-P990135Purity: 98.91%
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AMG-211
0 ImagesCat. No.: HY-P991469Purity: 99.26%Synonyms: MEDI-565
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Anti-CD59 Antibody
0 ImagesCat. No.: HY-P990356Purity: 99.82%Anti-CD59 Antibody is a CHO-expressed humanized antibody that targets CD59. The Anti-CD59 Antibody has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CD59 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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AMG-172
0 ImagesCat. No.: HY-185483AMG-172 is an antibody-drug conjugate (ADC) composed of a fully human IgG1 monoclonal anti-CD27L antibody conjugated to DM1 (HY-19792) via the non-cleavable linker MCC. AMG-172 releases the intracellular active component Lysine-MCC-DM through catabolism. Lysine-MCC-DM inhibits the assembly and disassembly dynamics of Microtubule and induces cell arrest at metaphase. AMG-172 can be used for research on relapsed/refractory clear cell renal cell carcinoma.
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MDX-1203
0 ImagesCat. No.: HY-185484Synonyms: BMS-936561MDX-1203 (BMS-936561) is an antibody-drug conjugate targeting CD70. MDX-1203 binds to CD70 and mediates the specific delivery of its conjugated cytotoxic payload to tumors. MDX-1203 delivers a DNA alkylating payload into cells. MDX-1203 can be used in research related to advanced clear cell renal cell carcinoma and relapsed/refractory B-cell non-Hodgkin lymphoma.
