BER-IN-1
BER-IN-1 is a base excision repair (BER) inhibtor, targeting DNA abasic sites. BER-IN-1 cleaves abasic sites via β- and β,δ-elimination mechanisms, disrupts the base excision repair (BER) pathway and leads to DNA double-strand breaks (DSBs). BER-IN-1 can enhance the effectiveness of the PARP inhibitor Olaparib (HY-10162) in homologous recombination (HR)-proficient cancer cells (MDA-MB-231, HeLa, and SKOV3). BER-IN-1 induces an S-phase arrest and apoptosis companied with Olaparib (HY-10162). BER-IN-1 can be used for the research of cancer, such as breast, cervical and ovarian cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C13H17N5
- Molecular Weight:243.31
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
PARP-1 |
BER-IN-1 (Compound BA-6) shows IC50 of 10.92 μM for MDA-MB-231, 6.37 μM for HeLa, 7.76 μM for SKOV3 and 5.53 μM for OVCAR3BRCA1−/− cells[1].
BER-IN-1 (0.7-50 μM, 24-72 h) significantly reduces cell viability companied with Olaparib (HY-10162) in MDA-MB-231, HeLa and OVCAR3BRCA1−/− cells[1].
BER-IN-1 (5-10 μM) inhibits colony formation companied with Olaparib in MDA-MB-231 and HeLa cancer cells[1].
BER-IN-1 (5-50 μM) increased prominent β-elimination products and induces DNA DSBs companied with Olaparib in MDA-MB-231 and HeLa cancer cells[1].
BER-IN-1 (5-10 μM, 24 h) induces S-phase arrest and apoptosis companied with Olaparib in MDA-MB-231 and HeLa cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-231, HeLa and OVCAR3BRCA1−/− cells
-
Concentration:0.7, 1.5, 3.1, 6.2, 12.5, 25 and 50 μM
-
Incubation Time:24 or 72 h, companied with Olaparib (0.15-200 μM)
-
Result:Significantly reduced cell viability.
-
Cell Line:MDA-MB-231 and HeLa cancer cells
-
Concentration:5 and 10 μM
-
Incubation Time:24 h, companied with Olaparib (5-10 μM)
-
Result:Increased cells in the G2/M phase and S-phase arrest.
Chemical Information
-
Molecular Weight 243.31
-
Formel C13H17N5
-
SMILES
NC1=CC=C2N=C(N(C)CCCN3C)C3=NC2=C1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BER-IN-1 Related Classifications
HY-175466 Related Classifications
Powered by Bioz