Art. -Nr.: HY-112080

BAY-6035

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BAY-6035, a chemical probe, is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC₅₀ of 88 nM.

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Reinheit: 99.51%
CAS. Nr.: 2247890-13-5
Formel: C₂₂H₂₈N₄O₃
Molecular Weight:396.48

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

BAY-6035 Chemical Structure

CAS. Nr.: 2247890-13-5

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

BAY-6035, a chemical probe, is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC₅₀ of 88 nM^[1].

IC₅₀ & Target^[1]

SMYD3

88 nM (IC₅₀)

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
COLO-679	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Antiproliferative activity against human COLO-679 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Antiproliferative activity against human COLO-679 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]
HaCaT	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Antiproliferative activity against human HaCaT cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Antiproliferative activity against human HaCaT cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]
HGC-27	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]
Hs-578T	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]
Hs746T	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Antiproliferative activity against human Hs746T cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Antiproliferative activity against human Hs746T cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]
HT-29	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]
Jurkat	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Antiproliferative activity against human Jurkat cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]
KYSE-30	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]
MCF-10A	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]
MDA-MB-231	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]
PaTu 8988t	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Antiproliferative activity against human PaTu 8988t cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Antiproliferative activity against human PaTu 8988t cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]
SUD4	IC₅₀	>1 x 10^-5mol/L Compound: Chemical probe: BAY-6035; Compound 31	Antiproliferative activity against human SU-DHL-4 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay Antiproliferative activity against human SU-DHL-4 cells assessed as inhibition of cell viability measured for 3 to 5 days by alamar blue staining based assay	[PMID: 34154424]

In Vitro

BAY-6035 inhibits in vitro methylation of MEKK2 peptide with an IC₅₀ of 88 nM and has more than 100-fold selectivity over other histone methyltransferases^[1].
BAY-6035 inhibits the methylation of MEKK2 in cells with an IC₅₀ of 70 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2247890-13-5
Appearance Solid
Molecular Weight 396.48
Formel C₂₂H₂₈N₄O₃
Color White to off-white
SMILES

O=C1C[C@H](C)N(C(N2CC(C3)C3C2)=O)C4=CC=C(C(NCCC5CC5)=O)C=C4N1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (252.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5222 mL

12.6110 mL

25.2220 mL

5 mM

0.5044 mL

2.5222 mL

5.0444 mL

10 mM

0.2522 mL

1.2611 mL

2.5222 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Edoardo F, et, al. Small-molecule inhibitors of lysine methyltransferases SMYD2 and SMYD3: current trends. Future Med Chem. 2019 Apr; 11(8): 901-921. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5222 mL	12.6110 mL	25.2220 mL	63.0549 mL
	5 mM	0.5044 mL	2.5222 mL	5.0444 mL	12.6110 mL
	10 mM	0.2522 mL	1.2611 mL	2.5222 mL	6.3055 mL
	15 mM	0.1681 mL	0.8407 mL	1.6815 mL	4.2037 mL
	20 mM	0.1261 mL	0.6305 mL	1.2611 mL	3.1527 mL
	25 mM	0.1009 mL	0.5044 mL	1.0089 mL	2.5222 mL
	30 mM	0.0841 mL	0.4204 mL	0.8407 mL	2.1018 mL
	40 mM	0.0631 mL	0.3153 mL	0.6305 mL	1.5764 mL
	50 mM	0.0504 mL	0.2522 mL	0.5044 mL	1.2611 mL
	60 mM	0.0420 mL	0.2102 mL	0.4204 mL	1.0509 mL
	80 mM	0.0315 mL	0.1576 mL	0.3153 mL	0.7882 mL
	100 mM	0.0252 mL	0.1261 mL	0.2522 mL	0.6305 mL

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BAY-6035

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Chemical Probe Library

Anti-Blood Cancer Compound Library

Transcription Factor-Targeted Library

Cancer Stem Cells Compound Library

Heterocyclic Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

Epigenetics Compound Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

Methylation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

BAY-6035

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Chemical Probe Library

Anti-Blood Cancer Compound Library

Transcription Factor-Targeted Library

Cancer Stem Cells Compound Library

Heterocyclic Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

Epigenetics Compound Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

Methylation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

BAY-6035 Related Classifications

HY-112080 Related Classifications