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Art. -Nr.: HY-134899

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CPI-1328

CPI-1328 is an EZH2 inhibitor with a K_i value of 63 fM.

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CAS. Nr.: 2390367-27-6
Formel: C₂₈H₃₆ClN₃O₄S
Molecular Weight:546.12

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

CPI-1328 Chemical Structure

CAS. Nr.: 2390367-27-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CPI-1328 is an EZH2 inhibitor with a K_i value of 63 fM.

IC₅₀ & Target

EZH2

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	0.849 nM Compound: 83	Antiproliferative activity against human HeLa cells Antiproliferative activity against human HeLa cells	[PMID: 35531606]
KARPAS-422	GI₅₀	5.7 nM Compound: 83	Antiproliferative activity against human KARPAS-422 cells assessed as inhibition of cell growth Antiproliferative activity against human KARPAS-422 cells assessed as inhibition of cell growth	[PMID: 35531606]

Chemical Information

CAS. Nr. 2390367-27-6
Molecular Weight 546.12
Formel C₂₈H₃₆ClN₃O₄S
SMILES

ClC1=C2C(O[C@](O2)([C@]3([H])CC[C@H](CC3)N(C)C)C)=C(C4=C1CCN(C4=O)CC5=C(C=C(NC5=O)C)SC)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Stuckey JI, et al. Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity. J Biol Chem. 2021 Jan-Jun;296:100349. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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CPI-1328

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CPI-1328 Related Classifications

HY-134899 Related Classifications